SG10201804076RA - Methods for multiplex detection of alleles associated with ophthalmic conditions - Google Patents
Methods for multiplex detection of alleles associated with ophthalmic conditionsInfo
- Publication number
- SG10201804076RA SG10201804076RA SG10201804076RA SG10201804076RA SG10201804076RA SG 10201804076R A SG10201804076R A SG 10201804076RA SG 10201804076R A SG10201804076R A SG 10201804076RA SG 10201804076R A SG10201804076R A SG 10201804076RA SG 10201804076R A SG10201804076R A SG 10201804076RA
- Authority
- SG
- Singapore
- Prior art keywords
- substrate
- lysis solution
- solution
- alleles associated
- methods
- Prior art date
Links
- 108700028369 Alleles Proteins 0.000 title abstract 3
- 238000001514 detection method Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 230000009089 cytolysis Effects 0.000 abstract 4
- 239000000758 substrate Substances 0.000 abstract 4
- 239000002773 nucleotide Substances 0.000 abstract 3
- 125000003729 nucleotide group Chemical group 0.000 abstract 3
- 108091092584 GDNA Proteins 0.000 abstract 2
- 208000003923 Hereditary Corneal Dystrophies Diseases 0.000 abstract 2
- 206010011005 corneal dystrophy Diseases 0.000 abstract 2
- 108020004414 DNA Proteins 0.000 abstract 1
- 101150017040 I gene Proteins 0.000 abstract 1
- 108091034117 Oligonucleotide Proteins 0.000 abstract 1
- 238000013019 agitation Methods 0.000 abstract 1
- 102000054765 polymorphisms of proteins Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6851—Quantitative amplification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2537/00—Reactions characterised by the reaction format or use of a specific feature
- C12Q2537/10—Reactions characterised by the reaction format or use of a specific feature the purpose or use of
- C12Q2537/143—Multiplexing, i.e. use of multiple primers or probes in a single reaction, usually for simultaneously analyse of multiple analysis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Analytical Chemistry (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Eye Examination Apparatus (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361905051P | 2013-11-15 | 2013-11-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG10201804076RA true SG10201804076RA (en) | 2018-06-28 |
Family
ID=53058284
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10201804076RA SG10201804076RA (en) | 2013-11-15 | 2014-11-17 | Methods for multiplex detection of alleles associated with ophthalmic conditions |
Country Status (9)
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101251538B1 (ko) | 2009-04-17 | 2013-04-08 | (주)아벨리노 | 아벨리노 각막이상증 진단용 프라이머 |
| KR101125212B1 (ko) | 2010-10-01 | 2012-03-21 | (주)아벨리노 | 아벨리노 각막이상증 진단용 시스템 |
| US10889850B2 (en) | 2013-03-15 | 2021-01-12 | Avellino Lab Usa, Inc. | Methods for improved isolation of genomic DNA templates for allele detection |
| EP3825413B1 (en) * | 2013-03-15 | 2024-03-06 | Avellino Lab USA, Inc. | Methods for improved isolation of genomic dna templates for allele detection |
| EP3068908B1 (en) | 2013-11-15 | 2021-01-06 | Avellino Lab USA, Inc. | Methods for multiplex detection of alleles associated with ophthalmic conditions |
| EP3374502B1 (en) * | 2015-11-13 | 2021-10-27 | Avellino Lab USA, Inc. | Methods for the treatment of corneal dystrophies |
| CN106480200A (zh) * | 2016-10-25 | 2017-03-08 | 北京亿昊基因技术有限公司 | 一种快速高效的与角膜营养不良相关基因突变位点的检测方法 |
| CN108085375B (zh) * | 2016-11-07 | 2020-10-16 | 北京华大通瀛科技有限公司 | 检测角膜营养不良基因多态性位点的基因型的方法及其试剂盒 |
| CA3059591A1 (en) | 2017-04-10 | 2018-10-18 | Avellino Lab Usa, Inc. | Methods for multiplex detection of alleles associated with corneal dystrophy |
| CN107523635A (zh) * | 2017-10-09 | 2017-12-29 | 湖南大地同年生物科技有限公司 | 一种tgfbi基因多态性快速检测试剂盒及其检测方法 |
| CN107858420A (zh) * | 2017-11-17 | 2018-03-30 | 奥斯汀生命科学技术公司 | 用于诊断人TGFβI基因124位点变异引起角膜营养不良的引物探针及检测方法 |
| KR200487603Y1 (ko) | 2018-02-01 | 2018-12-05 | 백병하 | 선풍기용 공기정화기구 |
