PE20220563A1 - Conjugados peptidicos de citotoxinas como terapeuticos - Google Patents
Conjugados peptidicos de citotoxinas como terapeuticosInfo
- Publication number
- PE20220563A1 PE20220563A1 PE2022000039A PE2022000039A PE20220563A1 PE 20220563 A1 PE20220563 A1 PE 20220563A1 PE 2022000039 A PE2022000039 A PE 2022000039A PE 2022000039 A PE2022000039 A PE 2022000039A PE 20220563 A1 PE20220563 A1 PE 20220563A1
- Authority
- PE
- Peru
- Prior art keywords
- cytotoxins
- topoisomerase
- peptide conjugates
- therapeutics
- diseases
- Prior art date
Links
- 231100000599 cytotoxic agent Toxicity 0.000 title abstract 2
- 239000002619 cytotoxin Substances 0.000 title abstract 2
- 239000000863 peptide conjugate Substances 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title 1
- 102000003915 DNA Topoisomerases Human genes 0.000 abstract 2
- 108090000323 DNA Topoisomerases Proteins 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 201000011510 cancer Diseases 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 229940123780 DNA topoisomerase I inhibitor Drugs 0.000 abstract 1
- 206010021143 Hypoxia Diseases 0.000 abstract 1
- 239000000365 Topoisomerase I Inhibitor Substances 0.000 abstract 1
- 230000002378 acidificating effect Effects 0.000 abstract 1
- 230000001146 hypoxic effect Effects 0.000 abstract 1
- 230000004770 neurodegeneration Effects 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 150000003384 small molecules Chemical group 0.000 abstract 1
- 230000008685 targeting Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
- C07D491/147—Ortho-condensed systems the condensed system containing one ring with oxygen as ring hetero atom and two rings with nitrogen as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/16—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Abstract
La presente invencion se refiere a conjugados peptidicos de citotoxinas tales como inhibidores de topoisomerasa I que son utiles para el tratamiento de enfermedades tal como cancer. Se proporciona un compuesto de Formula (I): R8 - Q - R7, o una sal farmaceuticamente aceptable del mismo, en donde: R7 es un peptido; R8 es una porcion dirigida a topoisomerasa I de molecula pequena, que se une a la topoisomerasa I; y Q es un enlazador, que se enlaza covalentemente a la porcion R7 y R8. Tambien se refiere al uso de estos compuestos en el tratamiento de enfermedades que involucran tejido enfermo acido o hipoxico, tales como cancer o enfermedades neurodegenerativas.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962872643P | 2019-07-10 | 2019-07-10 | |
US202063040859P | 2020-06-18 | 2020-06-18 | |
PCT/US2020/041411 WO2021007435A1 (en) | 2019-07-10 | 2020-07-09 | Peptide conjugates of cytotoxins as therapeutics |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20220563A1 true PE20220563A1 (es) | 2022-04-13 |
Family
ID=71787212
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2022000039A PE20220563A1 (es) | 2019-07-10 | 2020-07-09 | Conjugados peptidicos de citotoxinas como terapeuticos |
