ES2026746A6 - Un procedimiento para la preparacion de tetrazoles. - Google Patents

Un procedimiento para la preparacion de tetrazoles.

Info

Publication number
ES2026746A6
ES2026746A6 ES8902217A ES8902217A ES2026746A6 ES 2026746 A6 ES2026746 A6 ES 2026746A6 ES 8902217 A ES8902217 A ES 8902217A ES 8902217 A ES8902217 A ES 8902217A ES 2026746 A6 ES2026746 A6 ES 2026746A6
Authority
ES
Spain
Prior art keywords
alkyl
alkoxy
image
hydrogen
halogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES8902217A
Other languages
English (en)
Inventor
John J Wright
Sing-Yuen Sit
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Co
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of ES2026746A6 publication Critical patent/ES2026746A6/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

UN PROCEDIMIENTO PARA LA PREPARACION DE TETRAZOLES DE FORMULA XV DONDE RBS1 Y RBS4 INDEPENDIENTEMENTE SON H, HALOGENO, ALQUILO CSI1-4, ALCOXI CSI1-4 O TRIFOLUOROMETILO; RBS2, RBS3, RBS5 Y RBS6 SON, INDEPENDIENTEMENTE, H, HALOGENO, ALQUILO CSI1-4 O ALCOZI CSI1-4; <N> NO ES 0 O 2; TET ES UN GRUPO TETRAZOL OPCIONALMENTE SUSTITUIDO; RBS7 ES ALQUILO CSI1-4, (ALCOXI CSI1-4) ALQUILO INFERIOR, (2-METOXIETOXI) METILO O TRIFENILMETILO Y RBS9 ES UN GRUPO ESTER HIDROLIZABLE. EL PROCEDIMIENTO COMPRENDE HACER REACCIONAR UN COMPUESTO XIV CON EL DIANION DE UN ESTER DE ACETOACETATO GENERADO IN SITU. EL COMPUESTO XIV PUEDE OBTENERSE POR ALQUILACION DE UN COMPUESTO V SEGUIDO DE HIDROLISIS Y POSTERIOR OXIDACION DEL ALCOHOL PREVIAMTNE OBTENIDO Y, FINALMENTE, REACCION CON UNO O MAS EQUIVALENTES DE TRIFENILFOSFORANILEDACETALDEHIDO PARA DAR LOS CORRESPONDIENTES DI- O TRIENALDEHIDOS (XIV). SE PROPORCIONAN PROFARMACOS (XXXXV) POR REACCION DE UN COMPUESTO (IF) CON UN ESTER DE UN AMINOACIDO. LOS COMPUESTOS XIV Y XV SON UTILES COMO INTERMEDIOS DE SINTESIS DE OTROS TETRAZOLES INHIBIDORES DE LA HMBG-COA REDUCTASA ADECUADAS PARA EL TRATAMIENTO DE HIPERCOLESTEROLEMIA, HERPELIPOPROTEINEMIA Y ATEROSCLEROSIS. LOS PROFARMACOS (XXXXV) PUEDEN SER ADMINISTRADOR ORAL O PARENTERALMENTE.
ES8902217A 1987-02-25 1989-06-23 Un procedimiento para la preparacion de tetrazoles. Expired - Fee Related ES2026746A6 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1854287A 1987-02-25 1987-02-25
US07/151,513 US4897490A (en) 1987-02-25 1988-02-18 Antihypercholesterolemic tetrazole compounds

Publications (1)

Publication Number Publication Date
ES2026746A6 true ES2026746A6 (es) 1992-05-01

Family

ID=26691223

Family Applications (2)

Application Number Title Priority Date Filing Date
ES8800532A Expired ES2010246A6 (es) 1987-02-25 1988-02-24 Un compuesto.
ES8902217A Expired - Fee Related ES2026746A6 (es) 1987-02-25 1989-06-23 Un procedimiento para la preparacion de tetrazoles.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES8800532A Expired ES2010246A6 (es) 1987-02-25 1988-02-24 Un compuesto.

Country Status (31)

