SG11201808196UA - Neoantigens and methods of their use - Google Patents

Neoantigens and methods of their use

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Publication number
SG11201808196UA
SG11201808196UA SG11201808196UA SG11201808196UA SG11201808196UA SG 11201808196U A SG11201808196U A SG 11201808196UA SG 11201808196U A SG11201808196U A SG 11201808196UA SG 11201808196U A SG11201808196U A SG 11201808196UA SG 11201808196U A SG11201808196U A SG 11201808196UA
Authority
SG
Singapore
Prior art keywords
international
march
co7k
massachusetts
english
Prior art date
Application number
SG11201808196UA
Other languages
English (en)
Inventor
Michael Steven Rooney
Original Assignee
Neon Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neon Therapeutics Inc filed Critical Neon Therapeutics Inc
Publication of SG11201808196UA publication Critical patent/SG11201808196UA/en

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Families Citing this family (100)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015077717A1 (en) 2013-11-25 2015-05-28 The Broad Institute Inc. Compositions and methods for diagnosing, evaluating and treating cancer by means of the dna methylation status
US11725237B2 (en) 2013-12-05 2023-08-15 The Broad Institute Inc. Polymorphic gene typing and somatic change detection using sequencing data
CN106456724A (zh) 2013-12-20 2017-02-22 博德研究所 使用新抗原疫苗的联合疗法
EP3234193B1 (en) 2014-12-19 2020-07-15 Massachusetts Institute of Technology Molecular biomarkers for cancer immunotherapy
US10993997B2 (en) 2014-12-19 2021-05-04 The Broad Institute, Inc. Methods for profiling the t cell repertoire
AU2016264623B2 (en) 2015-05-20 2022-06-30 Dana-Farber Cancer Institute, Inc. Shared neoantigens
CN108495649A (zh) 2016-01-08 2018-09-04 瓦西博迪公司 治疗性抗癌新表位疫苗
WO2017177207A1 (en) 2016-04-07 2017-10-12 Bostongene, Llc Construction and methods of use of a therapeutic cancer vaccine library comprising fusion-specific vaccines
US11549149B2 (en) 2017-01-24 2023-01-10 The Broad Institute, Inc. Compositions and methods for detecting a mutant variant of a polynucleotide
WO2018148381A1 (en) * 2017-02-07 2018-08-16 Nantcell, Inc. Maximizing t-cell memory and compositions and methods therefor
TW201907937A (zh) 2017-05-08 2019-03-01 美商葛利史東腫瘤科技公司 阿爾法病毒新抗原載體
CN107188957A (zh) * 2017-07-06 2017-09-22 江苏迈健生物科技发展股份有限公司 抗原肽t790m‑1及其在制备治疗非小细胞肺癌的药物中的应用
CN107188956A (zh) * 2017-07-06 2017-09-22 江苏迈健生物科技发展股份有限公司 抗原肽t790m‑4及其在制备治疗非小细胞肺癌的药物中的应用
CN107325172A (zh) * 2017-07-06 2017-11-07 江苏迈健生物科技发展股份有限公司 抗原肽t790m‑2及其在制备治疗非小细胞肺癌的药物中的应用
EP3679064A4 (en) 2017-09-07 2021-06-02 Cue Biopharma, Inc. T-CELL-MODULATING MULTIMERAL POLYPEPTIDE WITH CONJUGATION SITES AND METHOD FOR USING THEREOF
WO2019055618A1 (en) 2017-09-15 2019-03-21 Arizona Board Of Regents On Behalf Of Arizona State University METHODS OF CLASSIFYING RESPONSES TO ANTICANCER IMMUNOTHERAPY
WO2019084538A1 (en) * 2017-10-27 2019-05-02 Board Of Regents, The University Of Texas System TUMOR SPECIFIC ANTIBODIES, T CELL RECEPTORS AND METHODS OF IDENTIFICATION THEREOF
