SG10201912910PA - Delivery of materials to anucleate cells - Google Patents

Delivery of materials to anucleate cells

Info

Publication number
SG10201912910PA
SG10201912910PA SG10201912910PA SG10201912910PA SG10201912910PA SG 10201912910P A SG10201912910P A SG 10201912910PA SG 10201912910P A SG10201912910P A SG 10201912910PA SG 10201912910P A SG10201912910P A SG 10201912910PA SG 10201912910P A SG10201912910P A SG 10201912910PA
Authority
SG
Singapore
Prior art keywords
delivery
materials
anucleate cells
anucleate
cells
Prior art date
Application number
SG10201912910PA
Other languages
English (en)
Inventor
Armon Sharei
Klavs Jensen
James Abshire
Jacquin Niles
Original Assignee
Massachusetts Inst Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Inst Technology filed Critical Massachusetts Inst Technology
Publication of SG10201912910PA publication Critical patent/SG10201912910PA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00Constructional details, e.g. recesses, hinges
    • C12M23/02Form or structure of the vessel
    • C12M23/16Microfluidic devices; Capillary tubes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14Blood; Artificial blood
    • A61K35/18Erythrocytes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/02Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06Antimalarials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06Antianaemics
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M35/00Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
    • C12M35/04Mechanical means, e.g. sonic waves, stretching forces, pressure or shear stimuli
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/87Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0634Cells from the blood or the immune system
    • C12N5/0641Erythrocytes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0634Cells from the blood or the immune system
    • C12N5/0644Platelets; Megakaryocytes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2521/00Culture process characterised by the use of hydrostatic pressure, flow or shear forces
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2527/00Culture process characterised by the use of mechanical forces, e.g. strain, vibration
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Sustainable Development (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Dispersion Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Mechanical Engineering (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Diabetes (AREA)
  • Medicinal Preparation (AREA)
SG10201912910PA 2015-07-09 2016-07-08 Delivery of materials to anucleate cells SG10201912910PA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201562190677P 2015-07-09 2015-07-09

Publications (1)

Publication Number Publication Date
SG10201912910PA true SG10201912910PA (en) 2020-02-27

Family

ID=57685865

Family Applications (1)

Application Number Title Priority Date Filing Date
SG10201912910PA SG10201912910PA (en) 2015-07-09 2016-07-08 Delivery of materials to anucleate cells

Country Status (8)

Country Link
US (2) US11299698B2 (fr)
EP (2) EP3320082B1 (fr)
JP (2) JP6925984B2 (fr)
CN (1) CN107922911A (fr)
AU (2) AU2016289530B2 (fr)
CA (1) CA2988996A1 (fr)
SG (1) SG10201912910PA (fr)
WO (1) WO2017008063A1 (fr)

