EA199900935A1 - Соединения индазоламида в качестве серотонинергических агентов - Google Patents

Соединения индазоламида в качестве серотонинергических агентов

Info

Publication number
EA199900935A1
EA199900935A1 EA199900935A EA199900935A EA199900935A1 EA 199900935 A1 EA199900935 A1 EA 199900935A1 EA 199900935 A EA199900935 A EA 199900935A EA 199900935 A EA199900935 A EA 199900935A EA 199900935 A1 EA199900935 A1 EA 199900935A1
Authority
EA
Eurasian Patent Office
Prior art keywords
serotoninergic agents
indazolamide
compounds
pharmaceutically acceptable
indazolamide compounds
Prior art date
Application number
EA199900935A
Other languages
English (en)
Other versions
EA002352B1 (ru
Inventor
Алессандра Алиси
Марио Бруфани
Никола Каццолла
Марилена Джаннанджели
Марио Пинца
Original Assignee
Ацьенде Кимике Рьюните Анджелини Франческо А.К.Р.А.Ф. С.П.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ацьенде Кимике Рьюните Анджелини Франческо А.К.Р.А.Ф. С.П.А. filed Critical Ацьенде Кимике Рьюните Анджелини Франческо А.К.Р.А.Ф. С.П.А.
Publication of EA199900935A1 publication Critical patent/EA199900935A1/ru
Publication of EA002352B1 publication Critical patent/EA002352B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Paints Or Removers (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Соединение, имеющее общую формулу (I),где R, R, R, R', R, Rи Rимеют значения, приведенные в описании, его соли присоединения кислот с фармацевтически приемлемыми органическими и неорганическими кислотами и его фармацевтически приемлемые четвертичные соли.Отчет о международном поиске был опубликован 1999.01.28.
EA199900935A 1997-04-15 1998-04-02 Производные индазоламида в качестве серотонинергических агентов EA002352B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT97MI000867A IT1291569B1 (it) 1997-04-15 1997-04-15 Indazolammidi come agenti serotoninergici
PCT/EP1998/002129 WO1998046589A2 (en) 1997-04-15 1998-04-02 Indazole amide compounds as serotoninergic agents

Publications (2)

Publication Number Publication Date
EA199900935A1 true EA199900935A1 (ru) 2000-04-24
EA002352B1 EA002352B1 (ru) 2002-04-25

Family

ID=11376888

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199900935A EA002352B1 (ru) 1997-04-15 1998-04-02 Производные индазоламида в качестве серотонинергических агентов

Country Status (27)

