SI0675110T1 - 1H-Indole-3-glyoxylamide sPLA2 inhibitors - Google Patents
1H-Indole-3-glyoxylamide sPLA2 inhibitorsInfo
- Publication number
- SI0675110T1 SI0675110T1 SI9530616T SI9530616T SI0675110T1 SI 0675110 T1 SI0675110 T1 SI 0675110T1 SI 9530616 T SI9530616 T SI 9530616T SI 9530616 T SI9530616 T SI 9530616T SI 0675110 T1 SI0675110 T1 SI 0675110T1
- Authority
- SI
- Slovenia
- Prior art keywords
- indole
- spla2 inhibitors
- glyoxylamide spla2
- glyoxylamide
- sub
- Prior art date
Links
- AWMLDBKLOPNOAR-UHFFFAOYSA-N indole-3-glyoxylamide Natural products C1=CC=C2C(C(=O)C(=O)N)=CNC2=C1 AWMLDBKLOPNOAR-UHFFFAOYSA-N 0.000 title abstract 3
- 102000005473 Secretory Phospholipases A2 Human genes 0.000 title 1
- 108010031873 Secretory Phospholipases A2 Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 206010040070 Septic Shock Diseases 0.000 abstract 1
- 235000014113 dietary fatty acids Nutrition 0.000 abstract 1
- 229930195729 fatty acid Natural products 0.000 abstract 1
- 239000000194 fatty acid Substances 0.000 abstract 1
- 150000004665 fatty acids Chemical class 0.000 abstract 1
- 150000002475 indoles Chemical class 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 230000036303 septic shock Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/22—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an aralkyl radical attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US22191694A | 1994-04-01 | 1994-04-01 | |
EP95302166A EP0675110B1 (en) | 1994-04-01 | 1995-03-31 | 1H-Indole-3-glyoxylamide sPLA2 inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
SI0675110T1 true SI0675110T1 (en) | 2002-12-31 |
Family
ID=22829963
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI9530616T SI0675110T1 (en) | 1994-04-01 | 1995-03-31 | 1H-Indole-3-glyoxylamide sPLA2 inhibitors |
Country Status (29)
Country | Link |
---|---|
US (6) | US5654326A (hu) |
EP (5) | EP2341045A1 (hu) |
JP (1) | JP3109974B2 (hu) |
KR (1) | KR100368707B1 (hu) |
CN (1) | CN1067054C (hu) |
AT (2) | ATE220394T1 (hu) |
AU (1) | AU688458B2 (hu) |
BR (1) | BR9501404A (hu) |
CA (1) | CA2146097C (hu) |
CO (1) | CO4370099A1 (hu) |
CZ (1) | CZ82295A3 (hu) |
DE (1) | DE69527322T2 (hu) |
DK (2) | DK1950200T3 (hu) |
ES (2) | ES2179088T3 (hu) |
FI (1) | FI114793B (hu) |
HU (1) | HUT72048A (hu) |
IL (1) | IL113210A (hu) |
MX (1) | MX9501608A (hu) |
MY (1) | MY112897A (hu) |
NO (1) | NO304186B1 (hu) |
NZ (1) | NZ270848A (hu) |
PE (1) | PE18696A1 (hu) |
PL (1) | PL180523B1 (hu) |
PT (1) | PT675110E (hu) |
RU (1) | RU2128169C1 (hu) |
SI (1) | SI0675110T1 (hu) |
TW (1) | TW383302B (hu) |
UA (1) | UA47387C2 (hu) |
ZA (1) | ZA952693B (hu) |
Families Citing this family (86)
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---|---|---|---|---|
PT675110E (pt) * | 1994-04-01 | 2002-11-29 | Lilly Co Eli | 1h-indole-3-glioxilamidas inibidoras da spla2 |
JPH08193074A (ja) * | 1994-11-18 | 1996-07-30 | Nippon Bayeragrochem Kk | 除草性1−シクロプロピルテトラゾリノン類 |
EP0751126A4 (en) * | 1995-01-06 | 1998-05-13 | Toray Industries | BENZOCONDENSE HETEROCYCLIC DERIVATIVE AND ITS USE |
US6630496B1 (en) | 1996-08-26 | 2003-10-07 | Genetics Institute Llc | Inhibitors of phospholipase enzymes |
DE19636150A1 (de) * | 1996-09-06 | 1998-03-12 | Asta Medica Ag | N-substituierte Indol-3-glyoxylamide mit antiasthmatischer, antiallergischer und immunsuppressiver/immunmodulierender Wirkung |