Families Citing this family (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2012326203B2 (en) * 2011-10-17 2017-11-30 Massachusetts Institute Of Technology Intracellular delivery
CA2921579C (fr) 2013-08-16 2021-09-21 Massachusetts Institute Of Technology Administration selective de materiau a des cellules
CA2964392A1 (fr) 2014-10-31 2016-05-06 Massachussetts Institute Of Technology Administration de biomolecules en direction de cellules du systeme immunitaire
CN113897285A (zh) 2014-11-14 2022-01-07 麻省理工学院 化合物和组合物向细胞中的破坏和场实现的递送
JP7278027B2 (ja) 2015-01-12 2023-05-19 マサチューセッツ インスティテュート オブ テクノロジー マイクロ流体送達による遺伝子編集
AU2016289530B2 (en) 2015-07-09 2021-05-06 Massachusetts Institute Of Technology Delivery of materials to anucleate cells
WO2017041051A1 (fr) 2015-09-04 2017-03-09 Sqz Biotechnologies Company Administration intracellulaire de biomolécules à des cellules comprenant une paroi cellulaire
WO2017173373A1 (fr) 2016-03-31 2017-10-05 Massachusetts Institute Of Technology Procédés et dispositifs microfluidiques à écoulement traversant présentant des interactions de surface de perturbation de membrane pour une administration intracellulaire
KR102430856B1 (ko) * 2016-05-03 2022-08-08 에스큐지 바이오테크놀로지스 컴퍼니 관용을 유도하는 생체분자의 세포내 전달
US11999931B2 (en) 2016-08-20 2024-06-04 The Regents Of The University Of California High-throughput system and method for the temporary permeabilization of cells
MX2019012845A (es) 2017-04-28 2019-11-28 Agrospheres Inc Composiciones y metodos para encapsular y administrar agroquimicos de forma escalable.
EP3615082A4 (fr) 2017-04-28 2021-05-26 Agrospheres, Inc. Compositions et procédés d'immobilisation d'enzyme
WO2019060903A1 (fr) 2017-09-25 2019-03-28 Agrospheres, Inc. Compositions et procédés de production et d'administration évolutive de produits biologiques
AU2018368786A1 (en) 2017-11-17 2020-06-18 Iovance Biotherapeutics, Inc. TIL expansion from fine needle aspirates and small biopsies
JP2021503885A (ja) 2017-11-22 2021-02-15 アイオバンス バイオセラピューティクス,インコーポレイテッド 末梢血からの末梢血リンパ球(pbl)の拡大培養
US11365390B2 (en) 2017-12-19 2022-06-21 Xcell Biosciences, Inc. Methods of modulating cell phenotype by way of regulating the gaseous environment
EP3728555A1 (fr) * 2017-12-21 2020-10-28 Politecnico di Milano Érythrocytes pour l'administration de médicament
US11713446B2 (en) 2018-01-08 2023-08-01 Iovance Biotherapeutics, Inc. Processes for generating TIL products enriched for tumor antigen-specific T-cells
TW201938177A (zh) 2018-01-08 2019-10-01 美商艾歐凡斯生物治療公司 產生富含腫瘤抗原特異性t細胞的腫瘤浸潤淋巴球(til)產物之方法
WO2019136459A1 (fr) 2018-01-08 2019-07-11 Iovance Biotherapeutics, Inc. Procédés de génération de produits de til enrichis pour des lymphocytes t spécifiques d'un antigène tumoral
CN109239406B (zh) * 2018-10-08 2020-03-31 西安交通大学 一种用于细胞器药物定位投递检测装置及投药检测方法
MX2021004775A (es) 2018-11-05 2021-06-08 Iovance Biotherapeutics Inc Expansion de linfocitos infiltrantes de tumores (tils) usando inhibidores de la via de proteina cinasa b (akt).
SG11202104630PA (en) 2018-11-05 2021-06-29 Iovance Biotherapeutics Inc Selection of improved tumor reactive t-cells
BR112021008573A2 (pt) 2018-11-05 2021-10-26 Iovance Biotherapeutics, Inc. Métodos para expandir linfócitos infiltrantes de tumor em uma população terapêutica de linfócitos infiltrantes de tumor, para tratar um sujeito com câncer e de expansão de células t, população terapêutica de linfócitos infiltrantes de tumor, composição de linfócitos infiltrantes de tumor, saco de infusão estéril, preparação criopreservada, e, uso da composição de linfócitos infiltrantes de tumor.
SG11202104663PA (en) 2018-11-05 2021-06-29 Iovance Biotherapeutics Inc Treatment of nsclc patients refractory for anti-pd-1 antibody
WO2020099592A1 (fr) 2018-11-15 2020-05-22 Erytech Pharma Combinaisons synergiques d'agents de déplétion de méthionine et de modulateurs de points de contrôle immunitaires
US20220193131A1 (en) 2018-12-19 2022-06-23 Iovance Biotherapeutics, Inc. Methods of Expanding Tumor Infiltrating Lymphocytes Using Engineered Cytokine Receptor Pairs and Uses Thereof
CA3131701A1 (fr) 2019-02-28 2020-09-03 Sqz Biotechnologies Company Administration de biomolecules a des pbmc pour modifier une reponse immunitaire
JP2022522473A (ja) 2019-03-01 2022-04-19 アイオバンス バイオセラピューティクス,インコーポレイテッド 液性腫瘍からの腫瘍浸潤リンパ球の拡大培養及びその治療的使用
AU2020271040A1 (en) 2019-04-08 2021-11-18 Sqz Biotechnologies Company Cartridge for use in a system for delivery of a payload into a cell
WO2020207456A1 (fr) * 2019-04-11 2020-10-15 The Chinese University Of Hong Kong Systèmes et procédés de rupture de membrane contrôlée
US20220249559A1 (en) 2019-05-13 2022-08-11 Iovance Biotherapeutics, Inc. Methods and compositions for selecting tumor infiltrating lymphocytes and uses of the same in immunotherapy
IT201900009831A1 (it) * 2019-06-21 2020-12-21 Milano Politecnico Eritrociti per la veicolazione di farmaci
JP2023506734A (ja) 2019-12-11 2023-02-20 アイオバンス バイオセラピューティクス,インコーポレイテッド 腫瘍浸潤リンパ球(til)の産生のためのプロセス及びそれを使用する方法
WO2021226085A1 (fr) 2020-05-04 2021-11-11 Iovance Biotherapeutics, Inc. Sélection de lymphocytes t réactifs à une tumeur améliorés
JP2023523855A (ja) 2020-05-04 2023-06-07 アイオバンス バイオセラピューティクス,インコーポレイテッド 腫瘍浸潤リンパ球の製造方法及び免疫療法におけるその使用
BR112022022614A2 (pt) 2020-05-11 2023-02-07 Hoffmann La Roche Métodos para estimular uma resposta imune, melhorar uma imunoterapia, tratar uma doença, reduzir crescimento tumoral, produzir um imunoconjugado e produzir uma composição, método de vacinação, imunoconjugados, composição, usos e kits
