MX9700173A - Procedimiento de preparacion de trihidrato de (2r,3s)-3- tert-butoxicarbonilamino-2- hidroxi-3- fenilpropionato- de 4-acetoxi-2alfa-benzoiloxi- 5beta,20- epoxi-1,7beta,10beta- trihidroxi-9- oxo-tax-11en-13alfa-ilo. - Google Patents

Procedimiento de preparacion de trihidrato de (2r,3s)-3- tert-butoxicarbonilamino-2- hidroxi-3- fenilpropionato- de 4-acetoxi-2alfa-benzoiloxi- 5beta,20- epoxi-1,7beta,10beta- trihidroxi-9- oxo-tax-11en-13alfa-ilo.

Info

Publication number
MX9700173A
MX9700173A MX9700173A MX9700173A MX9700173A MX 9700173 A MX9700173 A MX 9700173A MX 9700173 A MX9700173 A MX 9700173A MX 9700173 A MX9700173 A MX 9700173A MX 9700173 A MX9700173 A MX 9700173A
Authority
MX
Mexico
Prior art keywords
beta
alpha
droxy
butoxycarbonylamino
benzoyloxy
Prior art date
Application number
MX9700173A
Other languages
English (en)
Inventor
Jean-Rene Authelin
Jacques Doveze
Elie Fouque
Bernadette Mandard
Isabelle Taillepied
Original Assignee
Rhone Poulenc Rorer Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9465183&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX9700173(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa
Publication of MX9700173A publication Critical patent/MX9700173A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Abstract

La presente invencion concierne a un procedimiento de preparacion del trihidrato de (2R,3S)-3-ter-butoxicarbonil-amino-2-hidroxi-3-fen ilpropinato de 4-acetoxi-2alfa-benzoil-oxi-5beta,20-epoxi-1,7beta ,10beta-trihidroxi-9-oxo-tax-11-en-13alfa-ilo por cristalizacion a partir de una solucion hidro-alcoholica.
MX9700173A 1994-07-08 1995-07-07 Procedimiento de preparacion de trihidrato de (2r,3s)-3- tert-butoxicarbonilamino-2- hidroxi-3- fenilpropionato- de 4-acetoxi-2alfa-benzoiloxi- 5beta,20- epoxi-1,7beta,10beta- trihidroxi-9- oxo-tax-11en-13alfa-ilo. MX9700173A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9408479A FR2722191B1 (fr) 1994-07-08 1994-07-08 Procede de preparation du trihydrate du (2r,3s)-3-tertbutoxycarbonylamino-2-hydroxy-3-phenylpropionate de 4-acetoxy2alpha-benzoyloxy-5beta,20epoxy-1,7beta,10beta trihydroxy-9-oxo-tax-11-en-13alpha-yle
PCT/FR1995/000910 WO1996001815A1 (fr) 1994-07-08 1995-07-07 PROCEDE DE PREPARATION DU TRIHYDRATE DU (2R,3S)-3-TERT-BUTOXYCARBONYLAMINO-2-HYDROXY-3-PHENYLPROPIONATE DE 4-ACETOXY-2α-BENZOYLOXY-5β,20-EPOXY-1,7β,10β-TRIHYDROXY-9-OXO-TAX-11-EN-13α-YLE

Publications (1)

Publication Number Publication Date
MX9700173A true MX9700173A (es) 1997-04-30

Family

ID=9465183

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9700173A MX9700173A (es) 1994-07-08 1995-07-07 Procedimiento de preparacion de trihidrato de (2r,3s)-3- tert-butoxicarbonilamino-2- hidroxi-3- fenilpropionato- de 4-acetoxi-2alfa-benzoiloxi- 5beta,20- epoxi-1,7beta,10beta- trihidroxi-9- oxo-tax-11en-13alfa-ilo.