Country Link
US (1) US6197769B1 (ru)
EP (1) EP0975623B1 (ru)
JP (2) JP4578581B2 (ru)
KR (1) KR100563867B1 (ru)
CN (1) CN1318416C (ru)
AR (1) AR012426A1 (ru)
AT (1) ATE219490T1 (ru)
AU (1) AU740360B2 (ru)
BG (1) BG64006B1 (ru)
CA (1) CA2286870C (ru)
CZ (1) CZ295190B6 (ru)
DE (1) DE69806141T2 (ru)
DK (1) DK0975623T3 (ru)
EA (1) EA002352B1 (ru)
ES (1) ES2178205T3 (ru)
GE (1) GEP20022654B (ru)
HK (1) HK1027811A1 (ru)
HU (1) HU227973B1 (ru)
IL (1) IL132127A (ru)
IT (1) IT1291569B1 (ru)
PL (1) PL193308B1 (ru)
PT (1) PT975623E (ru)
SK (1) SK284731B6 (ru)
TR (1) TR199902546T2 (ru)
UA (1) UA58550C2 (ru)
WO (1) WO1998046589A2 (ru)
ZA (1) ZA982926B (ru)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1291569B1 (it) * 1997-04-15 1999-01-11 Angelini Ricerche Spa Indazolammidi come agenti serotoninergici
KR100849839B1 (ko) 2001-02-23 2008-08-01 머크 앤드 캄파니 인코포레이티드 Ｎ-치환된 비-아릴-헤테로사이클릭 ｎｍｄａ/ｎｒ2ｂ 길항제 및 이를 포함하는 약제학적 조성물
EP1390034A4 (en) * 2001-04-03 2005-07-13 Merck & Co Inc NMDA / NR2B NONARYL-HETEROCYCLO AMIDYL N-SUBSTITUTE ANTAGONISTS
ITMI20030287A1 (it) 2003-02-18 2004-08-19 Acraf Indazolammidi dotate di attivita' analgesica metodo, per
ITMI20030972A1 (it) 2003-05-15 2004-11-16 Acraf Indazolo dotato di attivita' analgesica, metodo per prepararlo e composizione farmaceutica che lo comprende.
ITMI20031468A1 (it) * 2003-07-18 2005-01-19 Acraf Farmaco ativo nel dolore neuropatico
TW200533348A (en) * 2004-02-18 2005-10-16 Theravance Inc Indazole-carboxamide compounds as 5-ht4 receptor agonists
TWI351282B (en) 2004-04-07 2011-11-01 Theravance Inc Quinolinone-carboxamide compounds as 5-ht4 recepto
US7728006B2 (en) * 2004-04-07 2010-06-01 Theravance, Inc. Quinolinone-carboxamide compounds as 5-HT4 receptor agonists
US8309575B2 (en) 2004-04-07 2012-11-13 Theravance, Inc. Quinolinone-carboxamide compounds as 5-HT4 receptor agonists
DE602005014566D1 (de) * 2004-11-05 2009-07-02 Theravance Inc Chinolinon-carboxamid-verbindungen
US7399862B2 (en) * 2004-11-05 2008-07-15 Theravance, Inc. 5-HT4 receptor agonist compounds
KR20070091665A (ko) * 2004-12-22 2007-09-11 세라밴스 인코포레이티드 인다졸－카르복사미드 화합물
EP1848716A1 (en) * 2005-02-17 2007-10-31 Theravance, Inc. Crystalline form of an indazole-carboxamide compound
MX2007010769A (es) * 2005-03-02 2008-03-07 Theravance Inc Compuestos de quinolina como agonistas de receptor 5-ht4.
ITMI20062230A1 (it) * 2006-11-22 2008-05-23 Acraf Composto 2-alchil-indazolico procedimento per preparalo e composizione farmaceutica che lo comprende
UA99927C2 (ru) * 2007-11-12 2012-10-25 Ацьенде Кимике Риуните Анджелини Франческо А.Чи.Р.А.Ф. С.П.А. Медикамент, который является активным при невропатической боли
US8377968B2 (en) 2008-06-02 2013-02-19 Zalicus Pharmaceuticals, Ltd. N-piperidinyl acetamide derivatives as calcium channel blockers
WO2012169649A1 (en) * 2011-06-07 2012-12-13 Dainippon Sumitomo Pharma Co., Ltd. Indazole- and pyrrolopyridine-derivative and pharmaceutical use thereof
ES2564961T3 (es) * 2012-02-21 2016-03-30 Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A. Compuestos de 1H-indazol-3-carboxamida como inhibidores de la glucógeno sintasa cinasa 3 beta
EA026952B1 (ru) * 2012-02-21 2017-06-30 Ацьенде Кимике Рьюните Анджелини Франческо А.К.Р.А.Ф. С.П.А. Применение 1h-индазол-3-карбоксамидных соединений в качестве ингибиторов гликогенсинтазы киназы 3-бета
US10208023B2 (en) 2013-03-01 2019-02-19 Mark G. DeGiacomo Heterocyclic inhibitors of the sodium channel
JP2022540253A (ja) 2019-07-11 2022-09-14 プラクシス プレシジョン メディシンズ， インコーポレイテッド Ｔ型カルシウムチャネル調節因子の製剤およびその使用方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9103862D0 (en) * 1991-02-25 1991-04-10 Glaxo Group Ltd Chemical compounds
CA2116024A1 (en) * 1991-08-20 1993-03-04 Francis David King 5-ht4 receptor antagonists
IL117438A (en) * 1995-03-16 2001-12-23 Lilly Co Eli Indazolecarboxamides, their preparation and pharmaceutical compositions containing them
CA2222532A1 (en) * 1995-05-31 1996-12-05 Nisshin Flour Milling Co., Ltd. Indazole derivatives having monocyclic amine
IT1291569B1 (it) * 1997-04-15 1999-01-11 Angelini Ricerche Spa Indazolammidi come agenti serotoninergici

Also Published As

Publication number Publication date
WO1998046589A2 (en) 1998-10-22
TR199902546T2 (xx) 2000-05-22
DK0975623T3 (da) 2002-10-14
CZ362599A3 (cs) 2000-04-12
DE69806141D1 (de) 2002-07-25
SK284731B6 (sk) 2005-10-06
HUP0002057A3 (en) 2002-01-28
KR100563867B1 (ko) 2006-03-24
JP4578581B2 (ja) 2010-11-10
CZ295190B6 (cs) 2005-06-15
UA58550C2 (ru) 2003-08-15
CN1252798A (zh) 2000-05-10
PL336348A1 (en) 2000-06-19
HUP0002057A2 (hu) 2001-04-28
DE69806141T2 (de) 2003-01-30
CA2286870A1 (en) 1998-10-22
AU7215998A (en) 1998-11-11
GEP20022654B (en) 2002-03-25
CN1318416C (zh) 2007-05-30
PT975623E (pt) 2002-10-31
US6197769B1 (en) 2001-03-06
IL132127A0 (en) 2001-03-19
ITMI970867A1 (it) 1998-10-15
SK142399A3 (en) 2000-08-14
WO1998046589A3 (en) 1999-01-28
HU227973B1 (hu) 2012-07-30
EP0975623B1 (en) 2002-06-19
IL132127A (en) 2005-06-19
JP2010195813A (ja) 2010-09-09
PL193308B1 (pl) 2007-01-31
AR012426A1 (es) 2000-10-18
JP5237324B2 (ja) 2013-07-17
AU740360B2 (en) 2001-11-01
HK1027811A1 (en) 2001-01-23
IT1291569B1 (it) 1999-01-11
ATE219490T1 (de) 2002-07-15
EP0975623A2 (en) 2000-02-02
BG103863A (en) 2000-07-31
CA2286870C (en) 2007-05-22
JP2001518906A (ja) 2001-10-16
ES2178205T3 (es) 2002-12-16
ZA982926B (en) 1998-10-09
BG64006B1 (bg) 2003-09-30
EA002352B1 (ru) 2002-04-25
KR20010006120A (ko) 2001-01-26

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU