SG120493G - N-tert-Butyl-decahydro-2(3-amino-2-hydroxy-4-phenyl-butyl) isoquinoline-3-carboxamide and asparaginyl derivatives thereof - Google Patents

N-tert-Butyl-decahydro-2(3-amino-2-hydroxy-4-phenyl-butyl) isoquinoline-3-carboxamide and asparaginyl derivatives thereof

Info

Publication number
SG120493G
SG120493G SG120493A SG120493A SG120493G SG 120493 G SG120493 G SG 120493G SG 120493 A SG120493 A SG 120493A SG 120493 A SG120493 A SG 120493A SG 120493 G SG120493 G SG 120493G
Authority
SG
Singapore
Prior art keywords
butyl
asparaginyl
decahydro
isoquinoline
carboxamide
Prior art date
Application number
SG120493A
Other languages
English (en)
Inventor
Joseph Armstrong Martin
Sally Redshaw
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to GB898927913A priority Critical patent/GB8927913D0/en
Priority to IN905MA1990 priority patent/IN172553B/en
Priority to EG68190A priority patent/EG19722A/xx
Priority to ZW174/90A priority patent/ZW17490A1/xx
Priority to MT1075A priority patent/MTP1075B/xx
Priority to MW88/90A priority patent/MW8890A1/xx
Priority to US07/615,534 priority patent/US5196438A/en
Priority to CS905765A priority patent/CZ280558B6/cs
Priority to CA002030433A priority patent/CA2030433C/en
Priority to SK5765-90A priority patent/SK280249B6/sk
Priority to FI973895A priority patent/FI973895A7/fi
Priority to ZA909743A priority patent/ZA909743B/xx
Priority to RO146474A priority patent/RO107942B1/ro
Priority to FI905983A priority patent/FI100883B/fi
Priority to MC902159A priority patent/MC2195A1/fr
Priority to IL9655090A priority patent/IL96550A/en
Priority to HU908076A priority patent/HU207298B/hu
Priority to MX023619A priority patent/MX173630B/es
Priority to KR90020078A priority patent/KR970005912B1/ko
Priority to AU67876/90A priority patent/AU634319B2/en
Priority to IS3651A priority patent/IS1803B/is
Priority to SI9012315A priority patent/SI9012315B/sl
Priority to NO905322A priority patent/NO176566C/no
Priority to CN90109931A priority patent/CN1034805C/zh
Priority to PT96145A priority patent/PT96145B/pt
Priority to IE445390A priority patent/IE67523B1/en
Priority to JP2409792A priority patent/JP2807093B2/ja
Priority to CU90197A priority patent/CU22305A3/es
Priority to ES90123697T priority patent/ES2072959T3/es
Priority to DE1996175051 priority patent/DE19675051I2/de
Priority to CN96107466A priority patent/CN1066329C/zh
Priority to DZ900221A priority patent/DZ1467A1/fr
Priority to AT90123697T priority patent/ATE122661T1/de
Priority to EP90123697A priority patent/EP0432695B1/en
Priority to BG093425A priority patent/BG51452A3/xx
Priority to GB9026776A priority patent/GB2239016B/en
Priority to DE69019481T priority patent/DE69019481T2/de
Priority to MA22289A priority patent/MA22014A1/fr
Priority to DK90123697.6T priority patent/DK0432695T3/da
Priority to LU90014C priority patent/LU90014I2/fr
Priority to BR909006264A priority patent/BR9006264A/pt
Priority to PL90288201A priority patent/PL165225B1/pl
Priority to OA59914A priority patent/OA09334A/xx
Priority to SU904831985A priority patent/RU2071470C1/ru
Priority to IDP14891A priority patent/ID1018B/id
Priority to HRP-2315/90A priority patent/HRP930341B1/xx
Priority to LTIP862A priority patent/LT3682B/lt
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Priority to SG120493A priority patent/SG120493G/en
Priority to HK1290/93A priority patent/HK129093A/xx
Publication of SG120493G publication Critical patent/SG120493G/en
Priority to HU95P/P00230P priority patent/HU211342A9/hu
Priority to GR950402228T priority patent/GR3017114T3/el
Priority to LV960153A priority patent/LV5738B4/xx
Priority to NL970013C priority patent/NL970013I2/nl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/021—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)n-C(=0)-, n being 5 or 6; for n > 6, classification in C07K5/06 - C07K5/10, according to the moiety having normal peptide bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Communicable Diseases (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Cleaning Or Clearing Of The Surface Of Open Water (AREA)
  • Measurement Of Force In General (AREA)
  • Confectionery (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SG120493A 1989-12-11 1993-11-02 N-tert-Butyl-decahydro-2(3-amino-2-hydroxy-4-phenyl-butyl) isoquinoline-3-carboxamide and asparaginyl derivatives thereof SG120493G (en)

Priority Applications (53)

