PE8697A1 - Procedimiento de preparacion del trihidrato de(2r,3s)-3-tert-butoxicarbonilamino -2-hidroxi-3-fenilpropionato de 4-acetoxi-2o-benzoiloxi-5�,20-epoxi-1,7�,10�-trihidroxi -9-oxo-tax-11-en-13o-ile - Google Patents

Procedimiento de preparacion del trihidrato de(2r,3s)-3-tert-butoxicarbonilamino -2-hidroxi-3-fenilpropionato de 4-acetoxi-2o-benzoiloxi-5�,20-epoxi-1,7�,10�-trihidroxi -9-oxo-tax-11-en-13o-ile

Info

Publication number
PE8697A1
PE8697A1 PE1995272899A PE27289995A PE8697A1 PE 8697 A1 PE8697 A1 PE 8697A1 PE 1995272899 A PE1995272899 A PE 1995272899A PE 27289995 A PE27289995 A PE 27289995A PE 8697 A1 PE8697 A1 PE 8697A1
Authority
PE
Peru
Prior art keywords
benzoiloxi
acetoxi
hidroxi
epoxi
tax
Prior art date
Application number
PE1995272899A
Other languages
English (en)
Spanish (es)
Inventor
Mandard Bernadette
Fouque Elie
Rene Authelin Jean
Doveze Jacques
Taillepied Isabelle
Original Assignee
Rhone Poulenc Rorer Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9465183&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE8697(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa
Publication of PE8697A1 publication Critical patent/PE8697A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
PE1995272899A 1994-07-08 1995-07-05 Procedimiento de preparacion del trihidrato de(2r,3s)-3-tert-butoxicarbonilamino -2-hidroxi-3-fenilpropionato de 4-acetoxi-2o-benzoiloxi-5�,20-epoxi-1,7�,10�-trihidroxi -9-oxo-tax-11-en-13o-ile PE8697A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9408479A FR2722191B1 (fr) 1994-07-08 1994-07-08 Procede de preparation du trihydrate du (2r,3s)-3-tertbutoxycarbonylamino-2-hydroxy-3-phenylpropionate de 4-acetoxy2alpha-benzoyloxy-5beta,20epoxy-1,7beta,10beta trihydroxy-9-oxo-tax-11-en-13alpha-yle

Publications (1)

Publication Number Publication Date
PE8697A1 true PE8697A1 (es) 1997-03-26

Family

ID=9465183

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1995272899A PE8697A1 (es) 1994-07-08 1995-07-05 Procedimiento de preparacion del trihidrato de(2r,3s)-3-tert-butoxicarbonilamino -2-hidroxi-3-fenilpropionato de 4-acetoxi-2o-benzoiloxi-5�,20-epoxi-1,7�,10�-trihidroxi -9-oxo-tax-11-en-13o-ile

Country Status (38)

Country Link
US (1) US6022985A (OSRAM)
EP (1) EP0770070B1 (OSRAM)
JP (1) JP3753155B2 (OSRAM)
KR (1) KR100391753B1 (OSRAM)
CN (1) CN1067996C (OSRAM)
AT (1) ATE171702T1 (OSRAM)
AU (1) AU706519B2 (OSRAM)
BR (1) BR9508789A (OSRAM)
CA (1) CA2193531C (OSRAM)
CO (1) CO4410189A1 (OSRAM)
CZ (1) CZ284695B6 (OSRAM)
DE (1) DE69505128T2 (OSRAM)
DK (1) DK0770070T3 (OSRAM)
DZ (1) DZ1905A1 (OSRAM)
ES (1) ES2121404T3 (OSRAM)
FI (1) FI119246B (OSRAM)
FR (1) FR2722191B1 (OSRAM)
GR (1) GR3027558T3 (OSRAM)
HU (1) HU220634B1 (OSRAM)
IL (1) IL114274A (OSRAM)
IN (1) IN183947B (OSRAM)
IS (1) IS2032B (OSRAM)
MA (1) MA23606A1 (OSRAM)
MX (1) MX9700173A (OSRAM)
MY (1) MY118481A (OSRAM)
NO (1) NO314500B1 (OSRAM)
NZ (1) NZ289455A (OSRAM)
PE (1) PE8697A1 (OSRAM)
PL (1) PL179876B1 (OSRAM)
RU (1) RU2126397C1 (OSRAM)
SI (1) SI0770070T1 (OSRAM)
SK (1) SK280520B6 (OSRAM)
TN (1) TNSN95071A1 (OSRAM)
TW (1) TW419473B (OSRAM)
UA (1) UA51624C2 (OSRAM)
UY (1) UY23991A1 (OSRAM)
WO (1) WO1996001815A1 (OSRAM)
ZA (1) ZA955646B (OSRAM)

