SG11201708858WA - Methods of treating cancer - Google Patents

Methods of treating cancer

Info

Publication number
SG11201708858WA
SG11201708858WA SG11201708858WA SG11201708858WA SG11201708858WA SG 11201708858W A SG11201708858W A SG 11201708858WA SG 11201708858W A SG11201708858W A SG 11201708858WA SG 11201708858W A SG11201708858W A SG 11201708858WA SG 11201708858W A SG11201708858W A SG 11201708858WA
Authority
SG
Singapore
Prior art keywords
methods
treating cancer
cancer
treating
Prior art date
Application number
SG11201708858WA
Other languages
English (en)
Inventor
Fiona Garner
Gary Hattersley
Original Assignee
Radius Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Radius Pharmaceuticals Inc filed Critical Radius Pharmaceuticals Inc
Publication of SG11201708858WA publication Critical patent/SG11201708858WA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A61K31/5685—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone having an oxo group in position 17, e.g. androsterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
SG11201708858WA 2015-04-29 2016-04-29 Methods of treating cancer SG11201708858WA (en)

Applications Claiming Priority (14)

Application Number Priority Date Filing Date Title
US201562154699P 2015-04-29 2015-04-29
US201562155451P 2015-04-30 2015-04-30
US201562158469P 2015-05-07 2015-05-07
US201562192940P 2015-07-15 2015-07-15
US201562192944P 2015-07-15 2015-07-15
US201562252085P 2015-11-06 2015-11-06
US201562252916P 2015-11-09 2015-11-09
US201562265663P 2015-12-10 2015-12-10
US201562265774P 2015-12-10 2015-12-10
US201562265696P 2015-12-10 2015-12-10
US201562265658P 2015-12-10 2015-12-10
US201662323576P 2016-04-15 2016-04-15
US201662323572P 2016-04-15 2016-04-15
PCT/US2016/030317 WO2016176665A1 (en) 2015-04-29 2016-04-29 Methods of treating cancer

Publications (1)

Publication Number Publication Date
SG11201708858WA true SG11201708858WA (en) 2017-11-29

Family

ID=57198783

Family Applications (4)

Application Number Title Priority Date Filing Date
SG11201708860SA SG11201708860SA (en) 2015-04-29 2016-04-29 Methods of treating cancer
SG11201708861VA SG11201708861VA (en) 2015-04-29 2016-04-29 Methods for treating cancer
SG11201708858WA SG11201708858WA (en) 2015-04-29 2016-04-29 Methods of treating cancer
SG10202104177VA SG10202104177VA (en) 2015-04-29 2016-04-29 Methods of treating cancer

Family Applications Before (2)

Application Number Title Priority Date Filing Date
SG11201708860SA SG11201708860SA (en) 2015-04-29 2016-04-29 Methods of treating cancer
SG11201708861VA SG11201708861VA (en) 2015-04-29 2016-04-29 Methods for treating cancer

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG10202104177VA SG10202104177VA (en) 2015-04-29 2016-04-29 Methods of treating cancer

Country Status (14)

