SG10201912910PA - Delivery of materials to anucleate cells - Google Patents
Delivery of materials to anucleate cellsInfo
- Publication number
- SG10201912910PA SG10201912910PA SG10201912910PA SG10201912910PA SG10201912910PA SG 10201912910P A SG10201912910P A SG 10201912910PA SG 10201912910P A SG10201912910P A SG 10201912910PA SG 10201912910P A SG10201912910P A SG 10201912910PA SG 10201912910P A SG10201912910P A SG 10201912910PA
- Authority
- SG
- Singapore
- Prior art keywords
- delivery
- materials
- anucleate cells
- anucleate
- cells
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/02—Form or structure of the vessel
- C12M23/16—Microfluidic devices; Capillary tubes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/18—Erythrocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
- C12M35/04—Mechanical means, e.g. sonic waves, stretching forces, pressure or shear stimuli
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0641—Erythrocytes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0644—Platelets; Megakaryocytes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2521/00—Culture process characterised by the use of hydrostatic pressure, flow or shear forces
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2527/00—Culture process characterised by the use of mechanical forces, e.g. strain, vibration
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Cell Biology (AREA)
- Immunology (AREA)
- Sustainable Development (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Dispersion Chemistry (AREA)
- Clinical Laboratory Science (AREA)
- Mechanical Engineering (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Tropical Medicine & Parasitology (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Developmental Biology & Embryology (AREA)
- Diabetes (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562190677P | 2015-07-09 | 2015-07-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG10201912910PA true SG10201912910PA (en) | 2020-02-27 |
Family
ID=57685865
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10201912910PA SG10201912910PA (en) | 2015-07-09 | 2016-07-08 | Delivery of materials to anucleate cells |
Country Status (8)
Country | Link |
---|---|
US (2) | US11299698B2 (fr) |
EP (2) | EP3320082B1 (fr) |
JP (2) | JP6925984B2 (fr) |
CN (1) | CN107922911A (fr) |
AU (2) | AU2016289530B2 (fr) |
CA (1) | CA2988996A1 (fr) |
SG (1) | SG10201912910PA (fr) |
WO (1) | WO2017008063A1 (fr) |
Families Citing this family (70)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2012326203B2 (en) * | 2011-10-17 | 2017-11-30 | Massachusetts Institute Of Technology | Intracellular delivery |
CA2921579C (fr) | 2013-08-16 | 2021-09-21 | Massachusetts Institute Of Technology | Administration selective de materiau a des cellules |
CA2964392A1 (fr) | 2014-10-31 | 2016-05-06 | Massachussetts Institute Of Technology | Administration de biomolecules en direction de cellules du systeme immunitaire |
CN113897285A (zh) | 2014-11-14 | 2022-01-07 | 麻省理工学院 | 化合物和组合物向细胞中的破坏和场实现的递送 |
JP7278027B2 (ja) | 2015-01-12 | 2023-05-19 | マサチューセッツ インスティテュート オブ テクノロジー | マイクロ流体送達による遺伝子編集 |
AU2016289530B2 (en) | 2015-07-09 | 2021-05-06 | Massachusetts Institute Of Technology | Delivery of materials to anucleate cells |
WO2017041051A1 (fr) | 2015-09-04 | 2017-03-09 | Sqz Biotechnologies Company | Administration intracellulaire de biomolécules à des cellules comprenant une paroi cellulaire |
WO2017173373A1 (fr) | 2016-03-31 | 2017-10-05 | Massachusetts Institute Of Technology | Procédés et dispositifs microfluidiques à écoulement traversant présentant des interactions de surface de perturbation de membrane pour une administration intracellulaire |
KR102430856B1 (ko) * | 2016-05-03 | 2022-08-08 | 에스큐지 바이오테크놀로지스 컴퍼니 | 관용을 유도하는 생체분자의 세포내 전달 |
US11999931B2 (en) | 2016-08-20 | 2024-06-04 | The Regents Of The University Of California | High-throughput system and method for the temporary permeabilization of cells |