EP4149440A1 (fr) 2020-05-11 2023-03-22 Erytech Pharma Vésicules extracellulaires de globules rouges (vecgr) contenant des cargos et procédés d'utilisation et de production de celles-ci
KR20230058389A (ko) 2020-07-29 2023-05-03 에스큐지 바이오테크놀로지스 컴퍼니 유핵 세포를 사용해 돌연변이체 ras에 대한 면역 반응을 자극하는 방법
JP2023535982A (ja) 2020-07-29 2023-08-22 スクイーズ バイオテクノロジーズ カンパニー 無核細胞を使用して変異型Rasに対する免疫応答を刺激する方法
WO2022076606A1 (fr) 2020-10-06 2022-04-14 Iovance Biotherapeutics, Inc. Traitement de patients souffrant de cpnpc avec des thérapies de lymphocytes infiltrant les tumeurs
CA3195019A1 (fr) 2020-10-06 2022-04-14 Maria Fardis Traitement de patients souffrant de cpnpc avec des therapies de lymphocytes infiltrant les tumeurs
EP4232554A1 (fr) 2020-11-18 2023-08-30 Cellfe, Inc. Procédés et systèmes pour la livraison de charges utiles dans des cellules biologiques par mécanoporation
WO2022125941A1 (fr) 2020-12-11 2022-06-16 Iovance Biotherapeutics, Inc. Traitement de patients atteints de cancer par des thérapies de lymphocytes infiltrant les tumeurs en combinaison avec des inhibiteurs de braf et/ou des inhibiteurs de mek
WO2022133140A1 (fr) 2020-12-17 2022-06-23 Iovance Biotherapeutics, Inc. Traitement avec des thérapies de lymphocytes infiltrant les tumeurs en combinaison avec des inhibiteurs de ctla-4 et de pd-1
WO2022133149A1 (fr) 2020-12-17 2022-06-23 Iovance Biotherapeutics, Inc. Traitement de cancers à l'aide de lymphocytes infiltrant les tumeurs
JP2024503279A (ja) 2020-12-29 2024-01-25 スクイーズ バイオテクノロジーズ カンパニー Pbmcの凍結保存のための製剤
WO2022147442A1 (fr) 2020-12-29 2022-07-07 Sqz Biotechnologies Company Formulations d'activation de porteurs d'antigène
EP4271711A1 (fr) 2020-12-29 2023-11-08 SQZ Biotechnologies Company Procédés pour le traitement de cancers avec des pbmc modifiées
WO2022147443A1 (fr) 2020-12-29 2022-07-07 Sqz Biotechnologies Company Méthodes de traitement de cancers par activation de porteurs d'antigène
WO2022165260A1 (fr) 2021-01-29 2022-08-04 Iovance Biotherapeutics, Inc. Procédés de fabrication de lymphocytes infiltrant les tumeurs modifiés et leur utilisation dans la thérapie cellulaire adoptive
US20240207318A1 (en) 2021-04-19 2024-06-27 Yongliang Zhang Chimeric costimulatory receptors, chemokine receptors, and the use of same in cellular immunotherapies
EP4373270A2 (fr) 2021-07-22 2024-05-29 Iovance Biotherapeutics, Inc. Procédé de cryoconservation de fragments de tumeur solide
EP4377446A1 (fr) 2021-07-28 2024-06-05 Iovance Biotherapeutics, Inc. Traitement de patients atteints d'un cancer avec des thérapies de lymphocytes infiltrant les tumeurs en combinaison avec des inhibiteurs de kras
EP4377447A1 (fr) 2021-07-29 2024-06-05 SQZ Biotechnologies Company Procédés pour générer des lymphocytes infiltrant les tumeurs améliorés par administration microfluidique
US20230187042A1 (en) 2021-10-27 2023-06-15 Iovance Biotherapeutics, Inc. Systems and methods for coordinating manufacturing of cells for patient-specific immunotherapy
WO2023086803A1 (fr) 2021-11-10 2023-05-19 Iovance Biotherapeutics, Inc. Procédés de traitement de multiplication utilisant des lymphocytes infiltrant les tumeurs cd8
WO2023087009A1 (fr) 2021-11-11 2023-05-19 Sqz Biotechnologies Company Procédés pour générer des lymphocytes infiltrant les tumeurs améliorés par administration microfluidique
WO2023147488A1 (fr) 2022-01-28 2023-08-03 Iovance Biotherapeutics, Inc. Compositions et procédés de lymphocytes infiltrant les tumeurs associés à la cytokine
WO2023147486A1 (fr) 2022-01-28 2023-08-03 Iovance Biotherapeutics, Inc. Lymphocytes infiltrant les tumeurs modifiés pour exprimer des charges utiles
CN114621979B (zh) * 2022-02-15 2024-04-09 北京大学 基于柔性可变截面微通道的细胞力学转染的方法和装置
WO2023196877A1 (fr) 2022-04-06 2023-10-12 Iovance Biotherapeutics, Inc. Traitement de patients souffrant de cpnpc avec des thérapies lymphocytaires infiltrant les tumeurs
WO2023201369A1 (fr) 2022-04-15 2023-10-19 Iovance Biotherapeutics, Inc. Processus d'expansion de til utilisant des combinaisons spécifiques de cytokine et/ou traitement akti
WO2023220608A1 (fr) 2022-05-10 2023-11-16 Iovance Biotherapeutics, Inc. Traitement de patients atteints d'un cancer avec des thérapies lymphocytaires infiltrant les tumeurs en combinaison avec un agoniste d'il-15r
WO2024026492A1 (fr) 2022-07-28 2024-02-01 Sqz Biotechnologies Company Méthodes de traitement du cancer avec des cellules présentatrices d'antigène améliorées
WO2024026491A2 (fr) 2022-07-28 2024-02-01 Sqz Biotechnologies Company Formulations de cellules présentatrices d'antigène améliorées
WO2024030758A1 (fr) 2022-08-01 2024-02-08 Iovance Biotherapeutics, Inc. Récepteurs de costimulation chimériques, récepteurs de chimiokines et leur utilisation dans des immunothérapies cellulaires
WO2024098024A1 (fr) 2022-11-04 2024-05-10 Iovance Biotherapeutics, Inc. Expansion de lymphocytes infiltrant les tumeurs à partir de tumeurs liquides et leurs utilisations thérapeutiques
WO2024112571A2 (fr) 2022-11-21 2024-05-30 Iovance Biotherapeutics, Inc. Procédés bidimensionnels pour l'expansion de lymphocytes infiltrant les tumeurs et thérapies associées
WO2024118836A1 (fr) 2022-11-30 2024-06-06 Iovance Biotherapeutics, Inc. Procédés de production de lymphocytes infiltrant les tumeurs à étape rep raccourcie