Application Number Priority Date Filing Date Title
GB898927913A GB8927913D0 (en) 1989-12-11 1989-12-11 Amino acid derivatives
IN905MA1990 IN172553B (OSRAM) 1989-12-11 1990-11-12
EG68190A EG19722A (en) 1989-12-11 1990-11-13 Process for preparing of amino acid derivatives
ZW174/90A ZW17490A1 (en) 1989-12-11 1990-11-14 Amino acid derivatives
MT1075A MTP1075B (en) 1989-12-11 1990-11-15 Amino acid derivatives
MW88/90A MW8890A1 (en) 1989-12-11 1990-11-19 Amino acid derivatives
US07/615,534 US5196438A (en) 1989-12-11 1990-11-19 Amino acid derivatives
CS905765A CZ280558B6 (cs) 1989-12-11 1990-11-21 Deriváty aminokyselin, způsob jejich výroby, jejich použití a léčiva na jejich bázi
CA002030433A CA2030433C (en) 1989-12-11 1990-11-21 New isoquinoline- carboxamide amino acid derivatives useful for treatment of viral diseases
SK5765-90A SK280249B6 (sk) 1989-12-11 1990-11-21 Deriváty aminokyselín, spôsob ich výroby, ich použ
FI973895A FI973895A7 (fi) 1989-12-11 1990-12-04 2-(3(S)-((L-asparaginyyli)amino)-2(R)-hydroksi-4-fenyylibutyyli)-N-tert-butyylidekahydro-(4aS,8aS)-isokinoliini-3(S)-karboksiamidijohdannaiset
ZA909743A ZA909743B (en) 1989-12-11 1990-12-04 Amino acid derivatives
RO146474A RO107942B1 (ro) 1989-12-11 1990-12-04 2-[3(S)-[(L-ASPARANGINIL) AMINO]-2-(R)-HIDROXI-4-FENIL BUTIL]-N-TERT-BUTIL-DECAHIDRO-(4a S, 8 a S)- -IZOCHINOLIN-3-(S)-CARBOXAMIDE SI INTERMEDIARI
FI905983A FI100883B (fi) 1989-12-11 1990-12-04 Menetelmä 2-£3(S)-£(L-asparaginyyli)amino|-2(R)-hydroksi-4-fenyylibuty yli|-N-tert-butyylidekahydro-(4aS,8aS)-isokinoliini-3(S)-karboksiamidi johdannaisten valmistamiseksi
MC902159A MC2195A1 (fr) 1989-12-11 1990-12-04 Derives d'acides amines
IL9655090A IL96550A (en) 1989-12-11 1990-12-05 Amino acid derivatives, their manufacture and pharmaceutical compositions containing them.
HU908076A HU207298B (en) 1989-12-11 1990-12-05 Process for producing perhydro-izoquinolin-amino-acid derivatives and pharmaceutical compositions containing them
MX023619A MX173630B (es) 1989-12-11 1990-12-06 Derivados de aminoacido, procedimiento para su preparacion y su preparacion y medicamento que los contiene
KR90020078A KR970005912B1 (en) 1989-12-11 1990-12-07 Amino acids derivatives
AU67876/90A AU634319B2 (en) 1989-12-11 1990-12-07 Amino acid derivatives
IS3651A IS1803B (is) 1989-12-11 1990-12-07 Amínósýruafleiður og aðferð til framleiðslu þeirra
SI9012315A SI9012315B (sl) 1989-12-11 1990-12-07 Derivati aminokislin
NO905322A NO176566C (no) 1989-12-11 1990-12-10 Analogifremgangsmåte ved fremstilling av terapeutisk aktive aminosyrederivater
CN90109931A CN1034805C (zh) 1989-12-11 1990-12-10 氨基酸衍生物的制备方法
PT96145A PT96145B (pt) 1989-12-11 1990-12-10 Processo para a preparacao de novos derivados de aminoacidos e de composicoes farmaceuticas que os contem
IE445390A IE67523B1 (en) 1989-12-11 1990-12-10 Amino acid derivatives
JP2409792A JP2807093B2 (ja) 1989-12-11 1990-12-10 アミノ酸誘導体
CU90197A CU22305A3 (es) 1989-12-11 1990-12-10 Procedimiento para la preparacion de un derivado de aminoacidos
ES90123697T ES2072959T3 (es) 1989-12-11 1990-12-10 Derivados de aminoacido.
DE1996175051 DE19675051I2 (de) 1989-12-11 1990-12-10 Aminosaeurederivate
CN96107466A CN1066329C (zh) 1989-12-11 1990-12-10 药物组合物的制备方法
DZ900221A DZ1467A1 (fr) 1989-12-11 1990-12-10 Dérivés d'acides amines.
AT90123697T ATE122661T1 (de) 1989-12-11 1990-12-10 Aminosäurederivate.
EP90123697A EP0432695B1 (en) 1989-12-11 1990-12-10 Amino acid derivatives
BG093425A BG51452A3 (bg) 1989-12-11 1990-12-10 Метод за получаване на производни на аминокиселини
GB9026776A GB2239016B (en) 1989-12-11 1990-12-10 N-tert-butyl-decahydro-2(3-amino-2-hydroxy-4-phenyl-butyl)isoquinoline-3-carbo xamide & asparaginyl derivatives thereof
DE69019481T DE69019481T2 (de) 1989-12-11 1990-12-10 Aminosäurederivate.
MA22289A MA22014A1 (fr) 1989-12-11 1990-12-10 Derives d'acides amines .
DK90123697.6T DK0432695T3 (da) 1989-12-11 1990-12-10 Aminosyrederivater
LU90014C LU90014I2 (fr) 1989-12-11 1990-12-10 Invirase ou un de ses dérivés ou sels pharmaceutiquement acceptables Saquinavir
BR909006264A BR9006264A (pt) 1989-12-11 1990-12-10 Derivados de aminoacidos e processo para a sua producao,medicamentos,usos de um derivado de aminoacido e processo para tratamento ou prevencao de infeccoes viroticas
PL90288201A PL165225B1 (pl) 1989-12-11 1990-12-11 Sposób wytwarzania nowych pochodnych aminokwasów PL PL
OA59914A OA09334A (fr) 1989-12-11 1990-12-11 "Dérivés d'acides aminés".
SU904831985A RU2071470C1 (ru) 1989-12-11 1990-12-11 Производные аминокислот и их кислотно-аддитивные соли
IDP14891A ID1018B (id) 1989-12-11 1991-08-28 N-tersier-butil-dekahidro-2(3-amino-2-hidroksi-4-fenil-butil) isokinolin-3-karboksamida dan turunan-turunan asparaginil darinya
HRP-2315/90A HRP930341B1 (en) 1989-12-11 1993-03-12 Amino acid derivatives
LTIP862A LT3682B (en) 1989-12-11 1993-08-16 Method for preparing amino acid derivatives and pharmaceuthical compositions thereof
SG120493A SG120493G (en) 1989-12-11 1993-11-02 N-tert-Butyl-decahydro-2(3-amino-2-hydroxy-4-phenyl-butyl) isoquinoline-3-carboxamide and asparaginyl derivatives thereof
HK1290/93A HK129093A (en) 1989-12-11 1993-11-25 N-tert-butyl-decahydro-2(3-amino-2-hydroxy-4-phenyl-butyl)isoquinoline-3-carboxamide & asparaginyl derivatives thereof
HU95P/P00230P HU211342A9 (en) 1989-12-11 1995-06-16 N-tert-butyl-decahydro-2(3-amino-2-hydroxy-4-phenyl-butyl)isoquinoline-3-carboxamide and asparaginyl derivatives thereof
GR950402228T GR3017114T3 (en) 1989-12-11 1995-08-11 Amino acid derivatives.
LV960153A LV5738B4 (lv) 1989-12-11 1996-05-24 Aminoskabju atvasinajumi
NL970013C NL970013I2 (nl) 1989-12-11 1997-03-07 Aminozuurderivaten.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB898927913A GB8927913D0 (en) 1989-12-11 1989-12-11 Amino acid derivatives
SG120493A SG120493G (en) 1989-12-11 1993-11-02 N-tert-Butyl-decahydro-2(3-amino-2-hydroxy-4-phenyl-butyl) isoquinoline-3-carboxamide and asparaginyl derivatives thereof