Country Status (17)
Country | Link |
---|---|
US (2) | US11634508B2 (es) |
EP (1) | EP3997093A1 (es) |
JP (1) | JP2022541749A (es) |
KR (1) | KR20220052918A (es) |
CN (1) | CN114341162A (es) |
AU (1) | AU2020309570A1 (es) |
BR (1) | BR112022000337A2 (es) |
CA (1) | CA3146560A1 (es) |
CL (1) | CL2022000038A1 (es) |
CO (1) | CO2022001316A2 (es) |
CR (1) | CR20220058A (es) |
EC (1) | ECSP22010228A (es) |
IL (1) | IL289658A (es) |
MX (1) | MX2022000449A (es) |
PE (1) | PE20220563A1 (es) |
TW (1) | TW202116778A (es) |
WO (1) | WO2021007435A1 (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX2022000450A (es) | 2019-07-10 | 2022-04-25 | Cybrexa 3 Inc | Conjugados peptídicos de agentes dirigidos a microtúbulos como terapéuticos. |
IL301793A (en) | 2020-09-30 | 2023-05-01 | Duality Biologics Suzhou Co Ltd | Anticancer compound and method for its preparation and use |
EP4274905A1 (en) | 2021-01-08 | 2023-11-15 | Cybrexa 2, Inc. | Process for preparing a conjugate linking moiety |
CA3218253A1 (en) | 2021-04-29 | 2022-11-03 | Cybrexa 2, Inc. | Dosing regimens of peptide conjugates of topoisomerase i inhibitors |
US11814394B2 (en) | 2021-11-16 | 2023-11-14 | Genequantum Healthcare (Suzhou) Co., Ltd. | Exatecan derivatives, linker-payloads, and conjugates and thereof |
WO2023091957A1 (en) * | 2021-11-17 | 2023-05-25 | Cybrexa 4, Inc. | Peptide conjugates of peptidic tubulin inhibitors as therapeutics |
TW202342025A (zh) * | 2022-03-18 | 2023-11-01 | 大陸商映恩生物製藥(蘇州)有限公司 | Gpc3抗體藥物偶聯物及其用途 |
WO2023191209A1 (ko) * | 2022-03-29 | 2023-10-05 | 주식회사 퓨전바이오텍 | 친수성 펩타이드를 포함하는 마이셀 및 이의 용도 |
Family Cites Families (96)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5658920A (en) | 1991-01-16 | 1997-08-19 | Daiichi Pharmaceutical Co., Ltd. | Substituted 1H,12H-benz-[DE]pyrano[3',4':6,7] indolizino[1,2-B]quinoline-10,13(9H,15H)-dione compound |
US6504029B1 (en) | 1995-04-10 | 2003-01-07 | Daiichi Pharmaceutical Co., Ltd. | Condensed-hexacyclic compounds and a process therefor |
BR9610051A (pt) | 1995-08-02 | 1999-12-21 | Univ Newcastle Ventures Ltd | Uso de um composto, processo de preparação do mesmo, formulação ou composição farmacêutica contendo um composto, composição farmacêutica, e, processo de tratamento terapeutico |
DE69707860T2 (de) | 1996-04-26 | 2002-04-11 | Daiichi Seiyaku Co | Verfahren zur herstellung von tetrahydroindolizinen |
TW409058B (en) | 1996-06-06 | 2000-10-21 | Daiichi Seiyaku Co | Method for preparation of a drug complex |
TW527183B (en) | 1996-06-06 | 2003-04-11 | Daiichi Seiyaku Co | Drug complex |
IN189180B (es) | 1997-07-09 | 2003-01-04 | Chong Kun Dang Corp | |
CA2333321A1 (en) | 1998-05-22 | 1999-12-02 | Daiichi Pharmaceutical Co., Ltd. | Drug complex |
MXPA01004239A (es) | 1998-10-30 | 2002-06-04 | Daiichi Seiyaku Co | Compuesto dds y metodo para la medicion del mismo. |
ID28787A (id) | 1998-11-03 | 2001-07-05 | Basf Ag | 2-fenilbenzimidazol tersubstitusi, pembuatannya dan penggunaannya |