Family Cites Families (123)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2502621C3 (de) 1975-01-23 1978-09-14 Kernforschungsanlage Juelich Gmbh, 5170 Juelich Messung elastischer und dielektrischer Eigenschaften der Membran lebender Zellen
US4376634A (en) 1980-05-30 1983-03-15 Mallinckrodt, Inc. Assay kit having syringe, dilution device and reagents within sealed container
US4478824A (en) 1983-08-08 1984-10-23 Franco Robert S Method for altering red blood cell function and survival
FR2569477B1 (fr) 1984-08-24 1987-01-02 Descartes Universite Rene Appareil et procede pour la determination de la deformabilite des globules rouges du sang
JP2720161B2 (ja) 1988-02-01 1998-02-25 株式会社アドバンス 細胞変形能測定装置
JP2685544B2 (ja) 1988-11-11 1997-12-03 株式会社日立製作所 血液フィルタおよび血液検査方法並びに血液検査装置
JP2532707B2 (ja) 1990-03-08 1996-09-11 佑二 菊池 血液回路及びこれを用いた血液測定装置及び血液測定方法
WO1991016073A1 (fr) 1990-04-24 1991-10-31 The University Of Newcastle Research Associates Limited Vaccin oral comportant un antigene associe en surface a des erythrocytes
US5658892A (en) 1993-01-15 1997-08-19 The General Hospital Corporation Compound delivery using high-pressure impulse transients
US6218166B1 (en) 1994-12-09 2001-04-17 John Wayne Cancer Institute Adjuvant incorporation into antigen carrying cells: compositions and methods
US6461867B1 (en) 1995-03-08 2002-10-08 The Scripps Research Institute Synthetic antigen presenting matrix
US6051409A (en) 1995-09-25 2000-04-18 Novartis Finance Corporation Method for achieving integration of exogenous DNA delivered by non-biological means to plant cells
US6133503A (en) 1995-10-31 2000-10-17 The Regents Of The University Of California Mammalian artificial chromosomes and methods of using same
AU725669B2 (en) 1995-12-04 2000-10-19 Puget Sound Blood Center Non-immunogenic and toleragenic platelet and red blood cell compositions
BR9708387A (pt) 1996-03-28 2000-01-04 Genitrix Llc Processo para vacinação de um mamìfero a um antìgeno selecionado, células patogênica e hospedeira, composição de vacina, ácido nucleico, e, opsonina engenheirada.
US5885470A (en) 1997-04-14 1999-03-23 Caliper Technologies Corporation Controlled fluid transport in microfabricated polymeric substrates
EP0882448B1 (fr) 1997-05-05 2005-01-12 DIDECO S.r.l. Méthode d'encapsulation d'agents biologiquement actifs dans des erythrocytes et appareil
US5842787A (en) 1997-10-09 1998-12-01 Caliper Technologies Corporation Microfluidic systems incorporating varied channel dimensions
SE9704076D0 (sv) 1997-11-06 1997-11-06 Holdingbolaget Vid Goeteborgs Method for permeabilisation of cell structures and use thereof
GB9816583D0 (en) * 1998-07-31 1998-09-30 Univ Ulster Nucleic acid carrier
US6562616B1 (en) 1999-06-21 2003-05-13 The General Hospital Corporation Methods and devices for cell culturing and organ assist systems
JP2002325572A (ja) 2000-12-25 2002-11-12 Univ Osaka 外来物質の導入方法
WO2002067863A2 (fr) 2001-02-22 2002-09-06 The Scepens Eye Research Institute, Inc. Cellules presentatrices de l'antigene tolerogenique et methode de traitement d'un patient souffrant d'un etat immuno-inflammatoire
WO2003020039A1 (fr) 2001-08-28 2003-03-13 Rush-Presbyterian-St. Luke's Medical Center Tolerance immunitaire a des antigenes predetermines
AU2002365542A1 (en) 2001-11-27 2003-06-10 Cellectricon Ab A method for combined parallel agent delivery and electroporation for cell structures and use thereof
US20030133922A1 (en) 2002-01-15 2003-07-17 Kasha John R. Oral tolerance using allogeneic platelets in ITP
EP2365325A1 (fr) 2002-06-05 2011-09-14 Panasonic Corporation Dispositif de mesure du potentiel extracellulaire et procédé de fabrication du dispositif
GB0214528D0 (en) 2002-06-24 2002-08-07 Univ Aberdeen Materials and methods for induction of immune tolerance
CA2513072A1 (fr) 2003-01-09 2004-07-29 Invitrogen Corporation Liberation et activation de cellules de complexes de polypeptides et d'acides nucleiques
US20060134067A1 (en) 2003-02-18 2006-06-22 Maxcyte, Inc. Loading of cells with antigens by electroporation