| CN108796062A (zh) * | 2018-06-06 | 2018-11-13 | 无锡正则精准医学检验有限公司 | 一种检测tgfbi基因多态性的试剂盒 |
| CN109406469B (zh) * | 2018-10-24 | 2021-04-09 | 中国医科大学 | 基于蛋白结合诱导dna双链变构的检测色氨酸的方法 |
| KR102241836B1 (ko) * | 2019-06-14 | 2021-04-21 | 솔젠트 (주) | 듀얼 체크 올리고를 이용한 유전자 다형성 검사 방법 |
| CN113088569A (zh) * | 2020-01-09 | 2021-07-09 | 北京中因科技有限公司 | 一种多重荧光定量pcr试剂盒 |
| CN113999899A (zh) * | 2020-07-28 | 2022-02-01 | 首都医科大学附属北京同仁医院 | 一种检测tgfbi基因突变的试剂盒 |
| CN115820837A (zh) * | 2022-11-04 | 2023-03-21 | 温州谱希基因科技有限公司 | 一种角膜营养不良的pcr检测试剂盒及其应用 |
| CN118222692A (zh) * | 2022-12-21 | 2024-06-21 | 北京中因医学检验实验室有限公司 | 一种人tgfbi基因分型检测的引物探针组合物及其应用 |
| CN117417997B (zh) * | 2023-10-26 | 2025-07-29 | 上海谱希和光基因科技有限公司 | 一种诊断圆锥角膜的基因组生物标志物组合 |
| TWI879353B (zh) * | 2023-12-27 | 2025-04-01 | 台南應用科技大學 | 兩對交叉引子的多目標設計方法 |
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| KR20110037379A (ko) * | 2009-10-06 | 2011-04-13 | 주식회사 크라운진 | 실시간 중합효소 연쇄반응과 고해상도 융해 분석을 이용한 아벨리노 각막이상증 검사 방법 및 이를 위한 검사 키트 |
| KR101125212B1 (ko) | 2010-10-01 | 2012-03-21 | (주)아벨리노 | 아벨리노 각막이상증 진단용 시스템 |
| EP3068908B1 (en) | 2013-11-15 | 2021-01-06 | Avellino Lab USA, Inc. | Methods for multiplex detection of alleles associated with ophthalmic conditions |
| CN106061510B (zh) | 2013-12-12 | 2020-02-14 | 布罗德研究所有限公司 | 用于基因组编辑的crispr-cas系统和组合物的递送、用途和治疗应用 |
-
2014
- 2014-11-17 EP EP14862501.5A patent/EP3068908B1/en active Active
- 2014-11-17 KR KR1020167015852A patent/KR102293785B1/ko active Active
- 2014-11-17 TW TW112128794A patent/TW202346604A/zh unknown
- 2014-11-17 EP EP21150206.7A patent/EP3872192A1/en not_active Withdrawn
- 2014-11-17 WO PCT/US2014/065975 patent/WO2015073978A2/en active Application Filing
- 2014-11-17 CN CN202110622983.2A patent/CN113604551A/zh active Pending
- 2014-11-17 KR KR1020217024701A patent/KR102483783B1/ko active Active
- 2014-11-17 TW TW103139861A patent/TWI755350B/zh not_active IP Right Cessation
- 2014-11-17 SG SG10201804076RA patent/SG10201804076RA/en unknown
- 2014-11-17 AU AU2014348279A patent/AU2014348279B2/en not_active Ceased
- 2014-11-17 KR KR1020227046070A patent/KR20230007558A/ko not_active Ceased
- 2014-11-17 JP JP2016531678A patent/JP6672147B2/ja not_active Expired - Fee Related
- 2014-11-17 TW TW111108208A patent/TWI812047B/zh not_active IP Right Cessation
- 2014-11-17 CN CN201480072417.7A patent/CN105899681B/zh not_active Expired - Fee Related
-
2016
- 2016-05-13 US US15/154,895 patent/US11525160B2/en active Active
-
2019
- 2019-10-04 JP JP2019183365A patent/JP7077289B2/ja active Active
-
2021
- 2021-05-06 AU AU2021202884A patent/AU2021202884B2/en not_active Ceased
-
2022
- 2022-12-12 US US18/064,444 patent/US20230348984A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU2021202884A1 (en) | 2021-06-03 |
| AU2014348279A9 (en) | 2016-07-28 |
| EP3068908A2 (en) | 2016-09-21 |
| US11525160B2 (en) | 2022-12-13 |
| AU2021202884B2 (en) | 2023-04-06 |
| CN113604551A (zh) | 2021-11-05 |
| TW202223098A (zh) | 2022-06-16 |
| EP3872192A1 (en) | 2021-09-01 |
| WO2015073978A3 (en) | 2015-07-16 |
| TWI812047B (zh) | 2023-08-11 |
| EP3068908B1 (en) | 2021-01-06 |
| CN105899681B (zh) | 2021-06-22 |
| KR20160079117A (ko) | 2016-07-05 |
| JP7077289B2 (ja) | 2022-05-30 |
| TW202346604A (zh) | 2023-12-01 |
| KR20230007558A (ko) | 2023-01-12 |
| KR102293785B1 (ko) | 2021-08-26 |
| JP2017501685A (ja) | 2017-01-19 |
| TW201610167A (zh) | 2016-03-16 |
| WO2015073978A9 (en) | 2016-06-23 |
| TWI755350B (zh) | 2022-02-21 |
| KR102483783B1 (ko) | 2022-12-30 |
| WO2015073978A2 (en) | 2015-05-21 |
| KR20210099204A (ko) | 2021-08-11 |
| US20230348984A1 (en) | 2023-11-02 |
| EP3068908A4 (en) | 2017-08-23 |
| AU2014348279A1 (en) | 2016-06-09 |
| CN105899681A (zh) | 2016-08-24 |
| AU2014348279B2 (en) | 2021-02-18 |
| JP2020039339A (ja) | 2020-03-19 |
| US20160319357A1 (en) | 2016-11-03 |
| JP6672147B2 (ja) | 2020-03-25 |
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