MX2019012845A (es) | 2017-04-28 | 2019-11-28 | Agrospheres Inc | Composiciones y metodos para encapsular y administrar agroquimicos de forma escalable. |
EP3615082A4 (fr) | 2017-04-28 | 2021-05-26 | Agrospheres, Inc. | Compositions et procédés d'immobilisation d'enzyme |
WO2019060903A1 (fr) | 2017-09-25 | 2019-03-28 | Agrospheres, Inc. | Compositions et procédés de production et d'administration évolutive de produits biologiques |
AU2018368786A1 (en) | 2017-11-17 | 2020-06-18 | Iovance Biotherapeutics, Inc. | TIL expansion from fine needle aspirates and small biopsies |
JP2021503885A (ja) | 2017-11-22 | 2021-02-15 | アイオバンス バイオセラピューティクス,インコーポレイテッド | 末梢血からの末梢血リンパ球(pbl)の拡大培養 |
US11365390B2 (en) | 2017-12-19 | 2022-06-21 | Xcell Biosciences, Inc. | Methods of modulating cell phenotype by way of regulating the gaseous environment |
EP3728555A1 (fr) * | 2017-12-21 | 2020-10-28 | Politecnico di Milano | Érythrocytes pour l'administration de médicament |
US11713446B2 (en) | 2018-01-08 | 2023-08-01 | Iovance Biotherapeutics, Inc. | Processes for generating TIL products enriched for tumor antigen-specific T-cells |
TW201938177A (zh) | 2018-01-08 | 2019-10-01 | 美商艾歐凡斯生物治療公司 | 產生富含腫瘤抗原特異性t細胞的腫瘤浸潤淋巴球(til)產物之方法 |
WO2019136459A1 (fr) | 2018-01-08 | 2019-07-11 | Iovance Biotherapeutics, Inc. | Procédés de génération de produits de til enrichis pour des lymphocytes t spécifiques d'un antigène tumoral |
CN109239406B (zh) * | 2018-10-08 | 2020-03-31 | 西安交通大学 | 一种用于细胞器药物定位投递检测装置及投药检测方法 |
MX2021004775A (es) | 2018-11-05 | 2021-06-08 | Iovance Biotherapeutics Inc | Expansion de linfocitos infiltrantes de tumores (tils) usando inhibidores de la via de proteina cinasa b (akt). |
SG11202104630PA (en) | 2018-11-05 | 2021-06-29 | Iovance Biotherapeutics Inc | Selection of improved tumor reactive t-cells |
BR112021008573A2 (pt) | 2018-11-05 | 2021-10-26 | Iovance Biotherapeutics, Inc. | Métodos para expandir linfócitos infiltrantes de tumor em uma população terapêutica de linfócitos infiltrantes de tumor, para tratar um sujeito com câncer e de expansão de células t, população terapêutica de linfócitos infiltrantes de tumor, composição de linfócitos infiltrantes de tumor, saco de infusão estéril, preparação criopreservada, e, uso da composição de linfócitos infiltrantes de tumor. |
SG11202104663PA (en) | 2018-11-05 | 2021-06-29 | Iovance Biotherapeutics Inc | Treatment of nsclc patients refractory for anti-pd-1 antibody |
WO2020099592A1 (fr) | 2018-11-15 | 2020-05-22 | Erytech Pharma | Combinaisons synergiques d'agents de déplétion de méthionine et de modulateurs de points de contrôle immunitaires |
US20220193131A1 (en) | 2018-12-19 | 2022-06-23 | Iovance Biotherapeutics, Inc. | Methods of Expanding Tumor Infiltrating Lymphocytes Using Engineered Cytokine Receptor Pairs and Uses Thereof |
CA3131701A1 (fr) | 2019-02-28 | 2020-09-03 | Sqz Biotechnologies Company | Administration de biomolecules a des pbmc pour modifier une reponse immunitaire |
JP2022522473A (ja) | 2019-03-01 | 2022-04-19 | アイオバンス バイオセラピューティクス,インコーポレイテッド | 液性腫瘍からの腫瘍浸潤リンパ球の拡大培養及びその治療的使用 |
AU2020271040A1 (en) | 2019-04-08 | 2021-11-18 | Sqz Biotechnologies Company | Cartridge for use in a system for delivery of a payload into a cell |
WO2020207456A1 (fr) * | 2019-04-11 | 2020-10-15 | The Chinese University Of Hong Kong | Systèmes et procédés de rupture de membrane contrôlée |
US20220249559A1 (en) | 2019-05-13 | 2022-08-11 | Iovance Biotherapeutics, Inc. | Methods and compositions for selecting tumor infiltrating lymphocytes and uses of the same in immunotherapy |
IT201900009831A1 (it) * | 2019-06-21 | 2020-12-21 | Milano Politecnico | Eritrociti per la veicolazione di farmaci |
JP2023506734A (ja) | 2019-12-11 | 2023-02-20 | アイオバンス バイオセラピューティクス,インコーポレイテッド | 腫瘍浸潤リンパ球(til)の産生のためのプロセス及びそれを使用する方法 |
WO2021226085A1 (fr) | 2020-05-04 | 2021-11-11 | Iovance Biotherapeutics, Inc. | Sélection de lymphocytes t réactifs à une tumeur améliorés |
JP2023523855A (ja) | 2020-05-04 | 2023-06-07 | アイオバンス バイオセラピューティクス,インコーポレイテッド | 腫瘍浸潤リンパ球の製造方法及び免疫療法におけるその使用 |
