SG150548A1 - Dna damage repair inhibitors for treatment of cancer - Google Patents
Dna damage repair inhibitors for treatment of cancerInfo
- Publication number
- SG150548A1 SG150548A1 SG200901339-2A SG2009013392A SG150548A1 SG 150548 A1 SG150548 A1 SG 150548A1 SG 2009013392 A SG2009013392 A SG 2009013392A SG 150548 A1 SG150548 A1 SG 150548A1
- Authority
- SG
- Singapore
- Prior art keywords
- treatment
- cancer
- dna damage
- damage repair
- repair inhibitors
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/4035—Isoindoles, e.g. phthalimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4706—4-Aminoquinolines; 8-Aminoquinolines, e.g. chloroquine, primaquine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US52624403P | 2003-12-01 | 2003-12-01 | |
GB0327844A GB0327844D0 (en) | 2003-12-01 | 2003-12-01 | Therapeutic methods and means |
Publications (1)
Publication Number | Publication Date |
---|---|
SG150548A1 true SG150548A1 (en) | 2009-03-30 |
Family
ID=34655227
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG200901339-2A SG150548A1 (en) | 2003-12-01 | 2004-11-30 | Dna damage repair inhibitors for treatment of cancer |
Country Status (23)
Country | Link |
---|---|
US (5) | US8071579B2 (ru) |
EP (2) | EP1684736B1 (ru) |
JP (2) | JP5545690B2 (ru) |
KR (1) | KR20060123403A (ru) |
CN (1) | CN102107008B (ru) |
AT (1) | ATE521341T1 (ru) |
AU (2) | AU2004294790B2 (ru) |
BR (1) | BRPI0417056A (ru) |
CA (1) | CA2547077C (ru) |
DK (2) | DK1684736T3 (ru) |
ES (2) | ES2371469T3 (ru) |
HK (1) | HK1089358A1 (ru) |
HU (1) | HUE025996T2 (ru) |
IL (1) | IL176013A (ru) |
MX (1) | MXPA06006120A (ru) |
NO (1) | NO335959B1 (ru) |
NZ (1) | NZ547984A (ru) |
PL (2) | PL1684736T3 (ru) |
PT (2) | PT2305221E (ru) |
RU (3) | RU2413515C2 (ru) |
SG (1) | SG150548A1 (ru) |
TW (1) | TWI338000B (ru) |
WO (1) | WO2005053662A1 (ru) |
Families Citing this family (105)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7151102B2 (en) * | 2000-10-30 | 2006-12-19 | Kudos Pharmaceuticals Limited | Phthalazinone derivatives |
US6956035B2 (en) | 2001-08-31 | 2005-10-18 | Inotek Pharmaceuticals Corporation | Isoquinoline derivatives and methods of use thereof |
EP1501822B1 (en) * | 2002-04-30 | 2010-12-15 | Kudos Pharmaceuticals Limited | Phthalazinone derivatives |
CA2517260A1 (en) | 2003-02-28 | 2005-02-03 | Inotek Pharmaceuticals Corporation | Tetracyclic benzamide derivatives and methods of use thereof |
US7449464B2 (en) | 2003-03-12 | 2008-11-11 | Kudos Pharmaceuticals Limited | Phthalazinone derivatives |
GB0305681D0 (en) | 2003-03-12 | 2003-04-16 | Kudos Pharm Ltd | Phthalazinone derivatives |
GB0317466D0 (en) * | 2003-07-25 | 2003-08-27 | Univ Sheffield | Use |
BRPI0412899B1 (pt) * | 2003-07-25 | 2021-10-05 | Cancer Research Technology Limited | Uso de um composto ou um sal farmaceuticamente aceitável do mesmo para a manufatura de um medicamento citotóxico para o tratamento de câncer de ovário, câncer de mama, câncer de próstata ou câncer pancreático |
JP5545690B2 (ja) * | 2003-12-01 | 2014-07-09 | クドス ファーマシューティカルズ リミテッド | 癌治療のためのdna損傷修復阻害剤 |
GB0419072D0 (en) | 2004-08-26 | 2004-09-29 | Kudos Pharm Ltd | Phthalazinone derivatives |
GB0428111D0 (en) * | 2004-12-22 | 2005-01-26 | Kudos Pharm Ltd | Pthalazinone derivatives |
CA2595290C (en) | 2005-01-19 | 2013-06-25 | Mgi Gp, Inc. | Diazabenzo[de]anthracen-3-one compounds and methods for inhibiting parp |
WO2006093667A1 (en) | 2005-02-25 | 2006-09-08 | Inotek Pharmaceuticals Corporation | Tetracyclic amino and carboxamido compounds and methods of use thereof |
WO2006135873A2 (en) * | 2005-06-10 | 2006-12-21 | Bipar Sciences, Inc. | Parp modulators and treatment of cancer |
JP5177429B2 (ja) * | 2005-07-18 | 2013-04-03 | バイパー サイエンシズ,インコーポレイティド | 癌の治療 |
WO2007025009A2 (en) | 2005-08-24 | 2007-03-01 | Inotek Pharmaceuticals Corporation | Indenoisoquinolinone analogs and methods of use thereof |
GB0521373D0 (en) * | 2005-10-20 | 2005-11-30 | Kudos Pharm Ltd | Pthalazinone derivatives |
CN101484436A (zh) * | 2006-06-15 | 2009-07-15 | 库多斯药物有限公司 | 作为parp抑制剂的2-氧基杂芳基酰胺衍生物 |
JP2009539963A (ja) * | 2006-06-15 | 2009-11-19 | クドス ファーマシューティカルズ リミテッド | Parp阻害剤 |
CN101484421A (zh) * | 2006-06-15 | 2009-07-15 | 库多斯药物有限公司 | 作为parp抑制剂的2-氧基苯甲酰胺衍生物 |
WO2008020180A2 (en) * | 2006-08-17 | 2008-02-21 | Kudos Pharmaceuticals Limited | Methods of increasing the sensitivity of cancer cells to dna damage |
CA2662337A1 (en) | 2006-09-05 | 2008-03-13 | Bipar Sciences, Inc. | Inhibition of fatty acid synthesis by parp inhibitors and methods of treatment thereof |
EP2059498A4 (en) | 2006-09-05 | 2011-01-12 | Bipar Sciences Inc | TREATMENT OF CANCER |
CA2662335A1 (en) * | 2006-09-05 | 2008-03-13 | Valeria Ossovskaya | Methods for designing parp inhibitors and uses thereof |
JP2010505811A (ja) | 2006-10-04 | 2010-02-25 | ファイザー・プロダクツ・インク | カルシウム受容体アンタゴニストとしてのピリド[4,3−d]ピリミジン−4(3H)−オン誘導体 |
TWI404716B (zh) | 2006-10-17 | 2013-08-11 | Kudos Pharm Ltd | 酞嗪酮(phthalazinone)衍生物 |
EP2092083A2 (en) * | 2006-10-20 | 2009-08-26 | Dana-Farber Cancer Institute | Dna damage repair inhibitors and methods for treating cancer |
CA2674075C (en) * | 2006-12-29 | 2012-10-30 | Charles P. Theuer | Antifolate agent combinations in the treatment of cancer |
RU2009135818A (ru) | 2007-02-28 | 2011-04-10 | Инотек Фармасьютикалз Корпорейшн (Us) | Инденоизохинолиноновые аналоги и способы их применения |
TW200900396A (en) * | 2007-04-10 | 2009-01-01 | Kudos Pharm Ltd | Phthalazinone derivatives |
MX2009012705A (es) * | 2007-05-25 | 2009-12-08 | Astrazeneca Ab | Combinacion de inhibidores de cinasa de control y poli(adp-ribosa)polimerasa-1 para el tratamiento de canceres. |
US20090023727A1 (en) * | 2007-07-05 | 2009-01-22 | Muhammad Hashim Javaid | Phthalazinone derivatives |
RU2010108008A (ru) | 2007-09-14 | 2011-10-20 | Астразенека Аб (Se) | Фталазиноновые производные |
RU2485122C2 (ru) * | 2007-10-03 | 2013-06-20 | Эйсэй Инк. | Соединения и композиции, ингибирующие parp, и способы их применения |
CA2702429A1 (en) * | 2007-10-17 | 2009-04-23 | Kudos Pharmaceuticals Limited | Crystalline form l 4-[3-(4-cyclopropanecarbonyl-piperazine-1-carbonyl)-4-fluoro-benzyl]-2h-phthalazin-1-one |
