SI0770070T1 - Method for preparing 4-acetoxy-2alpha-benzoyloxy-5alpha,20-epoxy-1,7beta,10beta-trihydroxy-9-oxo-tax-11-en-13alpha-yl(2r,3s)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate trihydrate - Google Patents

Method for preparing 4-acetoxy-2alpha-benzoyloxy-5alpha,20-epoxy-1,7beta,10beta-trihydroxy-9-oxo-tax-11-en-13alpha-yl(2r,3s)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate trihydrate

Info

Publication number
SI0770070T1
SI0770070T1 SI9530138T SI9530138T SI0770070T1 SI 0770070 T1 SI0770070 T1 SI 0770070T1 SI 9530138 T SI9530138 T SI 9530138T SI 9530138 T SI9530138 T SI 9530138T SI 0770070 T1 SI0770070 T1 SI 0770070T1
Authority
SI
Slovenia
Prior art keywords
beta
butoxycarbonylamino
benzoyloxy
trihydroxy
tax
Prior art date
Application number
SI9530138T
Other languages
English (en)
Slovenian (sl)
Inventor
Jean-Rene Authelin
Jacques Doveze
Elie Fouque
Bernadette Mandard
Isabelle Taillepied
Original Assignee
Rhone-Poulenc Rorer S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9465183&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SI0770070(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Rhone-Poulenc Rorer S.A. filed Critical Rhone-Poulenc Rorer S.A.
Publication of SI0770070T1 publication Critical patent/SI0770070T1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
SI9530138T 1994-07-08 1995-07-07 Method for preparing 4-acetoxy-2alpha-benzoyloxy-5alpha,20-epoxy-1,7beta,10beta-trihydroxy-9-oxo-tax-11-en-13alpha-yl(2r,3s)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate trihydrate SI0770070T1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9408479A FR2722191B1 (fr) 1994-07-08 1994-07-08 Procede de preparation du trihydrate du (2r,3s)-3-tertbutoxycarbonylamino-2-hydroxy-3-phenylpropionate de 4-acetoxy2alpha-benzoyloxy-5beta,20epoxy-1,7beta,10beta trihydroxy-9-oxo-tax-11-en-13alpha-yle
PCT/FR1995/000910 WO1996001815A1 (fr) 1994-07-08 1995-07-07 PROCEDE DE PREPARATION DU TRIHYDRATE DU (2R,3S)-3-TERT-BUTOXYCARBONYLAMINO-2-HYDROXY-3-PHENYLPROPIONATE DE 4-ACETOXY-2α-BENZOYLOXY-5β,20-EPOXY-1,7β,10β-TRIHYDROXY-9-OXO-TAX-11-EN-13α-YLE
EP95925022A EP0770070B1 (fr) 1994-07-08 1995-07-07 Procede de preparation du trihydrate du (2r,3s)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate de 4-acetoxy-2alpha-benzoyloxy-5beta,20-epoxy-1,7beta,10beta-trihydroxy-9-oxo-tax-11-en-13alpha-yle

Publications (1)

Publication Number Publication Date
SI0770070T1 true SI0770070T1 (en) 1998-12-31

Family

ID=9465183

Family Applications (1)

Application Number Title Priority Date Filing Date
SI9530138T SI0770070T1 (en) 1994-07-08 1995-07-07 Method for preparing 4-acetoxy-2alpha-benzoyloxy-5alpha,20-epoxy-1,7beta,10beta-trihydroxy-9-oxo-tax-11-en-13alpha-yl(2r,3s)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate trihydrate

Country Status (38)