BR112022022614A2 (pt) | 2020-05-11 | 2023-02-07 | Hoffmann La Roche | Métodos para estimular uma resposta imune, melhorar uma imunoterapia, tratar uma doença, reduzir crescimento tumoral, produzir um imunoconjugado e produzir uma composição, método de vacinação, imunoconjugados, composição, usos e kits |
EP4149440A1 (fr) | 2020-05-11 | 2023-03-22 | Erytech Pharma | Vésicules extracellulaires de globules rouges (vecgr) contenant des cargos et procédés d'utilisation et de production de celles-ci |
KR20230058389A (ko) | 2020-07-29 | 2023-05-03 | 에스큐지 바이오테크놀로지스 컴퍼니 | 유핵 세포를 사용해 돌연변이체 ras에 대한 면역 반응을 자극하는 방법 |
JP2023535982A (ja) | 2020-07-29 | 2023-08-22 | スクイーズ バイオテクノロジーズ カンパニー | 無核細胞を使用して変異型Rasに対する免疫応答を刺激する方法 |
WO2022076606A1 (fr) | 2020-10-06 | 2022-04-14 | Iovance Biotherapeutics, Inc. | Traitement de patients souffrant de cpnpc avec des thérapies de lymphocytes infiltrant les tumeurs |
CA3195019A1 (fr) | 2020-10-06 | 2022-04-14 | Maria Fardis | Traitement de patients souffrant de cpnpc avec des therapies de lymphocytes infiltrant les tumeurs |
EP4232554A1 (fr) | 2020-11-18 | 2023-08-30 | Cellfe, Inc. | Procédés et systèmes pour la livraison de charges utiles dans des cellules biologiques par mécanoporation |
WO2022125941A1 (fr) | 2020-12-11 | 2022-06-16 | Iovance Biotherapeutics, Inc. | Traitement de patients atteints de cancer par des thérapies de lymphocytes infiltrant les tumeurs en combinaison avec des inhibiteurs de braf et/ou des inhibiteurs de mek |
WO2022133140A1 (fr) | 2020-12-17 | 2022-06-23 | Iovance Biotherapeutics, Inc. | Traitement avec des thérapies de lymphocytes infiltrant les tumeurs en combinaison avec des inhibiteurs de ctla-4 et de pd-1 |
WO2022133149A1 (fr) | 2020-12-17 | 2022-06-23 | Iovance Biotherapeutics, Inc. | Traitement de cancers à l'aide de lymphocytes infiltrant les tumeurs |
JP2024503279A (ja) | 2020-12-29 | 2024-01-25 | スクイーズ バイオテクノロジーズ カンパニー | Pbmcの凍結保存のための製剤 |
WO2022147442A1 (fr) | 2020-12-29 | 2022-07-07 | Sqz Biotechnologies Company | Formulations d'activation de porteurs d'antigène |
EP4271711A1 (fr) | 2020-12-29 | 2023-11-08 | SQZ Biotechnologies Company | Procédés pour le traitement de cancers avec des pbmc modifiées |
WO2022147443A1 (fr) | 2020-12-29 | 2022-07-07 | Sqz Biotechnologies Company | Méthodes de traitement de cancers par activation de porteurs d'antigène |
WO2022165260A1 (fr) | 2021-01-29 | 2022-08-04 | Iovance Biotherapeutics, Inc. | Procédés de fabrication de lymphocytes infiltrant les tumeurs modifiés et leur utilisation dans la thérapie cellulaire adoptive |
US20240207318A1 (en) | 2021-04-19 | 2024-06-27 | Yongliang Zhang | Chimeric costimulatory receptors, chemokine receptors, and the use of same in cellular immunotherapies |
EP4373270A2 (fr) | 2021-07-22 | 2024-05-29 | Iovance Biotherapeutics, Inc. | Procédé de cryoconservation de fragments de tumeur solide |
EP4377446A1 (fr) | 2021-07-28 | 2024-06-05 | Iovance Biotherapeutics, Inc. | Traitement de patients atteints d'un cancer avec des thérapies de lymphocytes infiltrant les tumeurs en combinaison avec des inhibiteurs de kras |
EP4377447A1 (fr) | 2021-07-29 | 2024-06-05 | SQZ Biotechnologies Company | Procédés pour générer des lymphocytes infiltrant les tumeurs améliorés par administration microfluidique |
US20230187042A1 (en) | 2021-10-27 | 2023-06-15 | Iovance Biotherapeutics, Inc. | Systems and methods for coordinating manufacturing of cells for patient-specific immunotherapy |
WO2023086803A1 (fr) | 2021-11-10 | 2023-05-19 | Iovance Biotherapeutics, Inc. | Procédés de traitement de multiplication utilisant des lymphocytes infiltrant les tumeurs cd8 |
WO2023087009A1 (fr) | 2021-11-11 | 2023-05-19 | Sqz Biotechnologies Company | Procédés pour générer des lymphocytes infiltrant les tumeurs améliorés par administration microfluidique |
WO2023147488A1 (fr) | 2022-01-28 | 2023-08-03 | Iovance Biotherapeutics, Inc. | Compositions et procédés de lymphocytes infiltrant les tumeurs associés à la cytokine |
WO2023147486A1 (fr) | 2022-01-28 | 2023-08-03 | Iovance Biotherapeutics, Inc. | Lymphocytes infiltrant les tumeurs modifiés pour exprimer des charges utiles |