Country Link
US (1) US4897490A (es)
JP (1) JP2603324B2 (es)
KR (1) KR960001203B1 (es)
CN (1) CN1026110C (es)
AT (1) AT395589B (es)
AU (1) AU1395088A (es)
BE (1) BE1002116A3 (es)
CA (1) CA1328268C (es)
CH (1) CH676848A5 (es)
CS (1) CS271481B2 (es)
DE (1) DE3805801C2 (es)
DK (1) DK174822B1 (es)
EG (1) EG18341A (es)
ES (2) ES2010246A6 (es)
FI (1) FI96601C (es)
FR (1) FR2612924B1 (es)
GR (1) GR1000472B (es)
HU (3) HU204516B (es)
IE (1) IE61619B1 (es)
IL (1) IL85529A (es)
IT (1) IT1216751B (es)
LU (1) LU87144A1 (es)
MX (1) MX9202847A (es)
MY (1) MY103214A (es)
NL (1) NL8800465A (es)
NO (1) NO169438C (es)
NZ (1) NZ223620A (es)
PT (1) PT86820B (es)
SE (1) SE503618C2 (es)
WO (1) WO1988006584A1 (es)
YU (1) YU36388A (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3741509A1 (de) * 1987-12-08 1989-06-22 Hoechst Ag Verfahren zur herstellung optisch aktiver 3-desmethylmevalonsaeurederivate sowie zwischenprodukte
GB2244705B (en) * 1988-02-18 1992-07-15 Bristol Myers Co Preparation of antihypercholesterolemic tetrazole compounds and intermediates thereof
US4824959A (en) * 1988-02-18 1989-04-25 Bristol-Myers Company Intermediates for antihypercholesterolemic tetrazole compounds
US4870187A (en) * 1988-08-23 1989-09-26 Bristol-Myers Company Antihypercholesterolemic tetrazol-1-yl compounds
US5010205A (en) * 1988-08-23 1991-04-23 Bristol-Myers Company Antihypercholesterolemic tetrazol-1-yl intermediates
US4927944A (en) * 1988-08-25 1990-05-22 Bristol-Myers Company Antihypercholesterolemic nitrile compounds
FI94339C (fi) 1989-07-21 1995-08-25 Warner Lambert Co Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi
US5413935A (en) * 1991-04-24 1995-05-09 E. R. Squibb & Sons, Inc. Process for selecting an enantiomer of a hydroxy lactone using pseudomonas lipase
US5134155A (en) * 1991-08-08 1992-07-28 Ortho Pharmaceutical Corporation Tetrahydroindazole, tetrahydrocyclopentapyrazole, and hexahydrocycloheptapyrazole compounds and their use as HMG-coA reductase inhibitors
US5986095A (en) * 1992-01-06 1999-11-16 E.R. Squibb & Sons, Inc. Enantioselective preparation of halophenyl alcohols and acylates
US5278313A (en) * 1992-03-27 1994-01-11 E. R. Squibb & Sons, Inc. Process for the preparation of 1,3-dioxane derivatives useful in the preparation of HMG-COA reductase inhibitors
US5324662A (en) * 1992-05-15 1994-06-28 E. R. Squibb & Sons, Inc. Stereoselective microbial or enzymatic reduction of 3,5-dioxo esters to 3-hydroxy-5-oxo, 3-oxo-5-hydroxy, and 3,5-dihydroxy esters
US5284957A (en) * 1992-09-03 1994-02-08 Eli Lilly And Company Excitatory amino acid receptor antagonists
JPH06329679A (ja) * 1993-01-20 1994-11-29 Nissan Chem Ind Ltd 光学活性β−アミノアルコキシボラン錯体
CA2137049A1 (en) * 1993-12-15 1995-06-16 John K. Thottathil Amino acid salts of and methods for preparing antihypercholesterolemic tetrazole compounds
DE19714343A1 (de) 1997-04-08 1998-10-15 Bayer Ag Chromatographische Enantiomerentrennung von Lactonen
KR100668575B1 (ko) * 1997-12-19 2007-01-17 워너-램버트 익스포트 리미티드 1,3-디올의 합성방법
DE10216967A1 (de) * 2002-04-16 2003-11-13 Bayer Ag Verfahren zur Herstellung spezieller aromatischer Aldehyde
WO2009009152A1 (en) * 2007-07-12 2009-01-15 Teva Pharmaceutical Industries Ltd. Rosuvastatin intermediates and their preparation
KR101681041B1 (ko) 2015-07-15 2016-12-22 경북대학교병원 ＥＲＲγ 비활성화 리간드로서의 신규한 방향족 고리 화합물 유도체

