SG11202103317XA - Combinatorial cancer immunotherapy - Google Patents
Combinatorial cancer immunotherapyInfo
- Publication number
- SG11202103317XA SG11202103317XA SG11202103317XA SG11202103317XA SG11202103317XA SG 11202103317X A SG11202103317X A SG 11202103317XA SG 11202103317X A SG11202103317X A SG 11202103317XA SG 11202103317X A SG11202103317X A SG 11202103317XA SG 11202103317X A SG11202103317X A SG 11202103317XA
- Authority
- SG
- Singapore
- Prior art keywords
- cancer immunotherapy
- combinatorial cancer
- combinatorial
- immunotherapy
- cancer
- Prior art date
Links
- 238000002619 cancer immunotherapy Methods 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/208—IL-12
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/521—Chemokines
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5434—IL-12
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5443—IL-15
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0662—Stem cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0662—Stem cells
- C12N5/0668—Mesenchymal stem cells from other natural sources
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/12—Animals modified by administration of exogenous cells
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/15—Humanized animals
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0331—Animal model for proliferative diseases
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0393—Animal model comprising a reporter system for screening tests
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
- C12N2740/15041—Use of virus, viral particle or viral elements as a vector
- C12N2740/15043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16041—Use of virus, viral particle or viral elements as a vector
- C12N2740/16043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cell Biology (AREA)
- Wood Science & Technology (AREA)
- Developmental Biology & Embryology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Virology (AREA)
- Toxicology (AREA)
- Hematology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Rheumatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862747109P | 2018-10-17 | 2018-10-17 | |
US201862747114P | 2018-10-17 | 2018-10-17 | |
US201962843180P | 2019-05-03 | 2019-05-03 | |
PCT/US2019/056824 WO2020081869A1 (en) | 2018-10-17 | 2019-10-17 | Combinatorial cancer immunotherapy |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11202103317XA true SG11202103317XA (en) | 2021-05-28 |
Family
ID=70284815
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11202103317XA SG11202103317XA (en) | 2018-10-17 | 2019-10-17 | Combinatorial cancer immunotherapy |
Country Status (11)
Country | Link |
---|---|
US (2) | US10993967B2 (ja) |
EP (1) | EP3866813A4 (ja) |
JP (1) | JP2022512766A (ja) |
KR (1) | KR20210094534A (ja) |
CN (1) | CN113164518A (ja) |
AU (1) | AU2019359890A1 (ja) |
CA (1) | CA3116138A1 (ja) |
IL (1) | IL282080A (ja) |