CN114621979B (zh) * | 2022-02-15 | 2024-04-09 | 北京大学 | 基于柔性可变截面微通道的细胞力学转染的方法和装置 |
WO2023196877A1 (fr) | 2022-04-06 | 2023-10-12 | Iovance Biotherapeutics, Inc. | Traitement de patients souffrant de cpnpc avec des thérapies lymphocytaires infiltrant les tumeurs |
WO2023201369A1 (fr) | 2022-04-15 | 2023-10-19 | Iovance Biotherapeutics, Inc. | Processus d'expansion de til utilisant des combinaisons spécifiques de cytokine et/ou traitement akti |
WO2023220608A1 (fr) | 2022-05-10 | 2023-11-16 | Iovance Biotherapeutics, Inc. | Traitement de patients atteints d'un cancer avec des thérapies lymphocytaires infiltrant les tumeurs en combinaison avec un agoniste d'il-15r |
WO2024026492A1 (fr) | 2022-07-28 | 2024-02-01 | Sqz Biotechnologies Company | Méthodes de traitement du cancer avec des cellules présentatrices d'antigène améliorées |
WO2024026491A2 (fr) | 2022-07-28 | 2024-02-01 | Sqz Biotechnologies Company | Formulations de cellules présentatrices d'antigène améliorées |
WO2024030758A1 (fr) | 2022-08-01 | 2024-02-08 | Iovance Biotherapeutics, Inc. | Récepteurs de costimulation chimériques, récepteurs de chimiokines et leur utilisation dans des immunothérapies cellulaires |
WO2024098024A1 (fr) | 2022-11-04 | 2024-05-10 | Iovance Biotherapeutics, Inc. | Expansion de lymphocytes infiltrant les tumeurs à partir de tumeurs liquides et leurs utilisations thérapeutiques |
WO2024112571A2 (fr) | 2022-11-21 | 2024-05-30 | Iovance Biotherapeutics, Inc. | Procédés bidimensionnels pour l'expansion de lymphocytes infiltrant les tumeurs et thérapies associées |
WO2024118836A1 (fr) | 2022-11-30 | 2024-06-06 | Iovance Biotherapeutics, Inc. | Procédés de production de lymphocytes infiltrant les tumeurs à étape rep raccourcie |
Family Cites Families (123)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2502621C3 (de) | 1975-01-23 | 1978-09-14 | Kernforschungsanlage Juelich Gmbh, 5170 Juelich | Messung elastischer und dielektrischer Eigenschaften der Membran lebender Zellen |
US4376634A (en) | 1980-05-30 | 1983-03-15 | Mallinckrodt, Inc. | Assay kit having syringe, dilution device and reagents within sealed container |
US4478824A (en) | 1983-08-08 | 1984-10-23 | Franco Robert S | Method for altering red blood cell function and survival |
FR2569477B1 (fr) | 1984-08-24 | 1987-01-02 | Descartes Universite Rene | Appareil et procede pour la determination de la deformabilite des globules rouges du sang |
JP2720161B2 (ja) | 1988-02-01 | 1998-02-25 | 株式会社アドバンス | 細胞変形能測定装置 |
JP2685544B2 (ja) | 1988-11-11 | 1997-12-03 | 株式会社日立製作所 | 血液フィルタおよび血液検査方法並びに血液検査装置 |
JP2532707B2 (ja) | 1990-03-08 | 1996-09-11 | 佑二 菊池 | 血液回路及びこれを用いた血液測定装置及び血液測定方法 |
WO1991016073A1 (fr) | 1990-04-24 | 1991-10-31 | The University Of Newcastle Research Associates Limited | Vaccin oral comportant un antigene associe en surface a des erythrocytes |
US5658892A (en) | 1993-01-15 | 1997-08-19 | The General Hospital Corporation | Compound delivery using high-pressure impulse transients |
US6218166B1 (en) | 1994-12-09 | 2001-04-17 | John Wayne Cancer Institute | Adjuvant incorporation into antigen carrying cells: compositions and methods |
US6461867B1 (en) | 1995-03-08 | 2002-10-08 | The Scripps Research Institute | Synthetic antigen presenting matrix |
US6051409A (en) | 1995-09-25 | 2000-04-18 | Novartis Finance Corporation | Method for achieving integration of exogenous DNA delivered by non-biological means to plant cells |
US6133503A (en) | 1995-10-31 | 2000-10-17 | The Regents Of The University Of California | Mammalian artificial chromosomes and methods of using same |
AU725669B2 (en) | 1995-12-04 | 2000-10-19 | Puget Sound Blood Center | Non-immunogenic and toleragenic platelet and red blood cell compositions |
BR9708387A (pt) | 1996-03-28 | 2000-01-04 | Genitrix Llc | Processo para vacinação de um mamìfero a um antìgeno selecionado, células patogênica e hospedeira, composição de vacina, ácido nucleico, e, opsonina engenheirada. |
