SG10201501485QA - Microfluidics sorter for cell detection and isolation - Google Patents

Microfluidics sorter for cell detection and isolation

Info

Publication number
SG10201501485QA
SG10201501485QA SG10201501485QA SG10201501485QA SG10201501485QA SG 10201501485Q A SG10201501485Q A SG 10201501485QA SG 10201501485Q A SG10201501485Q A SG 10201501485QA SG 10201501485Q A SG10201501485Q A SG 10201501485QA SG 10201501485Q A SG10201501485Q A SG 10201501485QA
Authority
SG
Singapore
Prior art keywords
microfluidics
sorter
isolation
cell detection
cell
Prior art date
Application number
SG10201501485QA
Inventor
Chwee Teck Lim
Jongyoon Han
Han Wei Hou
Ali Asgar Bhagat
Vliet Krystyn J Van
Wong Cheng Lee
Original Assignee
Univ Singapore
Massachusetts Inst Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US31038710P priority Critical
Priority to US38388110P priority
Application filed by Univ Singapore, Massachusetts Inst Technology filed Critical Univ Singapore
Publication of SG10201501485QA publication Critical patent/SG10201501485QA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/04Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/025Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06Fluid handling related problems
    • B01L2200/0636Focussing flows, e.g. to laminate flows
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0861Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0403Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0457Moving fluids with specific forces or mechanical means specific forces passive flow or gravitation
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/08Regulating or influencing the flow resistance
    • B01L2400/084Passive control of flow resistance
    • B01L2400/086Passive control of flow resistance using baffles or other fixed flow obstructions
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N15/14Electro-optical investigation, e.g. flow cytometers
    • G01N15/1404Fluid conditioning in flow cytometers, e.g. flow cells; Supply; Control of flow
    • G01N2015/1415Control of particle position
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N15/14Electro-optical investigation, e.g. flow cytometers
    • G01N2015/149Sorting the particles
SG10201501485QA 2010-03-04 2011-03-04 Microfluidics sorter for cell detection and isolation SG10201501485QA (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US31038710P true 2010-03-04 2010-03-04
US38388110P true 2010-09-17 2010-09-17

Publications (1)

Publication Number Publication Date
SG10201501485QA true SG10201501485QA (en) 2015-04-29

Family

ID=44542605

Family Applications (2)

Application Number Title Priority Date Filing Date
SG2012062634A SG183468A1 (en) 2010-03-04 2011-03-04 Microfluidics sorter for cell detection and isolation
SG10201501485QA SG10201501485QA (en) 2010-03-04 2011-03-04 Microfluidics sorter for cell detection and isolation

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG2012062634A SG183468A1 (en) 2010-03-04 2011-03-04 Microfluidics sorter for cell detection and isolation

Country Status (8)

Country Link
US (1) US9458489B2 (en)
EP (1) EP2542661A4 (en)
JP (2) JP5840627B2 (en)
KR (1) KR20130000396A (en)
CN (2) CN107604039A (en)
AU (1) AU2011222582B2 (en)
SG (2) SG183468A1 (en)
WO (1) WO2011109762A1 (en)

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US10144009B2 (en) 2013-10-16 2018-12-04 Clearbridge Biomedics Pte Ltd Microfluidics sorter for cell detection and isolation
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US9709556B2 (en) 2013-12-11 2017-07-18 Analiza, Inc. Devices and methods for determining and/or isolating circulating cancer cells
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WO2015200857A1 (en) * 2014-06-27 2015-12-30 The Regents Of The University Of California Apparatus and method for label-free analysis of rare cells from bodily fluids
WO2016004101A1 (en) 2014-07-02 2016-01-07 The Regents Of The University Of California Devices for separating constituents in a sample and methods for use thereof
US20170296732A1 (en) * 2014-09-17 2017-10-19 Massachusetts Institute Of Technology System And Method For Inertial Focusing Microfiltration For Intra-Operative Blood Salvage Autotransfusion
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Also Published As

Publication number Publication date
JP2016005476A (en) 2016-01-14
AU2011222582B2 (en) 2015-10-15
JP2013521001A (en) 2013-06-10
JP5840627B2 (en) 2016-01-06
CN102884170A (en) 2013-01-16
WO2011109762A1 (en) 2011-09-09
CN107604039A (en) 2018-01-19
SG183468A1 (en) 2012-09-27
EP2542661A1 (en) 2013-01-09
EP2542661A4 (en) 2016-04-20
US9458489B2 (en) 2016-10-04
KR20130000396A (en) 2013-01-02
AU2011222582A1 (en) 2012-09-13
US20130130226A1 (en) 2013-05-23
JP6138874B2 (en) 2017-05-31

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