BR112020008512A2 (pt) 2017-10-31 2020-10-06 Pantarhei Bioscience B.V. métodos imunoterapêuticos para tratamento e/ou prevenção do câncer pulmonar
EP3706770A4 (en) * 2017-11-07 2021-10-27 Nektar Therapeutics IMMUNOTHERAPEUTIC COMBINATION FOR THE TREATMENT OF CANCER
BR112020010656A2 (pt) 2017-11-27 2020-11-10 Ose Immunotherapeutics tratamento aprimorado de câncer
CA3085486A1 (en) * 2017-12-15 2019-06-20 Baylor College Of Medicine Methods and compositions for the amplification of mrna
TW201930340A (zh) * 2017-12-18 2019-08-01 美商尼恩醫療公司 新抗原及其用途
WO2019140278A1 (en) * 2018-01-11 2019-07-18 Fred Hutchinson Cancer Research Center Immunotherapy targeting core binding factor antigens
WO2019147921A1 (en) * 2018-01-26 2019-08-01 Nantcell, Inc. Rapid verification of virus particle production for a personalized vaccine
CN108384846B (zh) * 2018-02-28 2020-06-16 固安博健生物技术有限公司 C11orf95基因及其表达产物在诊治类风湿性关节炎和骨关节炎方面的应用
US20210361734A1 (en) 2018-03-19 2021-11-25 9 Meters Biopharma, Inc. Compositions and methods for potentiating immune checkpoint inhibitor therapy
WO2019217837A1 (en) * 2018-05-11 2019-11-14 Memorial Sloan-Kettering Cancer Center T cell receptors targeting pik3ca mutations and uses thereof
WO2019237385A1 (zh) * 2018-06-16 2019-12-19 深圳市博奥康生物科技有限公司 用于敲除人TNFSF9基因的gRNA序列及其应用
WO2019246286A1 (en) * 2018-06-19 2019-12-26 Neon Therapeutics, Inc. Neoantigens and uses thereof
BR112020025615A2 (pt) * 2018-06-19 2021-03-23 Biontech Us Inc. neoantígenos e usos dos mesmos
BR112021001117A2 (pt) * 2018-07-22 2021-04-20 Health Research, Inc. células cancerígenas modificadas, composição farmacêutica, linha celular, métodos para fazer células cancerígenas modificadas e para estimular uma resposta imune, vetor de expressão isolado ou combinação de vetores de expressão isolados, e, uma ou mais células cancerígenas modificadas
WO2020023361A1 (en) * 2018-07-23 2020-01-30 H. Lee Moffitt Cancer Center And Research Institute Inc. Enhancing anti-tumor response in melanoma cells with defective sting signaling
US12005104B2 (en) 2018-07-26 2024-06-11 Curevac Netherlands B.V. Cancer vaccines for colorectal cancer
CA3106567A1 (en) 2018-07-26 2020-01-30 Frame Pharmaceuticals B.V. Cancer vaccines for kidney cancer
CA3106564A1 (en) 2018-07-26 2020-01-30 Frame Pharmaceuticals B.V. Cancer vaccines for breast cancer
US20220349010A1 (en) 2018-07-26 2022-11-03 Frame Pharmaceuticals B.V. Method of preparing subject-specific immunogenic compositions based on a neo open-reading-frame peptide database
WO2020022903A1 (en) 2018-07-26 2020-01-30 Frame Pharmaceuticals B.V. ARID1A, CDKN2A, KMT2B, KMT2D, TP53 and PTEN VACCINES FOR CANCER
US20210187088A1 (en) 2018-07-26 2021-06-24 Frame Pharmaceuticals B.V. Cancer vaccines for uterine cancer
KR20210029280A (ko) * 2018-08-02 2021-03-15 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 질환을 제거하기 위한 체크포인트-억제 항체와 상승작용하는 tlr1/2 작용제 디프로보심의 애쥬번트 효과
MX2021001837A (es) * 2018-08-16 2021-07-16 Biontech Us Inc Constructos del receptor de celulas t y usos de los mismos.