SG (1) | SG11202103317XA (ja) |
TW (1) | TW202035685A (ja) |
WO (1) | WO2020081869A1 (ja) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110996975A (zh) | 2017-04-13 | 2020-04-10 | 森迪生物科学公司 | 组合癌症免疫疗法 |
KR102286397B1 (ko) * | 2018-02-02 | 2021-08-05 | 주식회사 에스엘백시젠 | 신규 백신 면역보조제 |
AU2019359890A1 (en) | 2018-10-17 | 2021-06-03 | Senti Biosciences, Inc. | Combinatorial cancer immunotherapy |
US11419898B2 (en) | 2018-10-17 | 2022-08-23 | Senti Biosciences, Inc. | Combinatorial cancer immunotherapy |
EP4022067A4 (en) * | 2019-08-28 | 2023-12-20 | Senti Biosciences, Inc. | COMBINATORIAL CANCER IMMUNOTHERAPY |
CN112029730A (zh) * | 2020-05-20 | 2020-12-04 | 深圳市芥至和生物科技有限公司 | 一种基因修饰的间充质干细胞及其应用 |
CN116249544A (zh) * | 2020-05-26 | 2023-06-09 | 大学健康网络 | 用于治疗癌症的方法和组合物的组合细胞因子 |
WO2022011651A1 (zh) * | 2020-07-16 | 2022-01-20 | 上海交通大学 | 间充质干细胞靶向运输趋化因子和细胞因子的免疫疗法 |
CN111751532B (zh) * | 2020-07-20 | 2022-07-12 | 河南省医药科学研究院 | Piezo1蛋白作为食管癌标志物的应用 |
CN111849913B (zh) * | 2020-07-31 | 2021-05-25 | 南京北恒生物科技有限公司 | 工程化免疫细胞及其用途 |
RU2757502C1 (ru) * | 2020-10-20 | 2021-10-18 | федеральное государственное автономное образовательное учреждение высшего образования "Казанский (Приволжский) федеральный университет" (ФГАОУ ВО КФУ) | Генетическая кассета, содержащая кодон-оптимизированные нуклеотидные последовательности генов TRAIL, PTEN и IFNβ-1, и фармацевтическая композиция для лечения онкологических заболеваний |
JP2023548586A (ja) * | 2020-11-04 | 2023-11-17 | センティ バイオサイエンシズ インコーポレイテッド | タンパク質ペイロード放出 |
WO2022155500A1 (en) * | 2021-01-14 | 2022-07-21 | Senti Biosciences, Inc. | Secretable payload regulation |
JP2024509084A (ja) * | 2021-02-23 | 2024-02-29 | インターギャラクティック セラピューティクス インコーポレイテッド | 核酸ベクター及び使用方法 |
CN113061575B (zh) * | 2021-03-25 | 2023-04-07 | 中国人民解放军陆军军医大学 | 从大龄小鼠结肠固有层中分离纯化固有淋巴样细胞的方法 |
TW202317753A (zh) * | 2021-06-16 | 2023-05-01 | 美商聖堤生物科技股份有限公司 | 經武裝之嵌合受體及其使用方法 |
CN115873801A (zh) * | 2021-09-29 | 2023-03-31 | 南京北恒生物科技有限公司 | 工程化免疫细胞及其用途 |
WO2023064793A1 (en) * | 2021-10-14 | 2023-04-20 | Allegheny Singer Research Institute | Interleukin 7 and interleukin 21 fusion proteins |
CN114853899B (zh) * | 2021-11-02 | 2024-05-28 | 北京华奥玄德生物医药科技有限公司 | 一种il-12和il-18变体的融合蛋白及其制备方法和用途 |
WO2024054527A1 (en) * | 2022-09-06 | 2024-03-14 | The Research Institute At Nationwide Children's Hospital | Genetically engineered bone marrow derived myeloid cells for treatment of central nervous system tumors |
CN117778327A (zh) * | 2022-09-27 | 2024-03-29 | 清华大学 | 工程化的间充质干细胞及其用途 |
Family Cites Families (96)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5714585A (en) | 1987-10-26 | 1998-02-03 | Sterling Winthrop, Inc. | Antibodies that are immunoreactive with interleukin-7 |
US5328988A (en) | 1987-10-26 | 1994-07-12 | Immunex Corporation | Interleukin-7 |
US4965195A (en) | 1987-10-26 | 1990-10-23 | Immunex Corp. | Interleukin-7 |
US5486359A (en) | 1990-11-16 | 1996-01-23 | Osiris Therapeutics, Inc. | Human mesenchymal stem cells |