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4160100A (en) * 1973-03-23 1979-07-03 American Home Products Corporation Oxamic acid derivatives
US4054666A (en) * 1973-03-23 1977-10-18 American Home Products Corporation Compositions and methods of treating immediate hypersensitivity reactions with thiazolyl oxamic acid derivatives
US4013647A (en) * 1976-03-23 1977-03-22 American Home Products Corporation Morpholine containing tetrazole-5-carboxamide derivatives
JPS53147073A (en) * 1977-05-24 1978-12-21 Sankyo Co Ltd Mevalonolactone derivatives
US4567289A (en) * 1979-08-17 1986-01-28 Merck & Co., Inc. Substituted pyranone inhibitors of cholesterol synthesis
US4375475A (en) * 1979-08-17 1983-03-01 Merck & Co., Inc. Substituted pyranone inhibitors of cholesterol synthesis
IL60751A (en) * 1979-08-17 1985-04-30 Merck & Co Inc 6-(2'-((substituted phenyl)ethyl and-ethenyl)-4-hydroxy-tetrahydro-2h-pyran-2-one derivatives,their preparation and pharmaceutical compositions containing them
EP0068038B1 (en) * 1981-06-29 1985-09-25 Merck & Co. Inc. (+)-(4r,6s)-(e)-6-(2-(4'-fluoro-3,3',5-trimethyl-(1,1'-biphenyl)-2-yl)ethenyl)-3,4,5,6-tetrahydro-4-hydroxy-2h-pyran-2-one, a process for preparing and a pharmaceutical composition containing the same
DE3153060D2 (en) * 1981-12-10 1984-10-04 Willy Bayer Internal combustion engine
US4739073A (en) * 1983-11-04 1988-04-19 Sandoz Pharmaceuticals Corp. Intermediates in the synthesis of indole analogs of mevalonolactone and derivatives thereof
WO1984002131A1 (en) * 1982-11-22 1984-06-07 Sandoz Ag Analogs of mevalolactone and derivatives thereof, processes for their production, pharmaceutical compositions containing them and their use as pharmaceuticals
CA1268473A (en) * 1983-01-24 1990-05-01 Paul L. Anderson Analogs of mevalonolactone and derivatives thereof, processes for their production, pharmaceutical compositions containing them and their use as pharmaceuticals
CA1327360C (en) * 1983-11-14 1994-03-01 William F. Hoffman Oxo-analogs of mevinolin-like antihypercholesterolemic agents
US4613610A (en) * 1984-06-22 1986-09-23 Sandoz Pharmaceuticals Corp. Cholesterol biosynthesis inhibiting pyrazole analogs of mevalonolactone and its derivatives
HU198711B (en) * 1984-06-22 1989-11-28 Sandoz Ag Process for producing mevalolacton, derivatives and pyrazol analogues and pharmaceutical composition containing them
US4668794A (en) * 1985-05-22 1987-05-26 Sandoz Pharm. Corp. Intermediate imidazole acrolein analogs
US4621099A (en) * 1985-09-23 1986-11-04 Usv Pharmaceutical Corporation Polyene compounds useful in the treatment of allergic responses
US4681893A (en) * 1986-05-30 1987-07-21 Warner-Lambert Company Trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4-hydroxypyran-2-one inhibitors of cholesterol synthesis
US4678806A (en) * 1986-09-02 1987-07-07 Merck & Co., Inc. Prodrugs of antihypercholesterolemic compounds

Also Published As

Publication number Publication date
NO169438B (no) 1992-03-16
DK97288D0 (da) 1988-02-24
AU1395088A (en) 1988-09-26
SE8800638L (sv) 1988-09-21
HU896737D0 (en) 1990-02-28
DK174822B1 (da) 2003-12-08
HU203329B (en) 1991-07-29
CN1026110C (zh) 1994-10-05
HU204038B (en) 1991-11-28
BE1002116A3 (fr) 1990-07-10
FI880869A (fi) 1988-08-26
KR880009947A (ko) 1988-10-06
NO880809L (no) 1988-08-26
SE503618C2 (sv) 1996-07-15
GR880100101A (en) 1988-12-16
DE3805801C2 (de) 2001-03-01
CN88100911A (zh) 1988-09-28
CH676848A5 (es) 1991-03-15
GR1000472B (el) 1992-07-30
US4897490A (en) 1990-01-30
IL85529A0 (en) 1988-08-31
CS271481B2 (en) 1990-10-12
IL85529A (en) 1993-01-31
FR2612924A1 (fr) 1988-09-30
FI880869A0 (fi) 1988-02-24
HUT47259A (en) 1989-02-28
ES2010246A6 (es) 1989-11-01
DE3805801A1 (de) 1988-09-08
HU900669D0 (en) 1990-06-28
KR960001203B1 (ko) 1996-01-24
DK97288A (da) 1988-08-26
NZ223620A (en) 1991-07-26
IE880501L (en) 1988-08-25
MX9202847A (es) 1992-06-30
HU204516B (en) 1992-01-28
CS118088A2 (en) 1989-08-14
LU87144A1 (fr) 1988-09-20
AT395589B (de) 1993-01-25
EG18341A (en) 1993-08-30
IT1216751B (it) 1990-03-08
FI96601B (fi) 1996-04-15
JPH01502269A (ja) 1989-08-10
ATA46188A (de) 1992-06-15
IE61619B1 (en) 1994-11-16
PT86820A (pt) 1989-02-28
JP2603324B2 (ja) 1997-04-23
PT86820B (pt) 1995-03-01
SE8800638D0 (sv) 1988-02-24
NL8800465A (nl) 1988-09-16
NO880809D0 (no) 1988-02-24
NO169438C (no) 1992-06-24
FR2612924B1 (fr) 1991-01-11
IT8819525A0 (it) 1988-02-24
CA1328268C (en) 1994-04-05
FI96601C (fi) 1996-07-25
YU36388A (en) 1989-10-31
MY103214A (en) 1993-05-29
WO1988006584A1 (en) 1988-09-07

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Legal Events

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Effective date: 20110222