Country Link
US (10) US20180153828A1 (zh)
EP (4) EP3288382A4 (zh)
JP (8) JP6926065B2 (zh)
KR (6) KR102676705B1 (zh)
CN (5) CN108024540B (zh)
AU (3) AU2016256470B2 (zh)
BR (3) BR112017023228A2 (zh)
CA (3) CA2984195C (zh)
HK (3) HK1251409A1 (zh)
IL (7) IL307983A (zh)
MX (6) MX2021005561A (zh)
RU (3) RU2747228C2 (zh)
SG (4) SG11201708860SA (zh)
WO (3) WO2016176664A1 (zh)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9421264B2 (en) 2014-03-28 2016-08-23 Duke University Method of treating cancer using selective estrogen receptor modulators
DK3122426T3 (da) 2014-03-28 2023-04-03 Univ Duke Behandling af brystcancer ved anvendelse af selektive østrogenreceptormodulatorer
RU2747228C2 (ru) 2015-04-29 2021-04-29 Радиус Фармасьютикалз, Инк. Способы лечения рака
MY196486A (en) 2016-02-15 2023-04-17 Sanofi Sa 6,7-Dihydro-5h-Benzo[7]Annulene Derivatives as Estrogen Receptor Modulators
TWI794171B (zh) 2016-05-11 2023-03-01 美商滬亞生物國際有限公司 Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療
TWI808055B (zh) 2016-05-11 2023-07-11 美商滬亞生物國際有限公司 Hdac 抑制劑與 pd-1 抑制劑之組合治療
MX2019003311A (es) * 2016-09-27 2019-07-08 Radius Health Inc Metodos para tratamiento de cancer de ovario.
US20180098963A1 (en) 2016-10-11 2018-04-12 Duke University Lasofoxifene treatment of breast cancer
WO2018091153A1 (en) 2016-11-17 2018-05-24 Sanofi Novel substituted n-(3-fluoropropyl)-pyrrolidine compounds, processes for their preparation and therapeutic uses thereof
PL3565542T3 (pl) * 2017-01-05 2024-07-29 Radius Pharmaceuticals, Inc. Postacie polimorficzne rad1901-2hcl
BR112019019261A2 (pt) * 2017-03-16 2020-06-16 Eisai R & D Management Co., Ltd. Terapias de combinação para o tratamento de câncer de mama
US12012421B2 (en) 2017-07-07 2024-06-18 Hoffmann-La Roche Inc. Solid forms of [(1S)-1-[(2S,4R,5R)-5-(5-amino-2-oxo-thiazolo[4,5-d]pyrimidin-3-yl)-4-hydroxy-tetrahydrofuran-2-yl]propyl] acetate
EP3434272A1 (en) * 2017-07-25 2019-01-30 Sanofi Combination comprising palbociclib and 6-(2,4-dichlorophenyl)-5-[4-[(3s)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7h-benzo[7]annulene-2-carboxylic acid
EP3709997A1 (en) 2017-11-16 2020-09-23 Novartis AG Pharmaceutical combination comprising lsz102 and ribociclib
US12012420B2 (en) 2017-11-21 2024-06-18 Hoffmann-La Roche, Inc. Solid forms of [(1S)-1-[(2S,4R,5R)-5-(5-amino-2-oxo-thiazolo[4,5-d]pyrimidin-3-yl)-4-hydroxy-tetrahydrofuran-2-yl]propyl] acetate
JP2021504384A (ja) 2017-12-01 2021-02-15 ノバルティス アーゲー Ｌｓｚ１０２及びアルペリシブを含む医薬品の組合せ
EP3773524A4 (en) 2018-04-10 2021-12-22 Duke University TREATMENT OF BREAST CANCER WITH LASOFOXIFEN
CN110585429B (zh) * 2018-06-12 2022-10-21 江苏恒瑞医药股份有限公司 酪氨酸激酶抑制剂联合单克隆抗体以及紫杉醇类药物治疗肿瘤疾病的用途
WO2020010216A1 (en) * 2018-07-04 2020-01-09 Radius Pharmaceuticals, Inc. Polymorphic forms of rad 1901-2hcl
ES2924738T3 (es) 2018-09-07 2022-10-10 Sanofi Sa Proceso para la preparación de 6-(2,4-diclorofenil)-5-[4-[(3S)-1-(3-fluoropropil)pirrolidin-3-il]oxifenil]-8,9-dihidro-7H-benzo[7]anuleno-2-carboxilato de metilo y una sal del mismo
AU2019388900A1 (en) * 2018-11-30 2021-06-10 Radius Pharmaceuticals, Inc. Elacestrant in combination with abemaciclib in women with breast cancer
JOP20210138A1 (ar) * 2018-12-06 2023-01-30 Radius Pharmaceuticals Inc طرق علاج السرطان في نماذج تأوي طفرات esr1
JOP20210137A1 (ar) * 2018-12-06 2023-01-30 Radius Pharmaceuticals Inc طرق علاج سرطان مقاومة لمثبطات cdk4/6
CN113194956A (zh) * 2018-12-12 2021-07-30 凯莫森特里克斯股份有限公司 用于癌症治疗的cxcr7抑制剂
KR102341347B1 (ko) * 2019-11-28 2021-12-20 의료법인 성광의료재단 암 치료제에 대한 내성 암의 진단을 위한 조성물, 키트 및 방법
KR20220151616A (ko) * 2020-03-06 2022-11-15 올레마 파마슈티컬스 인코포레이티드 에스트로겐 수용체-연관 질환의 치료 방법
EP4149476A1 (en) * 2020-05-12 2023-03-22 Genentech, Inc. Treatment of breast cancer using combination therapies comprising gdc-9545 and a cdk4/6 inhibitor
CN113662942B (zh) * 2021-08-19 2023-02-07 中国人民解放军陆军军医大学第一附属医院 药物组合物及其在smo突变性髓母细胞瘤中的应用
WO2023064519A1 (en) 2021-10-14 2023-04-20 Teva Pharmaceuticals International Gmbh Solid state forms of elacestrant and processes for preparation thereof
GB202116903D0 (en) 2021-11-18 2022-01-05 Sermonix Pharmaceuticals Inc Lasofoxifene treatment of aromatase-resistant er+ cancer
WO2024104268A1 (zh) * 2022-11-15 2024-05-23 苏州科睿思制药有限公司 艾拉司群二盐酸盐的共晶及其制备方法和用途
KR20240105964A (ko) * 2022-12-29 2024-07-08 주식회사 삼양홀딩스 약동학적 특성이 우수한 풀베스트란트의 약학 조성물 및 그 제조 방법