US7968335B2 (en) 2004-06-17 2011-06-28 Ken Nakata Cell culturing method using biomechanical stimulation loading and system therefor
DE602005023616D1 (de) 2004-07-27 2010-10-28 Dsm Ip Assets Bv Verfahren zur herstellung von verbundfasern aus kohlenstoffnanoröhren und ultrahochmolekularem polyethylen
FR2873925B1 (fr) * 2004-08-05 2006-10-13 Erytech Pharma Soc Par Actions Procede et dispositif de lyse-rescellement pour l'incorporation de principe actif notamment asparaginase ou inositol hexaphosphate, dans des erythrocytes
ES2350895T3 (es) 2004-08-19 2011-01-28 University College Cardiff Consultants Limited Preparación de células t gamma delta humanas presentadoras de antígeno y su uso en inmunoterapia.
US20060134772A1 (en) 2004-11-18 2006-06-22 The Regents Of The University Of California System for locating cells and for cellular analysis
US8420078B2 (en) 2005-03-10 2013-04-16 Yeda Research And Development Co. Ltd. Methods and immunogenic cell preparations for treating antigen-associated diseases
US7704743B2 (en) 2005-03-30 2010-04-27 Georgia Tech Research Corporation Electrosonic cell manipulation device and method of use thereof
KR100760309B1 (ko) 2005-07-06 2007-10-05 한국과학기술원 미소필터를 이용한 미소입자 변형성 분석기
US7993821B2 (en) 2005-08-11 2011-08-09 University Of Washington Methods and apparatus for the isolation and enrichment of circulating tumor cells
WO2007067032A1 (fr) 2005-12-09 2007-06-14 Academisch Medisch Cemtrum Bij De Universiteit Van Amsterdam Moyen et methodes permettant d'influencer la stabilite de cellules
WO2007097934A2 (fr) 2006-02-17 2007-08-30 Elusys Therapeutics, Inc. Procédés et compositions permettant d'utiliser des érythrocytes comme véhicules de délivrance de médicaments
US8293524B2 (en) 2006-03-31 2012-10-23 Fluxion Biosciences Inc. Methods and apparatus for the manipulation of particle suspensions and testing thereof
US20070249038A1 (en) 2006-04-21 2007-10-25 Andrea Adamo Microfluidic device for single cell targeted operations
JP2010500921A (ja) 2006-08-17 2010-01-14 マサチューセッツ・インスティテュート・オブ・テクノロジー マイクロ流体インジェクションのための方法と装置
US20080241844A1 (en) 2007-02-06 2008-10-02 Network Biosystems, Inc. Devices and Methods for the Performance of Miniaturized In Vitro Assays
US20080311140A1 (en) 2007-05-29 2008-12-18 Baylor College Of Medicine Antigen specific immunosuppression by dendritic cell therapy
US8841135B2 (en) 2007-06-20 2014-09-23 University Of Washington Biochip for high-throughput screening of circulating tumor cells
WO2008156021A1 (fr) 2007-06-21 2008-12-24 National University Corporation Nagoya University Procédé d'introduction d'une substance étrangère dans une cellule ayant une paroi cellulaire
FR2919804B1 (fr) 2007-08-08 2010-08-27 Erytech Pharma Composition et vaccin therapeutique anti-tumoral
GB0718160D0 (en) 2007-09-18 2007-10-24 Medical Res Council Methods
EP2057998A1 (fr) 2007-10-31 2009-05-13 Universitätsklinikum Hamburg-Eppendorf Utilisation de cellules modifiées dans le traitement de la sclérose en plaques
KR100891487B1 (ko) 2007-11-01 2009-04-01 한국과학기술원 미세유체제어기술 기반으로 한 난모세포 또는 난자의 핵제거 시스템
US20100249621A1 (en) 2007-11-28 2010-09-30 Konica Minolta Opto, Inc. Blood fluidity measurement apparatus and blood fluidity measurement method
US20090280518A1 (en) 2008-05-12 2009-11-12 Massachusetts Institute Of Technology System for high throughput measurement of mechanical properties of cells
JP2010002582A (ja) 2008-06-19 2010-01-07 Konica Minolta Business Technologies Inc 画像形成装置
JP5137129B2 (ja) 2008-07-23 2013-02-06 国立大学法人山口大学 血液細胞の力学的特性測定装置
EP2321405A4 (fr) 2008-08-08 2012-09-12 Agency Science Tech & Res Dispositif d'écoulement continu microfluidique
US8211656B2 (en) 2008-08-13 2012-07-03 The Invention Science Fund I, Llc Biological targeting compositions and methods of using the same
US20110091973A1 (en) 2008-12-09 2011-04-21 Glaser Larry F Modified and fusion enhanced erythrocytes, cells and uses thereof
US9157550B2 (en) 2009-01-05 2015-10-13 The Board Of Trustees Of The University Of Illinois Microfluidic systems and methods
