MX9800927A - Compuestos de bencimidazol. - Google Patents

Compuestos de bencimidazol.

Info

Publication number
MX9800927A
MX9800927A MX9800927A MX9800927A MX9800927A MX 9800927 A MX9800927 A MX 9800927A MX 9800927 A MX9800927 A MX 9800927A MX 9800927 A MX9800927 A MX 9800927A MX 9800927 A MX9800927 A MX 9800927A
Authority
MX
Mexico
Prior art keywords
packet
routing decision
network
routing
packet routing
Prior art date
Application number
MX9800927A
Other languages
English (en)
Inventor
Roger John Griffin
Alan Hilary Calvert
Nicola Jane Curtin
David Richard Newell
Bernard Thomas Golding
Original Assignee
Univ Newcastle Ventures Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9515843.2A external-priority patent/GB9515843D0/en
Priority claimed from GBGB9611245.3A external-priority patent/GB9611245D0/en
Application filed by Univ Newcastle Ventures Ltd filed Critical Univ Newcastle Ventures Ltd
Publication of MX9800927A publication Critical patent/MX9800927A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/08—Radicals containing only hydrogen and carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/10—Radicals substituted by halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/14—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/16—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2

Abstract

La presente invencion describe un intervalo de compuestos de bencimidazol-4-carboxamida (I), los cuales pueden actuar como inhibidores potentes de la enzima de reparacion de ADN poli(ADP-ribosa) polimerasa o enzima PARP (EC 2.4.2.30), y que por medio de esto pueden proporcionar compuestos terapéuticos utiles para usarse en conjuncion con drogas citotoxicas dañinas al ADN o radioterapia, para potenciar los efectos de los ultimos. En la formula (I), R y R' pueden cada uno ser seleccionados independientemente de hidrogeno, alquilo, hidroxialquilo (por ejemplo CH2CH2OH), acilo (por ejemplo acetilo o benzoílo), o un grupo arilo opcionalmente substituido (por ejemplo fenilo) o aralquilo (por ejemplo bencilo o carboxibencilo). R es por lo general un grupo fenilo substituido en los compuestos más preferidos. Los compuestos también pueden ser usados en forma de sales farmacéuticamente aceptables o prodrogas.
MX9800927A 1995-08-02 1998-02-02 Compuestos de bencimidazol. MX9800927A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9515843.2A GB9515843D0 (en) 1995-08-02 1995-08-02 Benzimidazole compounds
GBGB9611245.3A GB9611245D0 (en) 1996-05-30 1996-05-30 Benzimidazole compounds

Publications (1)

Publication Number Publication Date
MX9800927A true MX9800927A (es) 1998-10-31

Family

ID=26307504

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9800927A MX9800927A (es) 1995-08-02 1998-02-02 Compuestos de bencimidazol.

Country Status (26)

Country Link
US (2) US6100283A (es)
EP (1) EP0841924B1 (es)
JP (1) JPH11510154A (es)
KR (1) KR100447539B1 (es)
CN (1) CN1159007C (es)
AP (1) AP866A (es)
AT (1) ATE225173T1 (es)
AU (1) AU714873B2 (es)
BR (1) BR9610051A (es)
CA (1) CA2225465A1 (es)
CZ (1) CZ30398A3 (es)
DE (1) DE69624115T2 (es)
DK (1) DK0841924T3 (es)
EA (1) EA000999B1 (es)
ES (1) ES2183004T3 (es)
HU (1) HUP9901092A3 (es)
IL (1) IL123147A (es)
MX (1) MX9800927A (es)
NO (1) NO317033B1 (es)
NZ (1) NZ313713A (es)
OA (1) OA10661A (es)
PL (1) PL324869A1 (es)
PT (1) PT841924E (es)
SK (1) SK13598A3 (es)
TR (1) TR199800127T1 (es)
WO (1) WO1997004771A1 (es)

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Publication number Publication date
PL324869A1 (en) 1998-06-22
IL123147A (en) 2004-02-19
US6310082B1 (en) 2001-10-30
CZ30398A3 (cs) 1998-06-17
EP0841924A1 (en) 1998-05-20
KR19990036086A (ko) 1999-05-25
NO317033B1 (no) 2004-07-26
BR9610051A (pt) 1999-12-21
DE69624115T2 (de) 2003-06-18
KR100447539B1 (ko) 2004-11-10
TR199800127T1 (xx) 1998-04-21
PT841924E (pt) 2003-02-28
AU714873B2 (en) 2000-01-13
AP9801183A0 (en) 1998-01-31
AP866A (en) 2000-08-17
ATE225173T1 (de) 2002-10-15
EP0841924B1 (en) 2002-10-02
DK0841924T3 (da) 2003-02-10
CA2225465A1 (en) 1997-02-13
HUP9901092A3 (en) 2001-11-28
DE69624115D1 (de) 2002-11-07
IL123147A0 (en) 1998-09-24
HUP9901092A2 (hu) 1999-07-28
NO980414D0 (no) 1998-01-30
SK13598A3 (en) 1998-06-03
WO1997004771A1 (en) 1997-02-13
NZ313713A (en) 2001-03-30
OA10661A (en) 2002-11-25
AU6624096A (en) 1997-02-26
US6100283A (en) 2000-08-08
EA000999B1 (ru) 2000-08-28
ES2183004T3 (es) 2003-03-16
JPH11510154A (ja) 1999-09-07
CN1159007C (zh) 2004-07-28
CN1195985A (zh) 1998-10-14
EA199800184A1 (ru) 1998-10-29
NO980414L (no) 1998-04-02

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