Family Cites Families (160)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3939346A1 (de) 1989-11-29 1991-06-06 Behringwerke Ag Arzneimitel zur subkutanen oder intramuskulaeren applikation enthaltend polypeptide
US5589452A (en) 1992-07-14 1996-12-31 Syntex (U.S.A.) Inc. Analogs of parathyroid hormone and parathyroid hormone related peptide: synthesis and use for the treatment of osteoporosis
US5977070A (en) 1992-07-14 1999-11-02 Piazza; Christin Teresa Pharmaceutical compositions for the nasal delivery of compounds useful for the treatment of osteoporosis
US5821225A (en) 1992-07-14 1998-10-13 Syntex (U.S.A.) Inc. Method for the treatment of corticosteroid induced osteopenia comprising administration of modified PTH or PTHrp
DE19517430A1 (de) 1995-05-12 1996-11-14 Boehringer Mannheim Gmbh Pharmazeutische Darreichungsform von Parathormon mit einer zwei- bis sechsstündigen Wirkstoff-Freisetzungsperiode
IT1285405B1 (it) 1995-06-06 1998-06-03 Alza Corp Modificazione di farmaci polipeptidici per accrescere il flusso per elettrotrasporto.
US6544949B1 (en) 1995-07-13 2003-04-08 Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. Analogs of parathyroid hormone
US5969095A (en) 1995-07-13 1999-10-19 Biomeasure, Inc. Analogs of parathyroid hormone
US5955574A (en) 1995-07-13 1999-09-21 Societe De Conseils De Recherches Et D'applications Scientifiques, S.A. Analogs of parathyroid hormone
US7410948B2 (en) 1995-07-13 2008-08-12 Societe De Conseils De Recherches Et D'applications Scientifiques, Sas Analogs of parathyroid hormone
US5723577A (en) 1995-07-13 1998-03-03 Biomeasure Inc. Analogs of parathyroid hormone
DE19538687A1 (de) 1995-10-17 1997-04-24 Boehringer Mannheim Gmbh Stabile pharmazeutische Darreichungsformen enthaltend Parathormon
DE19539574A1 (de) 1995-10-25 1997-04-30 Boehringer Mannheim Gmbh Zubereitungen und Verfahren zur Stabilisierung biologischer Materialien mittels Trocknungsverfahren ohne Einfrieren
TWI240627B (en) 1996-04-26 2005-10-01 Chugai Pharmaceutical Co Ltd Erythropoietin solution preparation
TW505654B (en) 1996-07-30 2002-10-11 Hoffmann La Roche Synthesis of analogs of PTH and PTHrP
EP2371962A3 (en) 1996-12-23 2011-12-21 Immunex Corporation Receptor activator of NF-KAPPA B, receptor is member of TNF receptor superfamily
US6136784A (en) 1997-01-08 2000-10-24 Amylin Pharmaceuticals, Inc. Amylin agonist pharmaceutical compositions containing insulin
US6316408B1 (en) 1997-04-16 2001-11-13 Amgen Inc. Methods of use for osetoprotegerin binding protein receptors
ZA988030B (en) 1997-09-09 1999-03-09 Hoffmann La Roche Fracture healing using pthrp analogs
US6770623B1 (en) 1997-12-09 2004-08-03 Eli Lilly And Company Stabilized teriparatide solutions
ZA9811127B (en) 1997-12-09 2000-07-11 Lilly Co Eli Stabilized teriparatide solutions.
US6050988A (en) 1997-12-11 2000-04-18 Alza Corporation Device for enhancing transdermal agent flux
DE69831268T2 (de) 1997-12-11 2006-03-09 Alza Corp., Palo Alto Vorrichtung zur erhöhung des transdermalen wirkstoffeflusses
EP0922467A3 (en) 1997-12-12 2000-05-24 Takeda Chemical Industries, Ltd. Iontophoretic drug delivery
JP4154017B2 (ja) 1997-12-30 2008-09-24 久光製薬株式会社 イオントフォレーシス装置および薬物ユニット
US6091975A (en) 1998-04-01 2000-07-18 Alza Corporation Minimally invasive detecting device
SE9801495D0 (sv) 1998-04-28 1998-04-28 Astra Ab Protein formulationa
US6316410B1 (en) 1999-09-22 2001-11-13 National Research Council Of Canada Parathyroid hormone analogues for the treatment of osteoporosis
WO2001036039A2 (en) 1999-11-17 2001-05-25 Novartis Ag Iontophoretic transdermal delivery of peptides
GB9930882D0 (en) 1999-12-30 2000-02-23 Nps Allelix Corp GLP-2 formulations