EP2405959A4 (fr) 2009-03-13 2013-10-16 Univ Tufts Procédés, appareils et trousses pour introduire du matériel génétique dans des cellules vivantes
US9017991B2 (en) 2009-03-13 2015-04-28 Tufts University Methods tip assemblies and kits for introducing material into cells
US20120107925A1 (en) 2009-03-20 2012-05-03 Mo Huang Li Devices for separating cells and methods of using them
WO2010129671A2 (fr) 2009-05-08 2010-11-11 Chauncey Sayre Procédé et appareil pour transformer un type de cellule en un autre type de cellule
GB0909754D0 (en) 2009-06-05 2009-07-22 Magnani Mauro Drug delivery systems
EP2449135B1 (fr) 2009-06-30 2016-01-06 Sangamo BioSciences, Inc. Criblage rapide de nucléases biologiquement actives et isolement de cellules modifiées par nucléases
WO2011005799A2 (fr) 2009-07-06 2011-01-13 Novartis Ag Molécules d'arn autorépliquantes et leurs utilisations
KR101125060B1 (ko) 2009-07-22 2012-03-21 한국과학기술원 입자를 포획하는 미세유체 소자 및 이를 이용한 입자 포획 방법
US9364831B2 (en) 2009-08-08 2016-06-14 The Regents Of The University Of California Pulsed laser triggered high speed microfluidic switch and applications in fluorescent activated cell sorting
AU2010311515B2 (en) 2009-10-27 2014-02-20 Erytech Pharma Composition to induce specific immune tolerance
CN102791865B (zh) 2009-12-21 2015-07-01 凯津公司 用于转染原生质体的改进技术
JP5624629B2 (ja) 2009-12-23 2014-11-12 サイトベラ,インコーポレイテッド 粒子を濾過するためのシステム及び方法
WO2011084882A2 (fr) 2010-01-05 2011-07-14 Contrafect Corporation Procédés et compositions pour une thérapie immunologique améliorée et le ciblage de bactéries à gram-positif
US8844570B2 (en) 2010-02-01 2014-09-30 California Institute Of Technology Generating binary states using a microfluidic channel
JP5704590B2 (ja) 2010-02-05 2015-04-22 国立大学法人東京農工大学 サイズ選択マイクロキャビティアレイを用いた循環腫瘍細胞の検出
SG10201501485QA (en) 2010-03-04 2015-04-29 Univ Singapore Microfluidics sorter for cell detection and isolation
US20110293558A1 (en) * 2010-03-22 2011-12-01 Massachusetts Institute Of Technology Material properties of t cells and related methods and compositions
JP6343147B2 (ja) * 2010-08-30 2018-06-13 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ 狭窄病変および血栓溶解療法のための剪断による制御放出
WO2015061458A1 (fr) 2013-10-22 2015-04-30 Cellanyx Diagnostics, Inc. Systèmes, dispositifs et procédés pour la culture, la manipulation et l'analyse microfluidiques de tissus et de cellules
DK2643345T5 (da) 2010-11-25 2021-05-17 Imnate Sarl Immunogene peptider til anvendelse til forebyggelse og/eller behandling af infektionssygdomme, autoimmune sygdomme, immunresponser på allofaktorer, allergisygdomme, tumorer, transplantatafstødning og immunresponser på virusvektorer anvendt til genterapi eller genvaccination
CA2825093A1 (fr) 2011-01-19 2012-07-26 The University Of British Columbia Appareil et procede de separation de particules
KR20140046408A (ko) 2011-02-25 2014-04-18 리컴비네틱스 인코포레이티드 유전자 변형 동물 및 이의 생산방법
JP6122388B2 (ja) 2011-02-28 2017-04-26 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ 細胞培養システム
CN103732731A (zh) 2011-05-27 2014-04-16 不列颠哥伦比亚大学 用于高通量分析的微流控细胞捕获和分析设备
MX2013013243A (es) 2011-07-05 2014-05-30 Sotio As Medios y metodos para activar la inmunoterapia celular del cancer utilizando celulas cancerosas destruidas mediante presion hidrostatica y celulas dendriticas.
US20130065314A1 (en) 2011-08-25 2013-03-14 Phytocentric Biotech Inc. Algal transformation systems, compositions and methods
AU2012326203B2 (en) * 2011-10-17 2017-11-30 Massachusetts Institute Of Technology Intracellular delivery
CA2876139A1 (fr) * 2012-06-07 2013-12-12 President And Fellows Of Harvard College Produits nanotherapeutiques pour le ciblage de medicament
US9255245B2 (en) 2012-07-03 2016-02-09 Agilent Technologies, Inc. Sample probes and methods for sampling intracellular material
CN110669746B (zh) 2012-10-23 2024-04-16 基因工具股份有限公司 用于切割靶dna的组合物及其用途
CN102925337B (zh) 2012-11-08 2014-06-18 武汉友芝友生物制药有限公司 一种微流体细胞捕获芯片及其制备方法