AU2008324203A1 (en) * | 2007-11-05 | 2009-05-14 | Novartis Ag | Methods and compositions for measuring Wnt activation and for treating Wnt-related cancers |
CN101917982B (zh) | 2007-11-12 | 2013-03-20 | 彼帕科学公司 | 使用4-碘-3-硝基苯甲酰胺与抗肿瘤剂组合治疗乳腺癌 |
UY31603A1 (es) | 2008-01-23 | 2009-08-31 | Derivados de ftalazinona | |
JP5436786B2 (ja) * | 2008-03-06 | 2014-03-05 | オリンパス株式会社 | 細胞周期計測方法 |
US8968540B2 (en) * | 2008-10-06 | 2015-03-03 | Arizona Board Of Regents, A Body Corporate Of The State Of Arizona Acting For And On Behalf Of Arizona State University | Trans-base tunnel reader for sequencing |
BRPI0920604B1 (pt) | 2008-10-07 | 2021-11-23 | Kudos Pharmaceuticals Limited | Formulação farmacêutica de liberação imediata na forma de uma dispersão sólida compreendendo como ativo o composto 4-[3-(4-ciclopropanocarbonil-piperazina-1-carbonil)-4-flúor- benzil]-2h-ftalazin-1-ona (olaparibe) |
CN102405045A (zh) * | 2009-02-27 | 2012-04-04 | 逊尼希思制药公司 | 利用sns-595 治疗具有降低的brca2 活性的癌症对象的方法 |
WO2010151664A2 (en) | 2009-06-26 | 2010-12-29 | Massachusetts Institute Of Technology | Compositions and methods for treating cancer and modulating stress granule formation |
US8435961B2 (en) * | 2009-06-26 | 2013-05-07 | Massachusetts Institute Of Technology | Methods and compositions for increasing the activity of inhibitory RNA |
US20110015393A1 (en) * | 2009-07-15 | 2011-01-20 | Astrazeneca Ab | Phthalazinone compound |
EP2322658A1 (en) | 2009-11-13 | 2011-05-18 | Centre National de la Recherche Scientifique (CNRS) | Signature for the diagnosis of breast cancer aggressiveness and genetic instability |
WO2011058367A2 (en) | 2009-11-13 | 2011-05-19 | Astrazeneca Ab | Diagnostic test for predicting responsiveness to treatment with poly(adp-ribose) polymerase (parp) inhibitor |
JP2013537045A (ja) * | 2010-09-15 | 2013-09-30 | アルマック ダイアグノスティックス リミテッド | 癌のための分子診断試験 |
CA2865468C (en) * | 2011-03-11 | 2021-05-04 | Sarissa Inc. | Methods of treating cancer by inhibition of dna repair proteins |
WO2012156501A1 (en) | 2011-05-18 | 2012-11-22 | Centre National De La Recherche Scientifique (Cnrs) | Signature for the diagnosis of cancer aggressiveness and genetic instability |
RU2665952C2 (ru) | 2011-07-22 | 2018-09-05 | Пасилекс Фармасьютикалз Инк. | Синтетическая летальность и лечение рака |
CN103130723B (zh) | 2011-11-30 | 2015-01-14 | 成都地奥制药集团有限公司 | 一种多聚(adp-核糖)聚合酶抑制剂 |
US9790556B2 (en) | 2012-01-05 | 2017-10-17 | Centre National De La Recherche Scientifique (Cnrs) | Signature for the diagnosis of lung cancer aggressiveness and genetic instability |
US10220051B2 (en) | 2012-03-29 | 2019-03-05 | Institute For Cancer Research | Combination of DNA repair inhibition with bendamustine or gemcitabine in the treatment of cancer |
US8927516B2 (en) * | 2012-03-29 | 2015-01-06 | Institute For Cancer Research | Combination of DNA repair inhibition with bendamustine or gemcitabine in the treatment of cancer |
RU2492242C1 (ru) * | 2012-04-24 | 2013-09-10 | Федеральное государственное бюджетное учреждение науки Институт химической биологии и фундаментальной медицины Сибирского отделения Российской академии наук (ИХБФМ СО РАН) | Способ оценки активности системы эксцизионной репарации нуклеотидов млекопитающих |
