SG48049A1 - Process i - Google Patents

Process i

Info

Publication number
SG48049A1
SG48049A1 SG1996006659A SG1996006659A SG48049A1 SG 48049 A1 SG48049 A1 SG 48049A1 SG 1996006659 A SG1996006659 A SG 1996006659A SG 1996006659 A SG1996006659 A SG 1996006659A SG 48049 A1 SG48049 A1 SG 48049A1
Authority
SG
Singapore
Prior art keywords
agglomerates
spheronizing
spheronization
agglomerating
tumbling
Prior art date
Application number
SG1996006659A
Other languages
English (en)
Inventor
Johan Falk
Eva Trofast
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE9303214A external-priority patent/SE9303214D0/xx
Priority claimed from SE9304271A external-priority patent/SE9304271D0/xx
Application filed by Astra Ab filed Critical Astra Ab
Publication of SG48049A1 publication Critical patent/SG48049A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/20—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by expressing the material, e.g. through sieves and fragmenting the extruded length

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Otolaryngology (AREA)
  • Pulmonology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)
  • Control Of Multiple Motors (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Exchange Systems With Centralized Control (AREA)
  • Stereophonic System (AREA)
  • Control Of Motors That Do Not Use Commutators (AREA)
  • Electrical Discharge Machining, Electrochemical Machining, And Combined Machining (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Mixers Of The Rotary Stirring Type (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • General Preparation And Processing Of Foods (AREA)
SG1996006659A 1993-10-01 1994-09-29 Process i SG48049A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE9303214A SE9303214D0 (sv) 1993-10-01 1993-10-01 Process I
SE9304271A SE9304271D0 (sv) 1993-12-22 1993-12-22 Process I
US08/317,033 US5551489A (en) 1993-10-01 1994-10-03 Agglomeration of finely divided powders

Publications (1)

Publication Number Publication Date
SG48049A1 true SG48049A1 (en) 1998-04-17

Family

ID=27355730

Family Applications (1)

Application Number Title Priority Date Filing Date
SG1996006659A SG48049A1 (en) 1993-10-01 1994-09-29 Process i

Country Status (23)

Country Link
US (1) US5551489A (zh)
EP (1) EP0721331B1 (zh)
JP (1) JP3732508B2 (zh)
CN (1) CN1110300C (zh)
AT (1) ATE209903T1 (zh)
AU (1) AU679789B2 (zh)
BR (1) BR9407686A (zh)
CZ (1) CZ289214B6 (zh)
DE (1) DE69429357T2 (zh)
DK (1) DK0721331T3 (zh)
EG (1) EG20677A (zh)
ES (1) ES2166786T3 (zh)
FI (1) FI116364B (zh)
HU (1) HU222355B1 (zh)
IL (1) IL111080A (zh)
NO (1) NO314836B1 (zh)
NZ (1) NZ274277A (zh)
PL (1) PL175564B1 (zh)
PT (1) PT721331E (zh)
RU (1) RU2170082C2 (zh)
SG (1) SG48049A1 (zh)
SK (1) SK283569B6 (zh)
WO (1) WO1995009615A1 (zh)

Families Citing this family (89)

