CY1109168T1 - Συνθεση νατριουχου φονταπαρινοξης υψηλης καθαροτητας - Google Patents
Συνθεση νατριουχου φονταπαρινοξης υψηλης καθαροτηταςInfo
- Publication number
- CY1109168T1 CY1109168T1 CY20091100645T CY091100645T CY1109168T1 CY 1109168 T1 CY1109168 T1 CY 1109168T1 CY 20091100645 T CY20091100645 T CY 20091100645T CY 091100645 T CY091100645 T CY 091100645T CY 1109168 T1 CY1109168 T1 CY 1109168T1
- Authority
- CY
- Cyprus
- Prior art keywords
- composition
- sodium
- fontaparinox
- clear
- pharmaceutical compositions
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7024—Esters of saccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
Abstract
Η παρούσα εφεύρεση αφορά μία σύνθεση νατριούχου φονταπαρινόξης υψηλής καθαρότητας, όπου στον καθαρισμό συμμετέχει ενεργός άνθρακας, μία μέθοδο παρασκευής αυτής της συνθέσεως για χρήση σε φαρμακευτικές συνθέσεις, καθώς και τις φαρμακευτικές συνθέσεις που την περιέχουν ως δραστικό παράγοντα.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US37526803A | 2003-02-27 | 2003-02-27 | |
EP04710418A EP1625135B1 (fr) | 2003-02-27 | 2004-02-12 | Composition de fondaparinux sodique de haute purete |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1109168T1 true CY1109168T1 (el) | 2014-07-02 |
Family
ID=32961215
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20091100645T CY1109168T1 (el) | 2003-02-27 | 2009-06-18 | Συνθεση νατριουχου φονταπαρινοξης υψηλης καθαροτητας |
Country Status (14)
Country | Link |
---|---|
US (1) | US20050020536A1 (el) |
EP (1) | EP1625135B1 (el) |
JP (1) | JP4594298B2 (el) |
AR (1) | AR044200A1 (el) |
AT (1) | ATE427953T1 (el) |
CY (1) | CY1109168T1 (el) |
DE (1) | DE602004020459D1 (el) |
DK (1) | DK1625135T3 (el) |
ES (1) | ES2322464T3 (el) |
HK (1) | HK1087719A1 (el) |
PT (1) | PT1625135E (el) |
SI (1) | SI1625135T1 (el) |
TW (1) | TWI335224B (el) |
WO (1) | WO2004078105A2 (el) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040171819A1 (en) | 2002-10-10 | 2004-09-02 | Aventis Pharma S.A. | Mixtures of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them |
WO2006121688A2 (en) * | 2005-05-05 | 2006-11-16 | Archipelago Holdings, Inc. | Anti-internalization order modifier |
US7635773B2 (en) | 2008-04-28 | 2009-12-22 | Cydex Pharmaceuticals, Inc. | Sulfoalkyl ether cyclodextrin compositions |
US8277143B2 (en) * | 2009-05-12 | 2012-10-02 | RSA Protective Technology, LLC | Surface mount vehicle anti-ram security systems |
EP3666786A1 (en) * | 2009-07-31 | 2020-06-17 | Reliable Biopharmaceutical Corporation | Process for preparing fondaparinux sodium and intermediates useful in the synthesis thereof |
US8420790B2 (en) | 2009-10-30 | 2013-04-16 | Reliable Biopharmaceutical Corporation | Efficient and scalable process for the manufacture of Fondaparinux sodium |
US20130005954A1 (en) * | 2011-06-28 | 2013-01-03 | Apicore, Llc | Process for preparing heparinoids and intermediates useful in the synthesis thereof |