US20010044431A1 (en) 2000-03-21 2001-11-22 Rodriguez Gustavo C. Prevention of ovarian cancer by administration of products that induce biologic effects in the ovarian epithelium
US20050124537A1 (en) 2000-04-27 2005-06-09 Amgen Inc. Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein
US6756480B2 (en) 2000-04-27 2004-06-29 Amgen Inc. Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein
DE60143360D1 (de) 2000-08-03 2010-12-09 Antares Pharma Ipl Ag Zusammensetzung zur transdermalen und/oder transmukosalen Verabreichung von Wirkstoffen, die ausreichende therapeutische Spiegel garantiert
SK2052003A3 (en) 2000-08-23 2003-07-01 Akzo Nobel Nv 10-Aryl-11-Hbenzo [b]fluorene derivatives and analogs for medicinal use
US7186683B2 (en) 2000-09-18 2007-03-06 Sanos Bioscience A/S Use of GLP for the treatment, prevention, diagnosis, and prognosis of bone-related and nutrition-related disorders
US7371721B2 (en) 2000-09-18 2008-05-13 Sanos Bioscience A/S Use of GLP-2 and related compounds for the treatment, prevention, diagnosis, and prognosis of bone-related disorders and calcium homeostasis related syndromes
WO2002094368A1 (en) 2000-10-26 2002-11-28 Alza Corporation Transdermal drug delivery devices having coated microprotrusions
ATE444773T1 (de) 2001-04-20 2009-10-15 Alza Corp Mikroprojektionsanordnung mit einem überzug, der ein vorteilhaftes mittel enthält
DK2295081T3 (en) 2001-06-26 2019-02-18 Amgen Inc Antibodies to OPGL
US6881203B2 (en) 2001-09-05 2005-04-19 3M Innovative Properties Company Microneedle arrays and methods of manufacturing the same
US8853266B2 (en) 2001-12-06 2014-10-07 University Of Tennessee Research Foundation Selective androgen receptor modulators for treating diabetes
RU2314760C2 (ru) 2001-12-20 2008-01-20 Алза Корпорейшн Микровыступы, пробивающие кожу, имеющие средство регулирования глубины пробивки
JP2005524630A (ja) 2002-01-14 2005-08-18 ノルディック・ビオサイエンス・エー／エス エストロゲン受容体を介する軟骨破壊の抑制
CA2472956A1 (en) 2002-02-14 2003-08-21 Bayer Pharmaceuticals Corporation Formulation strategies in stabilizing peptides in organic solvents and in dried states
AU2003239869A1 (en) 2002-05-23 2003-12-12 Michael Holick Use of a parathyroid hormone peptide analogs for the treatment of vaginal atrophy
TW200307553A (en) 2002-05-24 2003-12-16 Akzo Nobel Nv Treatment of post-menopausal complaints in breast cancer patients
EP1551438A2 (en) 2002-06-13 2005-07-13 Beth Israel Deaconess Medical Center, Inc. Analogs of parathyroid hormone and pth-related protein as bone anabolic agents
JP2006502116A (ja) 2002-07-12 2006-01-19 メダレックス， インク． タンパク質の酸化分解を防ぐ方法及び組成物
EP1523367A1 (en) 2002-07-19 2005-04-20 3M Innovative Properties Company Microneedle devices and microneedle delivery apparatus
US7411039B2 (en) 2002-10-14 2008-08-12 Novo Nordisk A/S GLP-2 compounds, formulations, and uses thereof
MXPA05003797A (es) 2002-10-14 2005-06-08 Novo Nordisk As Variantes de peptido-2 tipo glucagon.
US7662404B2 (en) 2002-10-31 2010-02-16 Transpharma Medical Ltd. Transdermal delivery system for dried particulate or lyophilized peptides and polypeptides
US7383084B2 (en) 2002-10-31 2008-06-03 Transpharma Medical Ltd. Transdermal delivery system for dried particulate or lyophilized medications
IL152574A (en) 2002-10-31 2009-09-22 Transpharma Medical Ltd A system for passing through the skin of dry items or dried medicines
US8133505B2 (en) 2002-10-31 2012-03-13 Transpharma Medical Ltd. Transdermal delivery system for dried particulate or lyophilized medications
CA2511966A1 (en) 2002-11-01 2004-07-22 Amgen Inc. Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein
US8080682B2 (en) 2006-08-24 2011-12-20 University Of Tennessee Research Foundation Substituted acylanilides and methods of use thereof
JP4500689B2 (ja) * 2002-12-26 2010-07-14 エーザイ・アール・アンド・ディー・マネジメント株式会社 選択的エストロゲン受容体モジュレーター