* Cited by examiner, † Cited by third party
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US5980949A (en) * 1994-10-03 1999-11-09 Astra Aktiebolag Formulation for inhalation
US5983956A (en) * 1994-10-03 1999-11-16 Astra Aktiebolag Formulation for inhalation
SE9700134D0 (sv) * 1997-01-20 1997-01-20 Astra Ab New formulation
US5654007A (en) * 1995-06-07 1997-08-05 Inhale Therapeutic Systems Methods and system for processing dispersible fine powders
DE19522899C1 (de) * 1995-06-23 1996-12-19 Hexal Pharmaforschung Gmbh Verfahren zum kontinuierlichen Ersintern eines Granulats
US5826633A (en) 1996-04-26 1998-10-27 Inhale Therapeutic Systems Powder filling systems, apparatus and methods
US5874064A (en) 1996-05-24 1999-02-23 Massachusetts Institute Of Technology Aerodynamically light particles for pulmonary drug delivery
US20020052310A1 (en) * 1997-09-15 2002-05-02 Massachusetts Institute Of Technology The Penn State Research Foundation Particles for inhalation having sustained release properties
US6652837B1 (en) 1996-05-24 2003-11-25 Massachusetts Institute Of Technology Preparation of novel particles for inhalation
SE9700133D0 (sv) * 1997-01-20 1997-01-20 Astra Ab New formulation
SE9700135D0 (sv) * 1997-01-20 1997-01-20 Astra Ab New formulation
US6503537B2 (en) 1997-03-20 2003-01-07 Schering Corporation Preparation of powder agglomerates
US6495167B2 (en) 1997-03-20 2002-12-17 Schering Corporation Preparation of powder agglomerates
ID24472A (id) * 1997-03-20 2000-07-20 Schering Corp Pembuatan aglomerat bubuk
EP0876814A1 (en) * 1997-05-07 1998-11-11 "PHARLYSE", Société Anonyme Dry powder inhaler excipient, process for its preparation and pharmaceutical compositions containing it
US6182712B1 (en) 1997-07-21 2001-02-06 Inhale Therapeutic Systems Power filling apparatus and methods for their use
US7052678B2 (en) 1997-09-15 2006-05-30 Massachusetts Institute Of Technology Particles for inhalation having sustained release properties
AU2081999A (en) * 1998-01-13 1999-08-02 Astrazeneca Uk Limited Pharmaceutical compostition comprising a compound having dopamine (D2) receptor agonist activity and a compound (B) having Beta2 adrenoreceptor agonist activity
SE9802073D0 (sv) 1998-06-11 1998-06-11 Astra Ab New use
US6956021B1 (en) * 1998-08-25 2005-10-18 Advanced Inhalation Research, Inc. Stable spray-dried protein formulations
US8722668B2 (en) * 1998-12-23 2014-05-13 Daryl W. Hochman Methods and compositions for the treatment of neuropathic pain and neuropsychiatric disorders
US20010036481A1 (en) * 1999-08-25 2001-11-01 Advanced Inhalation Research, Inc. Modulation of release from dry powder formulations
WO2001013891A2 (en) * 1999-08-25 2001-03-01 Advanced Inhalation Research, Inc. Modulation of release from dry powder formulations
US7678364B2 (en) 1999-08-25 2010-03-16 Alkermes, Inc. Particles for inhalation having sustained release properties
US6749835B1 (en) 1999-08-25 2004-06-15 Advanced Inhalation Research, Inc. Formulation for spray-drying large porous particles
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US20020141946A1 (en) * 2000-12-29 2002-10-03 Advanced Inhalation Research, Inc. Particles for inhalation having rapid release properties
CN100369904C (zh) 2001-02-14 2008-02-20 泰博特克药品有限公司 2-(取代-氨基)-苯并噻唑磺酰胺hiv蛋白酶抑制剂
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PT1387842E (pt) 2001-05-11 2009-07-20 Tibotec Pharm Ltd 2-aminobenzoxazolsulfonamidas inibidoras de largo espectro da protease hiv
WO2003043585A2 (en) * 2001-11-20 2003-05-30 Advanced Inhalation Research, Inc. Improved particulate compositions for pulmonary delivery
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EP1463502B1 (en) 2001-12-21 2011-07-13 Tibotec Pharmaceuticals Broadspectrum heterocyclic substituted phenyl containing sulfonamide hiv protease inhibitors
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SI1517899T1 (sl) 2002-05-17 2008-02-29 Tibotec Pharm Ltd Substituirani benzoksazol sulfonamidi sirokega spektra, ki so HIV proteazni inhibitorji
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EP2421518A2 (en) * 2009-04-24 2012-02-29 Schering Corporation Agglomerate formulations including active pharmaceutical agents with targeted particle sizes
ES2426410T3 (es) 2010-03-02 2013-10-23 Amakem Nv Amidas heterocíclicas como inhibidores de la ROCK
WO2011110852A1 (en) 2010-03-10 2011-09-15 Astrazeneca Ab Polymorphic forms of 6- [2- (4 -cyanophenyl) - 2h - pyrazol - 3 - yl] - 5 -methyl - 3 - oxo - 4 - (trifluoromethyl - phenyl) 3,4-dihydropyrazine-2-carboxylic acid ethylamide
GB201019043D0 (en) 2010-11-10 2010-12-22 Protea Biopharma N V Use of 2',5'-oligoadenylate derivative compounds
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GB201113689D0 (en) 2011-08-09 2011-09-21 Amakem Nv Novel PDE4 inhibitors
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CN103930427B (zh) 2011-09-30 2016-03-09 昂科迪塞恩股份有限公司 大环flt3激酶抑制剂
EP2810198B1 (en) 2012-01-30 2023-07-12 Universiteit Gent Anti-invasive compounds
GB201204756D0 (en) 2012-03-19 2012-05-02 Lewi Paulus J Triazines with suitable spacers for treatment and/or prevention of HIV infections
WO2014072419A1 (en) 2012-11-08 2014-05-15 Universiteit Antwerpen Novel anti-hiv compounds
JP2016510797A (ja) 2013-03-15 2016-04-11 オンコデザイン エス．ア． 大環状塩誘導性キナーゼ阻害剤
US9427376B2 (en) * 2013-10-10 2016-08-30 Chiesi Farmaceutici S.P.A. Process for preparing pharmaceutical formulations for inhalation comprising a high-dosage strength active ingredient
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WO2016003450A1 (en) 2014-07-01 2016-01-07 The Regents Of The University Of California Pkc-epsilon inhibitors
WO2016005340A1 (en) 2014-07-08 2016-01-14 Universiteit Gent Hamamelitannin analogues and uses thereof
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WO2017146994A1 (en) * 2016-02-24 2017-08-31 Merck Sharp & Dohme Corp. Controlled agglomeration of micronized drug or drug-excipient mixtures
WO2017157882A1 (en) 2016-03-14 2017-09-21 Université Catholique de Louvain Serine biosynthetic pathway inhibitors
WO2018065387A1 (en) 2016-10-04 2018-04-12 Universiteit Gent Novel hamamelitannin analogues and uses thereof
US10738002B2 (en) 2016-11-24 2020-08-11 Universitair Ziekenhuis Antwerpen Halogenated benzotropolones as ATG4B inhibitors
WO2018138358A1 (en) 2017-01-30 2018-08-02 Université de Liège Perk and ire-1a inhibitors against neurodevelopmental disorders
PL3621963T3 (pl) 2017-05-11 2024-05-20 Remynd N.V. Związki do leczenia epilepsji, zaburzeń neurodegeneracyjnych i innych zaburzeń oun
WO2019193091A1 (en) 2018-04-05 2019-10-10 Universiteit Hasselt Selective pde4d inhibitors against demyelinating diseases
CA3110661A1 (en) 2018-08-29 2020-03-05 University Of Massachusetts Inhibition of protein kinases to treat friedreich ataxia
WO2020229595A1 (en) 2019-05-14 2020-11-19 Molecular Targeted Radiopharmaceuticals Holding Gmbh (Mtr) Quinazoline-2,4-dione derivatives as parp inhibitors
WO2022157381A1 (en) 2021-01-25 2022-07-28 Universiteit Hasselt Phloretin for use in the treatment of neurodegenerative and demyelinating diseases
EP4387629A1 (en) 2021-08-18 2024-06-26 Katholieke Universiteit Leuven KU Leuven Research & Development 6-substituted- and 6,7-disubstituted-7-deazapurine ribonucleoside analogues
WO2023046900A1 (en) 2021-09-23 2023-03-30 Katholieke Universiteit Leuven Ribonucleoside analogues against -sars-cov-2
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Also Published As

