MX2021006575A - Composiciones y metodos para el tratamiento de trastornos del higado. - Google Patents

Composiciones y metodos para el tratamiento de trastornos del higado.

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Publication number
MX2021006575A
MX2021006575A MX2021006575A MX2021006575A MX2021006575A MX 2021006575 A MX2021006575 A MX 2021006575A MX 2021006575 A MX2021006575 A MX 2021006575A MX 2021006575 A MX2021006575 A MX 2021006575A MX 2021006575 A MX2021006575 A MX 2021006575A
Authority
MX
Mexico
Prior art keywords
compositions
treatment
methods
liver disorders
fatty liver
Prior art date
Application number
MX2021006575A
Other languages
English (en)
Inventor
Brian Lian
Hiroko Masamune
Original Assignee
Viking Therapeutics Inc
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Filing date
Publication date
Application filed by Viking Therapeutics Inc filed Critical Viking Therapeutics Inc
Publication of MX2021006575A publication Critical patent/MX2021006575A/es

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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
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    • A61K31/66—Phosphorus compounds
    • A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
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    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
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    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
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    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente divulgación está dirigida al uso de agonistas del receptor tiroideo de sales farmacéuticamente aceptables de los mismos, en combinación con un segundo agente farmacéutico para prevenir, tratar o atenuar enfermedades del hígado graso tales como esteatosis, enfermedad del hígado graso no alcohólico y esteatohepatitis no alcohólica.
MX2021006575A 2018-12-05 2019-12-04 Composiciones y metodos para el tratamiento de trastornos del higado. MX2021006575A (es)

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PCT/US2019/064548 WO2020117987A1 (en) 2018-12-05 2019-12-04 Compositions and methods for the treatment of liver disorders

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MX2007014502A (es) 2005-05-26 2008-02-07 Metabasis Therapeutics Inc Tiromimeticos para el tratamiento de enfermedades del higado graso.
JP2020500199A (ja) 2016-11-21 2020-01-09 バイキング・セラピューティクス・インコーポレイテッド グリコーゲン蓄積症の治療方法
EA201992703A1 (ru) 2017-06-05 2020-04-15 Вайкинг Терапьютикс, Инк. Композиции для лечения фиброза
CN112135832A (zh) 2018-03-22 2020-12-25 维京治疗公司 化合物的晶型和制备化合物的晶型的方法
CN112707892A (zh) * 2019-10-24 2021-04-27 苏州泽璟生物制药股份有限公司 哒嗪酮或哒嗪类化合物及其衍生物和药物组合物
US11752161B2 (en) 2020-03-27 2023-09-12 Gannex Pharma Co., Ltd. Pharmaceutical compositions, method of making and method of using thereof
US20230226038A1 (en) * 2020-06-09 2023-07-20 Viking Therapeutics, Inc. Compositions and methods for the treatment of liver disorders
WO2021259309A1 (zh) * 2020-06-24 2021-12-30 广州市恒诺康医药科技有限公司 Glp-1受体激动剂及其药物组合物和用途
CN111793066B (zh) * 2020-07-17 2022-04-08 瀚海新拓(杭州)生物医药有限公司 苯并五元杂环磺酰胺类化合物、其制备方法、药物组合物及应用
WO2023169456A1 (en) 2022-03-09 2023-09-14 Gasherbrum Bio , Inc. Heterocyclic glp-1 agonists
WO2023198140A1 (en) 2022-04-14 2023-10-19 Gasherbrum Bio, Inc. Heterocyclic glp-1 agonists

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JP2007512359A (ja) * 2003-11-19 2007-05-17 メタバシス・セラピューティクス・インコーポレイテッド 新規なリン含有甲状腺ホルモン様物質
MX2007014502A (es) * 2005-05-26 2008-02-07 Metabasis Therapeutics Inc Tiromimeticos para el tratamiento de enfermedades del higado graso.
EA024697B1 (ru) * 2009-04-27 2016-10-31 Иммурон Лимитед Применение композиции, содержащей обогащенный анти-lps-антителами иммуноглобулиновый препарат, для лечения заболеваний печени
WO2011038207A1 (en) * 2009-09-25 2011-03-31 Metabasis Therapeutics, Inc. Phosphorus-containing thyroid hormone receptor agonists and methods of use
HUE038437T2 (hu) * 2012-05-02 2018-10-29 Boehringer Ingelheim Int Az SSAO szubsztituált 3-halogén-allil-amin inhibitorai és ezek alkalmazásai
EP3612176A1 (en) * 2017-04-18 2020-02-26 Genfit Combination comprising a ppar agonist such as elafibranor and an acetyl-coa carboxylase (acc) inhibitor

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JP2022510690A (ja) 2022-01-27
CA3121620A1 (en) 2020-06-11
WO2020117987A1 (en) 2020-06-11
US20220016136A1 (en) 2022-01-20
BR112021010916A2 (pt) 2021-08-24
EP3890748A4 (en) 2022-12-21
EP3890748A1 (en) 2021-10-13
CN113365637A (zh) 2021-09-07
KR20210099612A (ko) 2021-08-12

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