Publications (1)

Publication Number Publication Date
SG120493G true SG120493G (en) 1994-01-21

Family

ID=26296345

Family Applications (1)

Application Number Title Priority Date Filing Date
SG120493A SG120493G (en) 1989-12-11 1993-11-02 N-tert-Butyl-decahydro-2(3-amino-2-hydroxy-4-phenyl-butyl) isoquinoline-3-carboxamide and asparaginyl derivatives thereof

Country Status (48)

Country Link
US (1) US5196438A (OSRAM)
EP (1) EP0432695B1 (OSRAM)
JP (1) JP2807093B2 (OSRAM)
KR (1) KR970005912B1 (OSRAM)
CN (2) CN1034805C (OSRAM)
AT (1) ATE122661T1 (OSRAM)
AU (1) AU634319B2 (OSRAM)
BG (1) BG51452A3 (OSRAM)
BR (1) BR9006264A (OSRAM)
CA (1) CA2030433C (OSRAM)
CU (1) CU22305A3 (OSRAM)
CZ (1) CZ280558B6 (OSRAM)
DE (2) DE19675051I2 (OSRAM)
DK (1) DK0432695T3 (OSRAM)
DZ (1) DZ1467A1 (OSRAM)
EG (1) EG19722A (OSRAM)
ES (1) ES2072959T3 (OSRAM)
FI (2) FI100883B (OSRAM)
GB (2) GB8927913D0 (OSRAM)
GR (1) GR3017114T3 (OSRAM)
HK (1) HK129093A (OSRAM)
HR (1) HRP930341B1 (OSRAM)
HU (2) HU207298B (OSRAM)
ID (1) ID1018B (OSRAM)
IE (1) IE67523B1 (OSRAM)
IL (1) IL96550A (OSRAM)
IN (1) IN172553B (OSRAM)
IS (1) IS1803B (OSRAM)
LT (1) LT3682B (OSRAM)
LU (1) LU90014I2 (OSRAM)
LV (1) LV5738B4 (OSRAM)
MA (1) MA22014A1 (OSRAM)
MC (1) MC2195A1 (OSRAM)
MT (1) MTP1075B (OSRAM)
MW (1) MW8890A1 (OSRAM)
MX (1) MX173630B (OSRAM)
NL (1) NL970013I2 (OSRAM)
NO (1) NO176566C (OSRAM)
OA (1) OA09334A (OSRAM)
PL (1) PL165225B1 (OSRAM)
PT (1) PT96145B (OSRAM)
RO (1) RO107942B1 (OSRAM)
RU (1) RU2071470C1 (OSRAM)
SG (1) SG120493G (OSRAM)
SI (1) SI9012315B (OSRAM)
SK (1) SK280249B6 (OSRAM)
ZA (1) ZA909743B (OSRAM)
ZW (1) ZW17490A1 (OSRAM)