US5885470A (en) | 1997-04-14 | 1999-03-23 | Caliper Technologies Corporation | Controlled fluid transport in microfabricated polymeric substrates |
EP0882448B1 (fr) | 1997-05-05 | 2005-01-12 | DIDECO S.r.l. | Méthode d'encapsulation d'agents biologiquement actifs dans des erythrocytes et appareil |
US5842787A (en) | 1997-10-09 | 1998-12-01 | Caliper Technologies Corporation | Microfluidic systems incorporating varied channel dimensions |
SE9704076D0 (sv) | 1997-11-06 | 1997-11-06 | Holdingbolaget Vid Goeteborgs | Method for permeabilisation of cell structures and use thereof |
GB9816583D0 (en) * | 1998-07-31 | 1998-09-30 | Univ Ulster | Nucleic acid carrier |
US6562616B1 (en) | 1999-06-21 | 2003-05-13 | The General Hospital Corporation | Methods and devices for cell culturing and organ assist systems |
JP2002325572A (ja) | 2000-12-25 | 2002-11-12 | Univ Osaka | 外来物質の導入方法 |
WO2002067863A2 (fr) | 2001-02-22 | 2002-09-06 | The Scepens Eye Research Institute, Inc. | Cellules presentatrices de l'antigene tolerogenique et methode de traitement d'un patient souffrant d'un etat immuno-inflammatoire |
WO2003020039A1 (fr) | 2001-08-28 | 2003-03-13 | Rush-Presbyterian-St. Luke's Medical Center | Tolerance immunitaire a des antigenes predetermines |
AU2002365542A1 (en) | 2001-11-27 | 2003-06-10 | Cellectricon Ab | A method for combined parallel agent delivery and electroporation for cell structures and use thereof |
US20030133922A1 (en) | 2002-01-15 | 2003-07-17 | Kasha John R. | Oral tolerance using allogeneic platelets in ITP |
EP2365325A1 (fr) | 2002-06-05 | 2011-09-14 | Panasonic Corporation | Dispositif de mesure du potentiel extracellulaire et procédé de fabrication du dispositif |
GB0214528D0 (en) | 2002-06-24 | 2002-08-07 | Univ Aberdeen | Materials and methods for induction of immune tolerance |
CA2513072A1 (fr) | 2003-01-09 | 2004-07-29 | Invitrogen Corporation | Liberation et activation de cellules de complexes de polypeptides et d'acides nucleiques |
US20060134067A1 (en) | 2003-02-18 | 2006-06-22 | Maxcyte, Inc. | Loading of cells with antigens by electroporation |
US7968335B2 (en) | 2004-06-17 | 2011-06-28 | Ken Nakata | Cell culturing method using biomechanical stimulation loading and system therefor |
DE602005023616D1 (de) | 2004-07-27 | 2010-10-28 | Dsm Ip Assets Bv | Verfahren zur herstellung von verbundfasern aus kohlenstoffnanoröhren und ultrahochmolekularem polyethylen |
FR2873925B1 (fr) * | 2004-08-05 | 2006-10-13 | Erytech Pharma Soc Par Actions | Procede et dispositif de lyse-rescellement pour l'incorporation de principe actif notamment asparaginase ou inositol hexaphosphate, dans des erythrocytes |
ES2350895T3 (es) | 2004-08-19 | 2011-01-28 | University College Cardiff Consultants Limited | Preparación de células t gamma delta humanas presentadoras de antígeno y su uso en inmunoterapia. |
US20060134772A1 (en) | 2004-11-18 | 2006-06-22 | The Regents Of The University Of California | System for locating cells and for cellular analysis |
US8420078B2 (en) | 2005-03-10 | 2013-04-16 | Yeda Research And Development Co. Ltd. | Methods and immunogenic cell preparations for treating antigen-associated diseases |
US7704743B2 (en) | 2005-03-30 | 2010-04-27 | Georgia Tech Research Corporation | Electrosonic cell manipulation device and method of use thereof |
KR100760309B1 (ko) | 2005-07-06 | 2007-10-05 | 한국과학기술원 | 미소필터를 이용한 미소입자 변형성 분석기 |
US7993821B2 (en) | 2005-08-11 | 2011-08-09 | University Of Washington | Methods and apparatus for the isolation and enrichment of circulating tumor cells |
WO2007067032A1 (fr) | 2005-12-09 | 2007-06-14 | Academisch Medisch Cemtrum Bij De Universiteit Van Amsterdam | Moyen et methodes permettant d'influencer la stabilite de cellules |
WO2007097934A2 (fr) | 2006-02-17 | 2007-08-30 | Elusys Therapeutics, Inc. | Procédés et compositions permettant d'utiliser des érythrocytes comme véhicules de délivrance de médicaments |
US8293524B2 (en) | 2006-03-31 | 2012-10-23 | Fluxion Biosciences Inc. | Methods and apparatus for the manipulation of particle suspensions and testing thereof |