CN102659859B (zh) * | 2012-04-11 | 2014-12-10 | 苏州纳微科技有限公司 | 单分散聚甲基丙烯酸酯离子交换层析介质在磺达肝癸钠柱层析纯化中的应用 |
CN103570774B (zh) * | 2012-08-07 | 2017-08-25 | 博瑞生物医药(苏州)股份有限公司 | 一种戊糖化合物的纯化方法 |
KR102112119B1 (ko) | 2012-10-22 | 2020-05-19 | 사이덱스 파마슈티칼스, 인크. | 알킬화된 시클로덱스트린 조성물 및 이의 제조 및 사용 방법 |
CN103864862B (zh) * | 2012-12-14 | 2017-10-17 | 博瑞生物医药(苏州)股份有限公司 | 一种戊糖化合物的纯化方法 |
US9346844B2 (en) | 2013-07-25 | 2016-05-24 | Scinopharm Taiwan, Ltd. | Process for the production of fondaparinux sodium |
US10072039B2 (en) | 2013-07-25 | 2018-09-11 | Scinopharm Taiwan, Ltd. | Process for the production of Fondaparinux sodium |
JP6321798B2 (ja) * | 2013-07-25 | 2018-05-09 | サイノファーム タイワン,リミティド | フォンダパリヌクスナトリウムを製造するための方法 |
CN103992364B (zh) * | 2014-03-25 | 2016-08-10 | 南京天翔医药科技有限公司 | 一种磺达肝癸钠的分离提取方法 |
CN103965269B (zh) * | 2014-04-16 | 2018-05-04 | 杭州华东医药集团新药研究院有限公司 | 低水分高纯度的磺达肝癸钠及其制备方法 |
US9873712B2 (en) * | 2014-10-03 | 2018-01-23 | Amphastar Pharmaceuticals, Inc. | Method of purifying idraparinux sodium |
US10688249B2 (en) * | 2015-06-11 | 2020-06-23 | Virchow Biotech Pvt. Ltd. | Multiple dose pharmaceutical compositions containing heparin and/or heparin-like compounds and devices and methods for delivering the same |
CN104910217B (zh) * | 2015-06-19 | 2018-04-17 | 天津红日药业股份有限公司 | 用于磺达肝癸钠质量控制的参比化合物 |
CN105037452B (zh) * | 2015-06-19 | 2018-10-09 | 天津红日药业股份有限公司 | 一种快速制备高纯度磺达肝癸钠的精制方法 |
CN107501359B (zh) * | 2017-08-24 | 2020-07-31 | 深圳市海滨制药有限公司 | 一种磺达肝癸钠杂质化合物及其制备方法与应用 |
CN114478663B (zh) * | 2020-11-12 | 2023-12-01 | 杭州中美华东制药有限公司 | 一种磺达肝癸钠杂质的制备方法 |
CN114591379A (zh) * | 2021-12-30 | 2022-06-07 | 淮北师范大学 | 一种磺达肝癸钠甲酰化杂质的制备方法 |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE664087A (el) * | 1956-03-29 | |||
US4025357A (en) * | 1975-04-14 | 1977-05-24 | A. E. Staley Manufacturing Company | Ion exchange enrichment of impure dextrose solutions |
JPS5577896A (en) * | 1978-12-07 | 1980-06-12 | Meiji Seika Kaisha Ltd | Preparation of high-purity maltose |
FR2456116A1 (fr) * | 1979-05-11 | 1980-12-05 | Sarget Lab | Nouvelle saponine triterpenique derivee de la caulophyllogenine et ses applications therapeutiques |
US4242501A (en) * | 1979-08-08 | 1980-12-30 | American Cyanamid Company | Purification of pneumococcal capsular polysaccharides |
US4502890A (en) * | 1981-03-02 | 1985-03-05 | Calgon Carbon Corporation | Purification of sugar liquors with activated carbon |
DE3118588C2 (de) * | 1981-05-11 | 1983-07-07 | Luitpold-Werk, Chemisch-Pharmazeutische Fabrik, 8000 München | Verfahren zur Herstellung eines injizierbaren hochreinen Chondroitinpolysulfates, hiernach erhältliches Produkt und pharmazeutische Zusammensetzung |
JPS5899497A (ja) * | 1981-11-27 | 1983-06-13 | Snow Brand Milk Prod Co Ltd | 新規なオリゴ糖、その製造法及びビフイドバクテリウム菌の増殖促進剤 |
JPS60102196A (ja) * | 1983-11-07 | 1985-06-06 | Daicel Chem Ind Ltd | 粗グリコシドの精製処理方法 |