US20060148893A1 (en) 2003-06-10 2006-07-06 Blanc Jean-Baptiste E Chemical compounds
JP2007505164A (ja) 2003-06-10 2007-03-08 スミスクライン ビーチャム コーポレーション アンドロゲン、グルココルチコイド、ミネラルコルチコイドおよびプロゲステロン受容体のモジュレーターとしての１−アミノナフタレン類
WO2005000309A2 (en) 2003-06-27 2005-01-06 Ionix Pharmaceuticals Limited Chemical compounds
BRPI0412029A (pt) 2003-06-30 2006-09-05 Alza Corp formulações para microprojeções revestidas contendo contra-ìons não-voláteis
PL1638468T3 (pl) 2003-06-30 2008-01-31 Alza Corp Sposób powlekania mikrowystępów do przekłuwania skóry
WO2005014034A1 (en) 2003-07-14 2005-02-17 Nps Allelix Corp. Stabilized formulation of parathyroid hormone
US7141544B2 (en) 2003-10-10 2006-11-28 Baxter International, Inc. Stabilization of pharmaceutical protein formulations with small peptides
US20050124625A1 (en) 2003-10-21 2005-06-09 Salvati Mark E. Piperazine derivatives and their use as modulators of nuclear hormone receptor function
GB0324551D0 (en) 2003-10-21 2003-11-26 Karobio Ab Novel compounds
EP1677687A4 (en) 2003-10-28 2008-09-17 Alza Corp ADMINISTRATION OF POLYMERIC CONJUGATES OF PEPTIDES AND THERAPEUTIC PROTEINS THROUGH COATED MICROPROTUBERANCES
CN100571643C (zh) 2003-10-31 2009-12-23 阿尔扎公司 用于微凸起阵列的自驱动施加器
BRPI0416042A (pt) 2003-11-13 2007-01-02 Alza Corp composição e aparelho para suprimento transdérmico
EP1687274A1 (en) 2003-11-20 2006-08-09 Warner-Lambert Company LLC Androgen receptor modulators
CN1905842A (zh) 2003-11-21 2007-01-31 阿尔扎公司 超声促进疫苗透皮释放的方法和系统
IL159273A0 (en) 2003-12-09 2004-06-01 Transpharma Medical Ltd Transdermal delivery system for sustained release of polypeptides
US20070196395A1 (en) 2003-12-12 2007-08-23 Mackerell Alexander Immunomodulatory compounds that target and inhibit the py'binding site of tyrosene kinase p56 lck sh2 domain
KR20130124576A (ko) 2004-01-07 2013-11-14 앙도르쉐르슈 인코포레이티드 헬릭스 12 배향형 스테로이드계 약학 제품
IL160033A0 (en) 2004-01-25 2004-06-20 Transpharma Medical Ltd Transdermal delivery system for polynucleotides
TWI359026B (en) 2004-02-12 2012-03-01 Sankyo Co Pharmaceutical composition for the osteoclast rela
GB0405033D0 (en) 2004-03-05 2004-04-07 Karobio Ab Novel pharmaceutical compositions
WO2005099707A1 (en) 2004-04-08 2005-10-27 Merck & Co., Inc. 17 beta-acetamide-4-azasteroids as androgen receptor modulators
AU2005247369A1 (en) 2004-05-10 2005-12-08 Mdrna, Inc. Compositions and methods for enhanced mucosal delivery of parathyroid hormone
US20080045504A1 (en) 2004-05-11 2008-02-21 Pfizer Products Inc. Benzonitrile Derivatives to Treat Musculoskeletal Frailty
EP1744683B1 (en) 2004-05-13 2016-03-16 Alza Corporation Apparatus and method for transdermal delivery of parathyroid hormone agents
EP1765406A4 (en) 2004-05-21 2012-11-28 Mediplex Corp ADDITIVES FOR IMPROVED MUCOSAL ABSORPTION OF THERAPEUTIC AGENTS
US7906137B2 (en) 2004-05-21 2011-03-15 Mediplex Corporation, Korea Delivery agents for enhancing mucosal absorption of therapeutic agents
US20090069226A1 (en) 2004-05-28 2009-03-12 Amylin Pharmaceuticals, Inc. Transmucosal delivery of peptides and proteins
TW200621282A (en) 2004-08-13 2006-07-01 Wyeth Corp Stabilizing formulations
CN101052398A (zh) 2004-10-29 2007-10-10 默克公司 作为雄激素受体调节剂的n－(吡啶－3－基)－2－苯基丁酰胺
EP1827564B1 (en) 2004-11-18 2015-07-29 3M Innovative Properties Company Masking method for coating a microneedle array
WO2006054299A2 (en) 2004-11-18 2006-05-26 Transpharma Medical Ltd. Combined micro-channel generation and iontophoresis for transdermal delivery of pharmaceutical agents
US8057842B2 (en) 2004-11-18 2011-11-15 3M Innovative Properties Company Method of contact coating a microneedle array
AU2006206272A1 (en) 2005-01-21 2006-07-27 Alza Corporation Therapeutic peptide formulations for coating microneedles with improved stabitity containing at least one counterion
