SE500217C2 - Förfarande för framställning av 7beta-amino-3-((z)-1-propen-1-yl)-3-cefem-4-karboxylsyra och estrar därav - Google Patents

Förfarande för framställning av 7beta-amino-3-((z)-1-propen-1-yl)-3-cefem-4-karboxylsyra och estrar därav

Info

Publication number
SE500217C2
SE500217C2 SE8601825A SE8601825A SE500217C2 SE 500217 C2 SE500217 C2 SE 500217C2 SE 8601825 A SE8601825 A SE 8601825A SE 8601825 A SE8601825 A SE 8601825A SE 500217 C2 SE500217 C2 SE 500217C2
Authority
SE
Sweden
Prior art keywords
mmol
mixture
compound
chloride
cephem
Prior art date
Application number
SE8601825A
Other languages
English (en)
Swedish (sv)
Other versions
SE8601825L (sv
SE8601825D0 (sv
Inventor
Hideaki Hoshi
Jun Okumura
Takayuki Naito
Yoshio Abe
Shimpei Aburaki
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of SE8601825D0 publication Critical patent/SE8601825D0/xx
Publication of SE8601825L publication Critical patent/SE8601825L/
Publication of SE500217C2 publication Critical patent/SE500217C2/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/18—7-Aminocephalosporanic or substituted 7-aminocephalosporanic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/22—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with radicals containing only hydrogen and carbon atoms, attached in position 3
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
SE8601825A 1985-04-22 1986-04-21 Förfarande för framställning av 7beta-amino-3-((z)-1-propen-1-yl)-3-cefem-4-karboxylsyra och estrar därav SE500217C2 (sv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US72587185A 1985-04-22 1985-04-22

Publications (3)

Publication Number Publication Date
SE8601825D0 SE8601825D0 (sv) 1986-04-21
SE8601825L SE8601825L (sv) 1986-10-23
SE500217C2 true SE500217C2 (sv) 1994-05-09

Family

ID=24916301

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8601825A SE500217C2 (sv) 1985-04-22 1986-04-21 Förfarande för framställning av 7beta-amino-3-((z)-1-propen-1-yl)-3-cefem-4-karboxylsyra och estrar därav

Country Status (38)

