CY1120378T1 - Υποκατεστημενα παραγωγα του διφαινυλο βουτανοϊκου φωσφονικου οξεος ως αναστολεις νερ (ουδετερης ενδοπεπτιδασης) - Google Patents

Υποκατεστημενα παραγωγα του διφαινυλο βουτανοϊκου φωσφονικου οξεος ως αναστολεις νερ (ουδετερης ενδοπεπτιδασης)

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Publication number
CY1120378T1
CY1120378T1 CY20181100677T CY181100677T CY1120378T1 CY 1120378 T1 CY1120378 T1 CY 1120378T1 CY 20181100677 T CY20181100677 T CY 20181100677T CY 181100677 T CY181100677 T CY 181100677T CY 1120378 T1 CY1120378 T1 CY 1120378T1
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CY
Cyprus
Prior art keywords
derivatized
substituted
phosphonic acid
acid binding
binding derivatives
Prior art date
Application number
CY20181100677T
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English (en)
Inventor
David Weninger Barnes
Scott Louis Cohen
Dean Franklin Rigel
Original Assignee
Novartis Ag
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Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CY1120378T1 publication Critical patent/CY1120378T1/el

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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
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    • C07F9/572—Five-membered rings
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    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring

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  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Η παρούσα εφεύρεση παρέχει μία ένωση του τύπου I· ή ένα φαρμακευτικά αποδεκτό άλας αυτής, στην οποία τα R1, R2 και R3 ορίζονται εδώ. Η εφεύρεση είναι επίσης συναφής με μία μέθοδο για την παρασκευή των ενώσεων της εφεύρεσης και τις θεραπευτικές της χρήσεις. Η παρούσα εφεύρεση παρέχει περαιτέρω φαρμακευτική σύνθεση των ενώσεων της εφεύρεσης και ένα συνδυασμό των φαρμακευτικών δραστικών παραγόντων και μιας ένωσης της εφεύρεσης.
CY20181100677T 2013-02-14 2018-06-28 Υποκατεστημενα παραγωγα του διφαινυλο βουτανοϊκου φωσφονικου οξεος ως αναστολεις νερ (ουδετερης ενδοπεπτιδασης) CY1120378T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361764679P 2013-02-14 2013-02-14
PCT/US2014/015980 WO2014126979A1 (en) 2013-02-14 2014-02-12 Substituted bisphenyl butanoic phosphonic acid derivatives as nep (neutral endopeptidase) inhibitors

Publications (1)

Publication Number Publication Date
CY1120378T1 true CY1120378T1 (el) 2019-07-10

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CY20181100677T CY1120378T1 (el) 2013-02-14 2018-06-28 Υποκατεστημενα παραγωγα του διφαινυλο βουτανοϊκου φωσφονικου οξεος ως αναστολεις νερ (ουδετερης ενδοπεπτιδασης)

Country Status (37)

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US (3) US9163040B2 (el)
EP (1) EP2956464B1 (el)
JP (1) JP6295277B2 (el)
KR (1) KR20150119109A (el)
CN (1) CN105073762B (el)
AP (1) AP2015008621A0 (el)
AR (1) AR094790A1 (el)
AU (1) AU2014216424B2 (el)
BR (1) BR112015019369A2 (el)
CA (1) CA2900027A1 (el)
CR (1) CR20150419A (el)
CU (1) CU24330B1 (el)
CY (1) CY1120378T1 (el)
DK (1) DK2956464T3 (el)
EA (1) EA028583B1 (el)
ES (1) ES2675216T3 (el)
HK (1) HK1212704A1 (el)
HR (1) HRP20180958T1 (el)
HU (1) HUE038248T2 (el)
IL (1) IL240336A0 (el)
LT (1) LT2956464T (el)
MA (1) MA38330B1 (el)
MX (1) MX367525B (el)
NZ (1) NZ710574A (el)
PE (1) PE20151666A1 (el)
PH (1) PH12015501752A1 (el)
PL (1) PL2956464T3 (el)
PT (1) PT2956464T (el)
RS (1) RS57358B1 (el)
SG (1) SG11201506018PA (el)
SI (1) SI2956464T1 (el)
TN (1) TN2015000324A1 (el)
TR (1) TR201808541T4 (el)
TW (1) TWI636057B (el)
UY (1) UY35325A (el)
WO (1) WO2014126979A1 (el)
ZA (1) ZA201505490B (el)

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PE20151666A1 (es) 2013-02-14 2015-11-19 Novartis Ag Derivados sustituidos del acido bisfenil butanoico fosfonico como inhibidores de la nep
WO2017020841A1 (zh) * 2015-08-03 2017-02-09 深圳信立泰药业股份有限公司 一种含有lcz696的药物组合物及其制备方法
CN105748420B (zh) * 2016-03-04 2018-11-06 山东省药学科学院 一种治疗心力衰竭的lcz696缓释骨架片的制备方法
CN107764910B (zh) * 2017-09-05 2020-02-07 华侨大学 一种沙库比曲缬沙坦三钠半五水合物胶囊有效成分的含量测定方法
UY38072A (es) 2018-02-07 2019-10-01 Novartis Ag Compuestos derivados de éster butanoico sustituido con bisfenilo como inhibidores de nep, composiciones y combinaciones de los mismos
UY38485A (es) 2018-11-27 2020-06-30 Novartis Ag Compuestos tetrámeros cíclicos como inhibidores de proproteína convertasa subtilisina/kexina tipo 9 (pcsk9), método de tratamiento, uso y su preparación
CN113166204A (zh) 2018-11-27 2021-07-23 诺华股份有限公司 作为治疗代谢障碍的蛋白质原转换酶枯草杆菌蛋白酶/kexin 9型（PCSK9）抑制剂的环状肽
EP3887363A1 (en) 2018-11-27 2021-10-06 Novartis AG Cyclic pentamer compounds as proprotein convertase subtilisin/kexin type 9 (pcsk9) inhibitors for the treatment of metabolic disorder
AU2021341508A1 (en) 2020-09-10 2023-05-25 Precirix N.V. Antibody fragment against fap
WO2023084449A1 (en) 2021-11-12 2023-05-19 Novartis Ag Diaminocyclopentylpyridine derivatives for the treatment of a disease or disorder
WO2023203135A1 (en) 2022-04-22 2023-10-26 Precirix N.V. Improved radiolabelled antibody
WO2023213801A1 (en) 2022-05-02 2023-11-09 Precirix N.V. Pre-targeting

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