RU97101875A - СПОСОБ ПОЛУЧЕНИЯ ТРИГИДРАТА (2R,3S)-3-ТРЕТ-БУТОКСИКАРБОНИЛАМИНО-2-ГИДРОКСИ-3- ФЕНИЛПРОПИОНАТА 4-АЦЕТОКСИ-2α-БЕНЗОИЛОКСИ-5β,,20-ЭПОКСИ- 1,7β,,10β-ТРИГИДРОКСИ-9-ОКСО-ТАКС-11-ЕН-13α-ИЛА - Google Patents
СПОСОБ ПОЛУЧЕНИЯ ТРИГИДРАТА (2R,3S)-3-ТРЕТ-БУТОКСИКАРБОНИЛАМИНО-2-ГИДРОКСИ-3- ФЕНИЛПРОПИОНАТА 4-АЦЕТОКСИ-2α-БЕНЗОИЛОКСИ-5β,,20-ЭПОКСИ- 1,7β,,10β-ТРИГИДРОКСИ-9-ОКСО-ТАКС-11-ЕН-13α-ИЛАInfo
- Publication number
- RU97101875A RU97101875A RU97101875/04A RU97101875A RU97101875A RU 97101875 A RU97101875 A RU 97101875A RU 97101875/04 A RU97101875/04 A RU 97101875/04A RU 97101875 A RU97101875 A RU 97101875A RU 97101875 A RU97101875 A RU 97101875A
- Authority
- RU
- Russia
- Prior art keywords
- phenylpropionate
- benzoyloxy
- tax
- acetoxy
- hydroxy
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title claims 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 4
- ZVAFCKLQJCZGAP-WDEREUQCSA-M (2R,3S)-2-hydroxy-3-[(2-methylpropan-2-yl)oxycarbonylamino]-3-phenylpropanoate Chemical compound CC(C)(C)OC(=O)N[C@H]([C@@H](O)C([O-])=O)C1=CC=CC=C1 ZVAFCKLQJCZGAP-WDEREUQCSA-M 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Vitamin C Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims 1
- 229960005070 ascorbic acid Drugs 0.000 claims 1
- 235000010323 ascorbic acid Nutrition 0.000 claims 1
- 239000011668 ascorbic acid Substances 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 125000004432 carbon atoms Chemical group C* 0.000 claims 1
- 238000002425 crystallisation Methods 0.000 claims 1
- 230000005712 crystallization Effects 0.000 claims 1
- 238000001035 drying Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- DNIAPMSPPWPWGF-UHFFFAOYSA-N propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 1
Claims (5)
1. Способ получения тригидрата (2R,3S)-3-трет.бутокси-карбониламино-2-гидрокси-3-фенилпропионата 4-ацетокси- 2α- бензоилокси- 5β, 20-эпокси- 1,7β, 10β- тригидрокси-9-оксо-такс-11-ен 13α- ила, отличающийся тем, что кристаллизуют (2R, 3S)-3-трет.бутоксикарбониламино-2-гидрокси-3-фенилпропионат 4-ацетокси- 2α- бензоилокси- 5β, 20-эпокси- 1,7β, 10β- тригидрокси-9-оксо-такс-11-ен- 13α- ила в смеси воды и алифатического спирта, содержащего 1-3 атома углерода, затем сушат полученный продукт в определенных условиях температуры, давления и влажности.
2. Способ по п. 1, отличающийся тем, что весовое отношение воды/спирта составляет около 2/1.
3. Способ по одному из п. 1 или 2, отличающийся тем, что в качестве спирта используют этанол.
4. Способ по п. 1, отличающийся тем, что сушку осуществляют при температуре около 40oC, при давлении 4 - 7 кПа и в атмосфере, относительная влажность которой около 80%.