AU781711B2 (en) | 1999-01-11 | 2005-06-09 | Agouron Pharmaceuticals, Inc. | Tricyclic inhibitors of poly(ADP-ribose) polymerases |
DE19920936A1 (de) | 1999-05-07 | 2000-11-09 | Basf Ag | Heterozyklisch substituierte Benzimidazole, deren Herstellung und Anwendung |
ECSP003637A (es) | 1999-08-31 | 2002-03-25 | Agouron Pharma | Inhibidores triciclicos de poli (adp-ribosa) polimerasas |
US6699876B2 (en) | 1999-11-18 | 2004-03-02 | Les Laboratoires Servier | Camptothecin analogue compounds |
WO2001041534A2 (en) | 1999-12-13 | 2001-06-14 | Eli Lilly And Company | Pseudomycin phosphate prodrugs |
BR0112417A (pt) | 2000-07-13 | 2003-07-01 | Daiichi Seiyaku Co | Composições farmacêuticas contendo composto dds |
US7151102B2 (en) | 2000-10-30 | 2006-12-19 | Kudos Pharmaceuticals Limited | Phthalazinone derivatives |
EP1487493B1 (en) | 2002-03-01 | 2010-01-20 | The Administrators of The Tulane Educational Fund | Conjugates of cytotoxic agents and biologically active peptides |
IL164022A0 (en) | 2002-03-20 | 2005-12-18 | Bristol Myers Squibb Co | Phosphate derivatives of fluoroxindole and pharmaceutical compositions containing the same |
CA2482806A1 (en) | 2002-04-30 | 2003-11-13 | Kudos Pharmaceuticals Limited | Phthalazinone derivatives |
US7449464B2 (en) | 2003-03-12 | 2008-11-11 | Kudos Pharmaceuticals Limited | Phthalazinone derivatives |
CA2520997A1 (en) | 2003-03-31 | 2004-10-14 | Stacie Sara Canan-Koch | Salts of tricyclic inhibitors of poly(adp-ribose) polymerases |
CA2930485C (en) | 2003-05-14 | 2018-04-10 | Immunogen, Inc. | Maytansinoid-antibody conjugate compositions |
US8088387B2 (en) | 2003-10-10 | 2012-01-03 | Immunogen Inc. | Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates |
EP3031810B1 (en) | 2003-05-20 | 2019-03-06 | ImmunoGen, Inc. | Maytansinoid-cell-binding agent conjugates |
US7276497B2 (en) | 2003-05-20 | 2007-10-02 | Immunogen Inc. | Cytotoxic agents comprising new maytansinoids |
DE602004025123D1 (en) | 2003-07-25 | 2010-03-04 | Pfizer | Tricyclische parp-hemmer |
GB0317466D0 (en) | 2003-07-25 | 2003-08-27 | Univ Sheffield | Use |
NZ547984A (en) | 2003-12-01 | 2009-03-31 | Kudos Pharm Ltd | DNA damage repair inhibitors for treatment of cancer |
WO2005082023A2 (en) | 2004-02-23 | 2005-09-09 | Genentech, Inc. | Heterocyclic self-immolative linkers and conjugates |
US8288557B2 (en) | 2004-07-23 | 2012-10-16 | Endocyte, Inc. | Bivalent linkers and conjugates thereof |
MX2007003314A (es) | 2004-09-22 | 2007-08-06 | Pfizer | Combinaciones terapeuticas que comprenden inhibidor de poli(adp-ribosa)polimerasas. |
KR100876520B1 (ko) | 2004-09-22 | 2008-12-31 | 화이자 인코포레이티드 | 폴리(adp-리보오스) 폴리머라제 억제제의 제조 방법 |
AU2005286191B2 (en) | 2004-09-22 | 2011-11-17 | Cancer Research Technology Ltd. | Polymorphic and amorphous forms of the phosphate salt of 8-fluoro-2-{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one |
DK1819359T3 (en) | 2004-12-09 | 2015-04-20 | Janssen Biotech Inc | ANTI-integrin immunoconjugates, processes for their preparation and their use |
