MX2021008010A - Composiciones y métodos para tratar las enfermedades del hígado graso no alcohólico (nafld). - Google Patents
Composiciones y métodos para tratar las enfermedades del hígado graso no alcohólico (nafld).Info
- Publication number
- MX2021008010A MX2021008010A MX2021008010A MX2021008010A MX2021008010A MX 2021008010 A MX2021008010 A MX 2021008010A MX 2021008010 A MX2021008010 A MX 2021008010A MX 2021008010 A MX2021008010 A MX 2021008010A MX 2021008010 A MX2021008010 A MX 2021008010A
- Authority
- MX
- Mexico
- Prior art keywords
- methods
- nafld
- fatty liver
- liver diseases
- alcoholic fatty
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
Se proporcionan en la presente métodos y tratamientos conjuntos útiles para el tratamiento de enfermedades del hígado graso no alcohólico (NAFLD). En particular, se proporcionan en la presente métodos y tratamientos conjuntos para tratar NAFLD mediante la administración de un tratamiento conjunto que comprende (a) el compuesto de la Fórmula (I), o una sal o un solvato aceptable desde el punto de vista farmacéutico de este, y (b) un inhibidor de SGLT-2, o una sal o un solvato aceptable desde el punto de vista farmacéutico de este, y/o (c) un agonista del receptor de GLP-1, o una sal o un solvato aceptable desde el punto de vista farmacéutico de este, y/o (d) metformina. También se proporcionan composiciones farmacéuticas y combinaciones farmacéuticas que comprenden el compuesto de la Fórmula (I) y un inhibidor de SGLT-2 y/o un agonista del receptor de GLP-1 y/o metformina.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862786618P | 2018-12-31 | 2018-12-31 | |
US201962827349P | 2019-04-01 | 2019-04-01 | |
PCT/US2019/068710 WO2020142365A1 (en) | 2018-12-31 | 2019-12-27 | Compositions and methods to treat non-alcoholic fatty liver diseases (nafld) |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2021008010A true MX2021008010A (es) | 2021-10-13 |
Family
ID=69188008
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2021008010A MX2021008010A (es) | 2018-12-31 | 2019-12-27 | Composiciones y métodos para tratar las enfermedades del hígado graso no alcohólico (nafld). |
Country Status (8)
Country | Link |
---|---|
US (1) | US20220143003A1 (es) |
EP (1) | EP3906022A1 (es) |
JP (1) | JP2022516509A (es) |
AU (1) | AU2019419390A1 (es) |
CA (1) | CA3125341A1 (es) |
IL (1) | IL284345A (es) |
MX (1) | MX2021008010A (es) |
WO (1) | WO2020142365A1 (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2016229982B2 (en) | 2015-03-09 | 2020-06-18 | Intekrin Therapeutics, Inc. | Methods for the treatment of nonalcoholic fatty liver disease and/or lipodystrophy |
MX2019011867A (es) | 2017-04-03 | 2020-01-09 | Coherus Biosciences Inc | Agonista de ppary para el tratamiento de la paralisis supranuclear progresiva. |
EP4045042A1 (en) * | 2019-10-15 | 2022-08-24 | Coherus Biosciences, Inc. | Compositions and methods to treat non-alcoholic fatty liver diseases (nafld) |
WO2022051316A1 (en) * | 2020-09-03 | 2022-03-10 | Coherus Biosciences, Inc. | Fixed dose combinations of chs-131 and a sglt-2 inhibitor |
WO2022051319A1 (en) * | 2020-09-03 | 2022-03-10 | Coherus Biosciences, Inc. | Fixed dose combinations of chs-131 and a dpp-4 inhibitor |
WO2022051321A1 (en) * | 2020-09-03 | 2022-03-10 | Coherus Biosciences, Inc. | Fixed dose combinations of chs-131 and a fxr agonist |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6583157B2 (en) | 1998-01-29 | 2003-06-24 | Tularik Inc. | Quinolinyl and benzothiazolyl modulators |
ATE413386T1 (de) | 1998-01-29 | 2008-11-15 | Amgen Inc | Ppar-gamma modulatoren |
US7041691B1 (en) | 1999-06-30 | 2006-05-09 | Amgen Inc. | Compounds for the modulation of PPARγ activity |
AU6118001A (en) | 2000-05-03 | 2001-11-12 | Tularik Inc | Combination therapeutic compositions and methods of use |
US7223761B2 (en) | 2003-10-03 | 2007-05-29 | Amgen Inc. | Salts and polymorphs of a potent antidiabetic compound |
US20050215882A1 (en) | 2004-03-23 | 2005-09-29 | The Regents Of The University Of Michigan | Noninvasive method to determine fat content of tissues using MRI |
JP5010918B2 (ja) * | 2004-07-21 | 2012-08-29 | キッセイ薬品工業株式会社 | 肝臓脂肪の異常蓄積に起因する疾患の進展抑制剤 |
MX2016011063A (es) | 2014-02-27 | 2016-11-30 | Nusirt Sciences Inc | Composiciones y metodos para la reduccion o prevencion de esteatosis hepatica. |
CN104299589B (zh) | 2014-10-29 | 2016-05-25 | 京东方科技集团股份有限公司 | 移位寄存器单元电路、移位寄存器、驱动方法及显示装置 |
KR20160061492A (ko) | 2014-11-21 | 2016-06-01 | 삼성디스플레이 주식회사 | 휴대용 먼지 센서 및 이를 이용한 휴대전화 |
AU2016229982B2 (en) * | 2015-03-09 | 2020-06-18 | Intekrin Therapeutics, Inc. | Methods for the treatment of nonalcoholic fatty liver disease and/or lipodystrophy |
US11350844B2 (en) | 2016-11-23 | 2022-06-07 | Mayo Foundation For Medical Education And Research | System and method for generating nonalcoholic fatty liver disease activity score (NAS) using magnetic resonance elastography |
EP3569250A4 (en) * | 2017-01-11 | 2020-11-04 | Kowa Company, Ltd. | MEDICINAL PRODUCT FOR THE PREVENTION AND TREATMENT OF NON-ALCOHOLIC HEPATIC STEATOSIS |
-
2019
- 2019-12-27 JP JP2021538209A patent/JP2022516509A/ja active Pending
- 2019-12-27 AU AU2019419390A patent/AU2019419390A1/en not_active Abandoned
- 2019-12-27 WO PCT/US2019/068710 patent/WO2020142365A1/en unknown
- 2019-12-27 MX MX2021008010A patent/MX2021008010A/es unknown
- 2019-12-27 EP EP19842553.0A patent/EP3906022A1/en active Pending
- 2019-12-27 US US17/419,559 patent/US20220143003A1/en active Pending
- 2019-12-27 CA CA3125341A patent/CA3125341A1/en active Pending
-
2021
- 2021-06-24 IL IL284345A patent/IL284345A/en unknown
Also Published As
Publication number | Publication date |
---|---|
US20220143003A1 (en) | 2022-05-12 |
IL284345A (en) | 2021-08-31 |
AU2019419390A1 (en) | 2021-09-02 |
EP3906022A1 (en) | 2021-11-10 |
WO2020142365A1 (en) | 2020-07-09 |
CA3125341A1 (en) | 2020-07-09 |
WO2020142365A9 (en) | 2020-12-10 |
JP2022516509A (ja) | 2022-02-28 |
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