US5919774A (en) * | 1996-12-10 | 1999-07-06 | Eli Lilly And Company | Pyrroles as sPLA2 inhibitors |
AU6229298A (en) * | 1997-02-20 | 1998-09-09 | Shionogi & Co., Ltd. | Indole dicarboxylic acid derivatives |
US5972988A (en) * | 1997-03-26 | 1999-10-26 | Eli Lilly And Company | Method for treatment of chronic bronchitis using indole compounds |
WO1998047507A1 (en) * | 1997-04-24 | 1998-10-29 | Shionogi & Co., Ltd. | Method for the treatment of stroke using n-heterocyclic glyoxylamide compounds |
TW455581B (en) * | 1997-06-26 | 2001-09-21 | Lilly Co Eli | Process for preparing 4-substituted-1H-indole-3-glyoxamides |
AU9123198A (en) * | 1997-08-28 | 1999-03-16 | Eli Lilly And Company | Method for treatment of non-rheumatoid athritis |
WO1999021545A1 (en) * | 1997-10-27 | 1999-05-06 | Eli Lilly And Company | ISOPROPYL ESTER PRODRUGS OF INDOLE sPLA2 INHIBITORS |
AU1279899A (en) * | 1997-10-27 | 1999-05-17 | Eli Lilly And Company | N,n-diethylglycolamido ester prodrugs of indole spla2 inhibitors |
WO1999021559A1 (en) | 1997-10-27 | 1999-05-06 | Eli Lilly And Company | MORPHOLINO-N-ETHYL ESTER PRODRUGS OF INDOLE sPLA2 INHIBITORS |
WO1999024033A1 (en) * | 1997-11-12 | 1999-05-20 | Shionogi & Co., Ltd. | Method for the treatment of disorders associated with apoptosis using n-heterocyclic glyoxylamide compounds |
AU1405899A (en) * | 1997-11-14 | 1999-06-07 | Eli Lilly And Company | Treatment for alzheimer's disease |
EP1043991A4 (en) * | 1997-11-14 | 2005-02-02 | Lilly Co Eli | TREATMENT OF ALZHEIMER DISEASE |
US6828344B1 (en) | 1998-02-25 | 2004-12-07 | Genetics Institute, Llc | Inhibitors of phospholipase enzymes |
US6916841B2 (en) * | 1998-02-25 | 2005-07-12 | Genetics Institute, Llc | Inhibitors of phospholipase enzymes |
PL343007A1 (en) * | 1998-02-25 | 2001-07-30 | Genetics Inst | Inhibitors of phospholipase enzymes |
US6500853B1 (en) | 1998-02-28 | 2002-12-31 | Genetics Institute, Llc | Inhibitors of phospholipase enzymes |
JP2002505282A (ja) * | 1998-03-03 | 2002-02-19 | 塩野義製薬株式会社 | ホスホリパーゼ阻害剤の[[3−(2−アミノ−1,2−ジオキソエチル)−2−エチル−1−フェニルメチル)−1h−インドール−4−イル]オキシ]酢酸ナトリウムを含む薬学的組成物 |
KR20010042307A (ko) | 1998-03-31 | 2001-05-25 | 시오노 요시히코 | 피롤로[1,2-a]피라진 sPLA2 억제제 |
CZ302588B6 (cs) * | 1998-04-02 | 2011-07-27 | Ziopharm Oncology, Inc. | Použití N-substituovaného indol-3-glyoxylamidu pro výrobu léciva |
DE19814838C2 (de) * | 1998-04-02 | 2001-01-18 | Asta Medica Ag | Indolyl-3-glyoxylsäure-Derivate mit Antitumorwirkung |
DZ2770A1 (fr) * | 1998-04-17 | 2003-12-01 | Lilly Co Eli | Procédé de préparation de 1h-indol-3 glyoxamides substituées en position 4. |
JP2002512222A (ja) * | 1998-04-17 | 2002-04-23 | イーライ・リリー・アンド・カンパニー | 4−ヒドロキシインドール、インダゾール、及び、カルバゾール化合物の製造方法 |
US6407261B1 (en) | 1998-04-17 | 2002-06-18 | Eli Lilly And Company | Process for preparing 4-hdyroxy indole, indazole and carbazole compounds |
SK16332000A3 (sk) * | 1998-05-01 | 2001-06-11 | Eli Lilly And Company | Ester ako inhibítor spla2 |
WO1999057100A1 (en) * | 1998-05-01 | 1999-11-11 | Eli Lilly And Company | Spla2 inhibitor compounds for treatment of disease |
CA2332528A1 (en) | 1998-05-21 | 1999-11-25 | Shionogi & Co., Ltd. | Pyrrolo[1,2-b]pyridazine spla2 inhibitory |
EP1100493A4 (en) | 1998-08-03 | 2001-10-24 | Lilly Co Eli | SPLA 2 INHIBITORS? OF THE INDOLTYPS |
CA2338855A1 (en) * | 1998-08-03 | 2000-02-17 | Eli Lilly And Company | Indole spla2 inhibitors |
