SE503618C2 - Antihyperkolesterolemiska tetrazolföreningar - Google Patents
Antihyperkolesterolemiska tetrazolföreningarInfo
- Publication number
- SE503618C2 SE503618C2 SE8800638A SE8800638A SE503618C2 SE 503618 C2 SE503618 C2 SE 503618C2 SE 8800638 A SE8800638 A SE 8800638A SE 8800638 A SE8800638 A SE 8800638A SE 503618 C2 SE503618 C2 SE 503618C2
- Authority
- SE
- Sweden
- Prior art keywords
- alkyl
- alkoxy
- image
- hydrogen
- halogen
- Prior art date
Links
- -1 tetrazole compounds Chemical class 0.000 title abstract 2
- 230000000326 anti-hypercholesterolaemic effect Effects 0.000 title 1
- 150000002431 hydrogen Chemical class 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 239000003529 anticholesteremic agent Substances 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 150000001768 cations Chemical class 0.000 abstract 1
- 235000012000 cholesterol Nutrition 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004185 ester group Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1854287A | 1987-02-25 | 1987-02-25 | |
| US07/151,513 US4897490A (en) | 1987-02-25 | 1988-02-18 | Antihypercholesterolemic tetrazole compounds |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| SE8800638D0 SE8800638D0 (sv) | 1988-02-24 |
| SE8800638L SE8800638L (sv) | 1988-09-21 |
| SE503618C3 SE503618C3 (sv) | 1988-09-21 |
| SE503618C2 true SE503618C2 (sv) | 1996-07-15 |
Family
ID=26691223
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE8800638A SE503618C2 (sv) | 1987-02-25 | 1988-02-24 | Antihyperkolesterolemiska tetrazolföreningar |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US4897490A (de) |
| JP (1) | JP2603324B2 (de) |
| KR (1) | KR960001203B1 (de) |
| CN (1) | CN1026110C (de) |
| AT (1) | AT395589B (de) |
| AU (1) | AU1395088A (de) |
| BE (1) | BE1002116A3 (de) |
| CA (1) | CA1328268C (de) |
| CH (1) | CH676848A5 (de) |
| CS (1) | CS271481B2 (de) |
| DE (1) | DE3805801C2 (de) |
| DK (1) | DK174822B1 (de) |
| EG (1) | EG18341A (de) |
| ES (2) | ES2010246A6 (de) |
| FI (1) | FI96601C (de) |
| FR (1) | FR2612924B1 (de) |
| GR (1) | GR1000472B (de) |
| HU (3) | HU204516B (de) |
| IE (1) | IE61619B1 (de) |
| IL (1) | IL85529A (de) |
| IT (1) | IT1216751B (de) |
| LU (1) | LU87144A1 (de) |
| MX (1) | MX9202847A (de) |
| MY (1) | MY103214A (de) |
| NL (1) | NL8800465A (de) |
| NO (1) | NO169438C (de) |
| NZ (1) | NZ223620A (de) |
| PT (1) | PT86820B (de) |
| SE (1) | SE503618C2 (de) |
| WO (1) | WO1988006584A1 (de) |
| YU (1) | YU36388A (de) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3741509A1 (de) * | 1987-12-08 | 1989-06-22 | Hoechst Ag | Verfahren zur herstellung optisch aktiver 3-desmethylmevalonsaeurederivate sowie zwischenprodukte |
| GB2244705B (en) * | 1988-02-18 | 1992-07-15 | Bristol Myers Co | Preparation of antihypercholesterolemic tetrazole compounds and intermediates thereof |
| US4824959A (en) * | 1988-02-18 | 1989-04-25 | Bristol-Myers Company | Intermediates for antihypercholesterolemic tetrazole compounds |
| US4870187A (en) * | 1988-08-23 | 1989-09-26 | Bristol-Myers Company | Antihypercholesterolemic tetrazol-1-yl compounds |
| US5010205A (en) * | 1988-08-23 | 1991-04-23 | Bristol-Myers Company | Antihypercholesterolemic tetrazol-1-yl intermediates |
| US4927944A (en) * | 1988-08-25 | 1990-05-22 | Bristol-Myers Company | Antihypercholesterolemic nitrile compounds |
| FI94339C (fi) | 1989-07-21 | 1995-08-25 | Warner Lambert Co | Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi |
| US5413935A (en) * | 1991-04-24 | 1995-05-09 | E. R. Squibb & Sons, Inc. | Process for selecting an enantiomer of a hydroxy lactone using pseudomonas lipase |