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JP2001523103A (ja) 1997-04-28 2001-11-20 ローヌ−プーラン・ロレ・エス・アー 腫瘍治療用血管形成アンタゴニストのアデノウイルスによる腫瘍内送達
SE510650C2 (sv) * 1997-05-30 1999-06-14 Astra Ab Ny förening
FR2794771B1 (fr) 1999-06-11 2001-08-10 Aventis Pharma Sa Adenovirus recombinants codant pour le transporteur specifique de l'iode (nis)
US6266619B1 (en) * 1999-07-20 2001-07-24 Halliburton Energy Services, Inc. System and method for real time reservoir management
US6853921B2 (en) 1999-07-20 2005-02-08 Halliburton Energy Services, Inc. System and method for real time reservoir management
GB9920548D0 (en) * 1999-08-31 1999-11-03 Rhone Poulenc Rorer Sa Treatment of hepatocellular carcinoma
US6891050B2 (en) * 2001-08-10 2005-05-10 Dabur India Limited Process for the preparation of taxanes such as paclitaxel, docetaxel and structurally similar analogs
US6881852B2 (en) * 2002-02-05 2005-04-19 Dabur India Limited Process of purification of paclitaxel and docetaxel
US7247738B2 (en) * 2002-05-07 2007-07-24 Dabur India Limited Method of preparation of anticancer taxanes using 3-[(substituted-2-trialkylsilyl) ethoxycarbonyl]-5-oxazolidine carboxylic acids
US6900342B2 (en) * 2002-05-10 2005-05-31 Dabur India Limited Anticancer taxanes such as paclitaxel, docetaxel and their structural analogs, and a method for the preparation thereof
US6838569B2 (en) * 2002-12-16 2005-01-04 Dabur India Limited Process for preparation of paclitaxel trihydrate and docetaxel trihydrate
US7584165B2 (en) * 2003-01-30 2009-09-01 Landmark Graphics Corporation Support apparatus, method and system for real time operations and maintenance
US8703982B2 (en) 2003-03-17 2014-04-22 Phyton Holdings Llc Purification of taxanes
CN1268619C (zh) * 2003-05-08 2006-08-09 上海迪赛诺化学制药有限公司 多烯紫杉醇三水化合物的制备方法
FR2859996B1 (fr) * 2003-09-19 2006-02-03 Aventis Pharma Sa Solvat acetonique du dimethoxy docetaxel et son procede de preparation
ES2325506T3 (es) 2003-12-12 2009-09-07 Quiral Quimica Do Brasil Procedimiento para la preparacion de principios activos farmaceuticos (api) anhidros e hidratados; composiciones farmaceuticas estables preparadas a partir de los mismos y usos de dichas composiciones.
US7142986B2 (en) * 2005-02-01 2006-11-28 Smith International, Inc. System for optimizing drilling in real time
CN100420681C (zh) * 2005-04-29 2008-09-24 上海奥锐特国际贸易有限公司 多烯紫杉醇三水物的制备方法
TWI417114B (zh) 2005-08-31 2013-12-01 Abraxis Bioscience Llc 具有增強穩定性之弱水溶性藥物之組合物及其製備方法
JP5368093B2 (ja) 2005-08-31 2013-12-18 アブラクシス バイオサイエンス， エルエルシー 増大した安定性を有する難水溶性薬剤の組成物および調製の方法
JP2008523111A (ja) * 2005-10-12 2008-07-03 シコール インコーポレイティド ドセタキセルの結晶形及びそれらの調製方法
KR100995390B1 (ko) 2006-01-02 2010-11-19 주식회사 삼양제넥스 무정형, 무수결정형 또는 수화 결정형 도세탁셀의 제조방법
BRPI0706580A2 (pt) * 2006-01-20 2011-03-29 Landmark Graphics Corp gerenciamento dinámico de sistema de produção
US20100160653A1 (en) * 2006-03-21 2010-06-24 Dr. Reddy's Laboratories Ltd. Docetaxel polymorphs and processes
KR101266549B1 (ko) * 2006-10-20 2013-05-24 시노팜 싱가포르 피티이 리미티드 결정형 무수 도세탁셀을 제조하는 방법
KR100868116B1 (ko) 2007-04-09 2008-11-10 한미약품 주식회사 도세탁셀·모노프로필렌글라이콜 내포화합물 및 이의제조방법
KR100878455B1 (ko) * 2007-04-10 2009-01-13 한미약품 주식회사 안정한 무수결정형 도세탁셀 및 이의 제조방법
EP2173732A4 (en) * 2007-07-04 2011-09-07 Reddys Lab Ltd Dr PROCESSES FOR THE PREPARATION OF DOCETAXEL AND POLYMORPHIC
ES2389518T3 (es) * 2008-01-18 2012-10-26 Indena S.P.A. Formas sólidas de ortataxel
EP2080763A1 (en) * 2008-01-18 2009-07-22 INDENA S.p.A. Crystalline form I of ortataxel
PL388144A1 (pl) 2009-05-29 2010-12-06 Przedsiębiorstwo Produkcyjno-Wdrożeniowe Ifotam Spółka Z Ograniczoną Odpowiedzialnością Solwaty (2R,3S)-3-tert-butoksykarbonylamino-2-hydroksy-3-fenylopropionianu 4-acetoksy-2α-benzoiloksy -5β,20-epoksy-1,7β,10β-trihydroksy-9-okso-taks-11-en-13α-ylu, sposób ich otrzymywania i zastosowanie
US8686165B2 (en) * 2009-11-04 2014-04-01 Emcure Pharmaceuticals Limited Process for preparation of taxane derivatives
CN102970990A (zh) 2010-05-03 2013-03-13 帝国制药美国公司 非水性紫杉烷前-乳剂制剂以及制备和使用该制剂的方法
WO2012160568A1 (en) * 2011-05-23 2012-11-29 Shilpa Medicare Limited Process for preparing docetaxel trihydrate polymorph
PT2753355T (pt) 2011-09-08 2019-02-01 Univ New York Vírus herpes simplex oncolítico e suas utilizações terapêuticas
US9745631B2 (en) 2011-12-20 2017-08-29 Dana-Farber Cancer Institute, Inc. Methods for diagnosing and treating oncogenic kras-associated cancer
BR112014024848A2 (pt) 2012-04-04 2017-07-11 Halozyme Inc terapia de combinação com um agente antihialuronano e um taxano direcionamento ao tumor
CA2874521A1 (en) 2012-05-24 2013-11-28 Dana-Farber Cancer Institute, Inc. Targeting the glutamine to pyruvate pathway for treatment of oncogenic kras-associated cancer
WO2014014518A1 (en) 2012-07-18 2014-01-23 Dana-Farber Cancer Institute, Inc. Methods for treating, preventing and predicting risk of developing breast cancer
JO3685B1 (ar) 2012-10-01 2020-08-27 Teikoku Pharma Usa Inc صيغ التشتيت الجسيمي للتاكسين غير المائي وطرق استخدامها
WO2014149871A1 (en) 2013-03-14 2014-09-25 Icahn School Of Medicine At Mount Sinai Autologous tumor lysate-loaded dendritic cell vaccine for treatment of liver cancer
US10130590B2 (en) 2013-10-01 2018-11-20 Dana-Farber Cancer Institute, Inc. Methods of treating cancer with atovaquone-related compounds
US10350264B2 (en) 2014-03-27 2019-07-16 Dana-Farber Cancer Institute, Inc. Compositions and methods for modulating NCOA4-mediated autophagic targeting of ferritin
MA39818A (fr) 2014-03-30 2017-02-08 Benevir Biopharm Inc Virus oncolytiques « armés » comprenant un inhibiteur de tap exogène et leurs utilisations thérapeutiques
WO2016205429A1 (en) 2015-06-15 2016-12-22 New York University Method of treatment using oncolytic viruses
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FR2601675B1 (fr) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent
US5229526A (en) * 1991-09-23 1993-07-20 Florida State University Metal alkoxides