Country Link
JP (1) JPS61249989A (xx)
KR (1) KR860008189A (xx)
CN (1) CN1015714B (xx)
AR (1) AR242581A1 (xx)
AT (1) AT392072B (xx)
AU (1) AU589170B2 (xx)
BE (1) BE904646A (xx)
CA (1) CA1273629A (xx)
CH (1) CH671399A5 (xx)
CS (1) CS270435B2 (xx)
CY (1) CY1571A (xx)
DD (1) DD244557A5 (xx)
DE (1) DE3613365A1 (xx)
DK (1) DK163584C (xx)
EG (1) EG18001A (xx)
ES (1) ES8800236A1 (xx)
FI (1) FI84268C (xx)
FR (1) FR2580652B1 (xx)
GB (1) GB2173798B (xx)
GR (1) GR861065B (xx)
HK (1) HK106290A (xx)
HU (1) HU195223B (xx)
IE (1) IE59014B1 (xx)
IT (1) IT1228241B (xx)
LU (1) LU86402A1 (xx)
MY (1) MY100694A (xx)
NL (1) NL192205C (xx)
NO (1) NO164659C (xx)
NZ (1) NZ215717A (xx)
OA (1) OA08245A (xx)
PT (1) PT82436B (xx)
SE (1) SE500217C2 (xx)
SG (1) SG90890G (xx)
SU (1) SU1435155A3 (xx)
YU (1) YU43697B (xx)
ZA (1) ZA862985B (xx)
ZM (1) ZM4286A1 (xx)
ZW (1) ZW9086A1 (xx)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4708955A (en) * 1985-06-24 1987-11-24 Bristol-Myers Company 3-(substituted)propenyl-7-aminothiazol-ylcephalosporanic acids and esters thereof
US4870168A (en) * 1987-02-26 1989-09-26 Bristol-Myers Company 3-Unsaturated alkyl cephems from 3-triflyl cephems
DE3933934A1 (de) * 1989-10-03 1991-04-11 Bayer Ag Verfahren zur herstellung von 7-amino-3-((z)-1-propen-1-yl)-3-cephem-4-carbonsaeure
ES2157199T3 (es) * 1991-03-08 2001-08-16 Biochemie Gmbh Nuevo procedimiento para la produccion de cefalosporinas y nuevos compuestos intermedios para este procedimiento.
KR950700311A (ko) 1992-02-05 1995-01-16 게오르게스 그렐리니, 한스 루돌프하우스 3-세펨-4-카복실산 유도체의 정제방법(Process for the purification of a 3-cephem-4-carboxylic acid derivatives)
AT399876B (de) * 1992-02-05 1995-08-25 Biochemie Gmbh Verfahren zur abreicherung von 7-amino-3-((e)-1- propen-1-yl)-3-cephem-4-carbonsäure
JPH07173168A (ja) * 1993-07-14 1995-07-11 Sumitomo Chem Co Ltd セフェム系化合物、その製法、およびそれのセフェム系抗生物質製造への利用
WO2004033464A1 (en) * 2002-10-08 2004-04-22 Ranbaxy Laboratories Limited Process for the preparation of (z)-isomer enriched 7-amino-3-propen-1-yl-3-cephem-4- carboxylic acid
EP1678186A4 (en) * 2003-10-30 2007-04-25 Cj Corp PROCESS FOR THE PREPARATION OF CEPHEM DERIVATIVES
JP4046708B2 (ja) * 2004-06-04 2008-02-13 明治製菓株式会社 ３−アルケニルセフェム化合物の製造方法
EP1809638B1 (en) 2004-11-01 2010-02-17 Hetero Drugs Limited A novel process for preparation of cefprozil intermediate
CN103183686B (zh) * 2011-12-30 2016-06-29 浙江新和成股份有限公司 7β-氨基-7α-甲氧基-3-头孢烯化合物的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4110534A (en) * 1970-01-23 1978-08-29 Glaxo Laboratories Limited Process for the preparation of 3-vinyl and substituted vinyl cephalosporins
US3769277A (en) * 1970-01-23 1973-10-30 Glaxo Lab Ltd Preparation of delta3-4 carboxy cephalosporins having a 3-vinyl or substituted 3-vinyl group
GB1342241A (en) * 1970-01-23 1974-01-03 Glaxo Lab Ltd Cephalosporin compounds
US4065620A (en) * 1971-06-14 1977-12-27 Eli Lilly And Company 3-(Substituted) vinyl cephalosporins
US4409214A (en) * 1979-11-19 1983-10-11 Fujisawa Pharmaceutical, Co., Ltd. 7-Acylamino-3-vinylcephalosporanic acid derivatives and processes for the preparation thereof
US4520022A (en) * 1983-01-28 1985-05-28 Bristol-Myers Company Substituted vinyl cephalosporins
AU566944B2 (en) * 1983-10-07 1987-11-05 Gist-Brocades N.V. Preparation of 3-cephem derivatives

