ES2196721T3 - Metodo para producir un derivado de acido fenilpropionico opticamente activo. - Google Patents
Metodo para producir un derivado de acido fenilpropionico opticamente activo.Info
- Publication number
- ES2196721T3 ES2196721T3 ES99301004T ES99301004T ES2196721T3 ES 2196721 T3 ES2196721 T3 ES 2196721T3 ES 99301004 T ES99301004 T ES 99301004T ES 99301004 T ES99301004 T ES 99301004T ES 2196721 T3 ES2196721 T3 ES 2196721T3
- Authority
- ES
- Spain
- Prior art keywords
- group
- optically active
- producing
- acid derivative
- phenylpropionic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
- C07C327/20—Esters of monothiocarboxylic acids
- C07C327/32—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/26—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids
- C07C303/28—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids by reaction of hydroxy compounds with sulfonic acids or derivatives thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
DERIVADOS DE ESTERES DE N - [(S) - 2 - (ACETILTIOMETIL) 1 - OXO - 3 - FENILPROPIL] - GLICINA OPTICAMENTE ACTIVOS DE FORMULA (IV) (EN LA QUE R 1 REPRESENTA HIDROGENO, UNA CADENA LATERAL DE AMINOACIDOS OPCIONALMENTE SUSTITUIDA Y UNA CADENA DE AMINOACIDOS PROTEGIDA; R 2 REPRESENTA UN GRUPO ALQUILO C 1 A C 18 , LINEAL O RAMIFICADO, OPCIONALMENTE SUSTITUIDO, O UN GRUPO BENCILO OPCIONALMENTE SUSTITUIDO; Y * REPRESENTA UN ATOMO DE CARBONO OPTICAMENTE ACTIVO) UTILES COMO AGENTES INHIBIDORES DE ENCEFALINA DE AGENTES INHIBIDORES DE ACE QUE SE PUEDEN PRODUCIR A BAJO COSTE A NIVEL INDUSTRIAL SOMETIENDO ESTERES DE ACIDO 2 HIDROXIMETIL - 3 - FENILPROPIONICO Y DE GLICINA OPTICAMENTE ACTIVOS A UNA CONDENSACION TRAS LO CUAL SE CONVIERTE EL GRUPO HIDROXILO EN UN GRUPO DE ELIMINACION Y SE SUSTITUYE EL GRUPO DE ELIMINACION POR UN GRUPO ACETILTIO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP3279198 | 1998-02-16 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2196721T3 true ES2196721T3 (es) | 2003-12-16 |
Family
ID=12368686
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES99301004T Expired - Lifetime ES2196721T3 (es) | 1998-02-16 | 1999-02-11 | Metodo para producir un derivado de acido fenilpropionico opticamente activo. |
Country Status (5)
Country | Link |
---|---|
US (3) | US6031121A (es) |
EP (1) | EP0937710B1 (es) |
CA (1) | CA2262224A1 (es) |
DE (1) | DE69906849T2 (es) |
ES (1) | ES2196721T3 (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2196721T3 (es) | 1998-02-16 | 2003-12-16 | Ajinomoto Kk | Metodo para producir un derivado de acido fenilpropionico opticamente activo. |
WO1999062511A1 (en) * | 1998-06-02 | 1999-12-09 | Bristol-Myers Squibb Company | Neurotrophic difluoroamide agents |
JP2004530647A (ja) * | 2001-01-30 | 2004-10-07 | メルク エンド カムパニー インコーポレーテッド | 高眼圧治療用眼薬組成物 |
AU2003203241A1 (en) * | 2002-01-17 | 2003-07-30 | Kaneka Corporation | Process for producing 2-aralkylpropionic acid derivative |
DK1490062T3 (da) * | 2002-03-26 | 2008-04-28 | Boehringer Ingelheim Pharma | Glukokortikoidmimetika, fremgangsmåder til fremstilling deraf, farmaceutiske sammensætninger og anvendelser deraf |
NZ538932A (en) * | 2002-08-29 | 2007-04-27 | Boehringer Ingelheim Pharma | 3-(sulfonamidoethyl)-indole derivatives for use as glucocorticoid mimetics in the treatment of inflammatory, allergic and proliferative disease |