US20070249038A1 (en) | 2006-04-21 | 2007-10-25 | Andrea Adamo | Microfluidic device for single cell targeted operations |
JP2010500921A (ja) | 2006-08-17 | 2010-01-14 | マサチューセッツ・インスティテュート・オブ・テクノロジー | マイクロ流体インジェクションのための方法と装置 |
US20080241844A1 (en) | 2007-02-06 | 2008-10-02 | Network Biosystems, Inc. | Devices and Methods for the Performance of Miniaturized In Vitro Assays |
US20080311140A1 (en) | 2007-05-29 | 2008-12-18 | Baylor College Of Medicine | Antigen specific immunosuppression by dendritic cell therapy |
US8841135B2 (en) | 2007-06-20 | 2014-09-23 | University Of Washington | Biochip for high-throughput screening of circulating tumor cells |
WO2008156021A1 (fr) | 2007-06-21 | 2008-12-24 | National University Corporation Nagoya University | Procédé d'introduction d'une substance étrangère dans une cellule ayant une paroi cellulaire |
FR2919804B1 (fr) | 2007-08-08 | 2010-08-27 | Erytech Pharma | Composition et vaccin therapeutique anti-tumoral |
GB0718160D0 (en) | 2007-09-18 | 2007-10-24 | Medical Res Council | Methods |
EP2057998A1 (fr) | 2007-10-31 | 2009-05-13 | Universitätsklinikum Hamburg-Eppendorf | Utilisation de cellules modifiées dans le traitement de la sclérose en plaques |
KR100891487B1 (ko) | 2007-11-01 | 2009-04-01 | 한국과학기술원 | 미세유체제어기술 기반으로 한 난모세포 또는 난자의 핵제거 시스템 |
US20100249621A1 (en) | 2007-11-28 | 2010-09-30 | Konica Minolta Opto, Inc. | Blood fluidity measurement apparatus and blood fluidity measurement method |
US20090280518A1 (en) | 2008-05-12 | 2009-11-12 | Massachusetts Institute Of Technology | System for high throughput measurement of mechanical properties of cells |
JP2010002582A (ja) | 2008-06-19 | 2010-01-07 | Konica Minolta Business Technologies Inc | 画像形成装置 |
JP5137129B2 (ja) | 2008-07-23 | 2013-02-06 | 国立大学法人山口大学 | 血液細胞の力学的特性測定装置 |
EP2321405A4 (fr) | 2008-08-08 | 2012-09-12 | Agency Science Tech & Res | Dispositif d'écoulement continu microfluidique |
US8211656B2 (en) | 2008-08-13 | 2012-07-03 | The Invention Science Fund I, Llc | Biological targeting compositions and methods of using the same |
US20110091973A1 (en) | 2008-12-09 | 2011-04-21 | Glaser Larry F | Modified and fusion enhanced erythrocytes, cells and uses thereof |
US9157550B2 (en) | 2009-01-05 | 2015-10-13 | The Board Of Trustees Of The University Of Illinois | Microfluidic systems and methods |
EP2405959A4 (fr) | 2009-03-13 | 2013-10-16 | Univ Tufts | Procédés, appareils et trousses pour introduire du matériel génétique dans des cellules vivantes |
US9017991B2 (en) | 2009-03-13 | 2015-04-28 | Tufts University | Methods tip assemblies and kits for introducing material into cells |
US20120107925A1 (en) | 2009-03-20 | 2012-05-03 | Mo Huang Li | Devices for separating cells and methods of using them |
WO2010129671A2 (fr) | 2009-05-08 | 2010-11-11 | Chauncey Sayre | Procédé et appareil pour transformer un type de cellule en un autre type de cellule |
GB0909754D0 (en) | 2009-06-05 | 2009-07-22 | Magnani Mauro | Drug delivery systems |
EP2449135B1 (fr) | 2009-06-30 | 2016-01-06 | Sangamo BioSciences, Inc. | Criblage rapide de nucléases biologiquement actives et isolement de cellules modifiées par nucléases |
WO2011005799A2 (fr) | 2009-07-06 | 2011-01-13 | Novartis Ag | Molécules d'arn autorépliquantes et leurs utilisations |
KR101125060B1 (ko) | 2009-07-22 | 2012-03-21 | 한국과학기술원 | 입자를 포획하는 미세유체 소자 및 이를 이용한 입자 포획 방법 |
US9364831B2 (en) | 2009-08-08 | 2016-06-14 | The Regents Of The University Of California | Pulsed laser triggered high speed microfluidic switch and applications in fluorescent activated cell sorting |
AU2010311515B2 (en) | 2009-10-27 | 2014-02-20 | Erytech Pharma | Composition to induce specific immune tolerance |
CN102791865B (zh) | 2009-12-21 | 2015-07-01 | 凯津公司 | 用于转染原生质体的改进技术 |
JP5624629B2 (ja) | 2009-12-23 | 2014-11-12 | サイトベラ,インコーポレイテッド | 粒子を濾過するためのシステム及び方法 |
WO2011084882A2 (fr) | 2010-01-05 | 2011-07-14 | Contrafect Corporation | Procédés et compositions pour une thérapie immunologique améliorée et le ciblage de bactéries à gram-positif |