Also Published As

Publication number Publication date
LU86402A1 (fr) 1986-11-05
IT8620162A0 (it) 1986-04-21
SU1435155A3 (ru) 1988-10-30
CS287286A2 (en) 1989-11-14
AR242581A1 (es) 1993-04-30
PT82436B (pt) 1988-11-30
FI84268C (fi) 1991-11-11
GB2173798B (en) 1988-11-30
FI861634A0 (fi) 1986-04-17
DK182486D0 (da) 1986-04-21
ES554215A0 (es) 1987-10-16
ZM4286A1 (en) 1989-03-27
HU195223B (en) 1988-04-28
FR2580652A1 (fr) 1986-10-24
CA1273629A (en) 1990-09-04
DE3613365C2 (xx) 1989-06-15
DE3613365A1 (de) 1987-01-02
JPS61249989A (ja) 1986-11-07
CY1571A (en) 1991-12-20
NO164659B (no) 1990-07-23
DK182486A (da) 1986-10-23
SG90890G (en) 1991-01-18
NO861430L (no) 1986-10-23
FI84268B (fi) 1991-07-31
NL8601011A (nl) 1986-11-17
OA08245A (fr) 1987-10-30
IT1228241B (it) 1991-06-05
EG18001A (en) 1991-11-30
AT392072B (de) 1991-01-25
GR861065B (en) 1986-09-01
IE861048L (en) 1986-10-22
DD244557A5 (de) 1987-04-08
SE8601825L (sv) 1986-10-23
GB8609661D0 (en) 1986-05-29
CS270435B2 (en) 1990-06-13
DK163584B (da) 1992-03-16
PT82436A (en) 1986-05-01
CN86102630A (zh) 1987-02-04
ZA862985B (en) 1986-12-30
FR2580652B1 (fr) 1989-01-06
GB2173798A (en) 1986-10-22
NL192205B (nl) 1996-11-01
NZ215717A (en) 1989-06-28
JPH0327554B2 (xx) 1991-04-16
YU65986A (en) 1987-12-31
YU43697B (en) 1989-10-31
IE59014B1 (en) 1993-12-15
MY100694A (en) 1991-01-17
NO164659C (no) 1990-10-31
BE904646A (fr) 1986-10-21
HK106290A (en) 1990-12-28
AU5616886A (en) 1986-11-06
NL192205C (nl) 1997-03-04
KR860008189A (ko) 1986-11-12
HUT41033A (en) 1987-03-30
SE8601825D0 (sv) 1986-04-21
ATA106786A (de) 1990-07-15
ZW9086A1 (en) 1986-12-03
FI861634A (fi) 1986-10-23
DK163584C (da) 1992-08-10
AU589170B2 (en) 1989-10-05
CN1015714B (zh) 1992-03-04
ES8800236A1 (es) 1987-10-16
CH671399A5 (xx) 1989-08-31

Similar Documents

Publication Publication Date Title
SU1303029A3 (ru) Способ получени производных цефалоспорина
EP0757691B1 (en) Cephalosporin synthesis
SE500217C2 (sv) Förfarande för framställning av 7beta-amino-3-((z)-1-propen-1-yl)-3-cefem-4-karboxylsyra och estrar därav
US4048311A (en) 7-Acyl-3-(sulfonic acid and sulfamoyl substituted tetrazolyl thiomethyl)cephalosporins
US4699979A (en) 7-amino-3-propenylcephalosporanic acid and esters thereof
US4093723A (en) 7-Acyl-3-(sulfonic acid and sulfamoyl substituted tetrazolyl thiomethyl) cephalosporins
US4994454A (en) Cepham derivatives
US4281117A (en) Process for 3-chloro cephalosporin nucleus
KR870000528B1 (ko) 3-아지도 세팔로스포린의 제조방법
US4159373A (en) 7-Acyl-3-(sulfonic acid and sulfamoyl substituted tetrazolyl thiomethyl) cephalosporins
US4659812A (en) Cephalosporin intermediates
US4334065A (en) Cephalosporin intermediates
US4075219A (en) Epimerization process
US4211703A (en) Phosphonoalkyl and esterified phosphonoalkyl substituted tetrazole thiols
EP0132987A1 (en) Improvements in or relating to deesterification to acids
US4112086A (en) 7β-Acylamino-3-(phosphonoalkyl and esterified phosphonoalkyl substituted tetrazolylthiomethyl)cephalosporins
KR950011746B1 (ko) 3-프로페닐세펨 유도체
FI72122C (fi) Foerfarande foer framstaellning av derivat av kefalosporin.
RU2010796C1 (ru) Способ получения производных 3-пропенилцефема или их фармакологически приемлемых солей
KR900004930B1 (ko) 7-아미노-3-프로페닐 세팔로스포란산 및 그 에스텔의 제조방법

Legal Events

Date Code Title Description
NUG Patent has lapsed