US5674486A (en) | 1991-06-25 | 1997-10-07 | San Diego Regional Cancer Center | Cancer immunotherapy with carrier cells |
US5981724A (en) | 1991-10-25 | 1999-11-09 | Immunex Corporation | DNA encoding CD40 ligand, a cytokine that binds CD40 |
AU4543193A (en) | 1992-06-22 | 1994-01-24 | Henry E. Young | Scar inhibitory factor and use thereof |
US7537932B1 (en) | 1993-05-19 | 2009-05-26 | Schering Corporation | Antibodies that bind purified mammalian FLT3 ligands |
CZ307995A3 (en) | 1993-05-24 | 1996-10-16 | Immunex Corp | Ligands for flt3 receptors |
US5554512A (en) | 1993-05-24 | 1996-09-10 | Immunex Corporation | Ligands for flt3 receptors |
US5536657A (en) | 1993-07-19 | 1996-07-16 | Hoffmann-La Roche Inc. | Recombinant DNA encoding human receptor for interleukin-12 |
US5591625A (en) | 1993-11-24 | 1997-01-07 | Case Western Reserve University | Transduced mesenchymal stem cells |
EP0772624B1 (en) | 1994-04-06 | 2000-09-13 | Immunex Corporation | Interleukin-15 |
US5780268A (en) | 1995-12-06 | 1998-07-14 | Incyte Pharmaceuticals | Chemokine expressed in a mixed lymphocyte reaction |
CA2751712C (en) | 1996-10-23 | 2016-11-22 | The Trustees Of The University Of Pennsylvania | Immunotherapy and improved vaccines |
JP2001522226A (ja) | 1997-01-31 | 2001-11-13 | リサーチ コーポレイション テクノロジーズ インコーポレイテッド | セミ−同種異系細胞での癌の免疫療法 |
US6153182A (en) | 1997-12-19 | 2000-11-28 | Uab Research Foundation | Lymphotactin as an adjuvant |
WO1999061617A1 (en) | 1998-05-29 | 1999-12-02 | Human Genome Sciences, Inc. | Interleukins-21 and 22 |
US20010023070A1 (en) | 1998-05-29 | 2001-09-20 | Reinhard Ebner | Interleukins-21 and 22 |
DE19833476B4 (de) | 1998-07-24 | 2005-08-25 | Huss, Ralf, Dr. | Genetisch modifizierte CD34-Negative, adhärent wachsende hämatopoetische Stammzellen und deren Verwendung in der Gentherapie |
US6392126B1 (en) | 1999-02-25 | 2002-05-21 | Pioneer Hi-Bred International, Inc. | Adenosine deaminase homologues and uses thereof |
US6307024B1 (en) | 1999-03-09 | 2001-10-23 | Zymogenetics, Inc. | Cytokine zalpha11 Ligand |
US6929932B2 (en) | 2001-11-05 | 2005-08-16 | Zymogenetics, Inc. | IL-21 antagonists |
EP1487463A2 (en) | 2002-03-02 | 2004-12-22 | Board Of Regents The University Of Texas System | Local production and/or delivery of anti-cancer agents by stromal cell precursors |
EP1589990B1 (en) | 2002-03-27 | 2012-11-14 | The Government of the United States of America, represented by The Secretary Department of Health and Human services | Il-21 for use in treating cancer |
US20040033217A1 (en) | 2002-05-31 | 2004-02-19 | Padmavathy Vanguri | Intraperitoneal delivery of genetically engineered mesenchymal stem cells |
CA2530255C (en) | 2003-06-27 | 2015-12-08 | Ethicon, Incorporated | Soft tissue repair and regeneration using postpartum-derived cells |
EP1658853A4 (en) | 2003-06-27 | 2009-07-08 | Renomedix Inst Inc | MEDIUM FOR INTERNAL ADMINISTRATION FOR DISEASES OF NERVES IN THE HEAD WITH MESENCYCLES AS AN ACTIVE SUBSTANCE |