US8697359B1 (en) 2012-12-12 2014-04-15 The Broad Institute, Inc. CRISPR-Cas systems and methods for altering expression of gene products
GB201300049D0 (en) 2013-01-03 2013-02-20 Transimmune Ag Method for obtaining immuno-stimulatory dendritic cells
GB201300052D0 (en) 2013-01-03 2013-02-20 Transimmune Ag Method for obtaining immuno-suppressive dendritic cells
WO2014120956A1 (fr) * 2013-01-30 2014-08-07 Asta Fluidic Technologies, Inc. Détection de globules rouges fœtaux basée sur la microfluidique
US9725709B2 (en) 2013-03-12 2017-08-08 OpenCell Technologies, Inc. Intracellular delivery and transfection methods and devices
AU2014236747B2 (en) 2013-03-15 2019-11-07 The Regents Of The University Of California High-throughput cargo delivery into live cells using photothermal platforms
KR20140115560A (ko) * 2013-03-21 2014-10-01 인하대학교 산학협력단 기계적 스트레스를 이용한 단세포 생물체 개질 방법 및 이에 사용되는 장치
AU2014248119B2 (en) 2013-04-03 2019-06-20 Memorial Sloan-Kettering Cancer Center Effective generation of tumor-targeted T-cells derived from pluripotent stem cells
KR101508974B1 (ko) 2013-05-14 2015-04-07 한국과학기술연구원 종양 세포의 검출장치 및 검출방법
CA2921579C (fr) 2013-08-16 2021-09-21 Massachusetts Institute Of Technology Administration selective de materiau a des cellules
WO2015103331A1 (fr) * 2013-12-31 2015-07-09 Canon U.S. Life Sciences, Inc. Procédés et systèmes pour lyse cellulaire à écoulement continu dans un dispositif microfluidique
WO2015153102A1 (fr) 2014-04-01 2015-10-08 Rubius Therapeutics, Inc. Méthodes et compositions d'immunomodulation
KR20230152175A (ko) 2014-04-18 2023-11-02 에디타스 메디신, 인코포레이티드 암 면역요법을 위한 crispr-cas-관련 방법, 조성물 및 구성성분
US10947526B2 (en) 2014-07-03 2021-03-16 Massachusetts Institute Of Technology Microfluidic assay for rapid optimization of cell electroporation
CA2964392A1 (fr) 2014-10-31 2016-05-06 Massachussetts Institute Of Technology Administration de biomolecules en direction de cellules du systeme immunitaire
CN113897285A (zh) 2014-11-14 2022-01-07 麻省理工学院 化合物和组合物向细胞中的破坏和场实现的递送
WO2016094715A2 (fr) 2014-12-10 2016-06-16 Berkeley Lights, Inc. Déplacement et sélection de micro-objets dans un appareil micro-fluidique
CA2973117C (fr) 2015-01-07 2019-04-16 Indee. Inc. Procede de transfection microfluidique mecanique et hydrodynamique et appareil correspondant
JP7278027B2 (ja) 2015-01-12 2023-05-19 マサチューセッツ インスティテュート オブ テクノロジー マイクロ流体送達による遺伝子編集
US20180135012A1 (en) 2015-05-13 2018-05-17 Rubius Therapeutics, Inc. Membrane-receiver complex therapeutics
GB201513278D0 (en) 2015-07-03 2015-09-09 Transimmune Ag And Yale University Device and method for obtaining immunostimulatory antigen-presenting cells
AU2016289530B2 (en) 2015-07-09 2021-05-06 Massachusetts Institute Of Technology Delivery of materials to anucleate cells
WO2017041050A1 (fr) 2015-09-04 2017-03-09 Sqz Biotechnologies Company Administration intracellulaire de biomolécules médiée par une surface présentant des pores
WO2017041051A1 (fr) 2015-09-04 2017-03-09 Sqz Biotechnologies Company Administration intracellulaire de biomolécules à des cellules comprenant une paroi cellulaire
WO2017106899A2 (fr) 2015-12-22 2017-06-29 Sangui Bio Pty. Ltd Méthodes thérapeutiques utilisant les érythrocytes
SG11201805253SA (en) 2016-01-11 2018-07-30 Rubius Therapeutics Inc Compositions and methods related to multimodal therapeutic cell systems for cancer indications
US20190017072A1 (en) 2016-01-12 2019-01-17 Sqz Biotechnologies Company Intracellular delivery of complexes
KR102430856B1 (ko) 2016-05-03 2022-08-08 에스큐지 바이오테크놀로지스 컴퍼니 관용을 유도하는 생체분자의 세포내 전달
WO2017192786A1 (fr) 2016-05-03 2017-11-09 Sqz Biotechnologies Company Administration intracellulaire de biomolécules pour induire une tolérance
US20170326213A1 (en) 2016-05-16 2017-11-16 Augusta University Research Institute, Inc. Protein-Coupled Red Blood Cell Compositions and Methods of Their Use
CN106244543A (zh) 2016-07-29 2016-12-21 北京时合生物科技有限公司 一种pbmc体外诱导分化成为树突状细胞的方法
WO2018089497A1 (fr) 2016-11-08 2018-05-17 Georgia Tech Research Corporation Procédés d'administration intracellulaire par convection

