ATE171702T1 - Verfahren zur herstellung von trihydrat von (2r,3s)-3-tert-butoxycarbonyl-amino-2-hydroxy-3 phenylpropionylsäure ester von 4-acetoxy-2alfa- benzoyloxy-5beta, 20-epoxy-1,7beta, 10beta- trihydroxy-9-oxo-tax-11-en-13alfa-yl - Google Patents

Verfahren zur herstellung von trihydrat von (2r,3s)-3-tert-butoxycarbonyl-amino-2-hydroxy-3 phenylpropionylsäure ester von 4-acetoxy-2alfa- benzoyloxy-5beta, 20-epoxy-1,7beta, 10beta- trihydroxy-9-oxo-tax-11-en-13alfa-yl

Info

Publication number
ATE171702T1
ATE171702T1 AT95925022T AT95925022T ATE171702T1 AT E171702 T1 ATE171702 T1 AT E171702T1 AT 95925022 T AT95925022 T AT 95925022T AT 95925022 T AT95925022 T AT 95925022T AT E171702 T1 ATE171702 T1 AT E171702T1
Authority
AT
Austria
Prior art keywords
beta
benzoyloxy
trihydroxy
tax
acetoxy
Prior art date
Application number
AT95925022T
Other languages
English (en)
Inventor
Jean-Rene Authelin
Jacques Doveze
Elie Fouque
Bernadette Mandard
Isabelle Taillepied
Original Assignee
Rhone Poulenc Rorer Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9465183&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE171702(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa
Application granted granted Critical
Publication of ATE171702T1 publication Critical patent/ATE171702T1/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
AT95925022T 1994-07-08 1995-07-07 Verfahren zur herstellung von trihydrat von (2r,3s)-3-tert-butoxycarbonyl-amino-2-hydroxy-3 phenylpropionylsäure ester von 4-acetoxy-2alfa- benzoyloxy-5beta, 20-epoxy-1,7beta, 10beta- trihydroxy-9-oxo-tax-11-en-13alfa-yl ATE171702T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9408479A FR2722191B1 (fr) 1994-07-08 1994-07-08 Procede de preparation du trihydrate du (2r,3s)-3-tertbutoxycarbonylamino-2-hydroxy-3-phenylpropionate de 4-acetoxy2alpha-benzoyloxy-5beta,20epoxy-1,7beta,10beta trihydroxy-9-oxo-tax-11-en-13alpha-yle

Publications (1)

Publication Number Publication Date
ATE171702T1 true ATE171702T1 (de) 1998-10-15

Family

ID=9465183

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95925022T ATE171702T1 (de) 1994-07-08 1995-07-07 Verfahren zur herstellung von trihydrat von (2r,3s)-3-tert-butoxycarbonyl-amino-2-hydroxy-3 phenylpropionylsäure ester von 4-acetoxy-2alfa- benzoyloxy-5beta, 20-epoxy-1,7beta, 10beta- trihydroxy-9-oxo-tax-11-en-13alfa-yl

Country Status (38)

Country Link
US (1) US6022985A (de)
EP (1) EP0770070B1 (de)
JP (1) JP3753155B2 (de)
KR (1) KR100391753B1 (de)
CN (1) CN1067996C (de)
AT (1) ATE171702T1 (de)
AU (1) AU706519B2 (de)
BR (1) BR9508789A (de)
CA (1) CA2193531C (de)
CO (1) CO4410189A1 (de)
CZ (1) CZ284695B6 (de)
DE (1) DE69505128T2 (de)
DK (1) DK0770070T3 (de)
DZ (1) DZ1905A1 (de)
ES (1) ES2121404T3 (de)
FI (1) FI119246B (de)
FR (1) FR2722191B1 (de)
GR (1) GR3027558T3 (de)
HU (1) HU220634B1 (de)
IL (1) IL114274A (de)
IN (1) IN183947B (de)
IS (1) IS2032B (de)
MA (1) MA23606A1 (de)
MX (1) MX9700173A (de)
MY (1) MY118481A (de)
NO (1) NO314500B1 (de)
NZ (1) NZ289455A (de)
PE (1) PE8697A1 (de)
PL (1) PL179876B1 (de)
RU (1) RU2126397C1 (de)
SI (1) SI0770070T1 (de)
SK (1) SK280520B6 (de)
TN (1) TNSN95071A1 (de)
TW (1) TW419473B (de)
UA (1) UA51624C2 (de)
UY (1) UY23991A1 (de)
WO (1) WO1996001815A1 (de)
ZA (1) ZA955646B (de)

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SE510650C2 (sv) * 1997-05-30 1999-06-14 Astra Ab Ny förening
FR2794771B1 (fr) 1999-06-11 2001-08-10 Aventis Pharma Sa Adenovirus recombinants codant pour le transporteur specifique de l'iode (nis)
US6266619B1 (en) * 1999-07-20 2001-07-24 Halliburton Energy Services, Inc. System and method for real time reservoir management
US6853921B2 (en) 1999-07-20 2005-02-08 Halliburton Energy Services, Inc. System and method for real time reservoir management
GB9920548D0 (en) * 1999-08-31 1999-11-03 Rhone Poulenc Rorer Sa Treatment of hepatocellular carcinoma
US6891050B2 (en) * 2001-08-10 2005-05-10 Dabur India Limited Process for the preparation of taxanes such as paclitaxel, docetaxel and structurally similar analogs
US6881852B2 (en) * 2002-02-05 2005-04-19 Dabur India Limited Process of purification of paclitaxel and docetaxel
US7247738B2 (en) * 2002-05-07 2007-07-24 Dabur India Limited Method of preparation of anticancer taxanes using 3-[(substituted-2-trialkylsilyl) ethoxycarbonyl]-5-oxazolidine carboxylic acids
US6900342B2 (en) * 2002-05-10 2005-05-31 Dabur India Limited Anticancer taxanes such as paclitaxel, docetaxel and their structural analogs, and a method for the preparation thereof
US6838569B2 (en) * 2002-12-16 2005-01-04 Dabur India Limited Process for preparation of paclitaxel trihydrate and docetaxel trihydrate
US7584165B2 (en) * 2003-01-30 2009-09-01 Landmark Graphics Corporation Support apparatus, method and system for real time operations and maintenance
US8703982B2 (en) 2003-03-17 2014-04-22 Phyton Holdings Llc Purification of taxanes
CN1268619C (zh) * 2003-05-08 2006-08-09 上海迪赛诺化学制药有限公司 多烯紫杉醇三水化合物的制备方法
EP1947094A3 (de) 2003-12-12 2009-02-18 Quiral Quimica Do Brasil Herstellungsverfahren für Taxanderivate
US7142986B2 (en) * 2005-02-01 2006-11-28 Smith International, Inc. System for optimizing drilling in real time
CN100420681C (zh) * 2005-04-29 2008-09-24 上海奥锐特国际贸易有限公司 多烯紫杉醇三水物的制备方法
TWI417114B (zh) * 2005-08-31 2013-12-01 Abraxis Bioscience Llc 具有增強穩定性之弱水溶性藥物之組合物及其製備方法
CN101291658B (zh) 2005-08-31 2014-04-16 阿布拉科斯生物科学有限公司 用于制备稳定性增加的水难溶性药物的组合物和方法
KR20070088784A (ko) * 2005-10-12 2007-08-29 시코르, 인크. 도세탁셀의 결정형 및 이의 제조 방법
KR100995390B1 (ko) 2006-01-02 2010-11-19 주식회사 삼양제넥스 무정형, 무수결정형 또는 수화 결정형 도세탁셀의 제조방법
WO2007084611A2 (en) * 2006-01-20 2007-07-26 Landmark Graphics Corporation Dynamic production system management
JP2009533330A (ja) * 2006-03-21 2009-09-17 ドクター レディズ ラボラトリーズ リミテッド ドセタキセルの多形体およびプロセス
CA2667416C (en) * 2006-10-20 2013-12-17 Scinopharm Singapore Pte, Ltd. Process for making crystalline anhydrous docetaxel
KR100868116B1 (ko) * 2007-04-09 2008-11-10 한미약품 주식회사 도세탁셀·모노프로필렌글라이콜 내포화합물 및 이의제조방법
KR100878455B1 (ko) * 2007-04-10 2009-01-13 한미약품 주식회사 안정한 무수결정형 도세탁셀 및 이의 제조방법
WO2009006590A2 (en) * 2007-07-04 2009-01-08 Dr. Reddy's Laboratories Ltd. Docetaxel process and polymorphs
EP2080763A1 (de) * 2008-01-18 2009-07-22 INDENA S.p.A. Ortataxel in Kristallform I
ES2389518T3 (es) 2008-01-18 2012-10-26 Indena S.P.A. Formas sólidas de ortataxel
PL388144A1 (pl) 2009-05-29 2010-12-06 Przedsiębiorstwo Produkcyjno-Wdrożeniowe Ifotam Spółka Z Ograniczoną Odpowiedzialnością Solwaty (2R,3S)-3-tert-butoksykarbonylamino-2-hydroksy-3-fenylopropionianu 4-acetoksy-2α-benzoiloksy -5β,20-epoksy-1,7β,10β-trihydroksy-9-okso-taks-11-en-13α-ylu, sposób ich otrzymywania i zastosowanie
US8686165B2 (en) * 2009-11-04 2014-04-01 Emcure Pharmaceuticals Limited Process for preparation of taxane derivatives
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WO2012160568A1 (en) * 2011-05-23 2012-11-29 Shilpa Medicare Limited Process for preparing docetaxel trihydrate polymorph
HUE041799T2 (hu) 2011-09-08 2019-05-28 Univ New York Onkolitikus Herpes simplex vírus és terápiás alkalmazásai
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WO2014149871A1 (en) 2013-03-14 2014-09-25 Icahn School Of Medicine At Mount Sinai Autologous tumor lysate-loaded dendritic cell vaccine for treatment of liver cancer
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WO2015149006A2 (en) 2014-03-27 2015-10-01 Dana-Farber Cancer Institute, Inc. Compositions and methods for modulating ncoa4-mediated autophagic targeting of ferritin
MA39818A (fr) 2014-03-30 2017-02-08 Benevir Biopharm Inc Virus oncolytiques « armés » comprenant un inhibiteur de tap exogène et leurs utilisations thérapeutiques
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FR2601675B1 (fr) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent
US5229526A (en) * 1991-09-23 1993-07-20 Florida State University Metal alkoxides

Also Published As

Publication number Publication date
KR100391753B1 (ko) 2004-02-11
HU9700041D0 (en) 1997-02-28
IL114274A0 (en) 1995-10-31
SK697A3 (en) 1997-06-04
CZ3597A3 (en) 1997-04-16
TNSN95071A1 (fr) 1996-02-06
NZ289455A (en) 1997-12-19
WO1996001815A1 (fr) 1996-01-25
JPH10502627A (ja) 1998-03-10
AU706519B2 (en) 1999-06-17
DZ1905A1 (fr) 2002-02-17
IN183947B (de) 2000-05-20
SI0770070T1 (en) 1998-12-31
EP0770070A1 (de) 1997-05-02
DE69505128D1 (de) 1998-11-05
UY23991A1 (es) 1995-09-20
DE69505128T2 (de) 1999-04-01
TW419473B (en) 2001-01-21
MY118481A (en) 2004-11-30
CN1067996C (zh) 2001-07-04
BR9508789A (pt) 1997-10-21
FI970069A (fi) 1997-01-07
AU2930595A (en) 1996-02-09
HUT76833A (en) 1997-11-28
FR2722191B1 (fr) 1996-08-23
KR970704721A (ko) 1997-09-06
DK0770070T3 (da) 1999-03-01
EP0770070B1 (de) 1998-09-30
CA2193531C (fr) 2006-12-05
IS2032B (is) 2005-08-15
US6022985A (en) 2000-02-08
GR3027558T3 (en) 1998-11-30
FI970069A0 (fi) 1997-01-07
FR2722191A1 (fr) 1996-01-12
ES2121404T3 (es) 1998-11-16
PL179876B1 (pl) 2000-11-30
ZA955646B (en) 1996-02-21
IS4411A (is) 1997-01-07
HU220634B1 (hu) 2002-03-28
MA23606A1 (fr) 1996-04-01
NO314500B1 (no) 2003-03-31
CA2193531A1 (fr) 1996-01-25
CZ284695B6 (cs) 1999-02-17
MX9700173A (es) 1997-04-30
UA51624C2 (uk) 2002-12-16
PE8697A1 (es) 1997-03-26
CO4410189A1 (es) 1997-01-09
CN1151741A (zh) 1997-06-11
FI119246B (fi) 2008-09-15
NO970007D0 (no) 1997-01-02
PL318195A1 (en) 1997-05-26
JP3753155B2 (ja) 2006-03-08
SK280520B6 (sk) 2000-03-13
NO970007L (no) 1997-01-02
RU2126397C1 (ru) 1999-02-20
IL114274A (en) 1999-04-11

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