WO2005082357A8 - Use of beta-lapachone for treating hematologic tumors - Google Patents

Use of beta-lapachone for treating hematologic tumors

Info

Publication number
WO2005082357A8
WO2005082357A8 PCT/US2005/005646 US2005005646W WO2005082357A8 WO 2005082357 A8 WO2005082357 A8 WO 2005082357A8 US 2005005646 W US2005005646 W US 2005005646W WO 2005082357 A8 WO2005082357 A8 WO 2005082357A8
Authority
WO
WIPO (PCT)
Prior art keywords
lapachone
beta
hematologic tumors
treating hematologic
hematologic
Prior art date
Application number
PCT/US2005/005646
Other languages
French (fr)
Other versions
WO2005082357A1 (en
Inventor
Chiang J Li
Youzhi Li
Original Assignee
Arqule Inc
Chiang J Li
Youzhi Li
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arqule Inc, Chiang J Li, Youzhi Li filed Critical Arqule Inc
Priority to EP05723507A priority Critical patent/EP1722775A1/en
Priority to JP2006554303A priority patent/JP2007523191A/en
Priority to CA002556789A priority patent/CA2556789A1/en
Publication of WO2005082357A1 publication Critical patent/WO2005082357A1/en
Publication of WO2005082357A8 publication Critical patent/WO2005082357A8/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)

Abstract

The present invention provides for methods that utilize agents effective in the treatment of hematologic cancers and pre-cancerous hematologic cancer conditions. Moreover, the present invention provides agents capable of acting as an inhibitor of cell proliferation in hematologic cells.
PCT/US2005/005646 2004-02-20 2005-02-18 Use of beta-lapachone for treating hematologic tumors WO2005082357A1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP05723507A EP1722775A1 (en) 2004-02-20 2005-02-18 Use of beta-lapachone for treating hematologic tumors
JP2006554303A JP2007523191A (en) 2004-02-20 2005-02-18 Use of β-lapachone for the treatment of blood tumors
CA002556789A CA2556789A1 (en) 2004-02-20 2005-02-18 Use of beta-lapachone for treating hematologic tumors

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US54591404P 2004-02-20 2004-02-20
US60/545,914 2004-02-20

Publications (2)

Publication Number Publication Date
WO2005082357A1 WO2005082357A1 (en) 2005-09-09
WO2005082357A8 true WO2005082357A8 (en) 2006-04-20

Family

ID=36168365

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/005646 WO2005082357A1 (en) 2004-02-20 2005-02-18 Use of beta-lapachone for treating hematologic tumors

Country Status (3)

Country Link
JP (1) JP2007523191A (en)
CA (1) CA2556789A1 (en)
WO (1) WO2005082357A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050187288A1 (en) * 2004-02-20 2005-08-25 Chiang Li Beta-lapachone and methods of treating cancer
US8614228B2 (en) 2004-08-11 2013-12-24 Arqule, Inc. Quinone prodrug compositions and methods of use
EP1877097B1 (en) 2004-08-11 2012-06-20 Arqule, Inc. Aminoacid conjugates of beta-lapachone for tumor targeting
ES2532656T3 (en) 2007-04-30 2015-03-30 Arqule, Inc. Quinone hydroxy sulfonate compounds and their uses
US20120142650A1 (en) * 2010-12-07 2012-06-07 John Hollingsworth Method for treating lung disease

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020169135A1 (en) * 2000-11-07 2002-11-14 Pardee Arthur B. Method of treating hematologic tumors and cancers
MXPA05005314A (en) * 2002-11-18 2005-10-19 Arqule Inc Novel lapachone compounds and methods of use thereof.
EP1575580A4 (en) * 2002-12-02 2009-06-10 Arqule Inc Method of treating cancers

Also Published As

Publication number Publication date
WO2005082357A1 (en) 2005-09-09
JP2007523191A (en) 2007-08-16
CA2556789A1 (en) 2005-09-09

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