US8844570B2 (en) | 2010-02-01 | 2014-09-30 | California Institute Of Technology | Generating binary states using a microfluidic channel |
JP5704590B2 (ja) | 2010-02-05 | 2015-04-22 | 国立大学法人東京農工大学 | サイズ選択マイクロキャビティアレイを用いた循環腫瘍細胞の検出 |
SG10201501485QA (en) | 2010-03-04 | 2015-04-29 | Univ Singapore | Microfluidics sorter for cell detection and isolation |
US20110293558A1 (en) * | 2010-03-22 | 2011-12-01 | Massachusetts Institute Of Technology | Material properties of t cells and related methods and compositions |
JP6343147B2 (ja) * | 2010-08-30 | 2018-06-13 | プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ | 狭窄病変および血栓溶解療法のための剪断による制御放出 |
WO2015061458A1 (fr) | 2013-10-22 | 2015-04-30 | Cellanyx Diagnostics, Inc. | Systèmes, dispositifs et procédés pour la culture, la manipulation et l'analyse microfluidiques de tissus et de cellules |
DK2643345T5 (da) | 2010-11-25 | 2021-05-17 | Imnate Sarl | Immunogene peptider til anvendelse til forebyggelse og/eller behandling af infektionssygdomme, autoimmune sygdomme, immunresponser på allofaktorer, allergisygdomme, tumorer, transplantatafstødning og immunresponser på virusvektorer anvendt til genterapi eller genvaccination |
CA2825093A1 (fr) | 2011-01-19 | 2012-07-26 | The University Of British Columbia | Appareil et procede de separation de particules |
KR20140046408A (ko) | 2011-02-25 | 2014-04-18 | 리컴비네틱스 인코포레이티드 | 유전자 변형 동물 및 이의 생산방법 |
JP6122388B2 (ja) | 2011-02-28 | 2017-04-26 | プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ | 細胞培養システム |
CN103732731A (zh) | 2011-05-27 | 2014-04-16 | 不列颠哥伦比亚大学 | 用于高通量分析的微流控细胞捕获和分析设备 |
MX2013013243A (es) | 2011-07-05 | 2014-05-30 | Sotio As | Medios y metodos para activar la inmunoterapia celular del cancer utilizando celulas cancerosas destruidas mediante presion hidrostatica y celulas dendriticas. |
US20130065314A1 (en) | 2011-08-25 | 2013-03-14 | Phytocentric Biotech Inc. | Algal transformation systems, compositions and methods |
AU2012326203B2 (en) * | 2011-10-17 | 2017-11-30 | Massachusetts Institute Of Technology | Intracellular delivery |
CA2876139A1 (fr) * | 2012-06-07 | 2013-12-12 | President And Fellows Of Harvard College | Produits nanotherapeutiques pour le ciblage de medicament |
US9255245B2 (en) | 2012-07-03 | 2016-02-09 | Agilent Technologies, Inc. | Sample probes and methods for sampling intracellular material |
CN110669746B (zh) | 2012-10-23 | 2024-04-16 | 基因工具股份有限公司 | 用于切割靶dna的组合物及其用途 |
CN102925337B (zh) | 2012-11-08 | 2014-06-18 | 武汉友芝友生物制药有限公司 | 一种微流体细胞捕获芯片及其制备方法 |
US8697359B1 (en) | 2012-12-12 | 2014-04-15 | The Broad Institute, Inc. | CRISPR-Cas systems and methods for altering expression of gene products |
GB201300049D0 (en) | 2013-01-03 | 2013-02-20 | Transimmune Ag | Method for obtaining immuno-stimulatory dendritic cells |
GB201300052D0 (en) | 2013-01-03 | 2013-02-20 | Transimmune Ag | Method for obtaining immuno-suppressive dendritic cells |
WO2014120956A1 (fr) * | 2013-01-30 | 2014-08-07 | Asta Fluidic Technologies, Inc. | Détection de globules rouges fœtaux basée sur la microfluidique |
US9725709B2 (en) | 2013-03-12 | 2017-08-08 | OpenCell Technologies, Inc. | Intracellular delivery and transfection methods and devices |
AU2014236747B2 (en) | 2013-03-15 | 2019-11-07 | The Regents Of The University Of California | High-throughput cargo delivery into live cells using photothermal platforms |
KR20140115560A (ko) * | 2013-03-21 | 2014-10-01 | 인하대학교 산학협력단 | 기계적 스트레스를 이용한 단세포 생물체 개질 방법 및 이에 사용되는 장치 |
AU2014248119B2 (en) | 2013-04-03 | 2019-06-20 | Memorial Sloan-Kettering Cancer Center | Effective generation of tumor-targeted T-cells derived from pluripotent stem cells |
KR101508974B1 (ko) | 2013-05-14 | 2015-04-07 | 한국과학기술연구원 | 종양 세포의 검출장치 및 검출방법 |
CA2921579C (fr) | 2013-08-16 | 2021-09-21 | Massachusetts Institute Of Technology | Administration selective de materiau a des cellules |
WO2015103331A1 (fr) * | 2013-12-31 | 2015-07-09 | Canon U.S. Life Sciences, Inc. | Procédés et systèmes pour lyse cellulaire à écoulement continu dans un dispositif microfluidique |