Publication number Publication date
NO961290L (no) 1996-03-29
IL111080A0 (en) 1994-11-28
NO961290D0 (no) 1996-03-29
PL313765A1 (en) 1996-07-22
FI961430A0 (fi) 1996-03-29
ES2166786T3 (es) 2002-05-01
EP0721331B1 (en) 2001-12-05
JPH09504224A (ja) 1997-04-28
BR9407686A (pt) 1997-02-04
DK0721331T3 (da) 2002-02-11
DE69429357D1 (de) 2002-01-17
EG20677A (en) 1999-11-30
HU9600821D0 (en) 1996-05-28
HUT74519A (en) 1997-01-28
NO314836B1 (no) 2003-06-02
CZ289214B6 (cs) 2001-12-12
AU679789B2 (en) 1997-07-10
FI961430A (fi) 1996-03-29
RU2170082C2 (ru) 2001-07-10
EP0721331A1 (en) 1996-07-17
PT721331E (pt) 2002-05-31
FI116364B (fi) 2005-11-15
IL111080A (en) 1999-08-17
AU7826194A (en) 1995-05-01
SK283569B6 (sk) 2003-09-11
US5551489A (en) 1996-09-03
CN1110300C (zh) 2003-06-04
CZ94296A3 (en) 1996-06-12
DE69429357T2 (de) 2002-08-14
ATE209903T1 (de) 2001-12-15
JP3732508B2 (ja) 2006-01-05
PL175564B1 (pl) 1999-01-29
WO1995009615A1 (en) 1995-04-13
SK39196A3 (en) 1997-06-04
NZ274277A (en) 1998-01-26
HU222355B1 (hu) 2003-06-28
CN1132476A (zh) 1996-10-02

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