5. Способ по п. 1, отличающийся тем, что кристаллизацию осуществляют в присутствии аскорбиновой кислоты.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR94/08479 | 1994-07-08 | ||
| FR9408479A FR2722191B1 (fr) | 1994-07-08 | 1994-07-08 | Procede de preparation du trihydrate du (2r,3s)-3-tertbutoxycarbonylamino-2-hydroxy-3-phenylpropionate de 4-acetoxy2alpha-benzoyloxy-5beta,20epoxy-1,7beta,10beta trihydroxy-9-oxo-tax-11-en-13alpha-yle |
| PCT/FR1995/000910 WO1996001815A1 (fr) | 1994-07-08 | 1995-07-07 | PROCEDE DE PREPARATION DU TRIHYDRATE DU (2R,3S)-3-TERT-BUTOXYCARBONYLAMINO-2-HYDROXY-3-PHENYLPROPIONATE DE 4-ACETOXY-2α-BENZOYLOXY-5β,20-EPOXY-1,7β,10β-TRIHYDROXY-9-OXO-TAX-11-EN-13α-YLE |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2126397C1 RU2126397C1 (ru) | 1999-02-20 |
| RU97101875A true RU97101875A (ru) | 1999-02-27 |
Family
ID=9465183
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU97101875A RU2126397C1 (ru) | 1994-07-08 | 1995-07-07 | СПОСОБ ПОЛУЧЕНИЯ ТРИГИДРАТА (2R, 3S)-3-ТРЕТ-БУТОКСИ-КАРБОНИЛАМИНО-2-ГИДРОКСИ-3- ФЕНИЛПРОПИОНАТА-4-АЦЕТОКСИ -2α- БЕНЗОИЛОКСИ -5β, 20-ЭПОКСИ -1,7β,10β- ТРИГИДРОКСИ-9-ОКСО- ТАКС-11-ЕН-13α-ИЛА |
Country Status (38)
| Country | Link |
|---|---|
| US (1) | US6022985A (ru) |
| EP (1) | EP0770070B1 (ru) |
| JP (1) | JP3753155B2 (ru) |
| KR (1) | KR100391753B1 (ru) |
| CN (1) | CN1067996C (ru) |
| AT (1) | ATE171702T1 (ru) |
| AU (1) | AU706519B2 (ru) |
| BR (1) | BR9508789A (ru) |
| CA (1) | CA2193531C (ru) |
| CO (1) | CO4410189A1 (ru) |
| CZ (1) | CZ284695B6 (ru) |
| DE (1) | DE69505128T2 (ru) |
| DK (1) | DK0770070T3 (ru) |
| DZ (1) | DZ1905A1 (ru) |
| ES (1) | ES2121404T3 (ru) |
| FI (1) | FI119246B (ru) |
| FR (1) | FR2722191B1 (ru) |
| GR (1) | GR3027558T3 (ru) |
| HU (1) | HU220634B1 (ru) |
| IL (1) | IL114274A (ru) |
| IN (1) | IN183947B (ru) |
| IS (1) | IS2032B (ru) |
| MA (1) | MA23606A1 (ru) |
| MX (1) | MX9700173A (ru) |
| MY (1) | MY118481A (ru) |
| NO (1) | NO314500B1 (ru) |
| NZ (1) | NZ289455A (ru) |
| PE (1) | PE8697A1 (ru) |
| PL (1) | PL179876B1 (ru) |
| RU (1) | RU2126397C1 (ru) |
| SI (1) | SI0770070T1 (ru) |
| SK (1) | SK280520B6 (ru) |
| TN (1) | TNSN95071A1 (ru) |
| TW (1) | TW419473B (ru) |
| UA (1) | UA51624C2 (ru) |
| UY (1) | UY23991A1 (ru) |
| WO (1) | WO1996001815A1 (ru) |
| ZA (1) | ZA955646B (ru) |
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| CN1177934C (zh) | 1997-04-28 | 2004-12-01 | 阿文蒂斯药物股份有限公司 | 腺病毒介导的肿瘤内投送血管生成拮抗剂用于肿瘤的治疗 |
| SE510650C2 (sv) * | 1997-05-30 | 1999-06-14 | Astra Ab | Ny förening |
| FR2794771B1 (fr) | 1999-06-11 | 2001-08-10 | Aventis Pharma Sa | Adenovirus recombinants codant pour le transporteur specifique de l'iode (nis) |
| US6853921B2 (en) | 1999-07-20 | 2005-02-08 | Halliburton Energy Services, Inc. | System and method for real time reservoir management |
| US6266619B1 (en) * | 1999-07-20 | 2001-07-24 | Halliburton Energy Services, Inc. | System and method for real time reservoir management |
| GB9920548D0 (en) * | 1999-08-31 | 1999-11-03 | Rhone Poulenc Rorer Sa | Treatment of hepatocellular carcinoma |
| US6891050B2 (en) * | 2001-08-10 | 2005-05-10 | Dabur India Limited | Process for the preparation of taxanes such as paclitaxel, docetaxel and structurally similar analogs |
| US6881852B2 (en) * | 2002-02-05 | 2005-04-19 | Dabur India Limited | Process of purification of paclitaxel and docetaxel |
| US7247738B2 (en) * | 2002-05-07 | 2007-07-24 | Dabur India Limited | Method of preparation of anticancer taxanes using 3-[(substituted-2-trialkylsilyl) ethoxycarbonyl]-5-oxazolidine carboxylic acids |
| US6900342B2 (en) * | 2002-05-10 | 2005-05-31 | Dabur India Limited | Anticancer taxanes such as paclitaxel, docetaxel and their structural analogs, and a method for the preparation thereof |
| US6838569B2 (en) * | 2002-12-16 | 2005-01-04 | Dabur India Limited | Process for preparation of paclitaxel trihydrate and docetaxel trihydrate |
| US7584165B2 (en) * | 2003-01-30 | 2009-09-01 | Landmark Graphics Corporation | Support apparatus, method and system for real time operations and maintenance |
| US8703982B2 (en) * | 2003-03-17 | 2014-04-22 | Phyton Holdings Llc | Purification of taxanes |
| CN1268619C (zh) * | 2003-05-08 | 2006-08-09 | 上海迪赛诺化学制药有限公司 | 多烯紫杉醇三水化合物的制备方法 |
| EP1694660B1 (en) | 2003-12-12 | 2009-04-08 | Quiral Quimica Do Brasil | Process for the preparation of anhydrous and hydrated active pharmaceutical ingredients (apis); stable pharmaceutical compositions prepared from the same and uses of said compositions |
| US7142986B2 (en) * | 2005-02-01 | 2006-11-28 | Smith International, Inc. | System for optimizing drilling in real time |
| CN100420681C (zh) * | 2005-04-29 | 2008-09-24 | 上海奥锐特国际贸易有限公司 | 多烯紫杉醇三水物的制备方法 |
| ES2719093T3 (es) * | 2005-08-31 | 2019-07-08 | Abraxis Bioscience Llc | Composiciones de fármacos poco solubles en agua con mayor estabilidad y métodos para su preparación |
| BRPI0615265A8 (pt) * | 2005-08-31 | 2018-03-06 | Abraxis Bioscience Llc | composições compreendendo agentes farmacêuticos pouco hidrossoluíveis e agentes antimicrobianos |
| KR20070088784A (ko) * | 2005-10-12 | 2007-08-29 | 시코르, 인크. | 도세탁셀의 결정형 및 이의 제조 방법 |
| KR100995390B1 (ko) | 2006-01-02 | 2010-11-19 | 주식회사 삼양제넥스 | 무정형, 무수결정형 또는 수화 결정형 도세탁셀의 제조방법 |
| US8195401B2 (en) * | 2006-01-20 | 2012-06-05 | Landmark Graphics Corporation | Dynamic production system management |
| WO2007109654A2 (en) * | 2006-03-21 | 2007-09-27 | Dr. Reddy's Laboratories Ltd. | Docetaxel polymorphs and processes |
| EP2330101A1 (en) * | 2006-10-20 | 2011-06-08 | Scinopharm Singapore Pte, Ltd. | Process for making crystalline docetaxel |
| KR100868116B1 (ko) | 2007-04-09 | 2008-11-10 | 한미약품 주식회사 | 도세탁셀·모노프로필렌글라이콜 내포화합물 및 이의제조방법 |
| KR100878455B1 (ko) * | 2007-04-10 | 2009-01-13 | 한미약품 주식회사 | 안정한 무수결정형 도세탁셀 및 이의 제조방법 |