US6325991B1 (en) | 1998-08-24 | 2001-12-04 | Susan E. Draheim | Methods and compositions for treating periodontal disease with an inhibitor of secretory phospholipase A2 |
US6576654B1 (en) | 1998-09-23 | 2003-06-10 | Eli Lilly And Company | Method for the treatment of cystic fibrosis |
DZ2771A1 (fr) * | 1998-10-09 | 2003-12-01 | Lilly Co Eli | Procédé de préparation de 1h-indol-3 glyoxamides substituées en position 4. |
DE69931963D1 (de) * | 1998-10-14 | 2006-07-27 | Shionogi & Co | Spla2-inhibitoren zur behandlung von ischämischen reperfusionsschäden |
US20030149000A1 (en) * | 1998-11-10 | 2003-08-07 | Shionogi & Co., Ltd. | Method for the treatment of disorders associated with apoptosis using N-heterocyclic glyoxylamide compounds |
JP2002542148A (ja) * | 1998-12-21 | 2002-12-10 | イーライ・リリー・アンド・カンパニー | 敗血症の処置のための組み合わせ療法 |
JP2002532571A (ja) * | 1998-12-22 | 2002-10-02 | イーライ・リリー・アンド・カンパニー | 新規sPLA2インヒビター |
CA2356162A1 (en) | 1998-12-22 | 2000-06-29 | Eli Lilly And Company | Substituted tricyclics |
US6380397B1 (en) | 1999-04-15 | 2002-04-30 | Eli Lilly And Company | Process for preparing 4-substituted-1H-indole-3-glyoxamides |
US6274578B1 (en) | 1999-04-20 | 2001-08-14 | Eli Lilly And Company | sPLA2 inhibitor ester |
US6140327A (en) * | 1999-05-12 | 2000-10-31 | Eli Lilly And Company | Morpholino-n-ethyl ester derivative of an indole sPLA2 inhibitor |
CA2379208A1 (en) * | 1999-07-19 | 2001-01-25 | Eli Lilly & Company | Spla2 inhibitors |
US6706752B1 (en) | 1999-07-19 | 2004-03-16 | Eli Lilly And Company | sPLA2 inhibitors |
WO2001005789A1 (fr) | 1999-07-19 | 2001-01-25 | Shionogi & Co., Ltd. | Composes tricycliques a action inhibitrice a l'encontre de spla¿2? |
AU6023200A (en) | 1999-08-02 | 2001-02-19 | Shionogi & Co., Ltd. | Tricyclic compounds having spla2-inhibitory activities |
WO2001014378A1 (fr) | 1999-08-23 | 2001-03-01 | Shionogi & Co., Ltd. | DERIVES DE PYRROLOTRIAZINE A ACTIVITES INHIBANT sPLA¿2? |
JP2003509491A (ja) * | 1999-09-20 | 2003-03-11 | イーライ・リリー・アンド・カンパニー | 新規なsPLA2インヒビター |
US6831095B1 (en) | 1999-09-20 | 2004-12-14 | Eli Lilly And Company | Hydroxyfunctional amide 1h-indole derivatives active as sPLA2 inhibitors |
WO2001026653A1 (fr) * | 1999-10-15 | 2001-04-19 | Shionogi & Co., Ltd. | Inhibiteurs spla2 du type v et/ou du type x |
US6756376B1 (en) | 1999-11-15 | 2004-06-29 | Shionogi & Co., Ltd. | Tricyclic azaindolizine derivatives having an sPLA2-inhibitory activities |
AU2050001A (en) * | 1999-12-16 | 2001-06-25 | Eli Lilly And Company | Synthesis of indole-containing spla2 inhibitors |
WO2001044185A1 (en) * | 1999-12-16 | 2001-06-21 | Eli Lilly And Company | Carbon monoxide-based synthesis of spla2 inhibitors |
DE19962300A1 (de) * | 1999-12-23 | 2001-06-28 | Asta Medica Ag | Substituierte N-Benzyl-Indol-3-yl-glyoxylsäure-Derivate mit Antitumorwirkung |
JP2003519198A (ja) * | 2000-01-06 | 2003-06-17 | イーライ・リリー・アンド・カンパニー | 炎症性疾患および呼吸器疾患の処置のための併用療法 |
AU4599601A (en) * | 2000-01-07 | 2001-07-16 | Eli Lilly And Company | Substituted tricyclics |
US20030096854A1 (en) * | 2002-06-12 | 2003-05-22 | Ho-Shen Lin | Substituted tricyclics |
AU2001229252A1 (en) * | 2000-03-09 | 2001-09-17 | Eli Lilly And Company | Method for the treatment of renal dysfunction with spla2 inhibitors |