UY28526A1 (es) * | 2003-09-24 | 2005-04-29 | Boehringer Ingelheim Pharma | Miméticos de glucocorticoides, métodos de preparación composiciones farmacéuticas y usos de los mismos |
US7795272B2 (en) * | 2004-03-13 | 2010-09-14 | Boehringer Ingelheim Pharmaceutical, Inc. | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions and uses thereof |
ATE433958T1 (de) * | 2004-12-27 | 2009-07-15 | Boehringer Ingelheim Pharma | Glucocorticoid-mimetika, verfahren zu deren herstellung, pharmazeutische zusammensetzungen und deren verwendung |
DE602006010584D1 (de) * | 2005-09-30 | 2009-12-31 | Boehringer Ingelheim Pharma | Stereoselektive synthese bestimmter trifluormethylsubstituierter alkohole |
AU2007329548A1 (en) * | 2006-12-06 | 2008-06-12 | Boehringer Ingelheim International Gmbh | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof |
ES2381257T3 (es) * | 2008-06-06 | 2012-05-24 | Boehringer Ingelheim International Gmbh | Miméticos de glucocorticoides, métodos para su fabricación, composiciones farmacéuticas y usos de los mismos |
WO2011161646A2 (en) * | 2010-06-25 | 2011-12-29 | Ranbaxy Laboratories Limited | Process for the preparation of alvimopan or its pharmaceutically acceptable salt or solvate thereof |
WO2013021343A1 (en) * | 2011-08-05 | 2013-02-14 | Ranbaxy Laboratories Limited | Process for the optical resolution of () -3- (2 -benzyloxy- 5 - bromophenyl) - 3 - phenylpropionic |
CN107674010B (zh) * | 2017-08-29 | 2020-04-07 | 陕西汉江药业集团股份有限公司 | 一种依卡曲尔的制备方法和检测方法 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4798904A (en) * | 1983-10-03 | 1989-01-17 | E. R. Squibb & Sons, Inc. | Certain [(lower alkanoyl-thio)methyl-1-oxo-3-phenyl propyl amino]benzene lower alkanoic acid or ester derivatives which inhibit enkephalinase |
US4722810A (en) * | 1984-08-16 | 1988-02-02 | E. R. Squibb & Sons, Inc. | Enkephalinase inhibitors |
US5136076A (en) * | 1987-11-24 | 1992-08-04 | Societe Civile Bioprojet | Process for the preparation of amino acid-derived enatiomeric compounds |
FR2623498B1 (fr) * | 1987-11-24 | 1990-04-06 | Bioprojet Soc Civ | Nouveaux composes enantiomeres derives d'amino-acides, leur procede de preparation et leurs applications therapeutiques |
US5210266A (en) * | 1987-12-03 | 1993-05-11 | Dainippon Pharmaceutical Co., Ltd. | N-substituted mercaptopropanamide derivatives |
FR2707638B1 (fr) * | 1993-07-16 | 1995-08-18 | Bioprojet Soc Civ | Nouveaux dérivés d'amino-acides, leurs procédés de préparation et leur application thérapeutique. |
FR2744446B1 (fr) * | 1996-02-05 | 1998-04-17 | Bioprojet Soc Civ | Procede de synthese asymetrique des derives s-acyles de l'acide 2-mercaptomethyl 3-phenyl propanoique, application a la synthese de derives n-(mercaptoacyl) amino-acides |
JPH11106363A (ja) | 1997-10-03 | 1999-04-20 | Ajinomoto Co Inc | 光学活性2−ヒドロキシメチル−3−フェニルプロピオン酸の製造方法 |
ES2196721T3 (es) * | 1998-02-16 | 2003-12-16 | Ajinomoto Kk | Metodo para producir un derivado de acido fenilpropionico opticamente activo. |
-
1999
- 1999-02-11 ES ES99301004T patent/ES2196721T3/es not_active Expired - Lifetime
- 1999-02-11 EP EP99301004A patent/EP0937710B1/en not_active Expired - Lifetime