| US5134155A (en) * | 1991-08-08 | 1992-07-28 | Ortho Pharmaceutical Corporation | Tetrahydroindazole, tetrahydrocyclopentapyrazole, and hexahydrocycloheptapyrazole compounds and their use as HMG-coA reductase inhibitors |
| US5986095A (en) * | 1992-01-06 | 1999-11-16 | E.R. Squibb & Sons, Inc. | Enantioselective preparation of halophenyl alcohols and acylates |
| US5278313A (en) * | 1992-03-27 | 1994-01-11 | E. R. Squibb & Sons, Inc. | Process for the preparation of 1,3-dioxane derivatives useful in the preparation of HMG-COA reductase inhibitors |
| US5324662A (en) * | 1992-05-15 | 1994-06-28 | E. R. Squibb & Sons, Inc. | Stereoselective microbial or enzymatic reduction of 3,5-dioxo esters to 3-hydroxy-5-oxo, 3-oxo-5-hydroxy, and 3,5-dihydroxy esters |
| US5284957A (en) * | 1992-09-03 | 1994-02-08 | Eli Lilly And Company | Excitatory amino acid receptor antagonists |
| JPH06329679A (ja) * | 1993-01-20 | 1994-11-29 | Nissan Chem Ind Ltd | 光学活性β−アミノアルコキシボラン錯体 |
| CA2137049A1 (en) * | 1993-12-15 | 1995-06-16 | John K. Thottathil | Amino acid salts of and methods for preparing antihypercholesterolemic tetrazole compounds |
| DE19714343A1 (de) | 1997-04-08 | 1998-10-15 | Bayer Ag | Chromatographische Enantiomerentrennung von Lactonen |
| NZ504346A (en) * | 1997-12-19 | 2001-11-30 | Warner Lambert Exp Ltd | Process for the synthesis of 1,3-diols characterised by either reconcentration step with either trialkylborane or dialkylalkoxyborane or a mixture of both trialkylborane and dialkylalkoxyborane |
| DE10216967A1 (de) * | 2002-04-16 | 2003-11-13 | Bayer Ag | Verfahren zur Herstellung spezieller aromatischer Aldehyde |
| EP2178890A1 (de) * | 2007-07-12 | 2010-04-28 | Teva Pharmaceutical Industries Ltd. | Reinigung eines rosuvastatinzwischenprodukts mittels dünnschichtverdampfung und chemisches verfahren |
| KR101681041B1 (ko) | 2015-07-15 | 2016-12-22 | 경북대학교병원 | ＥＲＲγ 비활성화 리간드로서의 신규한 방향족 고리 화합물 유도체 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4054666A (en) * | 1973-03-23 | 1977-10-18 | American Home Products Corporation | Compositions and methods of treating immediate hypersensitivity reactions with thiazolyl oxamic acid derivatives |
| US4160100A (en) * | 1973-03-23 | 1979-07-03 | American Home Products Corporation | Oxamic acid derivatives |
| US4013647A (en) * | 1976-03-23 | 1977-03-22 | American Home Products Corporation | Morpholine containing tetrazole-5-carboxamide derivatives |
| JPS53147073A (en) * | 1977-05-24 | 1978-12-21 | Sankyo Co Ltd | Mevalonolactone derivatives |
| US4567289A (en) * | 1979-08-17 | 1986-01-28 | Merck & Co., Inc. | Substituted pyranone inhibitors of cholesterol synthesis |
| US4375475A (en) * | 1979-08-17 | 1983-03-01 | Merck & Co., Inc. | Substituted pyranone inhibitors of cholesterol synthesis |
| NZ194557A (en) * | 1979-08-17 | 1984-09-28 | Merck & Co Inc | Substituted pyranone derivatives;dihydroxy acids therefrom;pharmaceutical compositions |
| EP0068038B1 (de) * | 1981-06-29 | 1985-09-25 | Merck & Co. Inc. | (+)-(4R.6S)-(E)-6-(2-(4'-Fluor-3,3',5-trimethyl-(1,1'-biphenyl)-2-yl)ethenyl)-3,4,5,6-tetrahydro-4-hydroxy-2H-pyran-2-on, Verfahren zu seiner Herstellung und eine diese Verbindung enthaltende pharmazeutische Zusammensetzung |
| WO1983002131A1 (en) * | 1981-12-10 | 1983-06-23 | Willy Bayer | Internal combustion engine |
| WO1984002131A1 (en) * | 1982-11-22 | 1984-06-07 | Sandoz Ag | Analogs of mevalolactone and derivatives thereof, processes for their production, pharmaceutical compositions containing them and their use as pharmaceuticals |
| US4739073A (en) * | 1983-11-04 | 1988-04-19 | Sandoz Pharmaceuticals Corp. | Intermediates in the synthesis of indole analogs of mevalonolactone and derivatives thereof |