EP1846014B1 (en) | 2005-01-18 | 2012-10-24 | The Board of Governors for Higher Education State of Rhode Island and Providence Plantations | Selective delivery of molecules into cells or marking of cells in diseased tissue regions using environmentally sensitive transmembrane peptide |
US7301019B2 (en) | 2005-01-21 | 2007-11-27 | Immunogen, Inc. | Method for the preparation of maytansinoid esters |
AU2006213662B2 (en) | 2005-02-11 | 2010-08-05 | Immunogen, Inc. | Process for preparing stable drug conjugates |
KR20070120156A (ko) | 2005-04-15 | 2007-12-21 | 이뮤노젠 아이엔씨 | 종양에서 이종 또는 혼성 세포 집단의 제거 방법 |
EP1928503B1 (en) | 2005-08-24 | 2012-10-03 | ImmunoGen, Inc. | Process for preparing maytansinoid antibody conjugates |
CN101316834A (zh) | 2005-09-29 | 2008-12-03 | 艾博特公司 | 在2位取代有苯基的1h-苯并咪唑-4-甲酰胺是强效parp抑制剂 |
PL1945647T3 (pl) | 2005-11-08 | 2012-04-30 | Immunogen Inc | Procesy wytwarzania maytansinolu |
EP2329818A1 (en) | 2006-01-17 | 2011-06-08 | Abbott Laboratories | Combination therapy with PARP inhibitors |
UY30639A1 (es) | 2006-10-17 | 2008-05-31 | Kudos Pharm Ltd | Derivados sustituidos de 2h-ftalazin-1-ona, sus formas cristalinas, proceso de preparacion y aplicaciones |
RS51780B (en) | 2007-01-10 | 2011-12-31 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.R.L. | INDASOLS SUBSTITUTED BY AMIDE AS INHIBITORS OF POLY (ADP-Ribose) POLYMERASES (PARP) |
WO2008114114A2 (en) | 2007-03-16 | 2008-09-25 | Pfizer Products Inc. | Poly(adp-ribose) polymerases inhibitor for treating ophthalmic condition |
AU2008268432B2 (en) * | 2007-06-25 | 2015-01-15 | Endocyte, Inc. | Conjugates containing hydrophilic spacer linkers |
US8067613B2 (en) | 2007-07-16 | 2011-11-29 | Abbott Laboratories | Benzimidazole poly(ADP ribose)polymerase inhibitors |
EP3831380A3 (en) | 2007-08-17 | 2021-12-01 | Purdue Research Foundation | Psma binding ligand-linker conjugates and methods for using |
CA2722109A1 (en) | 2008-04-30 | 2009-11-05 | Immunogen, Inc. | Potent conjugates and hydrophilic linkers |
PT2437790T (pt) | 2009-06-03 | 2019-06-04 | Immunogen Inc | Métodos de conjugação |
US9353140B2 (en) | 2009-11-25 | 2016-05-31 | Academia Sinica | BQC-G, a tumor-selective anti-cancer prodrug |
ES2753748T3 (es) | 2010-02-12 | 2020-04-14 | Pfizer | Sales y polimorfos de 8-fluoro-2-{4-[(metilamino}metil]fenil}-1,3,4,5-tetrahidro-6H-azepino[5,4,3-cd]indol-6-ona |
WO2011106639A1 (en) | 2010-02-25 | 2011-09-01 | Purdue Research Foundation | Psma binding ligand-linker conjugates and methods for using |
EP2752422B1 (en) | 2010-03-31 | 2017-08-16 | Gilead Pharmasset LLC | Stereoselective synthesis of phosphorus containing actives |
ES2584381T3 (es) | 2010-05-05 | 2016-09-27 | Prolynx Llc | Liberación controlada de compuestos activos desde conjugados macromoleculares |
EP4321168A2 (en) | 2010-07-13 | 2024-02-14 | Yale University, Inc. | Environmentally sensitive compositions |
EP2603201B1 (en) | 2010-08-13 | 2020-03-11 | Rhode Island Board of Governors for Higher Education | Liposome compositions and methods of use thereof |