BR0002188A (pt) * | 2000-03-30 | 2001-11-13 | Brasil Compressores Sa | Processo de formação do pacote de lâminasmetálicas de estator de motor elétrico e pacotede lâminas metálicas |
AU2001252922A1 (en) * | 2000-04-19 | 2001-11-07 | Eli Lilly And Company | Azide cyclization-based synthesis and intermediates for spla2 inhibitors |
US6967200B2 (en) | 2000-06-29 | 2005-11-22 | Shionogi & Co., Ltd. | Remedies for cirrhosis |
WO2002000257A1 (fr) * | 2000-06-29 | 2002-01-03 | Shionogi & Co., Ltd. | Remedes a la maladie d'alzheimer |
TW583000B (en) * | 2000-06-29 | 2004-04-11 | Shionogi & Co | X-type sPLA2 inhibitor as a cancer therapeutical agent |
JPWO2002000621A1 (ja) * | 2000-06-29 | 2004-04-22 | 塩野義製薬株式会社 | X型sPLA2阻害作用を有する化合物 |
CA2413582A1 (en) * | 2000-07-14 | 2002-01-24 | Eli Lilly And Company | Use of a spla2 inhibitor for the treatment of sepsis |
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EP1358156B1 (en) * | 2000-12-18 | 2007-02-21 | Eli Lilly And Company | Benz(g) indoles and their use as spla2 inhibitors |
TWI314457B (hu) * | 2001-03-19 | 2009-09-11 | Shionogi & Co | |
US6730694B1 (en) | 2001-07-20 | 2004-05-04 | Eli Lilly And Company | sPLA2 inhibitors |
TWI323658B (en) | 2001-12-06 | 2010-04-21 | Nat Health Research Institutes | Novel compounds of indol-3-yl-2-oxyacetylamide derivatives, pharmaceutical composition thereof, and method for manufacturing the same |
AUPS282602A0 (en) | 2002-06-07 | 2002-06-27 | Garvan Institute Of Medical Research | Method of inhibiting cell proliferation |
DE10348022A1 (de) * | 2003-10-15 | 2005-05-25 | Imtm Gmbh | Neue Dipeptidylpeptidase IV-Inhibitoren zur funktionellen Beeinflussung unterschiedlicher Zellen und zur Behandlung immunologischer, entzündlicher, neuronaler und anderer Erkrankungen |
US20050244367A1 (en) * | 2004-05-03 | 2005-11-03 | Ilypsa, Inc. | Phospholipase inhibitors localized in the gastrointestinal lumen |
AU2006311766A1 (en) * | 2005-11-03 | 2007-05-18 | Ilypsa, Inc. | Indole compounds having C4-acidic substituents and use thereof as phospholipase-A2 inhibitors |
MX2008005666A (es) * | 2005-11-03 | 2009-03-02 | Ilypsa Inc | Compuestos multivalentes de indol y uso de los mismos como inhibidores de fosfolipasa-a2. |
CA2627349A1 (en) * | 2005-11-03 | 2007-05-18 | Ilypsa, Inc. | Azaindole compounds and use thereof as phospholipase-a2 inhibitors |
MX2008005660A (es) * | 2005-11-03 | 2008-12-15 | Ilypsa Inc | Compuestos de indol que tienen sustituyentes c4-amida y uso de los mismos como inhibidores de la fosfolipasa a2. |
US8048880B2 (en) * | 2007-05-03 | 2011-11-01 | Anthera Pharmaceuticals, Inc. | Treatment of cardiovascular disease and dyslipidemia using secretory phospholipase A2 (SPLA2) inhibitors and SPLA2 inhibitor combination therapies |
CA2722102C (en) * | 2008-04-28 | 2013-06-11 | Asahi Kasei Pharma Corporation | Phenylpropionic acid derivative and use thereof |
CA2749534A1 (en) * | 2009-01-08 | 2010-07-15 | Anthera Pharmaceuticals, Inc. | Secretory phospholipase a2 (spla2) inhibitor and niacin drug compositions and methods for treating cardiovascular disease and dyslipidemia |
NZ720946A (en) | 2009-04-29 | 2017-09-29 | Amarin Pharmaceuticals Ie Ltd | Pharmaceutical compositions comprising epa and a cardiovascular agent and methods of using the same |
CN101838232B (zh) * | 2009-07-07 | 2012-02-22 | 爱斯医药科技(南京)有限公司 | Varespladib的制备方法 |
