SG11202100934PA - Muscle targeting complexes and uses thereof for treating dystrophinopathies - Google Patents

Muscle targeting complexes and uses thereof for treating dystrophinopathies

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Publication number
SG11202100934PA
SG11202100934PA SG11202100934PA SG11202100934PA SG11202100934PA SG 11202100934P A SG11202100934P A SG 11202100934PA SG 11202100934P A SG11202100934P A SG 11202100934PA SG 11202100934P A SG11202100934P A SG 11202100934PA SG 11202100934P A SG11202100934P A SG 11202100934PA
Authority
SG
Singapore
Prior art keywords
muscle targeting
targeting complexes
dystrophinopathies
treating
treating dystrophinopathies
Prior art date
Application number
SG11202100934PA
Other languages
English (en)
Inventor
Romesh Subramanian
Mohammed Qatanani
Timothy Weeden
Original Assignee
Dyne Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dyne Therapeutics Inc filed Critical Dyne Therapeutics Inc
Publication of SG11202100934PA publication Critical patent/SG11202100934PA/en

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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6807—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug or compound being a sugar, nucleoside, nucleotide, nucleic acid, e.g. RNA antisense
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
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    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
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    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
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    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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    • C07K2317/00—Immunoglobulins specific features
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
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    • C—CHEMISTRY; METALLURGY
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SG11202100934PA 2018-08-02 2019-08-02 Muscle targeting complexes and uses thereof for treating dystrophinopathies SG11202100934PA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862714031P 2018-08-02 2018-08-02
US201962855766P 2019-05-31 2019-05-31
PCT/US2019/044949 WO2020028832A1 (en) 2018-08-02 2019-08-02 Muscle targeting complexes and uses thereof for treating dystrophinopathies

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SG11202100934PA true SG11202100934PA (en) 2021-02-25

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US (9) US20210308273A1 (https=)
EP (1) EP3829595A4 (https=)
JP (2) JP7611825B2 (https=)
KR (1) KR20210081322A (https=)
CN (1) CN112955153A (https=)
AU (1) AU2019312692A1 (https=)
CA (1) CA3108282A1 (https=)
IL (1) IL280527A (https=)
MX (1) MX2021001281A (https=)
SG (1) SG11202100934PA (https=)
WO (1) WO2020028832A1 (https=)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019513371A (ja) 2016-04-01 2019-05-30 アビディティー バイオサイエンシーズ エルエルシー 核酸ポリペプチド組成物とその使用
CA3108282A1 (en) 2018-08-02 2020-02-06 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating dystrophinopathies
SG11202100928QA (en) 2018-08-02 2021-02-25 Dyne Therapeutics Inc Muscle targeting complexes and uses thereof for treating facioscapulohumeral muscular dystrophy
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