US7052772B2 (en) | 2003-08-14 | 2006-05-30 | 3M Innovative Properties Company | Material for packaging electronic components |
US20050037306A1 (en) | 2003-08-16 | 2005-02-17 | Tetsuo Nakatsu | Candle system for enhancing burning and improving volatiles performance and a manufacturing method for the same |
WO2005037218A2 (en) | 2003-10-17 | 2005-04-28 | Actis Biologics, Inc. | Lentiviral vector delivery of il-21 for treatment of cancer |
EP1680138B1 (en) | 2003-10-17 | 2013-07-17 | Novo Nordisk A/S | Combination therapy |
GB0400031D0 (en) | 2004-01-03 | 2004-02-04 | Univ Sheffield | Depression treatment |
CA2551879A1 (en) * | 2004-01-15 | 2005-07-28 | Novo Nordisk A/S | Use of interleukin-21 for the treatment of autoimune diseases and allograft rejection |
DE102005057426A1 (de) | 2005-11-30 | 2007-05-31 | Andritz Küsters GmbH & Co. KG | Unterdruck-Bandfördervorrichtung zum Führen einer laufenden Bahn |
CA2636867C (en) | 2006-01-13 | 2015-12-01 | The Trustees Of The University Of Pennsylvania | Vaccines and immunotherapeutics using codon optimized il-15 and methods for using the same |
US7833754B2 (en) | 2006-01-13 | 2010-11-16 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | IL-12 for expression in mammalian cell |
CN102796743B (zh) | 2006-01-13 | 2015-11-18 | 美国政府健康及人类服务部国立卫生研究院 | 用于在哺乳动物细胞中表达的密码子优化的IL-15和IL-15Rα基因 |
KR100788930B1 (ko) | 2006-04-18 | 2007-12-27 | 포항공과대학교 산학협력단 | 항암 조성물 |
US8227437B2 (en) | 2006-06-22 | 2012-07-24 | Tai June Yoo | Restoration of hearing loss |
US7993918B2 (en) | 2006-08-04 | 2011-08-09 | Anthrogenesis Corporation | Tumor suppression using placental stem cells |
US8304931B2 (en) | 2006-12-18 | 2012-11-06 | Decicon, Inc. | Configurable power supply integrated circuit |
ES2569940T3 (es) | 2007-04-20 | 2016-05-13 | Sigma-Tau Rare Disease Ltd | Adenosina desaminasa recombinante estable |
CN101680039B (zh) | 2007-04-20 | 2016-08-24 | 希格马托罕见疾病有限公司 | 酶的抗癌治疗 |
US8765462B2 (en) | 2007-05-04 | 2014-07-01 | University Health Network | IL-12 immunotherapy for cancer |
AU2008260651B2 (en) | 2007-05-24 | 2014-06-12 | Apceth Gmbh & Co. Kg | CD34 stem cell-related methods and compositions |
CN101925575B (zh) | 2008-01-28 | 2014-06-18 | 株式会社爱茉莉太平洋 | 作为香草酸受体拮抗剂的化合物、其异构体或其药物学可接受的盐、及包含这些化合物的药物组合物 |
KR101629071B1 (ko) | 2008-10-08 | 2016-06-09 | 인트렉손 코포레이션 | 다수의 면역조절자를 발현하는 조작된 세포 및 그 용도 |
US8367409B2 (en) | 2008-11-19 | 2013-02-05 | Anthrogenesis Corporation | Amnion derived adherent cells |
BRPI1013771A2 (pt) | 2009-04-13 | 2016-04-05 | Apceth Gmbh & Co Kg | "células-tronco mesenquimais projetadas e método de uso das mesmas para tratar tumores." |
WO2010128636A1 (ja) | 2009-05-08 | 2010-11-11 | 日本電気株式会社 | 通信システム、通信装置、通信方法及びプログラム |
CN102812547B (zh) | 2010-03-19 | 2015-09-09 | 株式会社半导体能源研究所 | 半导体装置 |
KR20180108886A (ko) * | 2010-03-23 | 2018-10-04 | 인트렉손 코포레이션 | 치료적 단백질을 조건부로 발현하는 벡터,상기 벡터를 포함하는 숙주 세포 및 이의 용도 |