JP2008536868A (ja) 2005-04-15 2008-09-11 スミスクライン・ビーチャム・コーポレイション シアノアリールアミン
KR100700869B1 (ko) 2005-06-03 2007-03-29 재단법인 목암생명공학연구소 Ｐｔｈ, 완충제 및 안정제를 포함하는 안정한 ｐｔｈ조성물
US20090170907A1 (en) 2005-06-06 2009-07-02 Smithkline Beecham Corporation Chemical Compounds
US20090227571A1 (en) 2005-07-01 2009-09-10 Ligand Pharmaceuticals Incorporated Androgen Receptor Modulator Compounds and Methods
US20070021216A1 (en) 2005-07-19 2007-01-25 Sony Ericsson Mobile Communications Ab Seamless gaming method and apparatus
JP2008303145A (ja) 2005-09-22 2008-12-18 Takeda Chem Ind Ltd Ｇｒｋ阻害剤からなる強心薬
WO2007061964A1 (en) 2005-11-18 2007-05-31 3M Innovative Properties Company Methods for coating microneedles
AU2006336187A1 (en) 2005-12-28 2007-07-26 Alza Corporation Stable therapeutic formulations
AU2007225056A1 (en) 2006-03-15 2007-09-20 Alza Corporation Apparatus and method for transdermal delivery of parathyroid hormone agents to prevent or treat osteopenia
WO2007124411A1 (en) 2006-04-20 2007-11-01 3M Innovative Properties Company Device for applying a microneedle array
US8048383B2 (en) 2006-04-20 2011-11-01 Velocys, Inc. Process for treating and/or forming a non-Newtonian fluid using microchannel process technology
AU2007240317B2 (en) 2006-04-20 2012-11-29 Amgen Inc. Stable emulsion formulations
CN101085743B (zh) 2006-06-06 2012-02-15 浙江大德药业集团有限公司 含氟烷氧基康普立停衍生物及制法和用途
US8933130B2 (en) 2006-06-23 2015-01-13 Radius Health, Inc. Treatment of vasomotor symptoms with selective estrogen receptor modulators
MX2009000385A (es) 2006-07-12 2009-04-06 Univ Tennessee Res Foundation Acil-anilidas sustituidas y metodos de uso de las mismas.
WO2008023063A2 (en) 2006-08-25 2008-02-28 Ares Trading S.A. Treatment of cartilage disorders with fgf-18
CN1927815A (zh) 2006-09-25 2007-03-14 天津理工大学 邻苄胺基苯基醚化合物、化合物的衍生物及其制备方法与用途
US7803770B2 (en) 2006-10-03 2010-09-28 Radius Health, Inc. Method of treating osteoporosis comprising administration of PTHrP analog
RS56164B1 (sr) 2006-10-03 2017-11-30 Radius Health Inc Stabilna kompozicija koja sadrži pthrp i njene upotrebe
WO2008044033A1 (en) 2006-10-11 2008-04-17 Astrazeneca Ab Amide derivatives
JP5241517B2 (ja) 2007-02-06 2013-07-17 久光製薬株式会社 アレルギー診断用マイクロニードルデバイス
WO2008121602A1 (en) 2007-03-29 2008-10-09 Smithkline Beecham Corporation Chemical compounds
WO2008124000A2 (en) 2007-04-02 2008-10-16 Ligand Pharmaceuticals Incorporated Thiazole derivatives as androgen receptor modulator compounds
US9114238B2 (en) 2007-04-16 2015-08-25 Corium International, Inc. Solvent-cast microprotrusion arrays containing active ingredient
GB0707938D0 (en) 2007-04-25 2007-05-30 Univ Strathclyde Precipitation stabilising compositions
JP5350369B2 (ja) * 2007-05-31 2013-11-27 ダコ デンマーク アクティーゼルスカブ 乳癌治療および予後におけるｅｓｒコピー数変化の利用方法
US20110009387A1 (en) 2007-06-12 2011-01-13 Andrea Dawn Basso-Porcaro Histone h2ax (hh2ax) biomarker for fti sensitivity
EP2155226A4 (en) 2007-06-14 2010-07-28 Univ California COMPOUNDS FOR INHIBITING AGGREGATION OF PROTEINS AND METHODS OF MAKING AND USING SAME
US20120150023A1 (en) 2007-08-06 2012-06-14 Kaspar Roger L Microneedle arrays for active agent delivery
ES2612061T3 (es) 2007-09-28 2017-05-11 The Queen's University Of Belfast Dispositivo y método de suministro
WO2009054988A1 (en) 2007-10-23 2009-04-30 Alza Corporation Transdermal sustained release drug delivery
EP2052736A1 (en) 2007-10-26 2009-04-29 Nycomed Danmark ApS Parathyroid hormone formulations und uses thereof
WO2009065126A2 (en) 2007-11-16 2009-05-22 Boston Protein Solutions Excipients for protein stabilization
WO2009133861A1 (ja) 2008-04-28 2009-11-05 武田薬品工業株式会社 環状アミン化合物
WO2009137104A1 (en) * 2008-05-09 2009-11-12 Radius Health, Inc. Combination therapy for breastcancer comprising an antiestrogenic agent
