MX2016010293A - Micro-organoides, y metodos de fabricacion y usos los mismos. - Google Patents

Micro-organoides, y metodos de fabricacion y usos los mismos.

Info

Publication number
MX2016010293A
MX2016010293A MX2016010293A MX2016010293A MX2016010293A MX 2016010293 A MX2016010293 A MX 2016010293A MX 2016010293 A MX2016010293 A MX 2016010293A MX 2016010293 A MX2016010293 A MX 2016010293A MX 2016010293 A MX2016010293 A MX 2016010293A
Authority
MX
Mexico
Prior art keywords
organoids
micro
making
methods
same
Prior art date
Application number
MX2016010293A
Other languages
English (en)
Inventor
J Hariri Robert
Wang Jia-Lun
Ye Qian
B Bhatia Mohit
Hofgartner Wolfgang
Original Assignee
Anthrogenesis Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Anthrogenesis Corp filed Critical Anthrogenesis Corp
Publication of MX2016010293A publication Critical patent/MX2016010293A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/32—Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37—Digestive system
    • A61K35/39—Pancreas; Islets of Langerhans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37—Digestive system
    • A61K35/407—Liver; Hepatocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/44—Vessels; Vascular smooth muscle cells; Endothelial cells; Endothelial progenitor cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A61K35/50—Placenta; Placental stem cells; Amniotic fluid; Amnion; Amniotic stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0062—General methods for three-dimensional culture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cell Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Reproductive Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Vascular Medicine (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)

Abstract

En la presente invención se proporcionan micro-organoides, denominados aquí como unidades funcionales fisiológicas (FPU), que son capaces de reemplazar o aumentar una o más funciones fisiológicas en un individuo, que son útiles en el tratamiento de personas que carecen de, o que sufren de un déficit en dicha función fisiológica.
MX2016010293A 2014-02-11 2015-02-10 Micro-organoides, y metodos de fabricacion y usos los mismos. MX2016010293A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461938536P 2014-02-11 2014-02-11
PCT/US2015/015157 WO2015123183A1 (en) 2014-02-11 2015-02-10 Micro-organoids, and methods of making and using the same

Publications (1)

Publication Number Publication Date
MX2016010293A true MX2016010293A (es) 2017-02-23

Family

ID=53800559

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016010293A MX2016010293A (es) 2014-02-11 2015-02-10 Micro-organoides, y metodos de fabricacion y usos los mismos.

Country Status (11)

Country Link
US (2) US20160354408A1 (es)
EP (1) EP3104865A4 (es)
JP (3) JP2017507935A (es)
KR (2) KR20220093383A (es)
CN (1) CN106456669A (es)
AU (2) AU2015217406A1 (es)
CA (1) CA2939339C (es)
EA (1) EA201691607A1 (es)
HK (1) HK1232140A1 (es)
MX (1) MX2016010293A (es)
WO (1) WO2015123183A1 (es)