US9487800B2 (en) | 2010-09-08 | 2016-11-08 | Chemotherapeutisches Forschunginstitut Georg-Speyer-Haus | Interleukin 15 as selectable marker for gene transfer in lymphocytes |
WO2012051210A2 (en) | 2010-10-11 | 2012-04-19 | The Administrators Of The Tulane Educational Fund | Mesenchymal stem cells and related therapies |
NZ616405A (en) | 2011-04-08 | 2015-11-27 | Baylor College Medicine | Reversing the effects of the tumor microenvironment using chimeric cytokine receptors |
EP3692794A1 (en) | 2011-09-16 | 2020-08-12 | Baylor College of Medicine | Targeting the tumor microenvironment using manipulated nkt cells |
EP2872619B1 (en) | 2012-07-11 | 2018-02-14 | Imstem Biotechnology Inc. | Mesenchymal-like stem cells derived from human embryonic stem cells, methods and uses thereof |
CN104471059B (zh) | 2012-07-12 | 2018-04-17 | 珠海横琴爱姆斯坦生物科技有限公司 | 人胚胎干细胞衍生的间充质样干细胞、方法及其应用 |
KR20160041901A (ko) | 2013-06-19 | 2016-04-18 | 유니버시티 오브 마이애미 | 유방 암을 분류하고, 예측하며 치료하기 위한 분류 시스템, 방법 및 키트 |
JP2015030819A (ja) | 2013-08-05 | 2015-02-16 | 株式会社ジェイテクト | アクリルゴム組成物およびこれを備えたシール装置 |
WO2015035235A1 (en) | 2013-09-06 | 2015-03-12 | Consejo Nacional De Investigaciones Cientificas Y Tecnicas (Conicet) | Compositions and methods for increasing mesenchymal stromal cell migration to tumors |
MX2016010293A (es) | 2014-02-11 | 2017-02-23 | Anthrogenesis Corp | Micro-organoides, y metodos de fabricacion y usos los mismos. |
US10155024B2 (en) | 2014-03-28 | 2018-12-18 | The Catholic University Of Korea Industry-Academic Cooperation Foundation | Composition for preventing or treating B-cell lymphoma comprising IL-21 expressing mesenchymal stem cells |
JP6468712B2 (ja) | 2014-03-28 | 2019-02-13 | 大和ハウス工業株式会社 | 通信ユニット |
KR20160011916A (ko) | 2014-07-23 | 2016-02-02 | 삼성전자주식회사 | 얼굴 인식을 통한 사용자 식별 방법 및 장치 |
US9918718B2 (en) | 2014-08-08 | 2018-03-20 | DePuy Synthes Products, Inc. | Embolic coil delivery system with retractable mechanical release mechanism |
AU2015300966A1 (en) | 2014-08-08 | 2017-02-16 | Janssen Pharmaceutica Nv | Bruton's tyrosine kinase inhibitor combinations and uses thereof |
EP3656387A3 (en) | 2014-08-18 | 2020-07-01 | Apceth GmbH & Co. KG | Genetically modified mesenchymal stem cells expressing an immune response-stimulating cytokine to attract and/or activate immune cells |
US10869432B2 (en) | 2014-12-23 | 2020-12-22 | Husqvarna Ab | Lawn monitoring and maintenance via a robotic vehicle |
KR20160089688A (ko) | 2015-01-20 | 2016-07-28 | 삼성전자주식회사 | 엑스선 영상 장치, 및 그 제어방법 |
US20160237407A1 (en) * | 2015-02-17 | 2016-08-18 | Batu Biologics, Inc. | Universal donor chimeric antigen receptor cells |
WO2016146819A1 (en) | 2015-03-18 | 2016-09-22 | Apceth Gmbh & Co. Kg | Hypoxia-induced expression of therapeutic proteins in mesenchymal stem cells |
WO2016191283A2 (en) | 2015-05-22 | 2016-12-01 | University Of Houston System | Enzymatic immunomodulation of solid tumors and user thereof |