WO2010022176A1 (en) 2008-08-19 2010-02-25 Ferring International Center S.A. Methods of treatment for skeletal conditons
CN106880596A (zh) 2008-10-15 2017-06-23 精达制药公司 高浓缩药物颗粒、制剂、混悬剂及其应用
CA2742659C (en) 2008-11-04 2016-09-27 Aska Pharmaceutical Co., Ltd. Aqueous composition containing follicle-stimulating hormone
CA2742853C (en) 2008-11-18 2019-01-08 3M Innovative Properties Company Hollow microneedle array and method
KR101634836B1 (ko) 2008-12-26 2016-06-29 히사미쓰 세이야꾸 가부시키가이샤 마이크로 니들 디바이스
US20100203014A1 (en) 2009-02-04 2010-08-12 Aegis Therapeutics Llc Zwitterionic buffered acidic peptide and protein formulations
US20100226966A1 (en) 2009-03-03 2010-09-09 Daddona Peter E Method for transdermal controlled release drug delivery
WO2010118287A1 (en) 2009-04-10 2010-10-14 Radius Health, Inc. Selective androgen receptor modulators
WO2010124255A2 (en) 2009-04-24 2010-10-28 Corium International, Inc. Methods for manufacturing microprojection arrays
US10010706B2 (en) 2009-07-31 2018-07-03 3M Innovative Properties Company Hollow microneedle arrays
CA2779577A1 (en) 2009-11-02 2011-05-05 Therapeomic Ag Stabilized protein formulations and use thereof
US20110172609A1 (en) 2010-01-08 2011-07-14 Ratio, Inc. Microneedle component assembly for drug delivery device
CN101912600B (zh) 2010-01-11 2014-01-29 杨国汉 改善胰岛素在溶液中稳定性的方法
IE20100174A1 (en) 2010-03-25 2012-02-29 Trinity College Dublin Transdermal administration of peptides
JP6327852B2 (ja) 2010-05-04 2018-05-23 コリウム インターナショナル， インコーポレイテッド 微小突起アレイを使用した副甲状腺ホルモンの経皮送達のための方法及びデバイス
AU2011258288B2 (en) 2010-05-28 2015-02-12 Kindeva Drug Delivery L.P. Aqueous formulations for coating microneedle arrays
KR20190042762A (ko) * 2010-06-16 2019-04-24 앙도르쉐르슈 인코포레이티드 에스트로겐-관련 질병의 치료 또는 예방 방법
WO2012075375A1 (en) 2010-12-02 2012-06-07 Lanco Biosciences, Inc. Delivery of parathyroid hormones by microinjection systems
AU2012223279A1 (en) 2011-03-01 2013-09-26 Sloan-Kettering Institute For Cancer Research Parathyroid hormone analogs, compositions and uses thereof
MX2013012349A (es) 2011-04-22 2014-07-09 Radius Health Inc Metodo para suministro de farmaco para pth, pthrp y peptidos relacionados.
US9623087B2 (en) 2011-11-30 2017-04-18 3M Innovative Properties Company Microneedle device including a peptide therapeutic agent and an amino acid and methods of making and using the same
GB201217439D0 (en) 2012-09-28 2012-11-14 Topotarget As Combination therapy
WO2014203129A1 (en) * 2013-06-19 2014-12-24 Olema Pharmaceuticals, Inc. Combinations of benzopyran compounds, compositions and uses thereof
RU2015152171A (ru) 2013-06-19 2017-07-25 Серагон Фармасьютикалз, Инк. Азетидиновые модуляторы эстрогеновых рецепторов и их применения
CN104436194B (zh) 2013-09-18 2018-03-30 北京大学 具有协同增效作用的抗癌组合物
US10093982B2 (en) * 2014-01-27 2018-10-09 Dna-Seq, Inc. Methods and systems for determination of an effective therapeutic regimen and drug discovery
MX2016011636A (es) 2014-03-13 2016-12-12 Hoffmann La Roche Combinaciones terapeuticas con moduladores de receptor de estrogeno.
DK3122426T3 (da) * 2014-03-28 2023-04-03 Univ Duke Behandling af brystcancer ved anvendelse af selektive østrogenreceptormodulatorer
US9421264B2 (en) 2014-03-28 2016-08-23 Duke University Method of treating cancer using selective estrogen receptor modulators
WO2015160986A2 (en) 2014-04-16 2015-10-22 Infinity Pharmaceuticals, Inc. Combination therapies
US9845291B2 (en) 2014-12-18 2017-12-19 Genentech, Inc. Estrogen receptor modulators and uses thereof
AR104068A1 (es) * 2015-03-26 2017-06-21 Hoffmann La Roche Combinaciones de un compuesto inhibidor de fosfoinosítido 3-cinasa y un compuesto inhibidor de cdk4/6 para el tratamiento del cáncer
RU2747228C2 (ru) 2015-04-29 2021-04-29 Радиус Фармасьютикалз, Инк. Способы лечения рака