BR112013010853A2 (pt) | 2010-11-03 | 2016-08-16 | Immunogen Inc | "agentes citotóxicos compreendendo derivados de ansamitocina, composição farmacêutica e uso destes" |
TR201902180T4 (tr) | 2011-03-29 | 2019-03-21 | Immunogen Inc | Tek adimli bi̇r i̇şlem i̇le maytansi̇noi̇d anti̇kor konjugatlarinin hazirlanmasi |
SG193997A1 (en) | 2011-03-29 | 2013-11-29 | Immunogen Inc | Process for manufacturing conjugates of improved homogeneity |
MX350152B (es) | 2011-10-14 | 2017-08-29 | Medimmune Ltd | Pirrolobenzodiazepinas y conjugados de las mismas. |
CN104755494B (zh) | 2012-10-11 | 2018-09-07 | 第一三共株式会社 | 抗体-药物偶联物 |
ES2782248T3 (es) | 2012-10-19 | 2020-09-11 | Daiichi Sankyo Co Ltd | Conjugado de anticuerpo y fármaco producido por la unión a través de un enlazador que tiene estructura hidrófila |
EP2911701A4 (en) | 2012-10-23 | 2016-06-08 | Univ Johns Hopkins | Novel self-assembling drug amphiphiles and methods for synthesis and application |
WO2014093343A2 (en) | 2012-12-10 | 2014-06-19 | Massachusetts Institute Of Technology | Multistage nanoparticle drug delivery system for the treatment of solid tumors |
EP2961434A2 (en) | 2013-02-28 | 2016-01-06 | ImmunoGen, Inc. | Conjugates comprising cell-binding agents and cytotoxic agents |
AU2014369019B2 (en) | 2013-12-19 | 2020-09-17 | Seagen Inc. | Methylene carbamate linkers for use with targeted-drug conjugates |
WO2015108986A1 (en) | 2014-01-16 | 2015-07-23 | Clovis Oncology, Inc. | Use of parp inhibitors to treat breast or ovarian cancer patients showing a loss of heterozygosity |
JP2017114763A (ja) | 2014-03-26 | 2017-06-29 | 第一三共株式会社 | 抗cd98抗体−薬物コンジュゲート |
WO2015155976A1 (ja) | 2014-04-10 | 2015-10-15 | 第一三共株式会社 | 抗her2抗体-薬物コンジュゲート |
LT3129063T (lt) | 2014-04-10 | 2021-06-25 | Daiichi Sankyo Company, Limited | Anti-her3 antikūno-vaisto konjugatas |
AU2015305696B2 (en) | 2014-08-22 | 2019-08-29 | Pharma& Schweiz Gmbh | High dosage strength tablets of rucaparib |
EP3110447B1 (en) | 2014-09-16 | 2020-04-29 | Synermore Biologics Co., Ltd. | Anti-egfr antibody and uses of same |
CA2966932A1 (en) | 2014-11-19 | 2016-05-26 | Immunogen, Inc. | Process for preparing cell-binding agent-cytotoxic agent conjugates |
MA43354A (fr) | 2015-10-16 | 2018-08-22 | Genentech Inc | Conjugués médicamenteux à pont disulfure encombré |
LT3380486T (lt) | 2015-11-24 | 2020-05-11 | Theravance Biopharma R&D Ip, Llc | Jak inhibitoriaus junginio provaistai, skirti virškinimo trakto uždegiminės ligos gydymui |
KR102498258B1 (ko) | 2016-01-20 | 2023-02-10 | 삼성디스플레이 주식회사 | 표시 장치 |
US20170267727A1 (en) | 2016-03-04 | 2017-09-21 | Lehigh University | Conjugates of pH Low Insertion Peptide and Monomethyl Auristatins in the Treatment of Solid Tumors |
JP2019510085A (ja) | 2016-03-08 | 2019-04-11 | ロス ガトス ファーマスーティカルズ, インク.Los Gatos Pharmaceuticals, Inc. | 癌治療のためのナノ粒子ならびに方法および化合物 |
US20200078468A1 (en) | 2016-04-13 | 2020-03-12 | Tarveda Therapeutics, Inc. | Neurotensin receptor binding conjugates and formulations thereof |
GB201608885D0 (en) | 2016-05-20 | 2016-07-06 | Univ Birmingham | Treatment |