Also Published As

Publication number Publication date
WO2017008063A1 (fr) 2017-01-12
CN107922911A (zh) 2018-04-17
US20220195364A1 (en) 2022-06-23
EP3320082A1 (fr) 2018-05-16
AU2016289530B2 (en) 2021-05-06
EP4257675A3 (fr) 2024-01-03
EP3320082B1 (fr) 2023-05-24
JP6925984B2 (ja) 2021-08-25
JP2021176334A (ja) 2021-11-11
CA2988996A1 (fr) 2017-01-12
AU2021212058A1 (en) 2021-08-26
US20180201889A1 (en) 2018-07-19
EP3320082A4 (fr) 2019-02-27
EP4257675A2 (fr) 2023-10-11
JP2018518961A (ja) 2018-07-19
JP7255904B2 (ja) 2023-04-11
US11299698B2 (en) 2022-04-12
AU2016289530A1 (en) 2018-01-18

Similar Documents

Publication Publication Date Title
SG10201912910PA (en) Delivery of materials to anucleate cells
IL252005A0 (en) Transfer of biological molecules to immune cells
IL244113A0 (en) Selective delivery of substance to cells
IL246352B (en) Preparations and methods for preparing airway cells
PL2927316T3 (pl) Całkowita fermentacja oligosacharydów
GB2541833B (en) Improvements to implant surfaces
SG10201405946UA (en) Membrane with plurality of charges
ZA201606075B (en) Pharmaceutical compositions of sitagliptin
IL254618A0 (en) Improvements regarding sending messages in the group
IL251703A0 (en) A pharmaceutical preparation with improved stability
PL2991618T3 (pl) Stabilna kompozycja farmaceutyczna o wysokim stężeniu lewoleukoworyny
GB201400431D0 (en) Phospholipid compositions and their preparation
SG11201602828YA (en) Material and structures for cell delivery
GB201419540D0 (en) Delivery of drugs
IL249773A0 (en) Breaks up lumps of dry powder medicine
GB201403773D0 (en) Microneedle based cell delivery
PT3125867T (pt) Composição hiperosmolar de ácido hialurónico
GB201504683D0 (en) Improvements in or relating to manufacture of packing
SG11201702334SA (en) External preparation composition containing s-flurbiprofen
IL249130B (en) Preparation of piperidine-4-carbothioamide
PL3240529T3 (pl) Stabilne kompozycje farmaceutyczne zawierające mykafunginę
HK1254249A1 (zh) 用於遞送至大腸或下部分小腸的多孔材料製劑
PT3191106T (pt) Composição compreendendo uma microalga enriquecida em silício para uma utilização terapêutica
GB201408233D0 (en) Use of polyanionic composition
AU2015905048A0 (en) Delivery of cell derived factors