ES2178205T3 - Compuestos amida indazol como agentes serotoninergicos. - Google Patents

Compuestos amida indazol como agentes serotoninergicos.

Info

Publication number
ES2178205T3
ES2178205T3 ES98919257T ES98919257T ES2178205T3 ES 2178205 T3 ES2178205 T3 ES 2178205T3 ES 98919257 T ES98919257 T ES 98919257T ES 98919257 T ES98919257 T ES 98919257T ES 2178205 T3 ES2178205 T3 ES 2178205T3
Authority
ES
Spain
Prior art keywords
sup
amida
compound
serotoninergic agents
indazol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98919257T
Other languages
English (en)
Inventor
Alessandra Alisi
Mario Brufani
Nicola Cazzolla
Marilena Giannangeli
Mario Pinza
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Angelini Acraf SpA
Original Assignee
Aziende Chimiche Riunite Angelini Francesco ACRAF SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aziende Chimiche Riunite Angelini Francesco ACRAF SpA filed Critical Aziende Chimiche Riunite Angelini Francesco ACRAF SpA
Application granted granted Critical
Publication of ES2178205T3 publication Critical patent/ES2178205T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Paints Or Removers (AREA)

Abstract

La invención tiene por objeto un compuesto que tiene fórmula general (I) en la que R{sup,1}, R{sup,2} R{sup,3 } R''{sup,3} R{sup,4} R{sup,5} y R{sup,6} tienen el significado indicado en la descripción, la invención se refiere igualmente a sales de adicción ácidas de éste compuesto con ácidos orgánicos o inorgánicos farmacéuticamente aceptables y de las sales cuaternarias farmacéuticamente aceptables de éste compuesto.
ES98919257T 1997-04-15 1998-04-02 Compuestos amida indazol como agentes serotoninergicos. Expired - Lifetime ES2178205T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT97MI000867A IT1291569B1 (it) 1997-04-15 1997-04-15 Indazolammidi come agenti serotoninergici

Publications (1)

Publication Number Publication Date
ES2178205T3 true ES2178205T3 (es) 2002-12-16

Family

ID=11376888

Family Applications (1)

Application Number Title Priority Date Filing Date
ES98919257T Expired - Lifetime ES2178205T3 (es) 1997-04-15 1998-04-02 Compuestos amida indazol como agentes serotoninergicos.

Country Status (27)