Families Citing this family (121)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6878728B1 (en) 1999-06-11 2005-04-12 Vertex Pharmaceutical Incorporated Inhibitors of aspartyl protease
US20040122000A1 (en) * 1981-01-07 2004-06-24 Vertex Pharmaceuticals Incorporated. Inhibitors of aspartyl protease
US5614533A (en) * 1987-03-13 1997-03-25 Bio-Mega/Boehringer Ingelheim Research, Inc. Substituted pipecolinic acid derivatives as HIV protease inhibitors
USH1649H (en) 1987-07-31 1997-05-06 Barrish; Joel C. HIV protease inhibitor combinations
CA1340588C (en) * 1988-06-13 1999-06-08 Balraj Krishan Handa Amino acid derivatives
GB8927915D0 (en) * 1989-12-11 1990-02-14 Hoffmann La Roche Novel alcohols
US5430041A (en) * 1991-05-10 1995-07-04 Hoffmann-La Roche Inc. Amino acid derivatives having antiviral activity
CN1071930A (zh) * 1991-07-10 1993-05-12 伊莱利利公司 用作治疗艾滋病的人免疫缺陷病毒蛋白酶的抑制剂
US5508407A (en) * 1991-07-10 1996-04-16 Eli Lilly And Company Retroviral protease inhibitors
WO1993008184A1 (en) * 1991-10-23 1993-04-29 Merck & Co., Inc. Hiv protease inhibitors
CA2195027C (en) * 1991-11-08 2000-01-11 Joseph P. Vacca Hiv protease inhibitors useful for the treatment of aids
US5413999A (en) * 1991-11-08 1995-05-09 Merck & Co., Inc. HIV protease inhibitors useful for the treatment of AIDS
US5888992A (en) 1992-03-11 1999-03-30 Narhex Limited Polar substituted hydrocarbons
US6071895A (en) 1992-03-11 2000-06-06 Narhex Limited Polar-substituted hydrocarbons
CA2130754C (en) 1992-03-11 2005-02-08 Damian W. Grobelny Amine derivatives of oxo- and hydroxy-substituted hydrocarbons
ATE116640T1 (de) * 1992-03-13 1995-01-15 Bio Mega Boehringer Ingelheim Substituierte pipecoline-säurederivate als hiv- protease-hemmer.
EP0957093A3 (en) * 1992-05-21 2000-04-12 Monsanto Company Retrovial protease inhibitors
US5559256A (en) * 1992-07-20 1996-09-24 E. R. Squibb & Sons, Inc. Aminediol protease inhibitors
ES2177868T3 (es) 1992-08-25 2002-12-16 Searle & Co Hidroxietilaminosulfonamidas de alfa- y beta-aminoacidos utiles como inhibidores de proteasas retroviricas.
US5723490A (en) * 1992-09-08 1998-03-03 Vertex Pharmaceuticals Incorporated THF-containing sulfonamide inhibitors of aspartyl protease
IS2334B (is) * 1992-09-08 2008-02-15 Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) Aspartyl próteasi hemjari af nýjum flokki súlfonamíða
US5783701A (en) 1992-09-08 1998-07-21 Vertex Pharmaceuticals, Incorporated Sulfonamide inhibitors of aspartyl protease
TW372972B (en) * 1992-10-23 1999-11-01 Novartis Ag Antiretroviral acyl compounds
US5380849A (en) * 1992-11-09 1995-01-10 Merck & Co., Inc. Process for optically pure decahydroisoqiunolines
US5430150A (en) * 1992-12-16 1995-07-04 American Cyanamid Company Retroviral protease inhibitors
US5846993A (en) * 1992-12-22 1998-12-08 Agouron Pharmaceuticals, Inc. HIV protease inhibitors
MX9308016A (es) * 1992-12-22 1994-08-31 Lilly Co Eli Compuestos inhibidores de la proteasa del virus de la inmunodeficiencia humana, procedimiento para su preparacion y formulacion farmaceutica que los contiene.
MX9308025A (es) * 1992-12-22 1994-08-31 Lilly Co Eli Compuestos inhibidores de la proteasa del virus dela inmunodeficiencia humana, procedimiento para supreparacion y formulacion farmaceutica que los contiene.
US5491166A (en) * 1992-12-22 1996-02-13 Eli Lilly And Company Inhibitors of HIV protease useful for the treatment of AIDS
US5733906A (en) * 1993-10-12 1998-03-31 Eli Lilly And Company Inhibitors of HIV Protease useful for the treatment of Aids
US5484926A (en) 1993-10-07 1996-01-16 Agouron Pharmaceuticals, Inc. HIV protease inhibitors
US5434265A (en) * 1992-12-22 1995-07-18 Eli Lilly And Company Inhibitors of HIV protease
AU6161794A (en) * 1993-01-17 1994-08-15 Schering Corporation Peptides having anti-hiv activity
US5939430A (en) * 1993-02-22 1999-08-17 Merrell Pharmaceuticals Inc. Combinations of retroviral inhibitors
US5455353A (en) * 1993-03-24 1995-10-03 Hoffmann-La Roche Inc. 4-(benzyl-2-oxo-oxazolidin-5 ylmethyl)N tertbutyl-decahydroisoquinoline-3-carboxamides
ES2098080T3 (es) * 1993-07-15 1997-04-16 Hoffmann La Roche Procedimiento para la obtencion de un derivado de n-tert-butilisoquinolin-3-carboxamida y compuestos intermedios de este procedimiento.
CA2182090A1 (en) * 1994-02-02 1995-08-10 William Joseph Hornback Hiv protease inhibitors and intermediates