IN2015MN00002A (ru) | 2012-07-09 | 2015-10-16 | Lupin Ltd | |
US9512486B2 (en) * | 2012-08-06 | 2016-12-06 | The Institute Of Cancer Research: Royal Cancer Hospital | Materials, methods, and systems for treating cancer |
AU2014218621B2 (en) * | 2013-02-25 | 2019-11-07 | Sangamo Therapeutics, Inc. | Methods and compositions for enhancing nuclease-mediated gene disruption |
WO2015048718A2 (en) | 2013-09-30 | 2015-04-02 | Institute For Cancer Research D/B/A The Research Institute Of Fox Chase Cancer Center | Inhibition of thymine dna glycosylase in the treatment of cancer |
SG11201610500WA (en) | 2014-06-17 | 2017-01-27 | Vertex Pharma | Method for treating cancer using a combination of chk1 and atr inhibitors |
CN113791217A (zh) * | 2014-08-20 | 2021-12-14 | 阿尔伯特爱因斯坦医学院股份有限公司 | 用于评估癌症的种系风险的方法和组合物 |
ES2731437T3 (es) | 2014-11-21 | 2019-11-15 | Regeneron Pharma | Métodos y composiciones para la modificación genética dirigida mediante el uso de pares de ARN guías |
WO2016112177A1 (en) * | 2015-01-08 | 2016-07-14 | Yale University | Novel Compositions Useful for Killing DNA Repair-Deficient Cancer Cells, and Methods Using Same |
CN105985294B (zh) * | 2015-02-11 | 2020-12-25 | 四川科伦药物研究院有限公司 | 一种奥拉帕尼的制备方法 |
RU2686317C2 (ru) * | 2015-04-24 | 2019-04-25 | Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт фармакологии имени В.В. Закусова" | Замещенные 1,2,5-триметил- и 2,2,6,6-тетраметил-4-аминопиперидины, обладающие антиишемическим действием |
WO2016185406A1 (en) | 2015-05-19 | 2016-11-24 | Nadathur Estates Pvt. Ltd. | Method for identification of a deficient brca1 function |
US11788145B2 (en) | 2015-07-17 | 2023-10-17 | Pacylex Pharmaceuticals Inc. | Epigeneiic silencing of NMT2 |
EP3355926A4 (en) | 2015-09-30 | 2019-08-21 | Vertex Pharmaceuticals Inc. | METHOD FOR THE TREATMENT OF CANCER WITH A COMBINATION OF DNA DAMAGING AGENTS AND ATR INHIBITORS |
CN106699672B (zh) * | 2015-11-16 | 2019-10-29 | 上海博邦医药科技有限公司 | 一种奥拉帕尼无定型物及其制备方法 |
TWI730013B (zh) * | 2015-11-20 | 2021-06-11 | 生華生物科技股份有限公司 | 用於治療癌症的四環喹諾酮類似物組合療法 |
US10823738B2 (en) * | 2015-12-07 | 2020-11-03 | George Mason Research Foundation, Inc. | Methods for breast cancer treatment |
RU2639535C2 (ru) * | 2015-12-07 | 2017-12-21 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) | Способ скрининга противоопухолевых препаратов - ингибиторов parp1 на основе биохимических методов анализа |
ITUB20159206A1 (it) | 2015-12-22 | 2017-06-22 | Olon Spa | Forme cristalline e amorfe di olaparib |
US11702655B2 (en) * | 2016-02-22 | 2023-07-18 | New York Institute Of Technology | Method for treating cancer by disabling-BRCA1/FANCM interaction |
KR102661748B1 (ko) | 2016-05-20 | 2024-05-31 | 리제너론 파마슈티칼스 인코포레이티드 | 다중 가이드 RNAs를 이용한 면역학적 내성 파괴 방법 |
JP6682116B2 (ja) * | 2016-06-02 | 2020-04-15 | 国立大学法人 長崎大学 | ガン転移抑制剤 |
WO2018165615A1 (en) * | 2017-03-09 | 2018-09-13 | The Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Parp-1 and methods of use thereof |
CN107384916A (zh) * | 2017-08-03 | 2017-11-24 | 中国科学院成都生物研究所 | 一种广谱性的癌症治疗基因靶点及其应用 |
WO2019084086A1 (en) * | 2017-10-25 | 2019-05-02 | Dana-Farber Cancer Institute, Inc. | CANCER VACCINE COMPOSITIONS AND METHODS FOR USE IN THE TREATMENT OF CANCER |
WO2019133864A1 (en) | 2017-12-29 | 2019-07-04 | Accutar Biotechnology | DUAL INHIBITORS OF PARP1 and CDK |
EP3735297A1 (en) | 2018-01-05 | 2020-11-11 | Cybrexa 1, Inc. | Compounds, compositions, and methods for treatment of diseases involving acidic or hypoxic diseased tissues |
US11149300B1 (en) * | 2018-01-26 | 2021-10-19 | Cedars-Sinai Medical Center | Methods of treating gastrointestinal malignancies |
TW202000195A (zh) | 2018-02-15 | 2020-01-01 | 生華生物科技股份有限公司 | 喹啉酮類似物及其鹽、組合物及其使用方法 |
JP2022532342A (ja) | 2019-05-14 | 2022-07-14 | ニューベイション・バイオ・インコーポレイテッド | 抗がん核内ホルモン受容体標的化化合物 |
PE20220563A1 (es) | 2019-07-10 | 2022-04-13 | Cybrexa 2 Inc | Conjugados peptidicos de citotoxinas como terapeuticos |
JP2022541747A (ja) | 2019-07-10 | 2022-09-27 | サイブレクサ 3,インコーポレイテッド | 治療薬としての微小管標的化剤のペプチドコンジュゲート |
GB201913030D0 (en) * | 2019-09-10 | 2019-10-23 | Francis Crick Institute Ltd | Treatment of hr deficient cancer |
TW202131930A (zh) | 2019-11-13 | 2021-09-01 | 美商諾維雪碧歐公司 | 抗癌核荷爾蒙受體標靶化合物 |
KR20220128350A (ko) * | 2019-12-11 | 2022-09-20 | 리페어 세라퓨틱스 인크. | Parp 억제제와 조합되는 atr 억제제의 용도 |
WO2021133886A1 (en) | 2019-12-23 | 2021-07-01 | Accutar Biotechnology | Combinations of estrogen receptor degraders and cyclin-dependent kinase inhibitors for treating cancer |
WO2021178832A2 (en) * | 2020-03-06 | 2021-09-10 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. | Dna damage repair genes in cancer |
BR112022021521A2 (pt) | 2020-04-28 | 2023-01-24 | Rhizen Pharmaceuticals Ag | Compostos inovadores úteis como inibidores de poli(adp-ribose)polimerase (parp) |
WO2021262898A1 (en) * | 2020-06-24 | 2021-12-30 | Moma Therapeutics, Inc. | Compositions and methods for the treatment of cancer |
WO2022090938A1 (en) | 2020-10-31 | 2022-05-05 | Rhizen Pharmaceuticals Ag | Phthalazinone derivatives useful as parp inhibitors |
CN114805263B (zh) * | 2021-01-18 | 2023-05-05 | 四川大学 | 3-(羟基苄基)苯酞类化合物、其制备方法和用途 |
US11834458B2 (en) | 2021-03-23 | 2023-12-05 | Nuvation Bio Inc. | Anti-cancer nuclear hormone receptor-targeting compounds |
CN117396214A (zh) * | 2021-03-25 | 2024-01-12 | 宾夕法尼亚大学董事会 | 合成肽治疗剂的car-t递送 |
CN113024516B (zh) * | 2021-03-29 | 2022-05-17 | 中国药科大学 | 双靶点parp/ezh2抑制剂、制备方法及用途 |
MX2023011793A (es) | 2021-04-08 | 2023-10-12 | Rhizen Pharmaceuticals Ag | Inhibidores de poli(adenosin difosfato-ribosa) polimerasa. |
AU2022269568A1 (en) | 2021-05-03 | 2023-11-16 | Nuvation Bio Inc. | Anti-cancer nuclear hormone receptor-targeting compounds |
WO2023064619A1 (en) * | 2021-10-17 | 2023-04-20 | University of South Alabama Foundation for Research and Commercialization | Cancer treatment |
WO2023201338A1 (en) | 2022-04-15 | 2023-10-19 | Ideaya Biosciences, Inc. | Combination therapy comprising a mat2a inhibitor and a parp inhibitor |
WO2023233295A1 (en) | 2022-06-01 | 2023-12-07 | Ideaya Biosciences, Inc. | Thiadiazolyl derivatives as dna polymerase theta inhibitors and uses thereof |
CN115960018B (zh) * | 2022-12-19 | 2024-01-05 | 湖南岳靶生物医药有限公司 | 一种egfr抑制剂、组合物及其应用 |
Family Cites Families (65)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2707069A1 (de) * | 1977-02-18 | 1978-08-24 | Blaszczak Joseph W | Polymerisationsprodukt von formaldehyd und kohlehydraten, verfahren zu seiner herstellung und arzneimittel |
US5484951A (en) | 1990-10-19 | 1996-01-16 | Octamer, Incorporated | 5-iodo-6-amino-6-nitroso-1,2-benzopyrones useful as cytostatic and antiviral agents |
US5260195A (en) | 1991-01-03 | 1993-11-09 | Boehringer Mannheim Corporation | Nonaqueous polymeric reagent compositions and applications thereof |
US5464871A (en) | 1993-05-12 | 1995-11-07 | Octamer, Inc. | Aromatic nitro and nitroso compounds and their metabolites useful as anti-viral and anti-tumor agents |
US6153193A (en) * | 1993-04-28 | 2000-11-28 | Supratek Pharma Inc. | Compositions for targeting biological agents |
EP0600831A1 (de) | 1992-11-27 | 1994-06-08 | Ciba-Geigy Ag | Phthalazinonderivate |
US5587384A (en) | 1994-02-04 | 1996-12-24 | The Johns Hopkins University | Inhibitors of poly(ADP-ribose) synthetase and use thereof to treat NMDA neurotoxicity |
GB9404485D0 (en) | 1994-03-09 | 1994-04-20 | Cancer Res Campaign Tech | Benzamide analogues |
WO1996005307A2 (en) | 1994-08-12 | 1996-02-22 | Myriad Genetics, Inc. | 17q-LINKED BREAST AND OVARIAN CANCER SUSCEPTIBILITY GENE |
MX9701075A (es) | 1994-08-12 | 1998-03-31 | Myriad Genetics Inc | Mutaciones en vivo y polimorfismos en el gen de susceptibilidad al cancer de pecho y ovario enlazado con 17q. |
US5908861A (en) | 1997-05-13 | 1999-06-01 | Octamer, Inc. | Methods for treating inflammation and inflammatory disease using pADPRT inhibitors |
US6426415B1 (en) | 1997-09-03 | 2002-07-30 | Guilford Pharmaceuticals Inc. | Alkoxy-substituted compounds, methods and compositions for inhibiting parp activity |
US6514983B1 (en) | 1997-09-03 | 2003-02-04 | Guilford Pharmaceuticals Inc. | Compounds, methods and pharmaceutical compositions for treating neural or cardiovascular tissue damage |
US6635642B1 (en) | 1997-09-03 | 2003-10-21 | Guilford Pharmaceuticals Inc. | PARP inhibitors, pharmaceutical compositions comprising same, and methods of using same |
MXPA01007001A (es) | 1999-01-11 | 2002-07-30 | Agouron Pharma | Inhibidores triciclicos de poli (adp-ribosa) polimerasas. |
US6465448B1 (en) | 1999-08-13 | 2002-10-15 | Case Western Reserve University | Methoxyamine potentiation of temozolomide anti-cancer activity |
US6635677B2 (en) | 1999-08-13 | 2003-10-21 | Case Western Reserve University | Methoxyamine combinations in the treatment of cancer |
ECSP003637A (es) | 1999-08-31 | 2002-03-25 | Agouron Pharma | Inhibidores triciclicos de poli (adp-ribosa) polimerasas |
WO2001021615A1 (en) | 1999-09-17 | 2001-03-29 | Yamanouchi Pharmaceutical Co., Ltd. | Benzimidazole derivatives |
WO2001023390A2 (de) | 1999-09-28 | 2001-04-05 | Basf Aktiengesellschaft | Azepinoindol-derivate, deren herstellung und anwendung |
