SG146694A1 - 1,1,1-trifluoro-4-phenyl-4-methyl-2-(1h-pyrrolo-2,3-c pyridin-2- ylmethyl)pentan-2-ol derivatives and related compounds as glucocorticoid ligands for the treatment of inflammatory diseases and diabetes - Google Patents
1,1,1-trifluoro-4-phenyl-4-methyl-2-(1h-pyrrolo-2,3-c pyridin-2- ylmethyl)pentan-2-ol derivatives and related compounds as glucocorticoid ligands for the treatment of inflammatory diseases and diabetesInfo
- Publication number
- SG146694A1 SG146694A1 SG200807363-7A SG2008073637A SG146694A1 SG 146694 A1 SG146694 A1 SG 146694A1 SG 2008073637 A SG2008073637 A SG 2008073637A SG 146694 A1 SG146694 A1 SG 146694A1
- Authority
- SG
- Singapore
- Prior art keywords
- pentan
- pyrrolo
- ylmethyl
- trifluoro
- pyridin
- Prior art date
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- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
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EP (1) | EP1673088A1 (fr) |
JP (2) | JP4778430B2 (fr) |
KR (1) | KR101152690B1 (fr) |
CN (1) | CN101948425A (fr) |
AR (1) | AR046020A1 (fr) |
AU (1) | AU2004275757B2 (fr) |
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CA (1) | CA2539909C (fr) |
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KR20050036982A (ko) | 2002-08-29 | 2005-04-20 | 베링거 인겔하임 파마슈티칼즈, 인코포레이티드 | 염증, 알러지 및 증식성 질환의 치료에 글루코코르티코이드모사체로 사용하기 위한 3-(설폰아미도에틸)-인돌 유도체 |
JP2004139389A (ja) | 2002-10-18 | 2004-05-13 | Minolta Co Ltd | 画像データ管理装置、画像データ管理プログラム、および画像形成装置 |
US7112584B2 (en) | 2002-12-20 | 2006-09-26 | Schering Ag | Nonsteroidal antiinflammatory agents |
WO2004063163A1 (fr) * | 2003-01-03 | 2004-07-29 | Boehringer Ingelheim Pharmaceuticals, Inc. | Derives de 1-propanol et 1-propylamine et leur utilisation en tant que ligands de glucocorticoide |
DE602004022633D1 (de) | 2003-01-30 | 2009-10-01 | Boehringer Ingelheim Pharma | 2,4-diaminopyrimidinderivate, die sich als inhibitoren von pkc-theta eignen |
WO2004071389A2 (fr) | 2003-02-15 | 2004-08-26 | Glaxo Group Limited | Composés |
US20040224992A1 (en) | 2003-02-27 | 2004-11-11 | Boehringer Ingelheim Pharmaceuticals, Inc. | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof |
EP1615667A2 (fr) | 2003-04-11 | 2006-01-18 | Novo Nordisk A/S | Therapie combinatoire utilisant un inhibiteur de 11beta-hydroxysteroide deshydrogenase de type 1 et agoniste du recepteur de glucocorticoides |
CA2535644A1 (fr) | 2003-08-20 | 2005-03-03 | Amgen Inc. | Derives de pyrimdinone substitues et leurs procedes d'utilisation |
UY28526A1 (es) | 2003-09-24 | 2005-04-29 | Boehringer Ingelheim Pharma | Miméticos de glucocorticoides, métodos de preparación composiciones farmacéuticas y usos de los mismos |
ES2315713T3 (es) | 2003-10-03 | 2009-04-01 | Boehringer Ingelheim Pharmaceuticals Inc. | Sondas fluorescentes para su utilizacion en un ensayo de union de inhibidores de quinasas de proteinas. |
EP1675839B1 (fr) | 2003-10-16 | 2007-07-11 | Boehringer Ingelheim Pharmaceuticals Inc. | Synthese stereoselective de certains alcools a substitution trifluoromethyle |
US7795272B2 (en) | 2004-03-13 | 2010-09-14 | Boehringer Ingelheim Pharmaceutical, Inc. | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions and uses thereof |
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JP2007530541A (ja) | 2004-03-22 | 2007-11-01 | ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド | グルココルチコイドミメチックスとしてのα−トリフルオロメチルアルコール又はアミン |
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US7741361B2 (en) | 2004-12-27 | 2010-06-22 | Boehringer Ingelheim Pharmaceuticals, Inc. | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof |
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MX2007014811A (es) | 2005-06-10 | 2008-02-14 | Boehringer Ingelheim Int | Mimeticos de glucocorticoides, metodos para su fabricacion, composiciones farmaceuticas y usos de los mismos. |
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JP2009510063A (ja) | 2005-09-30 | 2009-03-12 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 特定のトリフルオロメチル置換アルコール類の立体選択的合成 |
DK2300472T3 (da) | 2008-06-06 | 2012-04-10 | Boehringer Ingelheim Int | Glucocorticoidmimetika, fremgangsmåder til disses fremstilling, farmaceutiske sammensætninger samt anvendelser deraf |
-
2004
- 2004-09-20 UY UY28526A patent/UY28526A1/es not_active Application Discontinuation
- 2004-09-21 PE PE2008001807A patent/PE20090219A1/es not_active Application Discontinuation
- 2004-09-21 PE PE2004000917A patent/PE20050951A1/es not_active Application Discontinuation
- 2004-09-21 PE PE2008001806A patent/PE20090218A1/es not_active Application Discontinuation
- 2004-09-21 PE PE2008001805A patent/PE20090217A1/es not_active Application Discontinuation
- 2004-09-22 TW TW093128656A patent/TWI340138B/zh not_active IP Right Cessation
- 2004-09-22 CA CA2539909A patent/CA2539909C/fr not_active Expired - Fee Related
- 2004-09-22 JP JP2006528127A patent/JP4778430B2/ja not_active Expired - Fee Related
- 2004-09-22 RU RU2006113696/04A patent/RU2006113696A/ru not_active Application Discontinuation
- 2004-09-22 SG SG200807363-7A patent/SG146694A1/en unknown
- 2004-09-22 US US10/947,420 patent/US8741897B2/en active Active
- 2004-09-22 AU AU2004275757A patent/AU2004275757B2/en not_active Ceased
- 2004-09-22 RS YUP-2006/0201A patent/RS20060201A/sr unknown
- 2004-09-22 MX MXPA06002880A patent/MXPA06002880A/es not_active Application Discontinuation
- 2004-09-22 WO PCT/US2004/031009 patent/WO2005030213A1/fr active Application Filing
- 2004-09-22 NZ NZ546666A patent/NZ546666A/en not_active IP Right Cessation
- 2004-09-22 CN CN2010102426640A patent/CN101948425A/zh active Pending
- 2004-09-22 BR BRPI0414591-7A patent/BRPI0414591A/pt not_active IP Right Cessation
- 2004-09-22 EP EP04788894A patent/EP1673088A1/fr not_active Withdrawn
- 2004-09-22 KR KR1020067007921A patent/KR101152690B1/ko not_active IP Right Cessation
- 2004-09-23 AR ARP040103429A patent/AR046020A1/es active Pending
-
2006
- 2006-03-21 IL IL174475A patent/IL174475A0/en unknown
- 2006-03-24 EC EC2006006459A patent/ECSP066459A/es unknown
- 2006-04-21 NO NO20061766A patent/NO20061766L/no not_active Application Discontinuation
-
2010
- 2010-05-06 JP JP2010106594A patent/JP2010209100A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
MXPA06002880A (es) | 2006-06-05 |
KR20060115858A (ko) | 2006-11-10 |
RU2006113696A (ru) | 2007-11-20 |
AU2004275757A1 (en) | 2005-04-07 |
RS20060201A (en) | 2008-08-07 |
US8741897B2 (en) | 2014-06-03 |
EP1673088A1 (fr) | 2006-06-28 |
BRPI0414591A (pt) | 2006-11-07 |
NO20061766L (no) | 2006-06-21 |
JP2007506750A (ja) | 2007-03-22 |
ECSP066459A (es) | 2006-09-18 |
TWI340138B (en) | 2011-04-11 |
CA2539909A1 (fr) | 2005-04-07 |
TW200526655A (en) | 2005-08-16 |
KR101152690B1 (ko) | 2012-07-05 |
AU2004275757B2 (en) | 2011-03-24 |
JP4778430B2 (ja) | 2011-09-21 |
US20050176706A1 (en) | 2005-08-11 |
JP2010209100A (ja) | 2010-09-24 |
NZ546666A (en) | 2010-02-26 |
PE20090218A1 (es) | 2009-03-28 |
CN101948425A (zh) | 2011-01-19 |
UY28526A1 (es) | 2005-04-29 |
IL174475A0 (en) | 2006-08-01 |
WO2005030213A1 (fr) | 2005-04-07 |
PE20050951A1 (es) | 2005-12-12 |
PE20090217A1 (es) | 2009-03-26 |
AR046020A1 (es) | 2005-11-23 |
CA2539909C (fr) | 2012-07-31 |
PE20090219A1 (es) | 2009-03-26 |
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