DE69512220T2 (de) * 1994-03-07 2000-03-16 Vertex Pharmaceuticals Inc. Sulfonamidderivate als aspartylprotease-inhibitoren
US5527829A (en) * 1994-05-23 1996-06-18 Agouron Pharmaceuticals, Inc. HIV protease inhibitors
US5470979A (en) * 1994-07-01 1995-11-28 American Cyanamid Company Asymmetric synthesis of bicyclic amino acid esters
US5523463A (en) * 1994-09-23 1996-06-04 Hoffmann-La Roche Inc. Method of producing halogenated and alpha-aminoalchohols
US5591885A (en) * 1994-09-23 1997-01-07 Hoffman-La Roche Inc. Process for the preparation of halogenated α-aminoketone compounds
US5691372A (en) * 1995-04-19 1997-11-25 Vertex Pharmaceuticals Incorporated Oxygenated-Heterocycle containing sulfonamide inhibitors of aspartyl protease
US6008228A (en) * 1995-06-06 1999-12-28 Hoffman-La Roche Inc. Pharmaceutical compositions containing proteinase inhibitors
SK282121B6 (sk) * 1995-06-06 2001-11-06 F. Hoffmann-La Roche Ag Farmaceutický prostriedok obsahujúci terapeuticky účinné množstvo inhibítora proteinázy
US6004957A (en) * 1995-06-07 1999-12-21 Vertex Pharmaceuticals, Incorporated Sulfonamide inhibitors of aspartyl protease
AU759386B2 (en) * 1995-06-29 2003-04-10 Abbvie Inc. Use of Ritonavir (ABT-538) for improving the pharmacokinetics of drugs metabolized by cytochrome P450 in a method of treating AIDS
US6037157A (en) 1995-06-29 2000-03-14 Abbott Laboratories Method for improving pharmacokinetics
EP0861085B1 (en) 1995-11-13 2005-07-20 Vitaleech Bioscience N.V. Anti-viral isolates obtained from leeches
US5914332A (en) 1995-12-13 1999-06-22 Abbott Laboratories Retroviral protease inhibiting compounds
US5883252A (en) * 1996-01-26 1999-03-16 Vertex Pharmaceuticals Incorporated Aspartyl protease inhibitors
US5587481A (en) * 1996-02-20 1996-12-24 The Monsanto Company Preparation of (S)-decahydroisoquinoline-3-carboxylic acid t-butylamide
EP0823424A1 (de) * 1996-08-09 1998-02-11 F. Hoffmann-La Roche Ag Verfahren zur Herstellung von Chinargin
US5914404A (en) * 1996-08-09 1999-06-22 Hoffmann-La Roche Inc. Process for the preparation of quinargine
US5925759A (en) 1996-09-05 1999-07-20 Agouron Pharmaceuticals, Inc. Methods of making HIV-protease inhibitors and intermediates for making HIV-protease inhibitors
US5705647A (en) * 1996-09-05 1998-01-06 Agouron Pharmaceuticals, Inc. Intermediates for making HIV-protease inhibitors
US5962725A (en) 1996-09-05 1999-10-05 Agouron Pharmaceuticals, Inc. Intermediate compounds useful for making HIV protease inhibitors such as nelfinavir
US6232333B1 (en) 1996-11-21 2001-05-15 Abbott Laboratories Pharmaceutical composition
EP0847994B1 (de) 1996-12-11 2003-04-09 F. Hoffmann-La Roche Ag Verfahren zur Herstellung gemischter Anhydride
US6001851A (en) * 1997-03-13 1999-12-14 Agouron Pharmaceuticals, Inc. HIV protease inhibitors
US6084107A (en) * 1997-09-05 2000-07-04 Agouron Pharmaceuticals, Inc. Intermediates for making HIV-protease inhibitors
US6143742A (en) * 1997-12-11 2000-11-07 Fuisz Technologies Ltd Treatment for necrotizing infections
US6436989B1 (en) 1997-12-24 2002-08-20 Vertex Pharmaceuticals, Incorporated Prodrugs of aspartyl protease inhibitors
FR2779653B1 (fr) * 1998-06-11 2002-12-20 Inst Nat Sante Rech Med Utilisation de composes modulateurs du proteasome en therapie
PT1086076E (pt) * 1998-06-19 2005-05-31 Vertex Pharma Inibidores de sulfonamida de aspartil protease
BR9914785A (pt) * 1998-10-21 2001-07-03 Fujisawa Pharmaceutical Co Formavìtrea de 8-[3-[n-[(e)-3-(6-acetamidopiridin-3-il) acriloilglicil]-n-metilamino]-2,6-diclorobenziloxi)-2- metilquinolina, processo para sua preparação, composição farmacêutica compreendendo a mesma, agente de prevenção, seu métodos e uso
KR100277723B1 (ko) 1998-12-14 2001-01-15 남창우 광학적으로 순수한 데카하이드로이소퀴놀린카르복사미드의 연속제조공정
US7635690B2 (en) * 1999-01-22 2009-12-22 Emory University HIV-1 mutations selected for by β-2′,3′-didehydro-2′,3′-dideoxy-5-fluorocytidine
US7115584B2 (en) * 1999-01-22 2006-10-03 Emory University HIV-1 mutations selected for by β-2′,3′-didehydro-2′,3′-dideoxy-5-fluorocytidine
US6765019B1 (en) 1999-05-06 2004-07-20 University Of Kentucky Research Foundation Permeable, water soluble, non-irritating prodrugs of chemotherapeutic agents with oxaalkanoic acids
AU778198B2 (en) * 1999-06-04 2004-11-25 Abbvie Inc. Improved pharmaceutical formulations