US20190133980A1 (en) | 2016-06-02 | 2019-05-09 | Yale University | Compositions and methods for targeting and treating homologous recombination-deficient tumors |
CA3032401A1 (en) | 2016-07-29 | 2018-02-01 | Memorial Sloan Kettering Cancer Center | Radiolabeled ligands for targeted pet/spect imaging and methods of their use |
MX2019001905A (es) | 2016-08-16 | 2019-05-15 | Aist | Peptido objetivo de tumor maligno. |
WO2018057912A1 (en) | 2016-09-22 | 2018-03-29 | Rhode Island Council On Postsecondary Education | FLUORESCENT COMPOUND COMPRISING A FLUOROPHORE CONJUGATED TO A pH -TRIGGERED POLYPEPTIDE |
EP3634498A4 (en) | 2017-06-09 | 2021-08-25 | Rhode Island Council on Postsecondary Education | CONNECTED AND OTHER PH-RIGIDED CONNECTIONS |
KR102422860B1 (ko) | 2017-08-31 | 2022-07-19 | 다이이찌 산쿄 가부시키가이샤 | 항체-약물 콘주게이트의 신규 제조 방법 |
WO2019136298A1 (en) | 2018-01-05 | 2019-07-11 | Cybrexa, Inc. | Compounds, compositions, and methods for treatment of diseases involving acidic or hypoxic diseased tissues |
KR20200109345A (ko) | 2018-01-12 | 2020-09-22 | 프로린크스 엘엘시 | 상승적 암 치료 |
HRP20230787T1 (hr) | 2018-05-18 | 2023-10-27 | Glycotope Gmbh | Anti-muc1 antitijelo |
TW202015740A (zh) | 2018-06-07 | 2020-05-01 | 美商西雅圖遺傳學公司 | 喜樹鹼結合物 |
CN109232719B (zh) | 2018-09-21 | 2021-06-29 | 中国科学院理化技术研究所 | 一种pH响应的抗菌肽及其制备方法和应用 |
US20200237926A1 (en) | 2019-01-28 | 2020-07-30 | Rhode Island Council On Postsecondary Education | pHLIP® targeted delivery of potent cytotoxic compounds |
US20220211863A1 (en) | 2019-03-29 | 2022-07-07 | Medimmune Limited | Compounds and conjugates thereof |
MX2022000450A (es) | 2019-07-10 | 2022-04-25 | Cybrexa 3 Inc | Conjugados peptídicos de agentes dirigidos a microtúbulos como terapéuticos. |
-
2020
- 2020-07-09 US US16/925,094 patent/US11634508B2/en active Active
- 2020-07-09 CR CR20220058A patent/CR20220058A/es unknown
- 2020-07-09 CN CN202080057842.4A patent/CN114341162A/zh active Pending
- 2020-07-09 TW TW109123269A patent/TW202116778A/zh unknown
- 2020-07-09 BR BR112022000337A patent/BR112022000337A2/pt unknown
- 2020-07-09 WO PCT/US2020/041411 patent/WO2021007435A1/en unknown
- 2020-07-09 AU AU2020309570A patent/AU2020309570A1/en active Pending
- 2020-07-09 MX MX2022000449A patent/MX2022000449A/es unknown
- 2020-07-09 JP JP2022501188A patent/JP2022541749A/ja active Pending
- 2020-07-09 KR KR1020227004522A patent/KR20220052918A/ko unknown
- 2020-07-09 CA CA3146560A patent/CA3146560A1/en active Pending
- 2020-07-09 EP EP20746521.2A patent/EP3997093A1/en active Pending
- 2020-07-09 PE PE2022000039A patent/PE20220563A1/es unknown
-
2022
- 2022-01-06 IL IL289658A patent/IL289658A/en unknown
- 2022-01-06 CL CL2022000038A patent/CL2022000038A1/es unknown
- 2022-02-09 CO CONC2022/0001316A patent/CO2022001316A2/es unknown
- 2022-02-09 EC ECSENADI202210228A patent/ECSP22010228A/es unknown
-
2023
- 2023-02-27 US US18/174,981 patent/US20240010755A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
US20210009719A1 (en) | 2021-01-14 |