Country Status (38)

Country Link
US (1) US6022985A (es)
EP (1) EP0770070B1 (es)
JP (1) JP3753155B2 (es)
KR (1) KR100391753B1 (es)
CN (1) CN1067996C (es)
AT (1) ATE171702T1 (es)
AU (1) AU706519B2 (es)
BR (1) BR9508789A (es)
CA (1) CA2193531C (es)
CO (1) CO4410189A1 (es)
CZ (1) CZ284695B6 (es)
DE (1) DE69505128T2 (es)
DK (1) DK0770070T3 (es)
DZ (1) DZ1905A1 (es)
ES (1) ES2121404T3 (es)
FI (1) FI119246B (es)
FR (1) FR2722191B1 (es)
GR (1) GR3027558T3 (es)
HU (1) HU220634B1 (es)
IL (1) IL114274A (es)
IN (1) IN183947B (es)
IS (1) IS2032B (es)
MA (1) MA23606A1 (es)
MX (1) MX9700173A (es)
MY (1) MY118481A (es)
NO (1) NO314500B1 (es)
NZ (1) NZ289455A (es)
PE (1) PE8697A1 (es)
PL (1) PL179876B1 (es)
RU (1) RU2126397C1 (es)
SI (1) SI0770070T1 (es)
SK (1) SK280520B6 (es)
TN (1) TNSN95071A1 (es)
TW (1) TW419473B (es)
UA (1) UA51624C2 (es)
UY (1) UY23991A1 (es)
WO (1) WO1996001815A1 (es)
ZA (1) ZA955646B (es)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1177934C (zh) 1997-04-28 2004-12-01 阿文蒂斯药物股份有限公司 腺病毒介导的肿瘤内投送血管生成拮抗剂用于肿瘤的治疗
SE510650C2 (sv) * 1997-05-30 1999-06-14 Astra Ab Ny förening
FR2794771B1 (fr) 1999-06-11 2001-08-10 Aventis Pharma Sa Adenovirus recombinants codant pour le transporteur specifique de l'iode (nis)
US6853921B2 (en) 1999-07-20 2005-02-08 Halliburton Energy Services, Inc. System and method for real time reservoir management
US6266619B1 (en) * 1999-07-20 2001-07-24 Halliburton Energy Services, Inc. System and method for real time reservoir management
GB9920548D0 (en) * 1999-08-31 1999-11-03 Rhone Poulenc Rorer Sa Treatment of hepatocellular carcinoma
US6891050B2 (en) * 2001-08-10 2005-05-10 Dabur India Limited Process for the preparation of taxanes such as paclitaxel, docetaxel and structurally similar analogs
US6881852B2 (en) * 2002-02-05 2005-04-19 Dabur India Limited Process of purification of paclitaxel and docetaxel
US7247738B2 (en) * 2002-05-07 2007-07-24 Dabur India Limited Method of preparation of anticancer taxanes using 3-[(substituted-2-trialkylsilyl) ethoxycarbonyl]-5-oxazolidine carboxylic acids
US6900342B2 (en) * 2002-05-10 2005-05-31 Dabur India Limited Anticancer taxanes such as paclitaxel, docetaxel and their structural analogs, and a method for the preparation thereof
US6838569B2 (en) * 2002-12-16 2005-01-04 Dabur India Limited Process for preparation of paclitaxel trihydrate and docetaxel trihydrate
US7584165B2 (en) * 2003-01-30 2009-09-01 Landmark Graphics Corporation Support apparatus, method and system for real time operations and maintenance
US8703982B2 (en) 2003-03-17 2014-04-22 Phyton Holdings Llc Purification of taxanes
CN1268619C (zh) * 2003-05-08 2006-08-09 上海迪赛诺化学制药有限公司 多烯紫杉醇三水化合物的制备方法
WO2005061474A1 (en) 2003-12-12 2005-07-07 Quiral Química Do Brasil Process for the preparation of anhydrous and hydrated active pharmaceutical ingredients (apis); stable pharmaceutical compositions prepared from the same and uses of said compositions
US7142986B2 (en) * 2005-02-01 2006-11-28 Smith International, Inc. System for optimizing drilling in real time
CN100420681C (zh) * 2005-04-29 2008-09-24 上海奥锐特国际贸易有限公司 多烯紫杉醇三水物的制备方法
US8034765B2 (en) * 2005-08-31 2011-10-11 Abraxis Bioscience, Llc Compositions and methods for preparation of poorly water soluble drugs with increased stability
KR101420445B1 (ko) * 2005-08-31 2014-07-16 아브락시스 바이오사이언스, 엘엘씨 수 난용성 제약학적 약제 및 항균제를 포함하는 조성물