US6589962B1 (en) 1999-07-20 2003-07-08 Merck & Co., Inc. Alpha-hydroxy-gamma-[[(carbocyclic-or heterocyclic-substituted)amino]carbonyl]alkanamide derivatives and uses thereof
JP2003504383A (ja) * 1999-07-20 2003-02-04 メルク エンド カムパニー インコーポレーテッド アルファ−ヒドロキシ−ガンマ−［［（炭素環式−又はヘテロ環式−置換）アミノ］カルボニル］アルカンアミド誘導体及びこれらの使用
JP2003514910A (ja) 1999-11-24 2003-04-22 メルク エンド カムパニー インコーポレーテッド Ｈｉｖプロテアーゼ阻害剤としてのガンマ−ヒドロキシ−２−（フルオロアルキルアミノカルボニル）−１−ピペラジンペンタンアミド類
IT1313682B1 (it) * 1999-11-25 2002-09-09 Archimica Spa Procedimento per la preparazione di (s)-n-terbutil-1,2,3,4-tetraidroisochinolin-3-carbossiammide.
SI1248600T1 (sl) 2000-01-19 2008-08-31 Abbott Lab Izboljšane farmacevtske formulacije inhibitorjev proteaze HIV
US6448245B1 (en) 2000-05-04 2002-09-10 The United States Of America As Represented By The Department Of Health And Human Services Methods of and compounds for inhibiting calpains
IT1318986B1 (it) * 2000-10-09 2003-09-19 Archimica S P A Ora Clariant L Procedimento per la preparazione di (s)-n-terbutil-1,2,3,4-tetraidroisochinolin-3-carbossiammide.
GB0028483D0 (en) 2000-11-22 2001-01-10 Hoffmann La Roche Hydroxyethylamine HIV protease inhibitors
US20030191121A1 (en) * 2001-08-09 2003-10-09 Miller Ross A. Piperazine carboxamide intermediates of HIV protease inhibitors and processes for their preparation
EP1463807A4 (en) 2001-12-19 2006-04-12 Bristol Myers Squibb Co FORMATHYDROGENASE FROM PICHIA PASTORIS AND USES THEREOF
EP2316468A1 (en) 2002-02-22 2011-05-04 Shire LLC Delivery system and methods for protecting and administering dextroamphetamine
US20040067216A1 (en) * 2002-02-22 2004-04-08 Karki Shyam B. Hiv protease inhibitors supported on cation exchange resins for oral administration
US7157489B2 (en) * 2002-03-12 2007-01-02 The Board Of Trustees Of The University Of Illinois HIV protease inhibitors
US7115652B2 (en) * 2002-06-17 2006-10-03 Sunesis Pharmaceuticals, Inc. Aspartyl protease inhibitors
EP1515944A1 (en) * 2002-06-17 2005-03-23 Sunesis Pharmaceuticals, Inc. Aspartyl protease inhibitors
KR20070087194A (ko) * 2003-07-11 2007-08-27 에프. 호프만-라 로슈 아게 사퀴나비르 메실레이트 경구 투여 형태
EP1604662A1 (en) * 2004-06-08 2005-12-14 Santhera Pharmaceuticals (Deutschland) Aktiengesellschaft 1-[(3R)-Amino-4-(2-fluoro-phenyl)-butyl]-pyrrolidine-(2R)-carboxylic acid benzyl amine derivatives and related compounds as dipeptidyl peptidase IV (DPP-IV) inhibitors for the treatment of type 2 diabetes mellitus
AU2005330489B2 (en) 2004-07-27 2011-08-25 Gilead Sciences, Inc. Nucleoside phosphonate conjugates as anti HIV agents
WO2006134612A1 (en) * 2005-06-16 2006-12-21 Hetero Drugs Limited A process for the preparation of saquinavir using novel intermediate
CN101631568B (zh) 2007-03-12 2012-08-22 尼克塔治疗公司 低聚物-蛋白酶抑制剂偶联物
CN101686972B (zh) * 2007-06-29 2013-08-14 吉里德科学公司 治疗用组合物和方法
CN103356622A (zh) * 2007-06-29 2013-10-23 吉里德科学公司 治疗用组合物及其用途
EP2203420A1 (en) * 2007-09-25 2010-07-07 Merck Sharp & Dohme Corp. Hiv protease inhibitors
WO2009114151A1 (en) * 2008-03-12 2009-09-17 Nektar Therapeutics Oligomer-amino acid and olgomer-atazanavir conjugates
US8173621B2 (en) 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
CA2745295C (en) 2008-12-09 2017-01-10 Gilead Sciences, Inc. Modulators of toll-like receptors
CL2009002208A1 (es) * 2008-12-23 2010-10-29 Gilead Pharmasset Llc Un compuesto (2s)-2-((((2r,3r,4r,5r)-5-(2-amino-6-etoxi-9h-purin-9-il)-4-fluoro-3-hidroxi-4-metiltetrahidrofuran-2-il)metoxi)(hidroxi)fosforilamino)propanoico, inhibidores de la replicacion de arn viral; composicion farmaceutica; y su uso en el tratamiento de infeccion por hepatitis c, virus del nilo occidental, entre otras.
KR20110104074A (ko) 2008-12-23 2011-09-21 파마셋 인코포레이티드 퓨린 뉴클레오시드의 합성
CL2009002207A1 (es) * 2008-12-23 2011-02-18 Gilead Pharmasset Llc Compuestos derivados de 3-hidroxi-5-(9h-purin-9-il)tetrahidrofuran-2-il, inhibidor de la replicacion de arn viral dependiente de arn; composicion farmaceutica; uso para el tratamiento de hepatitis c.
WO2010138338A1 (en) 2009-05-27 2010-12-02 Merck Sharp & Dohme Corp. Hiv protease inhibitors
WO2010144869A2 (en) 2009-06-12 2010-12-16 Nektar Therapeutics Protease inhibitors
DE102010004957A1 (de) 2010-01-14 2011-07-21 Universitätsklinikum Jena, 07743 Biologisch wirksame Moleküle zur Beeinflussung von Virus-, Bakterien-, Parasiten-infizierten Zellen und/oder Tumorzellen und Verfahren zu deren Anwendung