- 1999-02-11 DE DE69906849T patent/DE69906849T2/de not_active Expired - Fee Related
- 1999-02-16 US US09/249,848 patent/US6031121A/en not_active Expired - Fee Related
- 1999-02-16 CA CA002262224A patent/CA2262224A1/en not_active Abandoned
- 1999-12-07 US US09/455,936 patent/US6239305B1/en not_active Expired - Fee Related
-
2001
- 2001-03-20 US US09/811,592 patent/US6339170B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP0937710B1 (en) | 2003-04-16 |
US20010014754A1 (en) | 2001-08-16 |
DE69906849T2 (de) | 2004-01-22 |
CA2262224A1 (en) | 1999-08-16 |
US6239305B1 (en) | 2001-05-29 |
US6031121A (en) | 2000-02-29 |
EP0937710A1 (en) | 1999-08-25 |
US6339170B2 (en) | 2002-01-15 |
DE69906849D1 (de) | 2003-05-22 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2196721T3 (es) | Metodo para producir un derivado de acido fenilpropionico opticamente activo. | |
EA200401365A1 (ru) | Способы лечения илеуса | |
BR9713465A (pt) | Inibidores metalotprotease de amina cìclica sibstituìda | |
EA200500017A1 (ru) | Новые соединения | |
CY1109168T1 (el) | Συνθεση νατριουχου φονταπαρινοξης υψηλης καθαροτητας | |
ATE461923T1 (de) | Substituierte 1h-benzimidazol-4-carbonsäureamide sind wirksame parp-inhibitoren | |
NO20005237D0 (no) | Heterocyklisk substituerte amider anvendt som calpain- inhibitorer | |
ATE477351T1 (de) | Korrosionsinhibitierende zusammensetzungen | |
AR051965A1 (es) | Sales de la n-[2-( { (3r)-1-[trans-4-hidroxi-4-(6- metoxipiridin-3-il)-ciclohexil] pirrolidin-3- il} amino)-2- oxoetil]-3-(trifluormetil) benzamida | |
BR0104144A (pt) | Aditivo inibidor de corrosão não-carcinogênico, solução inibidora de corrosão, e, artigo | |
EA200201252A1 (ru) | Соединения, эффективные в качестве агонистов э2 - адренорецептора и ингибиторов фосфодиэстеразы pde4 | |
ES2178205T3 (es) | Compuestos amida indazol como agentes serotoninergicos. | |
BR0112254A (pt) | Lìquido para tratamento ácido e processo para tratamento de superfìcies de cobre | |
CY1111503T1 (el) | Υδατικο διαλυμα οξανεξιδινης, μεθοδος παρασκευης του ιδιου, και απολυμαντικο | |
HRP20050075B1 (hr) | Primjena specifiäśnog derivata cikliäśkog amina ili njegovih farmaceutski prihvatljivih soli u lijeäśenju ili prevenciji zatajenja srca | |
NZ302072A (en) | 1,3-diamino propyl stereomeric derivatives and organic acid and inorganic salts of their amine intermediates in the preparation of retroviral protease inhibitors | |
BR9916807A (pt) | Antagonistas de 5ht1 para terapia antidepressiva | |
PA8466101A1 (es) | Agentes terapeuticos | |
EA200100930A1 (ru) | Способ лечения хозл | |
AP2000001937A0 (en) | Method for identifying chemical active agents and active agents for inhibiting the 1-desoxy-d-xylulose-5-phosphate biosynthetic pathway. | |
BR0014314A (pt) | Processo para derivados de ácido fenilacético | |
BR0311365A (pt) | Sal de adição de ácido farmaceuticamente aceitável, processo para a preparação de um sal de adição de ácido formulação farmacêutica, uso de um sal de adição de ácido, e, método de tratamento de uma condição onde a inibição da trombina é requerida | |
ES2189080T3 (es) | Derivados de creatina para el asma. | |
NO20001783L (no) | Antigromidler som inneholder tiakloprid | |
CY1105699T1 (el) | Νεες φαρμακευτικες ενωσεις με αλφα2υποδοχεα δραστηριοτητας |