WO2007044950A2 (en) * 2005-10-12 2007-04-19 Sicor, Inc. Crystalline forms of docetaxel and processes for their preparation
KR100995390B1 (ko) 2006-01-02 2010-11-19 주식회사 삼양제넥스 무정형, 무수결정형 또는 수화 결정형 도세탁셀의 제조방법
US8195401B2 (en) * 2006-01-20 2012-06-05 Landmark Graphics Corporation Dynamic production system management
JP2009533330A (ja) * 2006-03-21 2009-09-17 ドクター レディズ ラボラトリーズ リミテッド ドセタキセルの多形体およびプロセス
KR101266549B1 (ko) * 2006-10-20 2013-05-24 시노팜 싱가포르 피티이 리미티드 결정형 무수 도세탁셀을 제조하는 방법
KR100868116B1 (ko) 2007-04-09 2008-11-10 한미약품 주식회사 도세탁셀·모노프로필렌글라이콜 내포화합물 및 이의제조방법
KR100878455B1 (ko) * 2007-04-10 2009-01-13 한미약품 주식회사 안정한 무수결정형 도세탁셀 및 이의 제조방법
WO2009006590A2 (en) * 2007-07-04 2009-01-08 Dr. Reddy's Laboratories Ltd. Docetaxel process and polymorphs
DK2080764T3 (da) 2008-01-18 2012-09-24 Indena Spa Faste former af ortataxel
EP2080763A1 (en) * 2008-01-18 2009-07-22 INDENA S.p.A. Crystalline form I of ortataxel
PL388144A1 (pl) 2009-05-29 2010-12-06 Przedsiębiorstwo Produkcyjno-Wdrożeniowe Ifotam Spółka Z Ograniczoną Odpowiedzialnością Solwaty (2R,3S)-3-tert-butoksykarbonylamino-2-hydroksy-3-fenylopropionianu 4-acetoksy-2α-benzoiloksy -5β,20-epoksy-1,7β,10β-trihydroksy-9-okso-taks-11-en-13α-ylu, sposób ich otrzymywania i zastosowanie
EP2330100B1 (en) 2009-11-04 2017-01-11 Emcure Pharmaceuticals Limited An improved process for preparation of taxane derivatives
SG185389A1 (en) 2010-05-03 2012-12-28 Teikoku Pharma Usa Inc Non-aqueous taxane pro-emulsion formulations and methods of making and using the same
WO2012160568A1 (en) * 2011-05-23 2012-11-29 Shilpa Medicare Limited Process for preparing docetaxel trihydrate polymorph
EP2753355B1 (en) 2011-09-08 2018-10-24 New York University Oncolytic herpes simplex virus and therapeutic uses thereof
WO2013096455A1 (en) 2011-12-20 2013-06-27 Dana-Farber Cancer Institute, Inc. Methods for diagnosing and treating oncogenic kras-associated cancer
PT2833905T (pt) 2012-04-04 2018-08-06 Halozyme Inc Terapia de combinação com hialuronidase e um taxano dirigido a tumor
CA2874521A1 (en) 2012-05-24 2013-11-28 Dana-Farber Cancer Institute, Inc. Targeting the glutamine to pyruvate pathway for treatment of oncogenic kras-associated cancer
US20150285802A1 (en) 2012-07-18 2015-10-08 Dana-Farber Cancer Institute, Inc. Methods for treating, preventing and predicting risk of developing breast cancer
JO3685B1 (ar) 2012-10-01 2020-08-27 Teikoku Pharma Usa Inc صيغ التشتيت الجسيمي للتاكسين غير المائي وطرق استخدامها
WO2014149871A1 (en) 2013-03-14 2014-09-25 Icahn School Of Medicine At Mount Sinai Autologous tumor lysate-loaded dendritic cell vaccine for treatment of liver cancer
WO2015050844A1 (en) 2013-10-01 2015-04-09 Dana-Farber Cancer Institute, Inc. Methods of treating cancer with atovaquone-related compounds
WO2015149006A2 (en) 2014-03-27 2015-10-01 Dana-Farber Cancer Institute, Inc. Compositions and methods for modulating ncoa4-mediated autophagic targeting of ferritin
MA39818A (fr) 2014-03-30 2017-02-08 Benevir Biopharm Inc Virus oncolytiques « armés » comprenant un inhibiteur de tap exogène et leurs utilisations thérapeutiques
US10967015B2 (en) 2015-06-15 2021-04-06 New York University Method of treatment using oncolytic viruses
US20190351031A1 (en) 2018-05-16 2019-11-21 Halozyme, Inc. Methods of selecting subjects for combination cancer therapy with a polymer-conjugated soluble ph20