WO2015153102A1 (fr) | 2014-04-01 | 2015-10-08 | Rubius Therapeutics, Inc. | Méthodes et compositions d'immunomodulation |
KR20230152175A (ko) | 2014-04-18 | 2023-11-02 | 에디타스 메디신, 인코포레이티드 | 암 면역요법을 위한 crispr-cas-관련 방법, 조성물 및 구성성분 |
US10947526B2 (en) | 2014-07-03 | 2021-03-16 | Massachusetts Institute Of Technology | Microfluidic assay for rapid optimization of cell electroporation |
CA2964392A1 (fr) | 2014-10-31 | 2016-05-06 | Massachussetts Institute Of Technology | Administration de biomolecules en direction de cellules du systeme immunitaire |
CN113897285A (zh) | 2014-11-14 | 2022-01-07 | 麻省理工学院 | 化合物和组合物向细胞中的破坏和场实现的递送 |
WO2016094715A2 (fr) | 2014-12-10 | 2016-06-16 | Berkeley Lights, Inc. | Déplacement et sélection de micro-objets dans un appareil micro-fluidique |
CA2973117C (fr) | 2015-01-07 | 2019-04-16 | Indee. Inc. | Procede de transfection microfluidique mecanique et hydrodynamique et appareil correspondant |
JP7278027B2 (ja) | 2015-01-12 | 2023-05-19 | マサチューセッツ インスティテュート オブ テクノロジー | マイクロ流体送達による遺伝子編集 |
US20180135012A1 (en) | 2015-05-13 | 2018-05-17 | Rubius Therapeutics, Inc. | Membrane-receiver complex therapeutics |
GB201513278D0 (en) | 2015-07-03 | 2015-09-09 | Transimmune Ag And Yale University | Device and method for obtaining immunostimulatory antigen-presenting cells |
AU2016289530B2 (en) | 2015-07-09 | 2021-05-06 | Massachusetts Institute Of Technology | Delivery of materials to anucleate cells |
WO2017041050A1 (fr) | 2015-09-04 | 2017-03-09 | Sqz Biotechnologies Company | Administration intracellulaire de biomolécules médiée par une surface présentant des pores |
WO2017041051A1 (fr) | 2015-09-04 | 2017-03-09 | Sqz Biotechnologies Company | Administration intracellulaire de biomolécules à des cellules comprenant une paroi cellulaire |
WO2017106899A2 (fr) | 2015-12-22 | 2017-06-29 | Sangui Bio Pty. Ltd | Méthodes thérapeutiques utilisant les érythrocytes |
SG11201805253SA (en) | 2016-01-11 | 2018-07-30 | Rubius Therapeutics Inc | Compositions and methods related to multimodal therapeutic cell systems for cancer indications |
US20190017072A1 (en) | 2016-01-12 | 2019-01-17 | Sqz Biotechnologies Company | Intracellular delivery of complexes |
KR102430856B1 (ko) | 2016-05-03 | 2022-08-08 | 에스큐지 바이오테크놀로지스 컴퍼니 | 관용을 유도하는 생체분자의 세포내 전달 |
WO2017192786A1 (fr) | 2016-05-03 | 2017-11-09 | Sqz Biotechnologies Company | Administration intracellulaire de biomolécules pour induire une tolérance |
US20170326213A1 (en) | 2016-05-16 | 2017-11-16 | Augusta University Research Institute, Inc. | Protein-Coupled Red Blood Cell Compositions and Methods of Their Use |
CN106244543A (zh) | 2016-07-29 | 2016-12-21 | 北京时合生物科技有限公司 | 一种pbmc体外诱导分化成为树突状细胞的方法 |
WO2018089497A1 (fr) | 2016-11-08 | 2018-05-17 | Georgia Tech Research Corporation | Procédés d'administration intracellulaire par convection |
-
2016
- 2016-07-08 AU AU2016289530A patent/AU2016289530B2/en active Active
- 2016-07-08 CN CN201680040081.5A patent/CN107922911A/zh active Pending
- 2016-07-08 WO PCT/US2016/041653 patent/WO2017008063A1/fr active Application Filing
- 2016-07-08 JP JP2017565959A patent/JP6925984B2/ja active Active
- 2016-07-08 CA CA2988996A patent/CA2988996A1/fr active Pending
- 2016-07-08 EP EP16822078.8A patent/EP3320082B1/fr active Active
- 2016-07-08 SG SG10201912910PA patent/SG10201912910PA/en unknown
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WO2017008063A1 (fr) | 2017-01-12 |
CN107922911A (zh) | 2018-04-17 |
US20220195364A1 (en) | 2022-06-23 |
EP3320082A1 (fr) | 2018-05-16 |
AU2016289530B2 (en) | 2021-05-06 |
EP4257675A3 (fr) | 2024-01-03 |
EP3320082B1 (fr) | 2023-05-24 |
JP6925984B2 (ja) | 2021-08-25 |
JP2021176334A (ja) | 2021-11-11 |
CA2988996A1 (fr) | 2017-01-12 |
AU2021212058A1 (en) | 2021-08-26 |
US20180201889A1 (en) | 2018-07-19 |
EP3320082A4 (fr) | 2019-02-27 |
EP4257675A2 (fr) | 2023-10-11 |
JP2018518961A (ja) | 2018-07-19 |
JP7255904B2 (ja) | 2023-04-11 |
US11299698B2 (en) | 2022-04-12 |
AU2016289530A1 (en) | 2018-01-18 |
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