US20110223131A1 (en) 2010-02-24 2011-09-15 Gilead Sciences, Inc. Antiviral compounds
MX2012011171A (es) 2010-03-31 2013-02-01 Gilead Pharmasset Llc Fosforamidatos de nucleosido.
EP2632895B1 (en) 2010-10-28 2018-10-03 Merck Canada Inc. Hiv protease inhibitors
EP2392926A1 (en) 2011-02-09 2011-12-07 Roche Diagnostics GmbH Urinary biomarkers in HIV infected subjects
WO2013059928A1 (en) 2011-10-26 2013-05-02 Merck Canada Inc. Hiv protease inhibitors
WO2013105118A1 (en) 2012-01-10 2013-07-18 Council Of Scientific & Industrial Research A process for synthesis of syn azido epoxide and its use as intermediate the synthesis of amprenavir & saquinavir
JP2015527403A (ja) 2012-09-11 2015-09-17 メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． Ｈｉｖプロテアーゼ阻害剤
JP2015536940A (ja) 2012-10-29 2015-12-24 シプラ・リミテッド 抗ウイルス性ホスホネート類似体及びその製造方法
WO2015013835A1 (en) 2013-07-31 2015-02-05 Merck Sharp & Dohme Corp. Piperazine derivatives as hiv protease inhibitors
EP3083609B1 (en) 2013-12-19 2018-08-15 Merck Sharp & Dohme Corp. Hiv protease inhibitors
WO2015095276A1 (en) 2013-12-19 2015-06-25 Merck Sharp & Dohme Corp. Hiv protease inhibitors
WO2015134366A1 (en) 2014-03-06 2015-09-11 Merck Sharp & Dohme Corp. Hiv protease inhibitors
US10138255B2 (en) 2014-03-10 2018-11-27 Merck Sharp & Dohme Corp. Piperazine derivatives as HIV protease inhibitors
WO2016001907A1 (en) 2014-07-02 2016-01-07 Prendergast Patrick T Mogroside iv and mogroside v as agonist/stimulator/un-blocking agent for toll-like receptor 4 and adjuvant for use in human/animal vaccine and to stimulate immunity against disease agents.
MA40238A (fr) 2014-07-11 2017-05-17 Gilead Sciences Inc Modulateurs de récepteurs de type toll pour le traitement du vih
EP3212196A4 (en) 2014-10-29 2018-07-11 Wisconsin Alumni Research Foundation Boronic acid inhibitors of hiv protease
AU2016322763A1 (en) 2015-09-15 2018-04-19 Gilead Sciences, Inc. Modulators of toll-like recptors for the treatment of HIV
US20230218644A1 (en) 2020-04-16 2023-07-13 Som Innovation Biotech, S.A. Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB933968A (en) * 1960-10-26 1963-08-14 May & Baker Ltd New phthalimide derivatives
US4123543A (en) * 1971-09-16 1978-10-31 Ab Kabi Derivatives of substituted indoline lactans with effect on the central nervous system
US3901897A (en) * 1972-10-05 1975-08-26 Squibb & Sons Inc 1,2,3,4,4a,5,6,7-octahydro-7-aryl-isoquinolines and derivatives thereof
US4329473A (en) * 1979-06-01 1982-05-11 Almquist Ronald G Oxoalkanoic acid derivatives as inhibitors of angiotensin converting enzyme
SE421551B (sv) * 1980-03-26 1982-01-04 Sandvik Ab Borrverktyg for rotations- och/eller slagborrning
US4470973A (en) * 1982-07-19 1984-09-11 E. R. Squibb & Sons, Inc. Substituted peptide compounds
US4812442A (en) * 1984-05-29 1989-03-14 Merck & Co., Inc. Tripeptide renin inhibitors
FR2575753B1 (fr) * 1985-01-07 1987-02-20 Adir Nouveaux derives peptidiques a structure polycyclique azotee, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
AT383762B (de) * 1985-12-23 1987-08-25 Plansee Metallwerk Verfahren zur herstellung mehrkomponentiger, kongruent erschmelzender lotmaterialien
CA1286989C (en) * 1985-12-26 1991-07-30 A. Arthur Gottlieb Immunoamplifiers and related compositions
WO1988000939A1 (fr) * 1986-07-25 1988-02-11 Banyu Pharmaceutical Co., Ltd. Derives d'amino-alcools optiquement actifs et procede pour leur preparation
DE3789347D1 (de) * 1986-10-14 1994-04-21 Banyu Pharma Co Ltd 5-Substituierte Amino-4-hydroxy-pentansäure-Derivate und deren Verwendung.
US4863905A (en) * 1987-02-04 1989-09-05 Warner-Lambert Company Renin inhibitors II
FR2610934B1 (fr) * 1987-02-13 1989-05-05 Adir Nouveaux derives peptidiques a structure polycyclique azotee, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
DE3717631A1 (de) * 1987-05-26 1988-12-15 Merck Patent Gmbh Aminosaeurederivate
DE3733296A1 (de) * 1987-10-02 1989-04-20 Merck Patent Gmbh Aminosaeurederivate
IL89900A0 (en) * 1988-04-12 1989-12-15 Merck & Co Inc Hiv protease inhibitors useful for the treatment of aids and pharmaceutical compositions containing them
CA1340588C (en) * 1988-06-13 1999-06-08 Balraj Krishan Handa Amino acid derivatives
DE4033062A1 (de) * 1990-10-18 1992-04-23 Merck Patent Gmbh Aminosaeurederivate
GB8927915D0 (en) * 1989-12-11 1990-02-14 Hoffmann La Roche Novel alcohols

