WO2005054183A3 - Quinolinone based protein kinase inhibitors - Google Patents

Quinolinone based protein kinase inhibitors Download PDF

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Publication number
WO2005054183A3
WO2005054183A3 PCT/US2004/040148 US2004040148W WO2005054183A3 WO 2005054183 A3 WO2005054183 A3 WO 2005054183A3 US 2004040148 W US2004040148 W US 2004040148W WO 2005054183 A3 WO2005054183 A3 WO 2005054183A3
Authority
WO
WIPO (PCT)
Prior art keywords
protein kinase
kinase inhibitors
based protein
quinolinone
quinolinone based
Prior art date
Application number
PCT/US2004/040148
Other languages
French (fr)
Other versions
WO2005054183A2 (en
Inventor
Congxin Liang
Original Assignee
Scripps Research Inst
Congxin Liang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scripps Research Inst, Congxin Liang filed Critical Scripps Research Inst
Publication of WO2005054183A2 publication Critical patent/WO2005054183A2/en
Publication of WO2005054183A3 publication Critical patent/WO2005054183A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Abstract

Hydroxy carboxy quinolinone based derivatives have enhanced and unexpected drug properties as inhibitors of protein kinases and are useful in treating disorders related to abnormal protein kinase activities such as cancer.
PCT/US2004/040148 2003-12-01 2004-12-01 Quinolinone based protein kinase inhibitors WO2005054183A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US52594503P 2003-12-01 2003-12-01
US60/525,945 2003-12-01
US54572104P 2004-02-18 2004-02-18
US60/545,721 2004-02-18

Publications (2)

Publication Number Publication Date
WO2005054183A2 WO2005054183A2 (en) 2005-06-16
WO2005054183A3 true WO2005054183A3 (en) 2005-09-29

Family

ID=34657205

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/US2004/040346 WO2005053692A1 (en) 2003-12-01 2004-12-01 Advanced quinolinone based protein kinase inhibitors
PCT/US2004/040148 WO2005054183A2 (en) 2003-12-01 2004-12-01 Quinolinone based protein kinase inhibitors

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PCT/US2004/040346 WO2005053692A1 (en) 2003-12-01 2004-12-01 Advanced quinolinone based protein kinase inhibitors

Country Status (1)

Country Link
WO (2) WO2005053692A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6756383B2 (en) 2000-09-01 2004-06-29 Chiron Corporation Heterocyclic derivatives of quinolinone benimidazoles
MXPA03002032A (en) 2000-09-11 2003-07-24 Chiron Corp Quinolinone derivatives.
CA2496164C (en) 2002-08-23 2010-11-09 Chiron Corporation Benzimidazole quinolinones and uses thereof
BRPI0507891A (en) * 2004-02-20 2007-07-24 Chiron Corp modulation of inflammatory and metastatic processes
CA2557398A1 (en) * 2004-02-26 2005-09-09 Hans-Peter Buchstaller Benzimidazolyl derivatives as kinase inhibitors
WO2010114896A1 (en) 2009-03-31 2010-10-07 Arqule, Inc. Substituted indolo-pyridinone compounds

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6800760B2 (en) * 2000-09-11 2004-10-05 Chiron Corporation Quinolinone derivatives

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2234698T3 (en) * 1999-10-19 2005-07-01 MERCK & CO., INC. THYROSINE KINASE INHIBITORS.
ES2235970T3 (en) * 1999-10-19 2005-07-16 MERCK & CO. INC. THYROSINE KINASE INHIBITORS.

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6800760B2 (en) * 2000-09-11 2004-10-05 Chiron Corporation Quinolinone derivatives

Also Published As

Publication number Publication date
WO2005053692A1 (en) 2005-06-16
WO2005054183A2 (en) 2005-06-16

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