Country Link
US (1) US6022985A (OSRAM)
EP (1) EP0770070B1 (OSRAM)
JP (1) JP3753155B2 (OSRAM)
KR (1) KR100391753B1 (OSRAM)
CN (1) CN1067996C (OSRAM)
AT (1) ATE171702T1 (OSRAM)
AU (1) AU706519B2 (OSRAM)
BR (1) BR9508789A (OSRAM)
CA (1) CA2193531C (OSRAM)
CO (1) CO4410189A1 (OSRAM)
CZ (1) CZ284695B6 (OSRAM)
DE (1) DE69505128T2 (OSRAM)
DK (1) DK0770070T3 (OSRAM)
DZ (1) DZ1905A1 (OSRAM)
ES (1) ES2121404T3 (OSRAM)
FI (1) FI119246B (OSRAM)
FR (1) FR2722191B1 (OSRAM)
GR (1) GR3027558T3 (OSRAM)
HU (1) HU220634B1 (OSRAM)
IL (1) IL114274A (OSRAM)
IN (1) IN183947B (OSRAM)
IS (1) IS2032B (OSRAM)
MA (1) MA23606A1 (OSRAM)
MX (1) MX9700173A (OSRAM)
MY (1) MY118481A (OSRAM)
NO (1) NO314500B1 (OSRAM)
NZ (1) NZ289455A (OSRAM)
PE (1) PE8697A1 (OSRAM)
PL (1) PL179876B1 (OSRAM)
RU (1) RU2126397C1 (OSRAM)
SI (1) SI0770070T1 (OSRAM)
SK (1) SK280520B6 (OSRAM)
TN (1) TNSN95071A1 (OSRAM)
TW (1) TW419473B (OSRAM)
UA (1) UA51624C2 (OSRAM)
UY (1) UY23991A1 (OSRAM)
WO (1) WO1996001815A1 (OSRAM)
ZA (1) ZA955646B (OSRAM)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001523103A (ja) 1997-04-28 2001-11-20 ローヌ−プーラン・ロレ・エス・アー 腫瘍治療用血管形成アンタゴニストのアデノウイルスによる腫瘍内送達
SE510650C2 (sv) * 1997-05-30 1999-06-14 Astra Ab Ny förening
FR2794771B1 (fr) 1999-06-11 2001-08-10 Aventis Pharma Sa Adenovirus recombinants codant pour le transporteur specifique de l'iode (nis)
US6266619B1 (en) * 1999-07-20 2001-07-24 Halliburton Energy Services, Inc. System and method for real time reservoir management
US6853921B2 (en) 1999-07-20 2005-02-08 Halliburton Energy Services, Inc. System and method for real time reservoir management
GB9920548D0 (en) * 1999-08-31 1999-11-03 Rhone Poulenc Rorer Sa Treatment of hepatocellular carcinoma
US6891050B2 (en) * 2001-08-10 2005-05-10 Dabur India Limited Process for the preparation of taxanes such as paclitaxel, docetaxel and structurally similar analogs
US6881852B2 (en) * 2002-02-05 2005-04-19 Dabur India Limited Process of purification of paclitaxel and docetaxel
US7247738B2 (en) * 2002-05-07 2007-07-24 Dabur India Limited Method of preparation of anticancer taxanes using 3-[(substituted-2-trialkylsilyl) ethoxycarbonyl]-5-oxazolidine carboxylic acids
US6900342B2 (en) * 2002-05-10 2005-05-31 Dabur India Limited Anticancer taxanes such as paclitaxel, docetaxel and their structural analogs, and a method for the preparation thereof
US6838569B2 (en) * 2002-12-16 2005-01-04 Dabur India Limited Process for preparation of paclitaxel trihydrate and docetaxel trihydrate
US7584165B2 (en) * 2003-01-30 2009-09-01 Landmark Graphics Corporation Support apparatus, method and system for real time operations and maintenance
US8703982B2 (en) 2003-03-17 2014-04-22 Phyton Holdings Llc Purification of taxanes
CN1268619C (zh) * 2003-05-08 2006-08-09 上海迪赛诺化学制药有限公司 多烯紫杉醇三水化合物的制备方法
FR2859996B1 (fr) * 2003-09-19 2006-02-03 Aventis Pharma Sa Solvat acetonique du dimethoxy docetaxel et son procede de preparation
ATE427943T1 (de) 2003-12-12 2009-04-15 Quiral Quimica Do Brasil Verfahren zur herstellung von wasserfreien und hydratisierten pharmazeutischen wirkstoffen (apis); aus diesen hergestellte stabile pharmazeutische zusammensetzungen und anwendungen fur diese zusammensetzungen
US7142986B2 (en) * 2005-02-01 2006-11-28 Smith International, Inc. System for optimizing drilling in real time
CN100420681C (zh) * 2005-04-29 2008-09-24 上海奥锐特国际贸易有限公司 多烯紫杉醇三水物的制备方法
JP5368093B2 (ja) * 2005-08-31 2013-12-18 アブラクシス バイオサイエンス， エルエルシー 増大した安定性を有する難水溶性薬剤の組成物および調製の方法
TR200801337T1 (tr) * 2005-08-31 2008-07-21 Abraxis Bioscience, Llc. Suda zayıf çözülebilen farmasötik ajanlar ve antimikrobiyal ajanlar içeren kompozisyonlar.