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PT675110E (pt) | 1994-04-01 | 2002-11-29 | Lilly Co Eli | 1h-indole-3-glioxilamidas inibidoras da spla2 |
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-
1995
- 1995-03-31 PT PT95302166T patent/PT675110E/pt unknown
- 1995-03-31 HU HU9500957A patent/HUT72048A/hu unknown
- 1995-03-31 AT AT95302166T patent/ATE220394T1/de active
- 1995-03-31 NZ NZ270848A patent/NZ270848A/en unknown
- 1995-03-31 FI FI951553A patent/FI114793B/fi not_active IP Right Cessation
- 1995-03-31 BR BR9501404A patent/BR9501404A/pt not_active IP Right Cessation
- 1995-03-31 EP EP10180825A patent/EP2341045A1/en not_active Withdrawn
- 1995-03-31 EP EP95302166A patent/EP0675110B1/en not_active Expired - Lifetime
- 1995-03-31 AU AU16217/95A patent/AU688458B2/en not_active Ceased
- 1995-03-31 CA CA002146097A patent/CA2146097C/en not_active Expired - Fee Related
- 1995-03-31 PE PE1995265383A patent/PE18696A1/es not_active Application Discontinuation
- 1995-03-31 JP JP07076117A patent/JP3109974B2/ja not_active Expired - Fee Related
- 1995-03-31 ES ES95302166T patent/ES2179088T3/es not_active Expired - Lifetime
- 1995-03-31 DE DE69527322T patent/DE69527322T2/de not_active Expired - Lifetime
- 1995-03-31 TW TW084103168A patent/TW383302B/zh not_active IP Right Cessation
- 1995-03-31 RU RU95104885/04A patent/RU2128169C1/ru not_active IP Right Cessation
- 1995-03-31 AT AT08001265T patent/ATE540923T1/de active
- 1995-03-31 EP EP08001265A patent/EP1950200B1/en not_active Expired - Lifetime
- 1995-03-31 IL IL11321095A patent/IL113210A/en not_active IP Right Cessation
- 1995-03-31 UA UA95038298A patent/UA47387C2/uk unknown
- 1995-03-31 DK DK08001265.1T patent/DK1950200T3/da active
- 1995-03-31 MX MX9501608A patent/MX9501608A/es unknown
- 1995-03-31 CZ CZ95822A patent/CZ82295A3/cs unknown
- 1995-03-31 CN CN95103320A patent/CN1067054C/zh not_active Expired - Fee Related
- 1995-03-31 SI SI9530616T patent/SI0675110T1/xx unknown
- 1995-03-31 MY MYPI95000820A patent/MY112897A/en unknown
- 1995-03-31 ES ES08001265T patent/ES2377223T3/es not_active Expired - Lifetime
- 1995-03-31 ZA ZA952693A patent/ZA952693B/xx unknown
- 1995-03-31 EP EP01130290A patent/EP1197484A2/en not_active Withdrawn
- 1995-03-31 EP EP00203897A patent/EP1081135A3/en not_active Withdrawn
- 1995-03-31 PL PL95307951A patent/PL180523B1/pl not_active IP Right Cessation
- 1995-03-31 NO NO951252A patent/NO304186B1/no not_active IP Right Cessation
- 1995-03-31 DK DK95302166T patent/DK0675110T3/da active
- 1995-03-31 KR KR1019950007267A patent/KR100368707B1/ko not_active IP Right Cessation
- 1995-03-31 CO CO95013251A patent/CO4370099A1/es unknown
- 1995-06-06 US US08/469,954 patent/US5654326A/en not_active Expired - Lifetime
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1997
- 1997-03-28 US US08/825,453 patent/US5733923A/en not_active Expired - Lifetime
- 1997-05-14 US US08/856,271 patent/US5919810A/en not_active Expired - Lifetime
- 1997-12-16 US US08/991,149 patent/US5919943A/en not_active Expired - Lifetime
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1999
- 1999-02-26 US US09/258,680 patent/US6175021B1/en not_active Expired - Fee Related
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2000
- 2000-11-16 US US09/714,364 patent/US6433001B1/en not_active Expired - Fee Related
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