UY23991A1 - PROCEDIMIENTO PARA LA PREPARACION DE LA FORMA TRIHIDRATADA DEL (2R,3S)-3-TERT-BUTOXICARBONILAMINO-2-HIDROXI-3-FENILPROPIONATO DE 4-ACETOXI-2-ALFA-BENZOILOXI-5ß,20-EPOXI-1-7ß,10ß-TRIHIDROXI-9-OXO-TAX-11-EN-ILO-13- ALFA POR CRISTALIZACION A PARTIR DE UNA SOLUCION HIDRO-ALCOHOLICA - Google Patents

PROCEDIMIENTO PARA LA PREPARACION DE LA FORMA TRIHIDRATADA DEL (2R,3S)-3-TERT-BUTOXICARBONILAMINO-2-HIDROXI-3-FENILPROPIONATO DE 4-ACETOXI-2-ALFA-BENZOILOXI-5ß,20-EPOXI-1-7ß,10ß-TRIHIDROXI-9-OXO-TAX-11-EN-ILO-13- ALFA POR CRISTALIZACION A PARTIR DE UNA SOLUCION HIDRO-ALCOHOLICA

Info

Publication number
UY23991A1
UY23991A1 UY23991A UY23991A UY23991A1 UY 23991 A1 UY23991 A1 UY 23991A1 UY 23991 A UY23991 A UY 23991A UY 23991 A UY23991 A UY 23991A UY 23991 A1 UY23991 A1 UY 23991A1
Authority
UY
Uruguay
Prior art keywords
alpha
epoxiß
beta
trihydroxy
tax
Prior art date
Application number
UY23991A
Other languages
English (en)
Inventor
Rene Authelin Jean
Jacques Doveze
Elie Fouque
Bernadette Mandard
Isabelle Taillepied
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9465183&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UY23991(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Publication of UY23991A1 publication Critical patent/UY23991A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Abstract

Procedimiento para la preparación de la forma trihidratada del (2R,3S)-3-tert-butoxicarbonilamino-2-hidroxi-3-fenilpropionato de 4-acetoxi-2-alfa-benzoiloxi-5ß,20-epoxi-1-7ß,10ß-trihidroxi-9-oxo-tax-11-en-13- alfa-ilo en una mezcla de agua y alcohol alifático que contiene de 1 a 3 átomos de carbono (de particular preferencia etanol), seguido por el secado del producto obtenido en condiciones determinadas de temperatura, de presión y de humedad. En una realización particular la cristalización se efectúa en presencia de ácido ascórbico y/o el secado es efectuado a una temperatura próxima a los 40ºC, bajo una presión comprendida entre 4 y 7 kPa, y en una atmósfera cuya humedad relativa es próxima al 80%. El compuesto presenta notables propiedades anticancerosas y antileucémicas.
UY23991A 1994-07-08 1995-07-03 PROCEDIMIENTO PARA LA PREPARACION DE LA FORMA TRIHIDRATADA DEL (2R,3S)-3-TERT-BUTOXICARBONILAMINO-2-HIDROXI-3-FENILPROPIONATO DE 4-ACETOXI-2-ALFA-BENZOILOXI-5ß,20-EPOXI-1-7ß,10ß-TRIHIDROXI-9-OXO-TAX-11-EN-ILO-13- ALFA POR CRISTALIZACION A PARTIR DE UNA SOLUCION HIDRO-ALCOHOLICA UY23991A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9408479A FR2722191B1 (fr) 1994-07-08 1994-07-08 Procede de preparation du trihydrate du (2r,3s)-3-tertbutoxycarbonylamino-2-hydroxy-3-phenylpropionate de 4-acetoxy2alpha-benzoyloxy-5beta,20epoxy-1,7beta,10beta trihydroxy-9-oxo-tax-11-en-13alpha-yle

Publications (1)

Publication Number Publication Date
UY23991A1 true UY23991A1 (es) 1995-09-20

Family

ID=9465183

Family Applications (1)

Application Number Title Priority Date Filing Date
UY23991A UY23991A1 (es) 1994-07-08 1995-07-03 PROCEDIMIENTO PARA LA PREPARACION DE LA FORMA TRIHIDRATADA DEL (2R,3S)-3-TERT-BUTOXICARBONILAMINO-2-HIDROXI-3-FENILPROPIONATO DE 4-ACETOXI-2-ALFA-BENZOILOXI-5ß,20-EPOXI-1-7ß,10ß-TRIHIDROXI-9-OXO-TAX-11-EN-ILO-13- ALFA POR CRISTALIZACION A PARTIR DE UNA SOLUCION HIDRO-ALCOHOLICA