Also Published As

Publication number Publication date
FI905983L (fi) 1991-06-12
SI9012315A (en) 1997-10-31
FI973895A0 (fi) 1997-10-06
CN1066329C (zh) 2001-05-30
DE19675051I2 (de) 2001-04-12
ZW17490A1 (en) 1992-06-17
PL165225B1 (pl) 1994-11-30
GR3017114T3 (en) 1995-11-30
ZA909743B (en) 1991-08-28
DE69019481T2 (de) 1995-11-09
PT96145B (pt) 1998-04-30
NO176566B (no) 1995-01-16
NL970013I2 (nl) 1997-09-01
EP0432695A2 (en) 1991-06-19
GB2239016B (en) 1993-08-04
AU6787690A (en) 1991-06-13
CU22305A3 (es) 1995-01-31
IS1803B (is) 2002-02-26
NO176566C (no) 1995-04-26
US5196438A (en) 1993-03-23
MX23619A (es) 1993-10-01
BR9006264A (pt) 1991-09-24
SK576590A3 (en) 1999-10-08
MC2195A1 (fr) 1992-10-05
IS3651A7 (is) 1991-06-12
CZ576590A3 (en) 1995-11-15
NL970013I1 (nl) 1997-05-01
GB9026776D0 (en) 1991-01-30
FI100883B (fi) 1998-03-13
DE69019481D1 (de) 1995-06-22
CZ280558B6 (cs) 1996-02-14
HUT56073A (en) 1991-07-29
SK280249B6 (sk) 1999-10-08
PT96145A (pt) 1991-09-30
FI973895L (fi) 1997-10-06
DK0432695T3 (da) 1995-09-11
JP2807093B2 (ja) 1998-09-30
HRP930341A2 (en) 1994-10-31
AU634319B2 (en) 1993-02-18
HU211342A9 (en) 1995-11-28
CN1034805C (zh) 1997-05-07
NO905322D0 (no) 1990-12-10
MTP1075B (en) 1991-07-31
LV5738A4 (lv) 1996-08-20
IE67523B1 (en) 1996-04-03
KR970005912B1 (en) 1997-04-22
ATE122661T1 (de) 1995-06-15
CN1052482A (zh) 1991-06-26
OA09334A (fr) 1992-09-15
FI973895A7 (fi) 1997-10-06
EG19722A (en) 1996-01-31
KR910011894A (ko) 1991-08-07
FI905983A0 (fi) 1990-12-04
LU90014I2 (fr) 1997-01-31
HU908076D0 (en) 1991-06-28
SI9012315B (sl) 1998-06-30
DZ1467A1 (fr) 2004-09-13
CN1138983A (zh) 1997-01-01
RO107942B1 (ro) 1994-01-31
CA2030433A1 (en) 1991-06-12
NO905322L (no) 1991-06-12
IL96550A (en) 1995-03-15
LTIP862A (en) 1995-03-27
CA2030433C (en) 1997-10-21
EP0432695A3 (en) 1991-12-18
RU2071470C1 (ru) 1997-01-10
ES2072959T3 (es) 1995-08-01
EP0432695B1 (en) 1995-05-17
HRP930341B1 (en) 1998-12-31
BG51452A3 (bg) 1993-05-14
ID1018B (id) 1996-10-18
LV5738B4 (lv) 1996-12-20
MW8890A1 (en) 1991-03-13
GB2239016A (en) 1991-06-19
PL288201A1 (en) 1991-09-09
MX173630B (es) 1994-03-18
HK129093A (en) 1993-12-03
HU207298B (en) 1993-03-29
MA22014A1 (fr) 1991-07-01
GB8927913D0 (en) 1990-02-14
IE904453A1 (en) 1991-06-19
LT3682B (en) 1996-01-25
IL96550A0 (en) 1991-09-16
JPH03255076A (ja) 1991-11-13
IN172553B (OSRAM) 1993-09-25

Similar Documents

Publication Publication Date Title
SG120493G (en) N-tert-Butyl-decahydro-2(3-amino-2-hydroxy-4-phenyl-butyl) isoquinoline-3-carboxamide and asparaginyl derivatives thereof
HUT41809A (en) Process for preparing dideoxy-nucleosides and pharmaceutical compositions containing such compounds
PL310895A1 (en) Hiv protease inhibitors in aids treating pharmaceutic compositions
MY111630A (en) Amino acid derivatives.
HUT42492A (en) Process for producing cepheme-carboxylic acid derivatives and pharmaceutical compositions containing them as active agents
IL109227A0 (en) Leustroducsin h, pharmaceutical composition containing the same, and processes for the preparation thereof