Also Published As

Publication number Publication date
JP2024120996A (ja) 2024-09-05
RU2017140674A3 (zh) 2019-09-27
JP6926065B2 (ja) 2021-08-25
IL310069A (en) 2024-03-01
EP3288382A4 (en) 2019-01-30
US20240099996A1 (en) 2024-03-28
JP2018518529A (ja) 2018-07-12
JP7262508B2 (ja) 2023-04-21
US20220339126A1 (en) 2022-10-27
MX2017013801A (es) 2018-08-15
JP2023052631A (ja) 2023-04-11
RU2737496C2 (ru) 2020-12-01
IL307981A (en) 2023-12-01
IL255148A0 (en) 2017-12-31
MX2017013794A (es) 2018-08-15
JP2018514549A (ja) 2018-06-07
IL255189B2 (en) 2024-04-01
MX2021005561A (es) 2022-07-01
IL307983A (en) 2023-12-01
JP7516472B2 (ja) 2024-07-16
US20220110890A1 (en) 2022-04-14
KR20180011780A (ko) 2018-02-02
CA2984195A1 (en) 2016-11-03
HK1251407A1 (zh) 2019-02-01
WO2016176665A1 (en) 2016-11-03
CN108135177B (zh) 2021-06-01
US20200038343A1 (en) 2020-02-06
MX2021003389A (es) 2021-05-28
CN108024540A (zh) 2018-05-11
US20240091177A1 (en) 2024-03-21
EP3288383A1 (en) 2018-03-07
KR20180042155A (ko) 2018-04-25
US20200368183A1 (en) 2020-11-26
IL297369B2 (en) 2024-06-01
CN108024541A (zh) 2018-05-11
AU2016256470A1 (en) 2017-12-14
US20180214393A1 (en) 2018-08-02
US11819480B2 (en) 2023-11-21
IL255189B1 (en) 2023-12-01
KR102676705B1 (ko) 2024-06-18
HK1251409A1 (zh) 2019-02-01
AU2016256471B2 (en) 2020-09-10
JP2022172039A (ja) 2022-11-14
KR20180043202A (ko) 2018-04-27
KR102682763B1 (ko) 2024-07-05
RU2745678C2 (ru) 2021-03-30
SG11201708861VA (en) 2017-11-29
MX2017013802A (es) 2018-08-15
AU2016256469A1 (en) 2017-12-14
IL255148B2 (en) 2023-04-01
IL255148B (en) 2022-12-01
MX2021004881A (es) 2021-07-21
US20180153828A1 (en) 2018-06-07
RU2017140675A3 (zh) 2019-09-27
JP2021102640A (ja) 2021-07-15
BR112017023233A2 (pt) 2018-11-06
KR20240095372A (ko) 2024-06-25
CA2984200A1 (en) 2016-11-03
CA2984357A1 (en) 2016-11-03
HK1251408A1 (zh) 2019-02-01
US20200046655A1 (en) 2020-02-13
EP3294065A1 (en) 2018-03-21
EP3288382A1 (en) 2018-03-07
EP4039253A1 (en) 2022-08-10
JP6926066B2 (ja) 2021-08-25
CN108024541B (zh) 2021-07-20
KR20240110098A (ko) 2024-07-12
IL255261B1 (en) 2023-11-01
AU2016256470B2 (en) 2020-10-15
AU2016256469A8 (en) 2017-12-21
IL255261B2 (en) 2024-03-01
KR20240097966A (ko) 2024-06-27
CN113288887A (zh) 2021-08-24
RU2747228C2 (ru) 2021-04-29
BR112017023269A2 (pt) 2018-11-06
CN108135177A (zh) 2018-06-08
WO2016176666A1 (en) 2016-11-03
CA2984195C (en) 2023-10-24
US20180169101A1 (en) 2018-06-21
RU2017140676A (ru) 2019-05-29
SG10202104177VA (en) 2021-05-28
WO2016176664A1 (en) 2016-11-03
CN108024540B (zh) 2021-09-17
EP3294065A4 (en) 2019-03-20
CA2984200C (en) 2024-03-19
IL255261A0 (en) 2017-12-31
RU2017140676A3 (zh) 2019-09-27
IL297369A (en) 2022-12-01
EP3288383A4 (en) 2019-01-23
AU2016256471A1 (en) 2017-12-21
JP2021105064A (ja) 2021-07-26
IL255189A0 (en) 2017-12-31
BR112017023228A2 (pt) 2018-11-06
CN113750091A (zh) 2021-12-07
RU2017140674A (ru) 2019-05-29
RU2017140675A (ru) 2019-05-29
IL297369B1 (en) 2024-02-01
JP2018514593A (ja) 2018-06-07
JP7019422B2 (ja) 2022-02-15
JP7146992B2 (ja) 2022-10-04
AU2016256469B2 (en) 2020-12-10
US11413258B2 (en) 2022-08-16
SG11201708860SA (en) 2017-11-29
KR102676629B1 (ko) 2024-06-18

Similar Documents

Publication Publication Date Title
HK1251409A1 (zh) 治療癌症的方法
ZA201804227B (en) Methods of treating cancer
HK1258098A1 (zh) 治療癌症的方法
IL275663A (en) Cancer treatment methods
SG10201801562PA (en) Combination method for treatment of cancer
HK1254258A1 (zh) 使用阿吡莫德治療癌症的方法
IL262342A (en) Cancer treatment methods
HK1250944A1 (zh) 用於治療癌症的方法
EP3325006A4 (en) METHOD FOR TREATING CD166-EXPRESSIVE CANCER
EP3119390A4 (en) Methods of treating cancer
IL263835A (en) Exosome-guided treatment of cancer
HK1250942A1 (zh) 用於治療癌症的方法
HK1250943A1 (zh) 用於治療癌症的方法
GB201408297D0 (en) Treatment of cancer
SG11202005163PA (en) Methods of treating cancer
IL269123A (en) Methods of treating cancer
EP3389670A4 (en) METHODS OF TREATING BREAST CANCER
GB201417456D0 (en) Treatment of cancer
GB201622214D0 (en) treatment of cancer
GB201512723D0 (en) Treatment of cancer
GB201604621D0 (en) Treatment of cancer
GB201604293D0 (en) Treatment of cancer
GB201507928D0 (en) Treatment of cancer
GB201504617D0 (en) Treatment of cancer
GB201409362D0 (en) Treatment of cancer