US4686102A (en) * | 1984-04-12 | 1987-08-11 | American Cyanamid Company | Multivalent pneumococcal vaccine and preparation thereof |
JPS61118336A (ja) * | 1984-11-13 | 1986-06-05 | Yonezawa Kagaku Kogyo Kk | ペンタクロルフエノ−ル及びその誘導体の精製法 |
JPH0673442B2 (ja) * | 1986-03-13 | 1994-09-21 | 明治製菓株式会社 | 食品の老化防止方法 |
SE453394B (sv) * | 1986-07-07 | 1988-02-01 | Pharmacia Ab | Forfarande for framstellning av sulfaterade polysackarider genom anvendning av ett reducerande medel for sulfateringsreaktionen |
JPS6398395A (ja) * | 1986-10-16 | 1988-04-28 | Katakura Chitsukarin Kk | キトサンオリゴ糖の製造法 |
US5756721A (en) * | 1991-01-16 | 1998-05-26 | National Starch And Chemical Investment Holding Corporation | Purification of polysaccharides |
US5569756A (en) * | 1995-03-21 | 1996-10-29 | American Maize-Products Company | Purification of chemically modified cyclodextrins |
DE19543052A1 (de) * | 1995-11-06 | 1997-05-07 | Schering Ag | Verfahren zur Herstellung und Reinigung von Fludarabin-Phosphat und die Verwendung von sauren Ionenaustauschern im Verfahren |
EP1235783B1 (en) * | 1999-08-30 | 2004-09-29 | Mossi & Ghisolfi International S.A. | A process for separation of the dipotassium salt of naphthalene dicarboxylic acid using activated carbon beds |
-
2004
- 2004-02-12 AT AT04710418T patent/ATE427953T1/de active
- 2004-02-12 PT PT04710418T patent/PT1625135E/pt unknown
- 2004-02-12 ES ES04710418T patent/ES2322464T3/es not_active Expired - Lifetime
- 2004-02-12 WO PCT/FR2004/000314 patent/WO2004078105A2/fr active Application Filing
- 2004-02-12 EP EP04710418A patent/EP1625135B1/fr not_active Expired - Lifetime
- 2004-02-12 DK DK04710418T patent/DK1625135T3/da active
- 2004-02-12 DE DE602004020459T patent/DE602004020459D1/de not_active Expired - Lifetime
- 2004-02-12 SI SI200431107T patent/SI1625135T1/sl unknown
- 2004-02-12 JP JP2006505669A patent/JP4594298B2/ja not_active Expired - Fee Related
- 2004-02-19 AR ARP040100513A patent/AR044200A1/es not_active Application Discontinuation
- 2004-02-19 TW TW093104096A patent/TWI335224B/zh not_active IP Right Cessation
- 2004-06-30 US US10/881,250 patent/US20050020536A1/en not_active Abandoned
-
2006
- 2006-07-17 HK HK06107978.5A patent/HK1087719A1/xx not_active IP Right Cessation
-
2009
- 2009-06-18 CY CY20091100645T patent/CY1109168T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
EP1625135A2 (fr) | 2006-02-15 |
ES2322464T3 (es) | 2009-06-22 |
ATE427953T1 (de) | 2009-04-15 |
WO2004078105A2 (fr) | 2004-09-16 |
EP1625135B1 (fr) | 2009-04-08 |
TWI335224B (en) | 2011-01-01 |
TW200501965A (en) | 2005-01-16 |
WO2004078105A3 (fr) | 2004-10-28 |
AR044200A1 (es) | 2005-09-07 |
JP2006519246A (ja) | 2006-08-24 |
PT1625135E (pt) | 2009-07-10 |
DE602004020459D1 (de) | 2009-05-20 |
DK1625135T3 (da) | 2009-06-22 |
JP4594298B2 (ja) | 2010-12-08 |
SI1625135T1 (sl) | 2009-08-31 |
HK1087719A1 (en) | 2006-10-20 |
US20050020536A1 (en) | 2005-01-27 |
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