| WO2009006590A2 (en) * | 2007-07-04 | 2009-01-08 | Dr. Reddy's Laboratories Ltd. | Docetaxel process and polymorphs |
| EP2080763A1 (en) * | 2008-01-18 | 2009-07-22 | INDENA S.p.A. | Crystalline form I of ortataxel |
| ES2389518T3 (es) | 2008-01-18 | 2012-10-26 | Indena S.P.A. | Formas sólidas de ortataxel |
| PL388144A1 (pl) | 2009-05-29 | 2010-12-06 | Przedsiębiorstwo Produkcyjno-Wdrożeniowe Ifotam Spółka Z Ograniczoną Odpowiedzialnością | Solwaty (2R,3S)-3-tert-butoksykarbonylamino-2-hydroksy-3-fenylopropionianu 4-acetoksy-2α-benzoiloksy -5β,20-epoksy-1,7β,10β-trihydroksy-9-okso-taks-11-en-13α-ylu, sposób ich otrzymywania i zastosowanie |
| US8686165B2 (en) * | 2009-11-04 | 2014-04-01 | Emcure Pharmaceuticals Limited | Process for preparation of taxane derivatives |
| CA2798180A1 (en) | 2010-05-03 | 2011-11-10 | Teikoku Pharma Usa, Inc. | Non-aqueous taxane pro-emulsion formulations and methods of making and using the same |
| WO2012160568A1 (en) * | 2011-05-23 | 2012-11-29 | Shilpa Medicare Limited | Process for preparing docetaxel trihydrate polymorph |
| SI2753355T1 (sl) | 2011-09-08 | 2019-02-28 | New York University | Onkolitični virus herpesa simpleksa in njegove terapevtske uporabe |
| WO2013096455A1 (en) | 2011-12-20 | 2013-06-27 | Dana-Farber Cancer Institute, Inc. | Methods for diagnosing and treating oncogenic kras-associated cancer |
| CN108686203A (zh) | 2012-04-04 | 2018-10-23 | 哈洛齐梅公司 | 使用抗透明质酸剂和肿瘤靶向紫杉烷的组合疗法 |
| WO2013177426A2 (en) | 2012-05-24 | 2013-11-28 | Dana-Farber Cancer Institute, Inc. | Targeting the glutamine to pyruvate pathway for treatment of oncogenic kras-associated cancer |
| US20150285802A1 (en) | 2012-07-18 | 2015-10-08 | Dana-Farber Cancer Institute, Inc. | Methods for treating, preventing and predicting risk of developing breast cancer |
| JO3685B1 (ar) | 2012-10-01 | 2020-08-27 | Teikoku Pharma Usa Inc | صيغ التشتيت الجسيمي للتاكسين غير المائي وطرق استخدامها |
| US10238723B2 (en) | 2013-03-14 | 2019-03-26 | Icahn School Of Medicine At Mount Sinai | Autologous tumor lysate-loaded dendritic cell vaccine for treatment of liver cancer |
| WO2015050844A1 (en) | 2013-10-01 | 2015-04-09 | Dana-Farber Cancer Institute, Inc. | Methods of treating cancer with atovaquone-related compounds |
| US10350264B2 (en) | 2014-03-27 | 2019-07-16 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for modulating NCOA4-mediated autophagic targeting of ferritin |
| MA39818A (fr) | 2014-03-30 | 2017-02-08 | Benevir Biopharm Inc | Virus oncolytiques « armés » comprenant un inhibiteur de tap exogène et leurs utilisations thérapeutiques |
| WO2016205429A1 (en) | 2015-06-15 | 2016-12-22 | New York University | Method of treatment using oncolytic viruses |
| US20190351031A1 (en) | 2018-05-16 | 2019-11-21 | Halozyme, Inc. | Methods of selecting subjects for combination cancer therapy with a polymer-conjugated soluble ph20 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2601675B1 (fr) * | 1986-07-17 | 1988-09-23 | Rhone Poulenc Sante | Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent |
| US5229526A (en) * | 1991-09-23 | 1993-07-20 | Florida State University | Metal alkoxides |
-
1994
- 1994-07-08 FR FR9408479A patent/FR2722191B1/fr not_active Expired - Fee Related
-
1995
- 1995-06-22 IL IL11427495A patent/IL114274A/xx not_active IP Right Cessation
- 1995-07-03 UY UY23991A patent/UY23991A1/es not_active IP Right Cessation
- 1995-07-04 DZ DZ950082A patent/DZ1905A1/fr active
- 1995-07-05 PE PE1995272899A patent/PE8697A1/es not_active IP Right Cessation
- 1995-07-05 TN TNTNSN95071A patent/TNSN95071A1/fr unknown
- 1995-07-06 TW TW084106974A patent/TW419473B/zh not_active IP Right Cessation
- 1995-07-06 ZA ZA955646A patent/ZA955646B/xx unknown
- 1995-07-06 IN IN1260DE1995 patent/IN183947B/en unknown
- 1995-07-06 MY MYPI95001895A patent/MY118481A/en unknown
- 1995-07-06 MA MA23945A patent/MA23606A1/fr unknown
- 1995-07-07 EP EP95925022A patent/EP0770070B1/fr not_active Expired - Lifetime
- 1995-07-07 PL PL95318195A patent/PL179876B1/pl unknown
- 1995-07-07 JP JP50415896A patent/JP3753155B2/ja not_active Expired - Fee Related
- 1995-07-07 WO PCT/FR1995/000910 patent/WO1996001815A1/fr active IP Right Grant
- 1995-07-07 US US08/776,333 patent/US6022985A/en not_active Expired - Lifetime
- 1995-07-07 CN CN95193984A patent/CN1067996C/zh not_active Expired - Lifetime
- 1995-07-07 RU RU97101875A patent/RU2126397C1/ru active
- 1995-07-07 AU AU29305/95A patent/AU706519B2/en not_active Expired
- 1995-07-07 SK SK6-97A patent/SK280520B6/sk not_active IP Right Cessation
- 1995-07-07 CO CO95029779A patent/CO4410189A1/es unknown
- 1995-07-07 BR BR9508789A patent/BR9508789A/pt not_active Application Discontinuation
- 1995-07-07 ES ES95925022T patent/ES2121404T3/es not_active Expired - Lifetime
- 1995-07-07 AT AT95925022T patent/ATE171702T1/de active
- 1995-07-07 MX MX9700173A patent/MX9700173A/es unknown
- 1995-07-07 DE DE69505128T patent/DE69505128T2/de not_active Expired - Lifetime
- 1995-07-07 CZ CZ9735A patent/CZ284695B6/cs not_active IP Right Cessation
- 1995-07-07 DK DK95925022T patent/DK0770070T3/da active
- 1995-07-07 KR KR1019970700118A patent/KR100391753B1/ko not_active IP Right Cessation
- 1995-07-07 NZ NZ289455A patent/NZ289455A/en not_active IP Right Cessation
- 1995-07-07 CA CA002193531A patent/CA2193531C/fr not_active Expired - Lifetime
- 1995-07-07 UA UA97010077A patent/UA51624C2/ru unknown
- 1995-07-07 HU HU9700041A patent/HU220634B1/hu unknown
- 1995-07-07 SI SI9530138T patent/SI0770070T1/xx unknown
-
1997
- 1997-01-02 NO NO19970007A patent/NO314500B1/no not_active IP Right Cessation
- 1997-01-07 FI FI970069A patent/FI119246B/fi not_active IP Right Cessation
- 1997-01-07 IS IS4411A patent/IS2032B/is unknown
-
1998
- 1998-01-01 GR GR980400355T patent/GR3027558T3/el unknown
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