Country Status (38)

Country Link
US (1) US6022985A (es)
EP (1) EP0770070B1 (es)
JP (1) JP3753155B2 (es)
KR (1) KR100391753B1 (es)
CN (1) CN1067996C (es)
AT (1) ATE171702T1 (es)
AU (1) AU706519B2 (es)
BR (1) BR9508789A (es)
CA (1) CA2193531C (es)
CO (1) CO4410189A1 (es)
CZ (1) CZ284695B6 (es)
DE (1) DE69505128T2 (es)
DK (1) DK0770070T3 (es)
DZ (1) DZ1905A1 (es)
ES (1) ES2121404T3 (es)
FI (1) FI119246B (es)
FR (1) FR2722191B1 (es)
GR (1) GR3027558T3 (es)
HU (1) HU220634B1 (es)
IL (1) IL114274A (es)
IN (1) IN183947B (es)
IS (1) IS2032B (es)
MA (1) MA23606A1 (es)
MX (1) MX9700173A (es)
MY (1) MY118481A (es)
NO (1) NO314500B1 (es)
NZ (1) NZ289455A (es)
PE (1) PE8697A1 (es)
PL (1) PL179876B1 (es)
RU (1) RU2126397C1 (es)
SI (1) SI0770070T1 (es)
SK (1) SK280520B6 (es)
TN (1) TNSN95071A1 (es)
TW (1) TW419473B (es)
UA (1) UA51624C2 (es)
UY (1) UY23991A1 (es)
WO (1) WO1996001815A1 (es)
ZA (1) ZA955646B (es)

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US6891050B2 (en) * 2001-08-10 2005-05-10 Dabur India Limited Process for the preparation of taxanes such as paclitaxel, docetaxel and structurally similar analogs
US6881852B2 (en) * 2002-02-05 2005-04-19 Dabur India Limited Process of purification of paclitaxel and docetaxel
US7247738B2 (en) * 2002-05-07 2007-07-24 Dabur India Limited Method of preparation of anticancer taxanes using 3-[(substituted-2-trialkylsilyl) ethoxycarbonyl]-5-oxazolidine carboxylic acids
US6900342B2 (en) * 2002-05-10 2005-05-31 Dabur India Limited Anticancer taxanes such as paclitaxel, docetaxel and their structural analogs, and a method for the preparation thereof
US6838569B2 (en) * 2002-12-16 2005-01-04 Dabur India Limited Process for preparation of paclitaxel trihydrate and docetaxel trihydrate
US7584165B2 (en) * 2003-01-30 2009-09-01 Landmark Graphics Corporation Support apparatus, method and system for real time operations and maintenance
US8703982B2 (en) * 2003-03-17 2014-04-22 Phyton Holdings Llc Purification of taxanes
CN1268619C (zh) * 2003-05-08 2006-08-09 上海迪赛诺化学制药有限公司 多烯紫杉醇三水化合物的制备方法
WO2005061474A1 (en) 2003-12-12 2005-07-07 Quiral Química Do Brasil Process for the preparation of anhydrous and hydrated active pharmaceutical ingredients (apis); stable pharmaceutical compositions prepared from the same and uses of said compositions
US7142986B2 (en) * 2005-02-01 2006-11-28 Smith International, Inc. System for optimizing drilling in real time
CN100420681C (zh) * 2005-04-29 2008-09-24 上海奥锐特国际贸易有限公司 多烯紫杉醇三水物的制备方法
CN101291659A (zh) * 2005-08-31 2008-10-22 阿布拉科斯生物科学有限公司 包含水难溶性药剂和抗微生物剂的组合物
US8034765B2 (en) * 2005-08-31 2011-10-11 Abraxis Bioscience, Llc Compositions and methods for preparation of poorly water soluble drugs with increased stability
US20070142457A1 (en) * 2005-10-12 2007-06-21 Alessandro Pontiroli Crystalline forms of docetaxel and processes for their preparation
KR100995390B1 (ko) 2006-01-02 2010-11-19 주식회사 삼양제넥스 무정형, 무수결정형 또는 수화 결정형 도세탁셀의 제조방법
EP1999492A4 (en) * 2006-01-20 2011-05-18 Landmark Graphics Corp DYNAMIC PRODUCTION MANAGEMENT SYSTEM
KR20080100264A (ko) * 2006-03-21 2008-11-14 닥터 레디스 레보러터리즈 리미티드 도세탁셀의 다형체와 그 제조방법
EP2330101A1 (en) * 2006-10-20 2011-06-08 Scinopharm Singapore Pte, Ltd. Process for making crystalline docetaxel
KR100868116B1 (ko) 2007-04-09 2008-11-10 한미약품 주식회사 도세탁셀·모노프로필렌글라이콜 내포화합물 및 이의제조방법
KR100878455B1 (ko) * 2007-04-10 2009-01-13 한미약품 주식회사 안정한 무수결정형 도세탁셀 및 이의 제조방법
US20100197944A1 (en) * 2007-07-04 2010-08-05 Dr. Reddy's Laboratories Limited Docetaxel process and polymorphs
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PL388144A1 (pl) 2009-05-29 2010-12-06 Przedsiębiorstwo Produkcyjno-Wdrożeniowe Ifotam Spółka Z Ograniczoną Odpowiedzialnością Solwaty (2R,3S)-3-tert-butoksykarbonylamino-2-hydroksy-3-fenylopropionianu 4-acetoksy-2α-benzoiloksy -5β,20-epoksy-1,7β,10β-trihydroksy-9-okso-taks-11-en-13α-ylu, sposób ich otrzymywania i zastosowanie
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WO2014149871A1 (en) 2013-03-14 2014-09-25 Icahn School Of Medicine At Mount Sinai Autologous tumor lysate-loaded dendritic cell vaccine for treatment of liver cancer
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Also Published As