CA2990177A1 (en) * | 2015-06-25 | 2016-12-29 | Icell Gene Therapeutics Llc | Chimeric antigen receptors (cars), compositions and methods thereof |
EP3318026B1 (en) | 2015-06-30 | 2020-04-08 | British Telecommunications public limited company | Model management in a dynamic qos environment |
JP6542917B2 (ja) | 2015-06-30 | 2019-07-10 | スミス アンド ネフュー インコーポレイテッド | ねじ式プラグを有する縫合糸アンカーシステム |
CN105206757B (zh) | 2015-11-05 | 2016-09-07 | 京东方科技集团股份有限公司 | 有机发光二极管及其制作方法、显示基板和显示装置 |
US10008344B2 (en) | 2015-11-11 | 2018-06-26 | Htc Corporation | Switch assembly and hand-held device |
WO2017133175A1 (en) | 2016-02-04 | 2017-08-10 | Nanjing Legend Biotech Co., Ltd. | Engineered mammalian cells for cancer therapy |
US20210205370A1 (en) * | 2016-02-18 | 2021-07-08 | Pluristem Ltd. | Methods and compositions for treating cancers and neoplasms |
KR101833971B1 (ko) | 2016-02-19 | 2018-03-02 | 사회복지법인 삼성생명공익재단 | 중간엽 줄기세포 또는 xcl1을 포함하는 근육질환의 예방 또는 치료용 약학적 조성물 |
CN108699153B (zh) | 2016-02-25 | 2022-09-23 | 细胞医学瑞士公司 | Pd-l1的结合成员 |
EP3462883B1 (en) | 2016-06-07 | 2023-08-16 | The Pacific Heart, Lung,&Blood Institute | Compositions and their use in treating cancer |
US20200283534A1 (en) * | 2016-06-24 | 2020-09-10 | iCell Gene Therapeuticics LLC | CHIMERIC ANTIGEN RECEPTORS (CARs), COMPOSITIONS AND METHODS THEREOF |
SG10201913631TA (en) * | 2016-08-19 | 2020-03-30 | Curevac Ag | Rna for cancer therapy |
WO2018071295A1 (en) | 2016-10-10 | 2018-04-19 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for inducible production of anti-inflammatory cytokines |
JP6607179B2 (ja) | 2016-12-15 | 2019-11-20 | トヨタ自動車株式会社 | 車両の制御装置 |
WO2018161038A1 (en) | 2017-03-03 | 2018-09-07 | Obsidian Therapeutics, Inc. | Il12 compositions and methods for immunotherapy |
WO2018161026A1 (en) | 2017-03-03 | 2018-09-07 | Obsidian Therapeutics, Inc. | Il15 compositions and methods for immunotherapy |
JP2020511528A (ja) | 2017-03-03 | 2020-04-16 | オブシディアン セラピューティクス, インコーポレイテッド | 免疫療法のための組成物及び方法 |
JP2020509773A (ja) | 2017-03-17 | 2020-04-02 | センティ バイオサイエンシズ インコーポレイテッド | 免疫調節性細胞回路 |
CN110996975A (zh) | 2017-04-13 | 2020-04-10 | 森迪生物科学公司 | 组合癌症免疫疗法 |
CA3063723A1 (en) | 2017-05-18 | 2018-11-22 | Modernatx, Inc. | Polynucleotides encoding tethered interleukin-12 (il12) polypeptides and uses thereof |
CN107916253A (zh) * | 2017-11-01 | 2018-04-17 | 上海隆耀生物科技有限公司 | 一种表达人源免疫刺激因子light的间充质干细胞的制备方法及制得的msc‑l细胞 |
AU2019359890A1 (en) | 2018-10-17 | 2021-06-03 | Senti Biosciences, Inc. | Combinatorial cancer immunotherapy |
-
2019
- 2019-10-17 AU AU2019359890A patent/AU2019359890A1/en active Pending
- 2019-10-17 CA CA3116138A patent/CA3116138A1/en active Pending
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JP2022512766A (ja) | 2022-02-07 |
CA3116138A1 (en) | 2020-04-23 |
IL282080A (en) | 2021-05-31 |
KR20210094534A (ko) | 2021-07-29 |
TW202035685A (zh) | 2020-10-01 |
US20200171093A1 (en) | 2020-06-04 |
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