US20240010755A1 (en) | 2024-01-11 |
WO2021007435A1 (en) | 2021-01-14 |
EP3997093A1 (en) | 2022-05-18 |
CO2022001316A2 (es) | 2022-05-10 |
CR20220058A (es) | 2022-07-19 |
TW202116778A (zh) | 2021-05-01 |
AU2020309570A1 (en) | 2022-02-03 |
CN114341162A (zh) | 2022-04-12 |
CA3146560A1 (en) | 2021-01-14 |
MX2022000449A (es) | 2022-04-25 |
CL2022000038A1 (es) | 2022-08-19 |
BR112022000337A2 (pt) | 2022-04-12 |
JP2022541749A (ja) | 2022-09-27 |
US11634508B2 (en) | 2023-04-25 |
ECSP22010228A (es) | 2022-05-31 |
KR20220052918A (ko) | 2022-04-28 |
IL289658A (en) | 2022-03-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PE20220563A1 (es) | Conjugados peptidicos de citotoxinas como terapeuticos | |
BR112022010383A2 (pt) | Compostos tricíclicos substituídos | |
CY1124882T1 (el) | Αναλογα 1,4-διϋποκατεστημενης πυριδαζινης και μεθοδοι για την θεραπευτικη αγωγη καταστασεων συναφων με ανεπαρκεια smn | |
CY1120088T1 (el) | Παραγωγα τυπου αζαϊνδαζολιου ή διαζαϊνδαζολιου ως φαρμακo | |
PE20181953A1 (es) | Conjugados de anticuerpo y farmaco basados en eribulina y metodos para su uso | |
CY1119942T1 (el) | Μεθοδοι θεραπειας της ψωριασης χρησιμοποιωντας ανταγωνιστες της il-17 | |
IN2014CN04961A (es) | ||
UY31800A (es) | Metodo de tratamiento de cancer usando un inhibidor de cmet y axl y un inhibidor de erbb | |
CR20130534A (es) | Nuevos derivados de imidazol útiles para el tratamiento de artritis | |
BR112016029916A2 (pt) | inibidores mnk e métodos correlatos | |
BR112012029405A8 (pt) | compostos macrocíclicos como inibidores de trk quinase | |
EA201692530A1 (ru) | Цитотоксические пептиды и их конъюгаты | |
CR10567A (es) | Peptidomimeticos de smac utiles como inhibidores de proteinas de apoptosis (iap) | |
SV2004001393A (es) | Benzamida, heteroarilamida y amidas inversas ref. pc23106 | |
CY1120378T1 (el) | Υποκατεστημενα παραγωγα του διφαινυλο βουτανοϊκου φωσφονικου οξεος ως αναστολεις νερ (ουδετερης ενδοπεπτιδασης) | |
CO6470847A2 (es) | Derivados amino-propiónicos sustituidos como inhibidores de neprilisina | |
PE20191660A1 (es) | Dendrimeros terapeuticos | |
UY30411A1 (es) | Derivados sustituidos del acetato de 2,3,4,-tetrahidroimidazo-[1,5-a]-pirimidin-6-amina, composiciones farmacéuticas y aplicaciones | |
EA201690247A1 (ru) | Аминометилбиарильные производные-ингибиторы фактора d комплемента и их применения | |
BR112015023705A2 (pt) | composto da fórmula (ia) ou um sal, hidrato, solvato ou forma cristalina farmaceuticamente aceitável do mesmo, composição farmacêutica, uso de um composto, composto e método para síntese do composto da fórmula (ia) | |
EA201291246A1 (ru) | Конденсированные бициклические ингибиторы киназы | |
CO2019002523A2 (es) | Inhibidores de dopamina–β–hidroxilasa penetrantes de la barrera hematoencefálica | |
CO2022001315A2 (es) | Conjugados peptídicos de agentes dirigidos a microtúbulos como terapéuticos | |
UY38625A (es) | Compuestos y su uso en el tratamiento del cáncer | |
PE20151603A1 (es) | Anticuerpos anti-lamp1 y conjugados anticuerpo farmaco, y usos de estos |