Publication number Publication date
MA23606A1 (fr) 1996-04-01
NO314500B1 (no) 2003-03-31
KR100391753B1 (ko) 2004-02-11
FI970069A0 (fi) 1997-01-07
FR2722191A1 (fr) 1996-01-12
EP0770070B1 (fr) 1998-09-30
BR9508789A (pt) 1997-10-21
US6022985A (en) 2000-02-08
NO970007L (no) 1997-01-02
JPH10502627A (ja) 1998-03-10
SK697A3 (en) 1997-06-04
CO4410189A1 (es) 1997-01-09
WO1996001815A1 (fr) 1996-01-25
CN1067996C (zh) 2001-07-04
CA2193531A1 (fr) 1996-01-25
HU220634B1 (hu) 2002-03-28
MY118481A (en) 2004-11-30
DE69505128T2 (de) 1999-04-01
TW419473B (en) 2001-01-21
KR970704721A (ko) 1997-09-06
CZ284695B6 (cs) 1999-02-17
GR3027558T3 (en) 1998-11-30
AU2930595A (en) 1996-02-09
FI119246B (fi) 2008-09-15
RU2126397C1 (ru) 1999-02-20
ATE171702T1 (de) 1998-10-15
SK280520B6 (sk) 2000-03-13
PE8697A1 (es) 1997-03-26
ZA955646B (en) 1996-02-21
IS4411A (is) 1997-01-07
TNSN95071A1 (fr) 1996-02-06
NO970007D0 (no) 1997-01-02
JP3753155B2 (ja) 2006-03-08
HU9700041D0 (en) 1997-02-28
IL114274A0 (en) 1995-10-31
IN183947B (es) 2000-05-20
CN1151741A (zh) 1997-06-11
DE69505128D1 (de) 1998-11-05
DK0770070T3 (da) 1999-03-01
PL179876B1 (pl) 2000-11-30
NZ289455A (en) 1997-12-19
EP0770070A1 (fr) 1997-05-02
DZ1905A1 (fr) 2002-02-17
HUT76833A (en) 1997-11-28
ES2121404T3 (es) 1998-11-16
MX9700173A (es) 1997-04-30
IL114274A (en) 1999-04-11
FR2722191B1 (fr) 1996-08-23
UA51624C2 (uk) 2002-12-16
SI0770070T1 (en) 1998-12-31
CZ3597A3 (en) 1997-04-16
PL318195A1 (en) 1997-05-26
CA2193531C (fr) 2006-12-05
IS2032B (is) 2005-08-15
AU706519B2 (en) 1999-06-17
FI970069A (fi) 1997-01-07

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