EP3841113A1 (en) * 2018-08-22 2021-06-30 Fred Hutchinson Cancer Research Center Immunotherapy targeting kras or her2 antigens
KR20210058825A (ko) * 2018-09-05 2021-05-24 백심 아게 병용 요법용 신생항원 표적화 dna 백신
US20210393752A1 (en) * 2018-11-06 2021-12-23 Icahn School Of Medicine At Mount Sinai Peptides, compositions and vaccines for treatment of microsatellite instablity hypermutated tumors and methods of use thereof
CN109438570B (zh) * 2018-11-28 2021-07-20 生命谷（海南）生物科技股份有限公司 肿瘤相关基因fgfr3突变短肽及其应用
AU2020207641A1 (en) 2019-01-10 2021-07-22 Janssen Biotech, Inc. Prostate neoantigens and their uses
WO2020163876A1 (en) * 2019-02-08 2020-08-13 The Regents Of The University Of California Compositions and methods involving layilin
CN114026116A (zh) 2019-02-20 2022-02-08 弗雷德哈钦森癌症研究中心 Ras新抗原特异性结合蛋白及其用途
EP3930747A4 (en) * 2019-02-27 2023-04-05 Nektar Therapeutics IMMUNOTHERAPEUTIC COMBINATION FOR THE TREATMENT OF CANCER
SG11202110879PA (en) * 2019-03-30 2021-10-28 Biontech Us Inc Compositions and methods for preparing t cell compositions and uses thereof
CN111777677A (zh) * 2019-04-04 2020-10-16 天津亨佳生物科技发展有限公司 一种egfr t790m 新抗原表位肽及其在治疗肿瘤中的应用
US20230085318A1 (en) * 2019-05-07 2023-03-16 Modernatx, Inc. Polynucleotides for disrupting immune cell activity and methods of use thereof
CN110201418B (zh) * 2019-05-09 2020-10-27 西安交通大学 一种基于固定化SNAP-tag融合蛋白的细胞膜色谱柱及其制备方法
CN114072516A (zh) 2019-05-30 2022-02-18 磨石生物公司 经修饰的腺病毒
DE102019114735A1 (de) * 2019-06-02 2020-12-03 PMCR GmbH HLA-Tumorantigenpeptiden der Klasse I und II zur Behandlung von Mamma-/Brustkarzinomen
CN114269357A (zh) * 2019-06-12 2022-04-01 百欧恩泰美国公司 新抗原组合物及其用途
WO2021011417A1 (en) * 2019-07-12 2021-01-21 The Regents Of The University Of California Chemically controlled monoclonal antibody target engagement
US20210024638A1 (en) * 2019-07-26 2021-01-28 Abl Bio Inc. Anti-egfr/anti-4-1bb bispecific antibody and use thereof
BR112022001336A8 (pt) * 2019-07-26 2023-02-07 Abl Bio Inc Anticorpo biespecífico anti-her2/anti-4-1bb e uso do mesmo
WO2021022081A1 (en) * 2019-07-30 2021-02-04 Breakbio Corp. Method for treating solid tumors
US20220307013A1 (en) * 2019-08-30 2022-09-29 The Regents Of The University Of California Gene fragment overexpression screening methodologies, and uses thereof
WO2021067550A1 (en) 2019-10-02 2021-04-08 Arizona Board Of Regents On Behalf Of Arizona State University Methods and compositions for identifying neoantigens for use in treating and preventing cancer
WO2021072218A1 (en) * 2019-10-10 2021-04-15 Pact Pharma, Inc. Method of treating immunotherapy non-responders with an autologous cell therapy
WO2021087838A1 (zh) * 2019-11-07 2021-05-14 深圳吉诺因生物科技有限公司 肿瘤特异性多肽序列及其应用
WO2021101965A1 (en) * 2019-11-18 2021-05-27 Epivax Oncology, Inc. Improved neo-epitope vaccines and methods of treating cancer
KR102410556B1 (ko) * 2020-01-16 2022-06-20 아주대학교산학협력단 미토콘드리아 타겟팅용 펩타이드
KR102397922B1 (ko) * 2020-02-19 2022-05-13 서울대학교 산학협력단 신규한 종양-관련 항원 단백질 olfm4 및 이의 용도