TW200730518A (en) * 2005-10-12 2007-08-16 Sicor Inc Crystalline forms of docetaxel and processes for their preparation
KR100995390B1 (ko) 2006-01-02 2010-11-19 주식회사 삼양제넥스 무정형, 무수결정형 또는 수화 결정형 도세탁셀의 제조방법
MX2008009308A (es) * 2006-01-20 2008-10-03 Landmark Graphics Corp Administracion del sistema de produccion dinamica.
AU2007226937A1 (en) * 2006-03-21 2007-09-27 Dr. Reddy's Laboratories Ltd. Docetaxel polymorphs and processes
NZ576355A (en) * 2006-10-20 2012-04-27 Scinopharm Singapore Pte Ltd Process for making crystalline anhydrous docetaxel
KR100868116B1 (ko) 2007-04-09 2008-11-10 한미약품 주식회사 도세탁셀·모노프로필렌글라이콜 내포화합물 및 이의제조방법
KR100878455B1 (ko) 2007-04-10 2009-01-13 한미약품 주식회사 안정한 무수결정형 도세탁셀 및 이의 제조방법
WO2009006590A2 (en) * 2007-07-04 2009-01-08 Dr. Reddy's Laboratories Ltd. Docetaxel process and polymorphs
EP2080763A1 (en) * 2008-01-18 2009-07-22 INDENA S.p.A. Crystalline form I of ortataxel
DK2080764T3 (da) * 2008-01-18 2012-09-24 Indena Spa Faste former af ortataxel
PL388144A1 (pl) 2009-05-29 2010-12-06 Przedsiębiorstwo Produkcyjno-Wdrożeniowe Ifotam Spółka Z Ograniczoną Odpowiedzialnością Solwaty (2R,3S)-3-tert-butoksykarbonylamino-2-hydroksy-3-fenylopropionianu 4-acetoksy-2α-benzoiloksy -5β,20-epoksy-1,7β,10β-trihydroksy-9-okso-taks-11-en-13α-ylu, sposób ich otrzymywania i zastosowanie
EP2330100B1 (en) 2009-11-04 2017-01-11 Emcure Pharmaceuticals Limited An improved process for preparation of taxane derivatives
BR112012028037A2 (pt) 2010-05-03 2016-08-02 Teikoku Pharma Usa Inc formulação de pró-emulsão líquida de taxano não aquosa, métodos para administrar um taxano a um paciente e para fabricar uma formulação de pró-emulsão de taxano, composição de emulsão de taxano, e, kit
WO2012160568A1 (en) * 2011-05-23 2012-11-29 Shilpa Medicare Limited Process for preparing docetaxel trihydrate polymorph
ES2704632T3 (es) 2011-09-08 2019-03-19 Univ New York Virus de herpes simplex oncolítico y sus usos terapéuticos
WO2013096455A1 (en) 2011-12-20 2013-06-27 Dana-Farber Cancer Institute, Inc. Methods for diagnosing and treating oncogenic kras-associated cancer
LT2833905T (lt) 2012-04-04 2018-07-10 Halozyme, Inc. Derinių terapija su hialuronidaze ir į naviką nukreiptu taksanu
CA2874521A1 (en) 2012-05-24 2013-11-28 Dana-Farber Cancer Institute, Inc. Targeting the glutamine to pyruvate pathway for treatment of oncogenic kras-associated cancer
US20150285802A1 (en) 2012-07-18 2015-10-08 Dana-Farber Cancer Institute, Inc. Methods for treating, preventing and predicting risk of developing breast cancer
JO3685B1 (ar) 2012-10-01 2020-08-27 Teikoku Pharma Usa Inc صيغ التشتيت الجسيمي للتاكسين غير المائي وطرق استخدامها
EP2968406A4 (en) 2013-03-14 2016-10-26 Icahn School Med Mount Sinai WITH AUTOLOGOUS TUMORLYSAT-LOADED DENDRITIC CELL VACCINE FOR THE TREATMENT OF LIVER CANCER
US10130590B2 (en) 2013-10-01 2018-11-20 Dana-Farber Cancer Institute, Inc. Methods of treating cancer with atovaquone-related compounds
WO2015149006A2 (en) 2014-03-27 2015-10-01 Dana-Farber Cancer Institute, Inc. Compositions and methods for modulating ncoa4-mediated autophagic targeting of ferritin
MA39818A (fr) 2014-03-30 2017-02-08 Benevir Biopharm Inc Virus oncolytiques « armés » comprenant un inhibiteur de tap exogène et leurs utilisations thérapeutiques
EP3307330B1 (en) 2015-06-15 2021-03-10 New York University Method of treatment using oncolytic viruses
WO2019222435A1 (en) 2018-05-16 2019-11-21 Halozyme, Inc. Methods of selecting subjects for combination cancer therapy with a polymer-conjugated soluble ph20