US6476048B1 (en) | 1999-12-07 | 2002-11-05 | Inotek Pharamaceuticals Corporation | Substituted phenanthridinones and methods of use thereof |
GB9930519D0 (en) | 1999-12-24 | 2000-02-16 | Phogen Limited | Uses of transport proteins |
AU2001240542A1 (en) | 2000-02-01 | 2001-08-14 | Basf Aktiengesellschaft | Heterocyclic compounds and their use as parp inhibitors |
WO2001066800A2 (en) * | 2000-03-07 | 2001-09-13 | Whitehead Institute For Biomedical Research | Human single nucleotide polymorphisms |
AU2001248748A1 (en) | 2000-04-18 | 2001-10-30 | Sumitomo Pharmaceuticals Company, Limited | Substituted piperazine compounds |
US7122679B2 (en) | 2000-05-09 | 2006-10-17 | Cephalon, Inc. | Multicyclic compounds and the use thereof |
DE10022925A1 (de) | 2000-05-11 | 2001-11-15 | Basf Ag | Substituierte Indole als PARP-Inhibitoren |
US6723733B2 (en) | 2000-05-19 | 2004-04-20 | Guilford Pharmaceuticals, Inc. | Sulfonamide and carbamide derivatives of 6(5H)phenanthridinones and their uses |
BR0113046A (pt) | 2000-08-08 | 2003-07-01 | Sanofi Synthelabo | Derivados de benzimidazol, preparação dos mesmos e aplicação dos mesmos em terapia |
US7151102B2 (en) * | 2000-10-30 | 2006-12-19 | Kudos Pharmaceuticals Limited | Phthalazinone derivatives |
GB2384776C (en) | 2000-10-30 | 2006-02-03 | Kudos Pharm Ltd | Phthalazinone derivatives |
CA2326464A1 (en) * | 2000-11-20 | 2002-05-20 | Aldo Perrone | Improved electrically operated paintball gun |
HUP0303841A2 (hu) * | 2001-02-20 | 2004-03-01 | Bristol-Myers Squibb Company | 2,4-Diszubsztituált-5-pirimidinkarboxamid-származékok mint KCNQ káliumcsatorna modulátorok és ezeket tartalmazó gyógyszerkészítmények és előállításuk |
JPWO2002068407A1 (ja) | 2001-02-28 | 2004-06-24 | 山之内製薬株式会社 | ベンゾイミダゾール化合物 |
ATE355278T1 (de) * | 2001-05-08 | 2006-03-15 | Kudos Pharm Ltd | Isochinolinon derivate als parp inhibitoren |
WO2002094790A1 (fr) | 2001-05-23 | 2002-11-28 | Mitsubishi Pharma Corporation | Compose heterocyclique condense et son utilisation medicale |
US7072771B2 (en) | 2001-06-07 | 2006-07-04 | University Of Kentucky Research Foundation | Selective PARP-1 targeting for designing chemo/radio sensitizing agents |
US6644295B2 (en) * | 2001-07-03 | 2003-11-11 | Smart Parts, Inc. | Pneumatic assembly for a paintball gun |
WO2003007959A1 (en) | 2001-07-16 | 2003-01-30 | Fujisawa Pharmaceutical Co., Ltd. | Quinoxaline derivatives which have parp inhibitory action |
US20030073692A1 (en) | 2001-08-07 | 2003-04-17 | Pharmacia & Upjohn S.P.A. | Amino-phthalazinone derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions containing them |
US20030034020A1 (en) * | 2001-08-14 | 2003-02-20 | Mario Irizarry | Components made of polymers with high luminous transmittance for compressed-gas-powered guns |
WO2003051879A1 (en) | 2001-12-14 | 2003-06-26 | Altana Pharma Ag | Known and novel 4,5-dihydro-imidazo[4,5,1-ij]quinolin-6-ones useful as poly(adp-ribose)polymerase inhibitors |
US7351530B1 (en) | 2001-12-20 | 2008-04-01 | Health Research, Inc. | Prognostic significance of molecular genetic aberrations on chromosome segment 11p15.5 in non-small-cell lung cancer |