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EP3185888B1 (en) * 2014-08-25 2023-06-07 Celularity Inc. Extracellular matrix compositions
CA2963704A1 (en) 2014-10-17 2016-04-21 Children's Hospital Medical Center In vivo model of human small intestine using pluripotent stem cells and methods of making and using same
CN106039421B (zh) * 2015-04-07 2018-06-12 四川蓝光英诺生物科技股份有限公司 一种包含内皮细胞的生物砖及其用途
EP3280463B1 (en) 2015-04-07 2021-06-09 Revotek Co., Ltd Compositions for cell-based three dimensional printing
TWI741980B (zh) * 2015-04-07 2021-10-11 大陸商四川藍光英諾生物科技股份有限公司 一種生物磚及其用途
CN106606804B (zh) * 2015-10-22 2020-05-12 四川蓝光英诺生物科技股份有限公司 一种制备复合结构的方法
CN107261994B (zh) * 2016-04-07 2019-10-29 四川蓝光英诺生物科技股份有限公司 一种核-壳结构的制备方法
CA3016641A1 (en) 2016-05-05 2017-11-09 Children's Hospital Medical Center Methods for the in vitro manufacture of gastric fundus tissue and compositions related to same
CN107432955B (zh) * 2016-09-14 2020-09-04 四川蓝光英诺生物科技股份有限公司 用于制备生物构建体的方法和试剂盒
US11439731B2 (en) 2016-09-14 2022-09-13 Revotek Co., Ltd. Artificial tissue progenitor and method for preparing the same
AU2017353982B2 (en) 2016-11-04 2021-05-06 Children's Hospital Medical Center Liver organoid compositions and methods of making and using same
WO2018106628A1 (en) 2016-12-05 2018-06-14 Children's Hospital Medical Center Colonic organoids and methods of making and using same
JP2020509773A (ja) * 2017-03-17 2020-04-02 センティ バイオサイエンシズ インコーポレイテッド 免疫調節性細胞回路
EP4317422A3 (en) 2017-04-13 2024-05-01 Senti Biosciences, Inc. Combinatorial cancer immunotherapy
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EP3727394A4 (en) 2017-12-21 2021-09-08 Children's Hospital Medical Center DIGITALIZED HUMAN ORGANOIDS AND METHOD OF USING THEREOF
AU2019270977B2 (en) * 2018-05-14 2025-01-02 Roosterbio, Inc. Methods and compositions related to extracellular material derived from hypertonic cell solutions
CN108660107B (zh) * 2018-05-21 2021-04-13 浙江大学 一种骨骼肌类器官构建方法
KR102103783B1 (ko) * 2018-06-21 2020-04-23 한국원자력의학원 침샘 조직의 탈세포화 세포외기질-하이드로겔 및 침샘 오거나이드를 제조하는 방법
WO2020018418A1 (en) * 2018-07-16 2020-01-23 Kansas State University Research Foundation Cell linkers for heterotypic cell spheroids
KR20250163421A (ko) 2018-07-26 2025-11-20 칠드런즈 호스피탈 메디칼 센터 간-담도-췌장 조직 및 이를 제조하는 방법
CN112823012A (zh) 2018-09-12 2021-05-18 儿童医院医学中心 用于产生造血干细胞及其衍生物的类器官组合物
US11419898B2 (en) 2018-10-17 2022-08-23 Senti Biosciences, Inc. Combinatorial cancer immunotherapy
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CN111500533B (zh) * 2019-01-31 2024-07-16 华东理工大学 干细胞发生器及其构建方法
CN111494711B (zh) 2019-01-31 2023-06-23 华东理工大学 干细胞发生器产生的干细胞用于治疗造血损伤
KR102334245B1 (ko) * 2019-05-29 2021-12-03 연세대학교 산학협력단 인간 미뢰 오가노이드의 배양용 조성물
EP3976066A4 (en) 2019-05-31 2023-06-28 Children's Hospital Medical Center Methods of generating and expanding hematopoietic stem cells
KR102179902B1 (ko) * 2019-08-08 2020-11-17 단국대학교 천안캠퍼스 산학협력단 상아모세포 분화용 지지체 및 이를 이용한 상아모세포로의 분화방법
CN113862154A (zh) * 2021-12-03 2021-12-31 东南大学苏州医疗器械研究院 用于器官组织三维培养的器官芯片及器官组织的培养方法
CN114807005B (zh) * 2022-04-09 2023-11-21 翌圣生物科技(上海)股份有限公司 使用动物尸体制备基质胶的方法
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Also Published As

Publication number Publication date
US20200246385A1 (en) 2020-08-06
AU2020233611A1 (en) 2020-10-01
CN106456669A (zh) 2017-02-22
JP2017507935A (ja) 2017-03-23
EP3104865A4 (en) 2017-11-22
US20160354408A1 (en) 2016-12-08
HK1232140A1 (zh) 2018-01-05
JP2022046512A (ja) 2022-03-23
JP2020037561A (ja) 2020-03-12
EA201691607A1 (ru) 2017-01-30
CA2939339C (en) 2023-03-14
AU2015217406A1 (en) 2016-08-25
WO2015123183A1 (en) 2015-08-20
KR20220093383A (ko) 2022-07-05
CA2939339A1 (en) 2015-08-20
KR20170008723A (ko) 2017-01-24
EP3104865A1 (en) 2016-12-21

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