Also Published As

Publication number Publication date
FI970069L (fi) 1997-01-07
US6022985A (en) 2000-02-08
CZ3597A3 (en) 1997-04-16
DE69505128D1 (de) 1998-11-05
CO4410189A1 (es) 1997-01-09
TW419473B (en) 2001-01-21
EP0770070A1 (fr) 1997-05-02
PL179876B1 (pl) 2000-11-30
TNSN95071A1 (fr) 1996-02-06
SI0770070T1 (en) 1998-12-31
CA2193531A1 (fr) 1996-01-25
ZA955646B (en) 1996-02-21
PL318195A1 (en) 1997-05-26
FR2722191A1 (fr) 1996-01-12
SK697A3 (en) 1997-06-04
NO970007D0 (no) 1997-01-02
EP0770070B1 (fr) 1998-09-30
FI119246B (fi) 2008-09-15
CN1151741A (zh) 1997-06-11
CA2193531C (fr) 2006-12-05
IS2032B (is) 2005-08-15
DE69505128T2 (de) 1999-04-01
HU220634B1 (hu) 2002-03-28
NZ289455A (en) 1997-12-19
KR970704721A (ko) 1997-09-06
UA51624C2 (uk) 2002-12-16
JP3753155B2 (ja) 2006-03-08
IS4411A (is) 1997-01-07
IN183947B (OSRAM) 2000-05-20
BR9508789A (pt) 1997-10-21
IL114274A0 (en) 1995-10-31
DK0770070T3 (da) 1999-03-01
SK280520B6 (sk) 2000-03-13
ATE171702T1 (de) 1998-10-15
DZ1905A1 (fr) 2002-02-17
NO970007L (no) 1997-01-02
JPH10502627A (ja) 1998-03-10
RU2126397C1 (ru) 1999-02-20
FI970069A0 (fi) 1997-01-07
AU706519B2 (en) 1999-06-17
GR3027558T3 (en) 1998-11-30
MA23606A1 (fr) 1996-04-01
NO314500B1 (no) 2003-03-31
UY23991A1 (es) 1995-09-20
CZ284695B6 (cs) 1999-02-17
KR100391753B1 (ko) 2004-02-11
IL114274A (en) 1999-04-11
CN1067996C (zh) 2001-07-04
MX9700173A (es) 1997-04-30
HUT76833A (en) 1997-11-28
HU9700041D0 (en) 1997-02-28
MY118481A (en) 2004-11-30
ES2121404T3 (es) 1998-11-16
AU2930595A (en) 1996-02-09
FR2722191B1 (fr) 1996-08-23
WO1996001815A1 (fr) 1996-01-25

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