JOP20210137A1 - طرق علاج سرطان مقاومة لمثبطات cdk4/6 - Google Patents

طرق علاج سرطان مقاومة لمثبطات cdk4/6

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Publication number
JOP20210137A1
JOP20210137A1 JOP/2021/0137A JOP20210137A JOP20210137A1 JO P20210137 A1 JOP20210137 A1 JO P20210137A1 JO P20210137 A JOP20210137 A JO P20210137A JO P20210137 A1 JOP20210137 A1 JO P20210137A1
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Jordan
Prior art keywords
estrogen receptor
receptor alpha
cdk4
cancer
methods
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JOP/2021/0137A
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English (en)
Inventor
Heike Arlt
Hitisha Patel
Teeru Bihani
Nianjun Tao
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Radius Pharmaceuticals Inc
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Publication date
Application filed by Radius Pharmaceuticals Inc filed Critical Radius Pharmaceuticals Inc
Publication of JOP20210137A1 publication Critical patent/JOP20210137A1/ar

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    • AHUMAN NECESSITIES
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    • A61K31/01Hydrocarbons
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
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    • A61K31/137Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41961,2,4-Triazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/566Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol having an oxo group in position 17, e.g. estrone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
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    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C12Q2600/00Oligonucleotides characterized by their use
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    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12Q2600/00Oligonucleotides characterized by their use
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
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  • Organic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
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  • Wood Science & Technology (AREA)
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  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
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  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

تم الكشف هنا عن طرق معالجة سرطان إيجابي ألفا لمستقبلات هرمون الاستروجين المقاوم لمثبط CDK4/6 في مريض له إما مستقبلات استروجين من النوع البري ألفا و/أو مستقبلات استروجين متحولة ألفا، وهي طريقة تشتمل على إعطاء المريض كمية فعالة علاجيًا من إيلاسيسترانت، أو ملح مقبول صيدلانيًا أو مذيب منه، حيث يشتمل مستقبل الأستروجين الطافر ألفا على طفرة واحدة أو أكثر تم اختيارها من المجموعة التي تتكون من D538G، Y537X 1، L536X 2، P535H، V534E، S463P، V392I، E380Q وتوليفات منها، حيث: X 1 هو S أو N أو C؛ وX 2 هو R أو Q. في بعض النماذج، يتم اختيار سرطان إيجابي ألفا لمستقبلات الاستروجين المقاوم لمستقبلات CDK4/6 من المجموعة التي تتكون من سرطان الثدي وسرطان الرحم وسرطان المبيض وسرطان الغدة النخامية.
JOP/2021/0137A 2018-12-06 2019-12-06 طرق علاج سرطان مقاومة لمثبطات cdk4/6 JOP20210137A1 (ar)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862776323P 2018-12-06 2018-12-06
PCT/US2019/065005 WO2020118213A1 (en) 2018-12-06 2019-12-06 Methods for treating cancer resistant to cdk4/6 inhibitors

Publications (1)

Publication Number Publication Date
JOP20210137A1 true JOP20210137A1 (ar) 2023-01-30

Family

ID=69063871

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2021/0137A JOP20210137A1 (ar) 2018-12-06 2019-12-06 طرق علاج سرطان مقاومة لمثبطات cdk4/6

Country Status (15)

Country Link
US (1) US20210330612A1 (ar)
EP (1) EP3890834A1 (ar)
JP (1) JP2022511498A (ar)
KR (1) KR20210100137A (ar)
CN (1) CN113164779A (ar)
AU (1) AU2019395093A1 (ar)
BR (1) BR112021010110A2 (ar)
CA (1) CA3121930A1 (ar)
EA (1) EA202191283A1 (ar)
IL (1) IL283659A (ar)
JO (1) JOP20210137A1 (ar)
MA (1) MA54388A (ar)
MX (1) MX2021006411A (ar)
SG (1) SG11202105531XA (ar)
WO (1) WO2020118213A1 (ar)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116744925A (zh) * 2020-12-14 2023-09-12 阿尔维纳斯运营股份有限公司 用四氢萘衍生物作为雌激素受体降解剂治疗乳腺癌的方法
GB202116745D0 (en) * 2021-11-19 2022-01-05 Institute Of Cancer Res Royal Cancer Hospital Prognostic and treatment response predictive method
CN115369089A (zh) * 2022-08-11 2022-11-22 中山大学孙逸仙纪念医院 两种er阳性her-2阴性乳腺癌cdk4/6抑制剂耐药株及其构建方法和用途

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7019422B2 (ja) * 2015-04-29 2022-02-15 ラジウス ファーマシューティカルズ,インコーポレイテッド 癌を治療するための方法
KR102557321B1 (ko) * 2017-01-05 2023-07-18 래디어스 파마슈티컬스, 인코포레이티드 Rad1901-2hcl의 다형 형태

Also Published As

Publication number Publication date
MA54388A (fr) 2021-10-13
EP3890834A1 (en) 2021-10-13
KR20210100137A (ko) 2021-08-13
US20210330612A1 (en) 2021-10-28
IL283659A (en) 2021-07-29
BR112021010110A2 (pt) 2021-08-24
CN113164779A (zh) 2021-07-23
EA202191283A1 (ru) 2021-10-13
SG11202105531XA (en) 2021-06-29
JP2022511498A (ja) 2022-01-31
MX2021006411A (es) 2021-07-21
WO2020118213A1 (en) 2020-06-11
AU2019395093A1 (en) 2021-06-24
CA3121930A1 (en) 2020-06-11

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