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2601675B1 (fr) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent
US5229526A (en) * 1991-09-23 1993-07-20 Florida State University Metal alkoxides

Also Published As

Publication number Publication date
TW419473B (en) 2001-01-21
SK280520B6 (sk) 2000-03-13
FR2722191B1 (fr) 1996-08-23
US6022985A (en) 2000-02-08
JPH10502627A (ja) 1998-03-10
DK0770070T3 (da) 1999-03-01
CA2193531C (fr) 2006-12-05
ATE171702T1 (de) 1998-10-15
KR100391753B1 (ko) 2004-02-11
CO4410189A1 (es) 1997-01-09
ZA955646B (en) 1996-02-21
CN1151741A (zh) 1997-06-11
AU2930595A (en) 1996-02-09
WO1996001815A1 (fr) 1996-01-25
FI970069L (fi) 1997-01-07
CZ284695B6 (cs) 1999-02-17
MA23606A1 (fr) 1996-04-01
NO314500B1 (no) 2003-03-31
ES2121404T3 (es) 1998-11-16
PE8697A1 (es) 1997-03-26
IL114274A (en) 1999-04-11
PL318195A1 (en) 1997-05-26
NO970007L (no) 1997-01-02
TNSN95071A1 (fr) 1996-02-06
FI970069A0 (fi) 1997-01-07
DE69505128D1 (de) 1998-11-05
CN1067996C (zh) 2001-07-04
FI119246B (fi) 2008-09-15
UY23991A1 (es) 1995-09-20
HU9700041D0 (en) 1997-02-28
NZ289455A (en) 1997-12-19
CZ3597A3 (en) 1997-04-16
HU220634B1 (hu) 2002-03-28
EP0770070B1 (fr) 1998-09-30
PL179876B1 (pl) 2000-11-30
KR970704721A (ko) 1997-09-06
IL114274A0 (en) 1995-10-31
SK697A3 (en) 1997-06-04
IS4411A (is) 1997-01-07
UA51624C2 (uk) 2002-12-16
NO970007D0 (no) 1997-01-02
DZ1905A1 (fr) 2002-02-17
IN183947B (OSRAM) 2000-05-20
MX9700173A (es) 1997-04-30
FR2722191A1 (fr) 1996-01-12
JP3753155B2 (ja) 2006-03-08
DE69505128T2 (de) 1999-04-01
AU706519B2 (en) 1999-06-17
BR9508789A (pt) 1997-10-21
RU2126397C1 (ru) 1999-02-20
MY118481A (en) 2004-11-30
GR3027558T3 (en) 1998-11-30
HUT76833A (en) 1997-11-28
CA2193531A1 (fr) 1996-01-25
IS2032B (is) 2005-08-15
EP0770070A1 (fr) 1997-05-02

Similar Documents

Publication Publication Date Title
GR3027558T3 (en) Method for preparing 4-acetoxy-2alpha-benzoyloxy-5alpha,20-epoxy-1,7beta,10beta-trihydroxy-9-oxo-tax-11-en-13alpha-yl(2r,3s)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate trihydrate
MD1976B2 (ro) Produs din tutun sau articole similare produselor din tutun conţinând substanţe naturale cu proprietăţi antioxidante şi procedeu de obţinere a acestora
ATE216576T1 (de) Vehrfahren zur herstellung von beta-lactam antibiotikum enthaltenden oralen dosisformen
CZ255793A3 (en) Process for preparing an admixture comprising micro-organisms with increased content of at least one trace element
TW356469B (en) Process for the preparation of 4,10-diacetoxy-2<alpha>-benzoyloxy-5<beta>, 20-epoxy-1,7<beta>-dihydroxy-9-oxo-tax-11-en-13<alpha>-YL(2R,3S)-3-benzoylamino-2-hydroxy-3-phenylpropionate trihydrate
EP0714877A3 (en) Process for the preparation of alpha-phenylethyl alcohol
DE69507150D1 (de) Gelbildende präparate, die optisch angereicherte gelbildner enthalten
AU3698797A (en) Method for producing natural diol-1,3 derivatives and corresponding natural 1,3-dioxane derivatives
JPS57144986A (en) Preparation of lipid having high content of gamma-linolenic acid
JPS57145896A (en) Glycolipid and its preparation by fermentation
PL310207A1 (en) Nisatidin containing pharmaceutical agent, method of obtaining nisatidin in its specific form and specific form of nisatidin as such
ES485529A1 (es) Un procedimiento para la produccion de ravidomicina
MD460G2 (ro) Procedeu de sinteză a cianocobalaminei
SU1791978A1 (ru) Кормовая добавка
HUT64291A (en) Method for racemizing non-racemic 3-oxo-cyclopentane-carboxylic acid or 3-oxo-cyclohexanecarboxylic acid, as well as their esters produced with alkohols containing 1 to 6 carbon atoms
OA06266A (fr) Procédé de préparation d'un extrait de globularia utile notamment en thérapeutiques.
MX9605277A (es) Procedimiento para obtener carboxilatos croman.
FR2705959B1 (fr) Procédé de synthèse stéréospécifique de leucotriène B4 sous sa configuration 6Z, 8E, 10E et produits intermédiaires.
RU92004454A (ru) Способ получения алкиладипатов
UA10958C2 (uk) Спосіб одержаhhя світлого hаповhювача