BR9610051A - Uso de um composto, processo de preparação do mesmo, formulação ou composição farmacêutica contendo um composto, composição farmacêutica, e, processo de tratamento terapeutico - Google Patents

Uso de um composto, processo de preparação do mesmo, formulação ou composição farmacêutica contendo um composto, composição farmacêutica, e, processo de tratamento terapeutico

Info

Publication number
BR9610051A
BR9610051A BR9610051-6A BR9610051A BR9610051A BR 9610051 A BR9610051 A BR 9610051A BR 9610051 A BR9610051 A BR 9610051A BR 9610051 A BR9610051 A BR 9610051A
Authority
BR
Brazil
Prior art keywords
compound
compounds
pharmaceutical
therapeutic treatment
composition containing
Prior art date
Application number
BR9610051-6A
Other languages
English (en)
Inventor
Nicola Jane Curtin
Roger John Griffin
Alan Hilary Calvert
David Richard Newell
Bernard Thomas Golding
Original Assignee
Univ Newcastle Ventures Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9515843.2A external-priority patent/GB9515843D0/en
Priority claimed from GBGB9611245.3A external-priority patent/GB9611245D0/en
Application filed by Univ Newcastle Ventures Ltd filed Critical Univ Newcastle Ventures Ltd
Publication of BR9610051A publication Critical patent/BR9610051A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/08—Radicals containing only hydrogen and carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/10—Radicals substituted by halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/14—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/16—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Data Exchanges In Wide-Area Networks (AREA)

Abstract

"USO DE UM COMPOSTO, PROCESSO DE PREPARAçãO DO MESMO, FORMULAçãO OU COMPOSIçãO FARMACêUTICA CONTENDO UM COMPOSTO, COMPOSIçãO FARMACêUTICA, E, PROCESSO DE TRATAMENTO TERAPêUTICO". é exposta uma faixa de compostos benzimidazol-4-carboxamida (I), que podem agir como inibidores potentes de enzimas de reparo de DNA poli (ADP-ribose) polimerase ou da enzima PARP (EC 2.4.2.30), e que podem propocionar, deste modo, composto terapêuticos úteis para uso em conjunção com drogas citotóxicas que danificam o DNA ou com radioterapia para potencializar os efeitos da última. Na fórmula (I): R e R' podem ser, cada qual, selecionado independentemente de um grupo hidrogênio, alquila, hidrozialquila (por exemplo CH~ 2~CH~ 2~OH), acila (por exemplo, acetila ou benzoíla) ou arila opcionalmente substituída (por exemplo, fenila) ou aralquila (por exemplo benzila ou carboxibenzila). R é geralmente um grupo fenila substituído na maioria dos compostos preferidos. Os compostos podem ser também usados sob a forma de sais ou pró-drogas farmaceuticamente aceitáveis.
BR9610051-6A 1995-08-02 1996-07-30 Uso de um composto, processo de preparação do mesmo, formulação ou composição farmacêutica contendo um composto, composição farmacêutica, e, processo de tratamento terapeutico BR9610051A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9515843.2A GB9515843D0 (en) 1995-08-02 1995-08-02 Benzimidazole compounds
GBGB9611245.3A GB9611245D0 (en) 1996-05-30 1996-05-30 Benzimidazole compounds
PCT/GB1996/001832 WO1997004771A1 (en) 1995-08-02 1996-07-30 Benzimidazole compounds

Publications (1)

Publication Number Publication Date
BR9610051A true BR9610051A (pt) 1999-12-21

Family

ID=26307504

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9610051-6A BR9610051A (pt) 1995-08-02 1996-07-30 Uso de um composto, processo de preparação do mesmo, formulação ou composição farmacêutica contendo um composto, composição farmacêutica, e, processo de tratamento terapeutico

Country Status (26)

Country Link
US (2) US6100283A (pt)
EP (1) EP0841924B1 (pt)
JP (1) JPH11510154A (pt)
KR (1) KR100447539B1 (pt)
CN (1) CN1159007C (pt)
AP (1) AP866A (pt)
AT (1) ATE225173T1 (pt)
AU (1) AU714873B2 (pt)
BR (1) BR9610051A (pt)
CA (1) CA2225465A1 (pt)
CZ (1) CZ30398A3 (pt)
DE (1) DE69624115T2 (pt)
DK (1) DK0841924T3 (pt)
EA (1) EA000999B1 (pt)
ES (1) ES2183004T3 (pt)
HU (1) HUP9901092A3 (pt)
IL (1) IL123147A (pt)
MX (1) MX9800927A (pt)
NO (1) NO317033B1 (pt)
NZ (1) NZ313713A (pt)
OA (1) OA10661A (pt)
PL (1) PL324869A1 (pt)
PT (1) PT841924E (pt)
SK (1) SK13598A3 (pt)
TR (1) TR199800127T1 (pt)
WO (1) WO1997004771A1 (pt)

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AP866A (en) 2000-08-17
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IL123147A0 (en) 1998-09-24
KR19990036086A (ko) 1999-05-25
AU714873B2 (en) 2000-01-13
CN1195985A (zh) 1998-10-14
PL324869A1 (en) 1998-06-22
NO980414D0 (no) 1998-01-30
NO317033B1 (no) 2004-07-26
EP0841924A1 (en) 1998-05-20
CZ30398A3 (cs) 1998-06-17
AU6624096A (en) 1997-02-26
HUP9901092A2 (hu) 1999-07-28
IL123147A (en) 2004-02-19
PT841924E (pt) 2003-02-28
HUP9901092A3 (en) 2001-11-28
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US6310082B1 (en) 2001-10-30
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CA2225465A1 (en) 1997-02-13
WO1997004771A1 (en) 1997-02-13
KR100447539B1 (ko) 2004-11-10
CN1159007C (zh) 2004-07-28
SK13598A3 (en) 1998-06-03
NO980414L (no) 1998-04-02
DE69624115D1 (de) 2002-11-07
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DE69624115T2 (de) 2003-06-18
DK0841924T3 (da) 2003-02-10
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