KR102159921B1 (ko) * 2020-03-24 2020-09-25 주식회사 테라젠바이오 펩타이드 서열 및 hla 대립유전자 서열을 이용하여 신생항원을 예측하는 방법 및 컴퓨터 프로그램
CN111729084B (zh) * 2020-04-30 2021-05-11 南京北恒生物科技有限公司 Sting激动剂与工程化免疫细胞的组合疗法
US11130787B2 (en) * 2020-06-11 2021-09-28 MBF Therapeutics, Inc. Alphaherpesvirus glycoprotein d-encoding nucleic acid constructs and methods
CN115698033A (zh) * 2020-06-13 2023-02-03 完整组学公司 用于新抗原分析的方法和系统
WO2021259963A1 (en) 2020-06-23 2021-12-30 Pandora Endocrine Innovation B.V. Immunization against wnt4 for treatment and prophylaxis of breast cancer
CA3187258A1 (en) * 2020-08-06 2022-02-10 Karin Jooss Multiepitope vaccine cassettes
CN112023062A (zh) * 2020-09-18 2020-12-04 北京基因安科技有限公司 一个用可溶性IgE受体抑制过敏反应的方法
EP4225358A1 (en) * 2020-10-06 2023-08-16 The Regents of the University of California Motif neoepitopes for cancer immunotherapy
EP4228693A1 (en) 2020-10-13 2023-08-23 Janssen Biotech, Inc. Bioengineered t cell mediated immunity, materials and other methods for modulating cluster of differentiation iv &/or viii
WO2022099157A1 (en) * 2020-11-06 2022-05-12 Cue Biopharma, Inc. Antigen presenting polypeptide complexes and methods of use thereof
US11421015B2 (en) 2020-12-07 2022-08-23 Think Therapeutics, Inc. Method of compact peptide vaccines using residue optimization
EP4247850A1 (en) 2020-11-20 2023-09-27 Simcere Innovation, Inc. Armed dual car-t compositions and methods for cancer immunotherapy
US20240091359A1 (en) * 2021-01-28 2024-03-21 H. Lee Moffitt Cancer Center And Research Institute, Inc. Novel esr1 derived peptides and uses thereof for neoantigen therapy
US20240299520A1 (en) * 2021-02-09 2024-09-12 Virginia Commonwealth University Mini circular rna therapeutics and vaccines and methods of use thereof
CN117377683A (zh) * 2021-02-25 2024-01-09 西湖生物医药科技(杭州)有限公司 新抗原肽及其在治疗braf基因突变相关疾病中的用途
CN113173985A (zh) * 2021-03-24 2021-07-27 深圳市新靶向生物科技有限公司 一种与结直肠癌驱动基因突变相关的抗原肽及其应用
EP4326325A1 (en) * 2021-04-23 2024-02-28 Flow Pharma Inc. Vaccine for sars-cov-2
US11464842B1 (en) 2021-04-28 2022-10-11 Think Therapeutics, Inc. Compositions and method for optimized peptide vaccines using residue optimization
US20240226147A1 (en) * 2021-05-06 2024-07-11 Astrin Biosciences Inc. Trojan circulating tumor cells
CN117999355A (zh) 2021-08-24 2024-05-07 生物技术欧洲股份公司 体外转录技术
WO2023059606A1 (en) * 2021-10-06 2023-04-13 Cancervax, Inc. Methods and compositions for cancer treatment
EP4419122A1 (en) 2021-10-19 2024-08-28 Sciencemed Spólka Z Ograniczona Odpowiedzialnoscia Male contraception
CN114478712B (zh) * 2022-03-29 2022-09-23 深圳吉诺因生物科技有限公司 Hpv抗原表位及其鉴定方法、应用
CN114605499B (zh) * 2022-04-07 2023-06-23 华中科技大学同济医学院附属协和医院 一种可拮抗rbsm1蛋白rna结合活性的多肽rip-18及其应用
WO2023215579A1 (en) * 2022-05-06 2023-11-09 The Children's Medical Center Corporation Anaplastic lymphoma kinase (alk) cancer vaccines and methods of use thereof
KR20240017325A (ko) * 2022-07-29 2024-02-07 주식회사 엘지화학 항원 전달용 재조합 융합 단백질 및 이의 이용
WO2024083345A1 (en) 2022-10-21 2024-04-25 BioNTech SE Methods and uses associated with liquid compositions
