PL2991618T3 - Stabilna kompozycja farmaceutyczna o wysokim stężeniu lewoleukoworyny - Google Patents
Stabilna kompozycja farmaceutyczna o wysokim stężeniu lewoleukoworynyInfo
- Publication number
- PL2991618T3 PL2991618T3 PL14721211T PL14721211T PL2991618T3 PL 2991618 T3 PL2991618 T3 PL 2991618T3 PL 14721211 T PL14721211 T PL 14721211T PL 14721211 T PL14721211 T PL 14721211T PL 2991618 T3 PL2991618 T3 PL 2991618T3
- Authority
- PL
- Poland
- Prior art keywords
- levoleucovorin
- pharmaceutical composition
- high strength
- stable high
- strength pharmaceutical
- Prior art date
Links
- VVIAGPKUTFNRDU-STQMWFEESA-N (6S)-5-formyltetrahydrofolic acid Chemical group C([C@H]1CNC=2N=C(NC(=O)C=2N1C=O)N)NC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 VVIAGPKUTFNRDU-STQMWFEESA-N 0.000 title 1
- 229940008678 levoleucovorin Drugs 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13002298.1A EP2799060A1 (en) | 2013-04-30 | 2013-04-30 | Stable high dose pharmaceutical composition comprising levoleucovorin |
| PCT/EP2014/001152 WO2014177273A1 (en) | 2013-04-30 | 2014-04-30 | Stable high strength pharmaceutical composition of levoleucovorin |
| EP14721211.2A EP2991618B8 (en) | 2013-04-30 | 2014-04-30 | Stable high strength pharmaceutical composition of levoleucovorin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2991618T3 true PL2991618T3 (pl) | 2019-08-30 |
Family
ID=48226927
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL14721211T PL2991618T3 (pl) | 2013-04-30 | 2014-04-30 | Stabilna kompozycja farmaceutyczna o wysokim stężeniu lewoleukoworyny |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US9301922B1 (pl) |
| EP (2) | EP2799060A1 (pl) |
| JP (1) | JP6366685B2 (pl) |
| AU (1) | AU2014261790B2 (pl) |
| ES (1) | ES2719348T3 (pl) |
| PL (1) | PL2991618T3 (pl) |
| WO (1) | WO2014177273A1 (pl) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102014004512A1 (de) * | 2014-03-28 | 2015-10-01 | Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts Bereich Universitätsmedizin | Anorganisch-organische Hybridverbindung |
| KR101683635B1 (ko) | 2014-12-29 | 2016-12-09 | 가천대학교 산학협력단 | 락테이트 금속염을 포함하는 암 치료용 약학 조성물 |
| EP3461826A1 (en) | 2017-09-29 | 2019-04-03 | Aprofol AG | Multifunctional folate salts |
| CN120241688A (zh) | 2018-01-12 | 2025-07-04 | 麦提麦迪制药有限公司 | 乳酸钙在制备用于治疗疾病的药物组合物、食物或营养组合物中的用途 |
| EP3586849A1 (en) * | 2018-06-29 | 2020-01-01 | Aprofol AG | Folate preparations |
| EP3646873A1 (en) | 2018-10-31 | 2020-05-06 | Aprofol AG | Folate salts |
| US20210393636A1 (en) * | 2019-02-28 | 2021-12-23 | Clark Gerald Sullivan | Treatment of cns and developmental disorders using high dose 5-formyl-(6s)-tetrahydrofolate |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4931441A (en) | 1988-11-09 | 1990-06-05 | Luitpold Pharmaceuticals, Inc. | Stabilized aqueous leucovorin calcium compositions |
| DK0416232T3 (da) * | 1989-08-21 | 1995-09-18 | American Cyanamid Co | Stabil injicerbar farmaceutisk formulering med folsyre- og leukovorinsalte og fremgangsmåde |
| US6812215B2 (en) | 2000-06-02 | 2004-11-02 | MERCK Patent Gesellschaft mit beschränkter Haftung | Compositions for the treatment of inflammatory joint diseases and osteoporosis |
| CH697021A5 (de) * | 2003-06-26 | 2008-03-31 | Merck Eprova Ag | Stabile pharmazeutische Zusammensetzungen von 5, 10-Methylentetrahydrofolat. |
| DE602005026352D1 (de) | 2004-09-15 | 2011-03-31 | Nipro Corp | Wässrige, stabile (6S)-Folinsäurelösung zur Injektion |
| JP4956942B2 (ja) * | 2004-09-15 | 2012-06-20 | ニプロ株式会社 | 安定化された注射用水溶液製剤 |
| US20110223241A1 (en) * | 2008-10-16 | 2011-09-15 | Celator Pharmaceuticals, Inc. | Combination methods and compositions |
-
2013
- 2013-04-30 EP EP13002298.1A patent/EP2799060A1/en not_active Withdrawn
-
2014
- 2014-04-30 ES ES14721211T patent/ES2719348T3/es active Active
- 2014-04-30 PL PL14721211T patent/PL2991618T3/pl unknown
- 2014-04-30 AU AU2014261790A patent/AU2014261790B2/en active Active
- 2014-04-30 WO PCT/EP2014/001152 patent/WO2014177273A1/en not_active Ceased
- 2014-04-30 US US14/787,984 patent/US9301922B1/en active Active
- 2014-04-30 JP JP2016510964A patent/JP6366685B2/ja active Active
- 2014-04-30 EP EP14721211.2A patent/EP2991618B8/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| AU2014261790A1 (en) | 2015-11-12 |
| JP2016519122A (ja) | 2016-06-30 |
| US20160081926A1 (en) | 2016-03-24 |
| EP2991618B8 (en) | 2019-05-15 |
| EP2991618B1 (en) | 2019-01-09 |
| US9301922B1 (en) | 2016-04-05 |
| EP2991618A1 (en) | 2016-03-09 |
| ES2719348T3 (es) | 2019-07-09 |
| AU2014261790B2 (en) | 2018-11-29 |
| EP2799060A1 (en) | 2014-11-05 |
| JP6366685B2 (ja) | 2018-08-01 |
| WO2014177273A1 (en) | 2014-11-06 |
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