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2601675B1 (fr) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent
US5229526A (en) * 1991-09-23 1993-07-20 Florida State University Metal alkoxides

Also Published As

Publication number Publication date
JP3753155B2 (ja) 2006-03-08
CA2193531A1 (fr) 1996-01-25
KR100391753B1 (ko) 2004-02-11
ZA955646B (en) 1996-02-21
FI119246B (fi) 2008-09-15
AU2930595A (en) 1996-02-09
TW419473B (en) 2001-01-21
MA23606A1 (fr) 1996-04-01
NO314500B1 (no) 2003-03-31
HU220634B1 (hu) 2002-03-28
DE69505128T2 (de) 1999-04-01
CN1151741A (zh) 1997-06-11
FI970069A (fi) 1997-01-07
GR3027558T3 (en) 1998-11-30
SK280520B6 (sk) 2000-03-13
SK697A3 (en) 1997-06-04
AU706519B2 (en) 1999-06-17
KR970704721A (ko) 1997-09-06
PL179876B1 (pl) 2000-11-30
MY118481A (en) 2004-11-30
US6022985A (en) 2000-02-08
IL114274A (en) 1999-04-11
EP0770070B1 (fr) 1998-09-30
CZ284695B6 (cs) 1999-02-17
TNSN95071A1 (fr) 1996-02-06
IN183947B (es) 2000-05-20
EP0770070A1 (fr) 1997-05-02
PL318195A1 (en) 1997-05-26
FR2722191B1 (fr) 1996-08-23
NO970007L (no) 1997-01-02
FR2722191A1 (fr) 1996-01-12
NZ289455A (en) 1997-12-19
NO970007D0 (no) 1997-01-02
JPH10502627A (ja) 1998-03-10
CN1067996C (zh) 2001-07-04
CZ3597A3 (en) 1997-04-16
RU2126397C1 (ru) 1999-02-20
PE8697A1 (es) 1997-03-26
WO1996001815A1 (fr) 1996-01-25
ES2121404T3 (es) 1998-11-16
IS4411A (is) 1997-01-07
IL114274A0 (en) 1995-10-31
UY23991A1 (es) 1995-09-20
ATE171702T1 (de) 1998-10-15
SI0770070T1 (en) 1998-12-31
UA51624C2 (uk) 2002-12-16
DE69505128D1 (de) 1998-11-05
HU9700041D0 (en) 1997-02-28
FI970069A0 (fi) 1997-01-07
IS2032B (is) 2005-08-15
BR9508789A (pt) 1997-10-21
CO4410189A1 (es) 1997-01-09
DK0770070T3 (da) 1999-03-01
HUT76833A (en) 1997-11-28
CA2193531C (fr) 2006-12-05
DZ1905A1 (fr) 2002-02-17