WO2024102764A1 (en) * 2022-11-07 2024-05-16 The Wistar Institute Of Anatomy And Biology Compositions comprising neoantigens and methods of enhancing anti-pd1 therapy
WO2024144372A1 (ko) * 2022-12-30 2024-07-04 주식회사 엘지화학 시스테인 잔기가 변형된 항원 전달용 재조합 융합 단백질 및 이의 이용
WO2024148181A2 (en) * 2023-01-04 2024-07-11 Board Of Regents, The University Of Texas System T cell receptors targeting the highly prevalent kras g12c mutation on hla-a*11:01 in lung cancer
WO2024148178A2 (en) * 2023-01-04 2024-07-11 Board Of Regents, The University Of Texas System T cell receptors targeting the highly prevalent kras g12c mutation on hla-a*03:01 in lung cancer
WO2024148185A2 (en) * 2023-01-04 2024-07-11 Board Of Regents, The University Of Texas System T cell receptors targeting the highly prevalent kras g12v mutation on hla-a*11:01 in lung cancer
WO2024148183A2 (en) * 2023-01-04 2024-07-11 Board Of Regents, The University Of Texas System T cell receptors targeting the highly prevalent kras g12v mutation on hla-a*03:01 in lung cancer
CN116970058B (zh) * 2023-09-22 2023-12-15 成都朗谷生物科技股份有限公司 针对tp53基因r249s突变的肿瘤新抗原多肽及其应用

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2343602A1 (en) * 2000-04-18 2001-10-18 Genset Est's and encoded human proteins
DE602005005196T2 (de) * 2005-09-05 2008-06-26 Immatics Biotechnologies Gmbh Tumor-assoziierte Peptide, welche an unterschiedliche menschliche Leukozytenantigene der Klasse II binden
ES2330013T3 (es) * 2005-09-05 2009-12-03 Immatics Biotechnologies Gmbh Peptidos asociados a tumores unidos a moleculas del antigeno de leucocito humano (hla) de clase i o ii y vacunas contra el cancer relacionadas.
TWI610939B (zh) 2007-02-21 2018-01-11 腫瘤療法 科學股份有限公司 表現腫瘤相關抗原之癌症的胜肽疫苗
NZ580444A (en) * 2007-03-19 2012-02-24 Globeimmune Inc Compositions and methods for targeted ablation of mutational escape of targeted therapies for cancer
EP2071334A1 (en) * 2007-12-14 2009-06-17 Transmedi SA Compositions and methods of detecting TIABS
US20110165566A1 (en) 2009-07-09 2011-07-07 Wittliff James L Methods of optimizing treatment of breast cancer
CN103492590A (zh) 2011-02-22 2014-01-01 卡里斯生命科学卢森堡控股有限责任公司 循环生物标志物
WO2012177925A1 (en) 2011-06-21 2012-12-27 The Board Institute, Inc. Akt inhibitors for treating cancer expressing a magi3 - akt3 fusion gene
DE18200782T1 (de) * 2012-04-02 2021-10-21 Modernatx, Inc. Modifizierte polynukleotide zur herstellung von proteinen im zusammenhang mit erkrankungen beim menschen
US20190099475A1 (en) * 2015-04-08 2019-04-04 Nantomics, Llc Cancer neoepitopes
CA3172686A1 (en) * 2015-04-23 2016-10-27 Nantomics, Llc Cancer neoepitopes
AU2016264623B2 (en) * 2015-05-20 2022-06-30 Dana-Farber Cancer Institute, Inc. Shared neoantigens
GB201521894D0 (en) * 2015-12-11 2016-01-27 Immatics Biotechnologies Gmbh Novel peptides and combination of peptides for use in immunotherapy against various cancers

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