EA199800184A1 - Соединение бензимидазола - Google Patents

Соединение бензимидазола

Info

Publication number
EA199800184A1
EA199800184A1 EA199800184A EA199800184A EA199800184A1 EA 199800184 A1 EA199800184 A1 EA 199800184A1 EA 199800184 A EA199800184 A EA 199800184A EA 199800184 A EA199800184 A EA 199800184A EA 199800184 A1 EA199800184 A1 EA 199800184A1
Authority
EA
Eurasian Patent Office
Prior art keywords
compounds
dna
group
benzimidazole
chchoh
Prior art date
Application number
EA199800184A
Other languages
English (en)
Other versions
EA000999B1 (ru
Inventor
Роджер Джон Гриффин
Элан Хилари Калверт
Никола Джэйн Кертин
Дэвид Ричард Ньюэлл
Бернард Томас Голдинг
Original Assignee
Ньюкастл Юниверсити Венчерз Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9515843.2A external-priority patent/GB9515843D0/en
Priority claimed from GBGB9611245.3A external-priority patent/GB9611245D0/en
Application filed by Ньюкастл Юниверсити Венчерз Лимитед filed Critical Ньюкастл Юниверсити Венчерз Лимитед
Publication of EA199800184A1 publication Critical patent/EA199800184A1/ru
Publication of EA000999B1 publication Critical patent/EA000999B1/ru

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/08—Radicals containing only hydrogen and carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/10—Radicals substituted by halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/14—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/16—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Data Exchanges In Wide-Area Networks (AREA)
  • Saccharide Compounds (AREA)

Abstract

В настоящем изобретении раскрыт ряд соединений бензимидазол-4-карбоксамида (1)которые являются сильнодействующими ингибиторами поли(ADP-рибоза)полимеразы-фермента, восстанавливающими ДНК или PARP фермент (ЕС 2.4.2.30), и которые являются полезными терапевтическими соединениями для использования в сочетании с ДНК-повреждающими цитотоксическими лекарственными средствами или радиотерапией для того, чтобы усилить действия последних. В формуле (1) R и R', каждый независимо может быть выбран из водорода, алкильной, гидроксиалкильной (например, CHCHOH), ацильной (например, ацетил или бензоил) или необязательно замещенной арильной (например, фенил) или аралкильной (например, бензил или карбоксибензил) группы. R обычно представляет замещенную фенильную группу в большинстве предпочтительных соединений. Соединения можно использовать также в форме фармацевтически приемлемых солей или пролекарств.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199800184A 1995-08-02 1996-07-30 Соединение бензимидазола EA000999B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9515843.2A GB9515843D0 (en) 1995-08-02 1995-08-02 Benzimidazole compounds
GBGB9611245.3A GB9611245D0 (en) 1996-05-30 1996-05-30 Benzimidazole compounds
PCT/GB1996/001832 WO1997004771A1 (en) 1995-08-02 1996-07-30 Benzimidazole compounds

Publications (2)

Publication Number Publication Date
EA199800184A1 true EA199800184A1 (ru) 1998-10-29
EA000999B1 EA000999B1 (ru) 2000-08-28

Family

ID=26307504

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199800184A EA000999B1 (ru) 1995-08-02 1996-07-30 Соединение бензимидазола

Country Status (26)

Country Link
US (2) US6100283A (ru)
EP (1) EP0841924B1 (ru)
JP (1) JPH11510154A (ru)
KR (1) KR100447539B1 (ru)
CN (1) CN1159007C (ru)
AP (1) AP866A (ru)
AT (1) ATE225173T1 (ru)
AU (1) AU714873B2 (ru)
BR (1) BR9610051A (ru)
CA (1) CA2225465A1 (ru)
CZ (1) CZ30398A3 (ru)
DE (1) DE69624115T2 (ru)
DK (1) DK0841924T3 (ru)
EA (1) EA000999B1 (ru)
ES (1) ES2183004T3 (ru)
HU (1) HUP9901092A3 (ru)
IL (1) IL123147A (ru)
MX (1) MX9800927A (ru)
NO (1) NO317033B1 (ru)
NZ (1) NZ313713A (ru)
OA (1) OA10661A (ru)
PL (1) PL324869A1 (ru)
PT (1) PT841924E (ru)
SK (1) SK13598A3 (ru)
TR (1) TR199800127T1 (ru)
WO (1) WO1997004771A1 (ru)

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WO1997004771A1 (en) 1997-02-13
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DE69624115D1 (de) 2002-11-07
EP0841924B1 (en) 2002-10-02
AP866A (en) 2000-08-17
CN1159007C (zh) 2004-07-28
TR199800127T1 (xx) 1998-04-21
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NO980414D0 (no) 1998-01-30
AU714873B2 (en) 2000-01-13
MX9800927A (es) 1998-10-31
NO980414L (no) 1998-04-02
BR9610051A (pt) 1999-12-21
CN1195985A (zh) 1998-10-14
KR19990036086A (ko) 1999-05-25
ATE225173T1 (de) 2002-10-15
US6310082B1 (en) 2001-10-30
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EA000999B1 (ru) 2000-08-28
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CZ30398A3 (cs) 1998-06-17
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