Similar Documents

Publication Publication Date Title
MX9700173A (es) Procedimiento de preparacion de trihidrato de (2r,3s)-3- tert-butoxicarbonilamino-2- hidroxi-3- fenilpropionato- de 4-acetoxi-2alfa-benzoiloxi- 5beta,20- epoxi-1,7beta,10beta- trihidroxi-9- oxo-tax-11en-13alfa-ilo.
LTIP1891A (en) Method for the purification of taxoides
HU904470D0 (en) Fungicidal oxazolidinones
HUT50092A (en) Process for producing 1,3-glycols from epoxides
GB2359077B (en) Pushout mechanism for I.S. machine
EP0469829A3 (en) Process for making 1,3-diols from epoxides
ZA964749B (en) Method for preparing N,N'disubstituted cyclic ureas.
EP0498555A3 (en) Pushout for i.s. machine
TW198026B (es)
BG101794A (en) Method for the preparation of trihydrate of (2r, 3s)-3-benzoylamino-2-hydroxy-3-phenylpropionate of 4, 10-diacetoxy-2 alpha-benzoyloxy-5 beta, 20-epoxy-1,7 beta -dihydroxy-9-oco-tax-11-en-13 alpha-yl
MX9604466A (es) Proceso de preparacion de 7-trialquilsilil-baccatina iii.
IT8720345A0 (it) Macchina per cucire modulare, predisposta per il comando di dispositivi ausiliari.
CA2211808A1 (fr) Procede de preparation du trihydrate du (2r,3s)-3-benzoylamino-2-hydroxy-3-phenylpropionate de 4,10-diacetoxy-2.alpha.-benzoyloxy-5.beta.,20-epoxy-1,7.beta.-dihydroxy-9-oxo-tax-11-en-13.alpha.-yle
ZA9210103B (en) A process for preparing 4,6-dialkoxy-pyrimidines.
EP0598623A3 (en) Machine with device for keeping the error conditions.
MX9804604A (es) Dihidrato del (2r, 3s)-3-ter-butoxicarbonilamino-2-hidroxi-3-fenilpropionato de 4,iobeta-diacetoxi-2alfa-benzoiloxi-5beta, 20-epoxi-1-hidroxi-9-oxo-19-nor-ciclopropa[g]tax-11- en-13alfa-ilo, y su procedimiento de preparacion.
SI0805806T1 (en) Method for preparing 4,10-diacetoxy-2alfa-benzoyloxy-5beta,20-epoxy-1,7beta-dihydroxy-9-oxo-tax-11-en-13alfa-yl (2r,3s)-3-benzoylamino-2-hydroxy-3-phenylpropionate trihydrate
TW350842B (en) Novel process for the preparation of form I ranitidine hydrochloride
HU9700775D0 (en) Process for producing taxane derivatives with using (2r,3s)-beta-phenyl-isoserine
AR244245A1 (es) Procedimiento para preparar directamente fibras de 1,2-polibutadieno sindiotactico
HUT64168A (en) Computer controlled telecommunication device, as well as arrangement for said device
ES1001262U (es) Recipiente perfeccionado para productos insecticidas
HU9300718D0 (en) Method for producing 1,2,3,9-tetrahydro-9-methyl-3-/(2-methyl-1h-imidazole-1-yl)methyl/-4h-carbazole-4-one
AU635400B2 (en) Intermediates for producing benzo(5,6)cycloheptapyridines
IL98705A0 (en) Process for preparing bis(4-allyloxy-3,5-dibromophenyl)-sulfone