| ES8609193A1 (es) * | 1983-01-24 | 1986-07-16 | Sandoz Ag | Procedimiento para preparar analogos de mevalonolactona y derivados de los mismos |
| CA1327360C (en) * | 1983-11-14 | 1994-03-01 | William F. Hoffman | Oxo-analogs of mevinolin-like antihypercholesterolemic agents |
| US4613610A (en) * | 1984-06-22 | 1986-09-23 | Sandoz Pharmaceuticals Corp. | Cholesterol biosynthesis inhibiting pyrazole analogs of mevalonolactone and its derivatives |
| KR890001651B1 (ko) * | 1984-06-22 | 1989-05-12 | 산도즈 파마슈티칼스 코포레이션 | 메발로노락톤의 피라졸 동족체 및 이의 유도체의 제조방법 |
| US4668794A (en) * | 1985-05-22 | 1987-05-26 | Sandoz Pharm. Corp. | Intermediate imidazole acrolein analogs |
| US4621099A (en) * | 1985-09-23 | 1986-11-04 | Usv Pharmaceutical Corporation | Polyene compounds useful in the treatment of allergic responses |
| US4681893A (en) * | 1986-05-30 | 1987-07-21 | Warner-Lambert Company | Trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4-hydroxypyran-2-one inhibitors of cholesterol synthesis |
| US4678806A (en) * | 1986-09-02 | 1987-07-07 | Merck & Co., Inc. | Prodrugs of antihypercholesterolemic compounds |
-
1988
- 1988-02-18 US US07/151,513 patent/US4897490A/en not_active Expired - Lifetime
- 1988-02-24 EG EG107/88A patent/EG18341A/xx active
- 1988-02-24 NO NO880809A patent/NO169438C/no not_active IP Right Cessation
- 1988-02-24 AT AT0046188A patent/AT395589B/de not_active IP Right Cessation
- 1988-02-24 NZ NZ223620A patent/NZ223620A/en unknown
- 1988-02-24 HU HU896737A patent/HU204516B/hu unknown
- 1988-02-24 NL NL8800465A patent/NL8800465A/nl not_active Application Discontinuation
- 1988-02-24 IL IL85529A patent/IL85529A/xx not_active IP Right Cessation
- 1988-02-24 DE DE3805801A patent/DE3805801C2/de not_active Expired - Lifetime
- 1988-02-24 CS CS881180A patent/CS271481B2/cs not_active IP Right Cessation
- 1988-02-24 SE SE8800638A patent/SE503618C2/xx not_active IP Right Cessation
- 1988-02-24 JP JP63502491A patent/JP2603324B2/ja not_active Expired - Lifetime
- 1988-02-24 PT PT86820A patent/PT86820B/pt not_active IP Right Cessation
- 1988-02-24 CH CH692/88A patent/CH676848A5/de not_active IP Right Cessation
- 1988-02-24 IT IT8819525A patent/IT1216751B/it active
- 1988-02-24 KR KR1019880002010A patent/KR960001203B1/ko not_active IP Right Cessation
- 1988-02-24 MY MYPI88000178A patent/MY103214A/en unknown
- 1988-02-24 HU HU90669A patent/HU203329B/hu unknown
- 1988-02-24 IE IE50188A patent/IE61619B1/en not_active IP Right Cessation
- 1988-02-24 ES ES8800532A patent/ES2010246A6/es not_active Expired
- 1988-02-24 CA CA000559667A patent/CA1328268C/en not_active Expired - Fee Related
- 1988-02-24 FR FR888802211A patent/FR2612924B1/fr not_active Expired - Lifetime
- 1988-02-24 AU AU13950/88A patent/AU1395088A/en not_active Abandoned
- 1988-02-24 WO PCT/US1988/000462 patent/WO1988006584A1/en unknown
- 1988-02-24 HU HU88886A patent/HU204038B/hu unknown
- 1988-02-24 DK DK198800972A patent/DK174822B1/da not_active IP Right Cessation
- 1988-02-24 GR GR880100101A patent/GR1000472B/el not_active IP Right Cessation
- 1988-02-24 FI FI880869A patent/FI96601C/fi active IP Right Grant
- 1988-02-25 YU YU00363/88A patent/YU36388A/xx unknown
- 1988-02-25 BE BE8800220A patent/BE1002116A3/fr not_active IP Right Cessation
- 1988-02-25 LU LU87144A patent/LU87144A1/fr unknown
- 1988-02-25 CN CN88100911A patent/CN1026110C/zh not_active Expired - Lifetime
-
1989
- 1989-06-23 ES ES8902217A patent/ES2026746A6/es not_active Expired - Fee Related
-
1992
- 1992-06-12 MX MX9202847A patent/MX9202847A/es unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NUG | Patent has lapsed |