Country Link
US (1) US6197769B1 (es)
EP (1) EP0975623B1 (es)
JP (2) JP4578581B2 (es)
KR (1) KR100563867B1 (es)
CN (1) CN1318416C (es)
AR (1) AR012426A1 (es)
AT (1) ATE219490T1 (es)
AU (1) AU740360B2 (es)
BG (1) BG64006B1 (es)
CA (1) CA2286870C (es)
CZ (1) CZ295190B6 (es)
DE (1) DE69806141T2 (es)
DK (1) DK0975623T3 (es)
EA (1) EA002352B1 (es)
ES (1) ES2178205T3 (es)
GE (1) GEP20022654B (es)
HK (1) HK1027811A1 (es)
HU (1) HU227973B1 (es)
IL (1) IL132127A (es)
IT (1) IT1291569B1 (es)
PL (1) PL193308B1 (es)
PT (1) PT975623E (es)
SK (1) SK284731B6 (es)
TR (1) TR199902546T2 (es)
UA (1) UA58550C2 (es)
WO (1) WO1998046589A2 (es)
ZA (1) ZA982926B (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1291569B1 (it) * 1997-04-15 1999-01-11 Angelini Ricerche Spa Indazolammidi come agenti serotoninergici
IL157254A0 (en) 2001-02-23 2004-02-19 Merck & Co Inc N-substituted nonaryl-heterocyclic nmda/mr2b antagonists
WO2002080928A1 (en) * 2001-04-03 2002-10-17 Merck & Co., Inc. N-substituted nonaryl-heterocyclo amidyl nmda/nr2b antagonists
ITMI20030287A1 (it) 2003-02-18 2004-08-19 Acraf Indazolammidi dotate di attivita' analgesica metodo, per
ITMI20030972A1 (it) * 2003-05-15 2004-11-16 Acraf Indazolo dotato di attivita' analgesica, metodo per prepararlo e composizione farmaceutica che lo comprende.
ITMI20031468A1 (it) 2003-07-18 2005-01-19 Acraf Farmaco ativo nel dolore neuropatico
TW200533348A (en) * 2004-02-18 2005-10-16 Theravance Inc Indazole-carboxamide compounds as 5-ht4 receptor agonists
US7728006B2 (en) * 2004-04-07 2010-06-01 Theravance, Inc. Quinolinone-carboxamide compounds as 5-HT4 receptor agonists
US8309575B2 (en) 2004-04-07 2012-11-13 Theravance, Inc. Quinolinone-carboxamide compounds as 5-HT4 receptor agonists
TWI351282B (en) 2004-04-07 2011-11-01 Theravance Inc Quinolinone-carboxamide compounds as 5-ht4 recepto
WO2006052640A1 (en) * 2004-11-05 2006-05-18 Theravance, Inc. 5-ht4 receptor agonist compounds
ES2327142T3 (es) * 2004-11-05 2009-10-26 Theravance, Inc. Compuestos de quinolinona-carboxamida.
NZ555180A (en) * 2004-12-22 2010-09-30 Theravance Inc Indazole-carboxamide compounds useful as 5-HT4 receptor agonists
JP2008530225A (ja) * 2005-02-17 2008-08-07 セラヴァンス， インコーポレーテッド インダゾール−カルボキサミド化合物の結晶型
NZ560828A (en) * 2005-03-02 2011-01-28 Theravance Inc Quinolinone compounds as 5-HT4 receptor agonists
ITMI20062230A1 (it) * 2006-11-22 2008-05-23 Acraf Composto 2-alchil-indazolico procedimento per preparalo e composizione farmaceutica che lo comprende
UA99927C2 (uk) * 2007-11-12 2012-10-25 Ацьенде Кимике Риуните Анджелини Франческо А.Чи.Р.А.Ф. С.П.А. Медикамент, який є активним при невропатичному болі
US8377968B2 (en) * 2008-06-02 2013-02-19 Zalicus Pharmaceuticals, Ltd. N-piperidinyl acetamide derivatives as calcium channel blockers
EP2718283A4 (en) * 2011-06-07 2014-10-29 Sumitomo Dainippon Pharma Co Ltd INDAZOLE AND PYRROLOPYRIDINE DERIVATIVE AND PHARMACEUTICAL USE THEREOF
MX351288B (es) * 2012-02-21 2017-10-09 Acraf Uso de compuestos de 1h-indazol-3-carboxamida como beta inhibidores de glucogeno sintasa quinasa 3 beta.
PL2817302T3 (pl) * 2012-02-21 2016-06-30 Acraf Związki 1H-indazolo-3-karboksyamidowe jako inhibitory kinazy syntazy glikogenu 3-beta
WO2014134306A1 (en) 2013-03-01 2014-09-04 Zalicus Pharmaceuticals, Ltd. Heterocyclic inhibitors of the sodium channel
CN114340670A (zh) 2019-07-11 2022-04-12 普拉克西斯精密药物股份有限公司 T-型钙通道调节剂的制剂及其使用方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9103862D0 (en) * 1991-02-25 1991-04-10 Glaxo Group Ltd Chemical compounds
AU2435092A (en) * 1991-08-20 1993-03-16 Smithkline Beecham Plc 5-ht4 receptor antagonists
IL117438A (en) * 1995-03-16 2001-12-23 Lilly Co Eli Indazolecarboxamides, their preparation and pharmaceutical compositions containing them
KR19990022096A (ko) * 1995-05-31 1999-03-25 쇼다 오사무 모노시클릭 아미노기를 갖는 인다졸 유도체
IT1291569B1 (it) * 1997-04-15 1999-01-11 Angelini Ricerche Spa Indazolammidi come agenti serotoninergici

Also Published As

Publication number Publication date
ATE219490T1 (de) 2002-07-15
BG64006B1 (bg) 2003-09-30
EA002352B1 (ru) 2002-04-25
TR199902546T2 (xx) 2000-05-22
EP0975623B1 (en) 2002-06-19
HU227973B1 (hu) 2012-07-30
WO1998046589A3 (en) 1999-01-28
AU740360B2 (en) 2001-11-01
JP2010195813A (ja) 2010-09-09
IL132127A (en) 2005-06-19
JP2001518906A (ja) 2001-10-16
PL336348A1 (en) 2000-06-19
BG103863A (en) 2000-07-31
AU7215998A (en) 1998-11-11
HUP0002057A3 (en) 2002-01-28
IT1291569B1 (it) 1999-01-11
DE69806141T2 (de) 2003-01-30
SK142399A3 (en) 2000-08-14
ZA982926B (en) 1998-10-09
KR20010006120A (ko) 2001-01-26
EA199900935A1 (ru) 2000-04-24
HK1027811A1 (en) 2001-01-23
HUP0002057A2 (hu) 2001-04-28
US6197769B1 (en) 2001-03-06
PL193308B1 (pl) 2007-01-31
GEP20022654B (en) 2002-03-25
CA2286870A1 (en) 1998-10-22
EP0975623A2 (en) 2000-02-02
CA2286870C (en) 2007-05-22
SK284731B6 (sk) 2005-10-06
WO1998046589A2 (en) 1998-10-22
JP5237324B2 (ja) 2013-07-17
DE69806141D1 (de) 2002-07-25
CN1318416C (zh) 2007-05-30
ITMI970867A1 (it) 1998-10-15
JP4578581B2 (ja) 2010-11-10
IL132127A0 (en) 2001-03-19
PT975623E (pt) 2002-10-31
DK0975623T3 (da) 2002-10-14
CZ295190B6 (cs) 2005-06-15
CN1252798A (zh) 2000-05-10
UA58550C2 (uk) 2003-08-15
KR100563867B1 (ko) 2006-03-24
CZ362599A3 (cs) 2000-04-12
AR012426A1 (es) 2000-10-18

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