SG11201606577YA - TARGETED TGFβ INHIBITION - Google Patents

TARGETED TGFβ INHIBITION

Info

Publication number
SG11201606577YA
SG11201606577YA SG11201606577YA SG11201606577YA SG11201606577YA SG 11201606577Y A SG11201606577Y A SG 11201606577YA SG 11201606577Y A SG11201606577Y A SG 11201606577YA SG 11201606577Y A SG11201606577Y A SG 11201606577YA SG 11201606577Y A SG11201606577Y A SG 11201606577YA
Authority
SG
Singapore
Prior art keywords
tgfβ inhibition
targeted
targeted tgfβ
inhibition
tgfβ
Prior art date
Application number
SG11201606577YA
Other languages
English (en)
Inventor
Kin-Ming Lo
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of SG11201606577YA publication Critical patent/SG11201606577YA/en

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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/495—Transforming growth factor [TGF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70532—B7 molecules, e.g. CD80, CD86
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Neurology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Biomedical Technology (AREA)
  • Reproductive Health (AREA)
SG11201606577YA 2014-02-10 2015-02-10 TARGETED TGFβ INHIBITION SG11201606577YA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461938048P 2014-02-10 2014-02-10
PCT/EP2015/052781 WO2015118175A2 (en) 2014-02-10 2015-02-10 TARGETED TGFβ INHIBITION

Publications (1)

Publication Number Publication Date
SG11201606577YA true SG11201606577YA (en) 2016-09-29

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Application Number Title Priority Date Filing Date
SG11201606577YA SG11201606577YA (en) 2014-02-10 2015-02-10 TARGETED TGFβ INHIBITION
SG10202108879SA SG10202108879SA (en) 2014-02-10 2015-02-10 TARGETED TGFβ INHIBITION

Family Applications After (1)

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SG10202108879SA SG10202108879SA (en) 2014-02-10 2015-02-10 TARGETED TGFβ INHIBITION

Country Status (28)

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US (4) US9676863B2 (enExample)
EP (2) EP3105246B1 (enExample)
JP (2) JP6731346B2 (enExample)
KR (1) KR102363008B1 (enExample)
CN (2) CN106103488B (enExample)
AU (3) AU2015213988B2 (enExample)
BR (1) BR112016014952A2 (enExample)
CA (1) CA2934979A1 (enExample)
CL (1) CL2016002017A1 (enExample)
CY (1) CY1124408T1 (enExample)
DK (2) DK3889172T3 (enExample)
ES (2) ES2876430T3 (enExample)
HR (1) HRP20210977T1 (enExample)
HU (1) HUE054873T2 (enExample)
IL (2) IL246968B (enExample)
LT (1) LT3105246T (enExample)
MX (2) MX381141B (enExample)
NZ (1) NZ721364A (enExample)
PE (2) PE20161096A1 (enExample)
PH (1) PH12016501549A1 (enExample)
PL (1) PL3105246T3 (enExample)
PT (1) PT3105246T (enExample)
RS (1) RS62038B1 (enExample)
RU (2) RU2021114500A (enExample)
SG (2) SG11201606577YA (enExample)
SI (1) SI3105246T1 (enExample)
SM (1) SMT202100542T1 (enExample)
WO (1) WO2015118175A2 (enExample)

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HUE054873T2 (hu) 2021-10-28
US20230056881A1 (en) 2023-02-23
US11370819B2 (en) 2022-06-28
EP3105246B1 (en) 2021-03-31
RU2752424C2 (ru) 2021-07-28
AU2022200365A1 (en) 2022-02-17
CY1124408T1 (el) 2022-07-22
CA2934979A1 (en) 2015-08-13
PE20161096A1 (es) 2016-10-22
PT3105246T (pt) 2021-06-28
PL3105246T3 (pl) 2021-11-29
IL281565B (en) 2021-12-01
ES2992668T3 (en) 2024-12-16
IL246968A0 (en) 2016-09-29
US20200055949A1 (en) 2020-02-20
CN113549159A (zh) 2021-10-26
LT3105246T (lt) 2021-08-25
KR20160119197A (ko) 2016-10-12
AU2019246876A1 (en) 2019-10-31
JP2017506217A (ja) 2017-03-02
AU2015213988A1 (en) 2016-07-07
DK3105246T3 (da) 2021-06-14
AU2015213988B2 (en) 2019-07-11
JP2020174674A (ja) 2020-10-29
CN106103488A (zh) 2016-11-09
SMT202100542T1 (it) 2021-11-12
IL281565A (en) 2021-05-31
HRP20210977T1 (hr) 2021-09-17
NZ721364A (en) 2023-04-28
SI3105246T1 (sl) 2021-11-30
AU2019246876B2 (en) 2021-10-21
CN106103488B (zh) 2021-07-30
DK3889172T3 (da) 2024-06-17
PH12016501549A1 (en) 2016-10-03
KR102363008B1 (ko) 2022-02-16
MX2016010067A (es) 2016-10-07
EP3889172A1 (en) 2021-10-06
EP3889172B1 (en) 2024-05-01
WO2015118175A3 (en) 2015-10-08
PE20210168A1 (es) 2021-01-28
EP3105246A2 (en) 2016-12-21
RS62038B1 (sr) 2021-07-30
CL2016002017A1 (es) 2017-06-09
RU2021114500A (ru) 2021-06-07
BR112016014952A2 (pt) 2017-09-19
US9676863B2 (en) 2017-06-13
MX381141B (es) 2025-03-12

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