AUPR975601A0 (en) | 2001-12-24 | 2002-01-31 | Fujisawa Pharmaceutical Co., Ltd. | Quinazolinone derivatives |
US7157452B2 (en) | 2001-12-31 | 2007-01-02 | Mgi Gp, Inc. | Substituted 4,9-dihydrocyclopenta{imn}phenanthridine-5-ones derivatives thereof and their uses |
AUPS019702A0 (en) | 2002-01-29 | 2002-02-21 | Fujisawa Pharmaceutical Co., Ltd. | Condensed heterocyclic compounds |
DE60336890D1 (de) | 2002-02-19 | 2011-06-09 | Ono Pharmaceutical Co | Kondensierte pyridazinderivat-verbindungen und die verbindungen als wirkstoff enthaltende arzneimittel |
PT1485377E (pt) | 2002-02-25 | 2010-03-12 | Kudos Pharm Ltd | Piranonas úteis como inibidores da atm |
US7237545B2 (en) * | 2002-03-06 | 2007-07-03 | Aj Acquisition I Llc | Compressed gas-powered projectile accelerator |
US7886731B2 (en) * | 2002-03-06 | 2011-02-15 | Kee Action Sports I Llc | Compressed gas gun having reduced breakaway-friction and high pressure dynamic separable seal flow control device |
US6708685B2 (en) * | 2002-03-06 | 2004-03-23 | National Paintball Supply, Inc. | Compressed gas-powered projectile accelerator |
US20030229004A1 (en) | 2002-03-20 | 2003-12-11 | Pangene Corporation | Modulation of tumor cells using BER inhibitors in combination with a sensitizing agent and DSBR inhibitors |
AUPS137402A0 (en) | 2002-03-26 | 2002-05-09 | Fujisawa Pharmaceutical Co., Ltd. | Novel tricyclic compounds |
EP1501822B1 (en) * | 2002-04-30 | 2010-12-15 | Kudos Pharmaceuticals Limited | Phthalazinone derivatives |
WO2004008976A1 (en) | 2002-07-19 | 2004-01-29 | Osteotech, Inc. | Chisels and procedure for insertion of spinal implant in a spinal disc space |
US6732726B2 (en) * | 2002-08-28 | 2004-05-11 | Avalon Manufacturing Company | Paint ball gun having a front mounted gas cylinder |
GB0305681D0 (en) * | 2003-03-12 | 2003-04-16 | Kudos Pharm Ltd | Phthalazinone derivatives |
KR101146806B1 (ko) * | 2003-03-12 | 2012-05-22 | 메이브릿지 리미티드 | 프탈라지논 유도체 |
US7176188B2 (en) | 2003-05-07 | 2007-02-13 | UniversitéLaval | Method of lethally sensitizing human and animal cells |
BRPI0412899B1 (pt) | 2003-07-25 | 2021-10-05 | Cancer Research Technology Limited | Uso de um composto ou um sal farmaceuticamente aceitável do mesmo para a manufatura de um medicamento citotóxico para o tratamento de câncer de ovário, câncer de mama, câncer de próstata ou câncer pancreático |
GB0317466D0 (en) | 2003-07-25 | 2003-08-27 | Univ Sheffield | Use |
JP5545690B2 (ja) | 2003-12-01 | 2014-07-09 | クドス ファーマシューティカルズ リミテッド | 癌治療のためのdna損傷修復阻害剤 |
US20050155591A1 (en) * | 2003-12-29 | 2005-07-21 | Glenn Forster | Electronically controlled gas-powered guns for firing paintballs |
US20060011185A1 (en) * | 2004-06-18 | 2006-01-19 | Npf Limited | Paintball marker with an air balanced exhaust poppet valve with bias closure |
US20060185657A1 (en) * | 2005-02-24 | 2006-08-24 | Stanley Gabrel | Paintball gun with power assisted trigger |
-
2004
- 2004-11-30 JP JP2006540625A patent/JP5545690B2/ja active Active
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