SE453996B - Forfarande for framstellning av 3-hydroxi-ml-236b-derivat - Google Patents
Forfarande for framstellning av 3-hydroxi-ml-236b-derivatInfo
- Publication number
- SE453996B SE453996B SE8206580A SE8206580A SE453996B SE 453996 B SE453996 B SE 453996B SE 8206580 A SE8206580 A SE 8206580A SE 8206580 A SE8206580 A SE 8206580A SE 453996 B SE453996 B SE 453996B
- Authority
- SE
- Sweden
- Prior art keywords
- compound
- nocardia
- microorganism
- formula
- enzyme
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/42—Hydroxy-carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/62—Carboxylic acid esters
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/365—Nocardia
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/872—Nocardia
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Cardiology (AREA)
- Veterinary Medicine (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pyrane Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP56186641A JPS5889191A (ja) | 1981-11-20 | 1981-11-20 | 3−ヒドロキシ−ml−236b誘導体の製造法 |
Publications (3)
Publication Number | Publication Date |
---|---|
SE8206580D0 SE8206580D0 (sv) | 1982-11-18 |
SE8206580L SE8206580L (sv) | 1983-05-21 |
SE453996B true SE453996B (sv) | 1988-03-21 |
Family
ID=16192138
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE8206580A SE453996B (sv) | 1981-11-20 | 1982-11-18 | Forfarande for framstellning av 3-hydroxi-ml-236b-derivat |
Country Status (18)
Country | Link |
---|---|
US (1) | US4537859A (de) |
JP (1) | JPS5889191A (de) |
KR (1) | KR880002483B1 (de) |
AT (1) | AT387585B (de) |
AU (1) | AU551720B2 (de) |
BE (1) | BE895080A (de) |
CA (1) | CA1186647A (de) |
CH (1) | CH651065A5 (de) |
DE (1) | DE3242849A1 (de) |
DK (1) | DK159328C (de) |
ES (1) | ES517542A0 (de) |
FI (1) | FI70925C (de) |
FR (1) | FR2516935A1 (de) |
GB (1) | GB2111052B (de) |
IT (1) | IT1191235B (de) |
NL (1) | NL194373C (de) |
SE (1) | SE453996B (de) |
ZA (1) | ZA828535B (de) |
Families Citing this family (85)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0215665B1 (de) * | 1985-09-13 | 1991-11-21 | Sankyo Company Limited | Hydroxy-ML-236B-Derivate, deren Herstellung und Anwendung |
US4940727A (en) * | 1986-06-23 | 1990-07-10 | Merck & Co., Inc. | Novel HMG-CoA reductase inhibitors |
US5116870A (en) * | 1986-06-23 | 1992-05-26 | Merck & Co., Inc. | HMG-CoA reductase inhibitors |
USRE36481E (en) * | 1986-06-23 | 2000-01-04 | Merck & Co., Inc. | HMG-CoA reductase inhibitors |
US4833258A (en) * | 1987-02-17 | 1989-05-23 | Merck & Co., Inc. | Intermediates useful in the preparation of HMG-COA reductase inhibitors |
DE3869282D1 (de) * | 1987-09-02 | 1992-04-23 | Merck & Co Inc | Inhibitoren von hmg-coa-reduktase. |
US4997848A (en) | 1987-10-27 | 1991-03-05 | Sankyo Company, Limited | Octahydronaphthalene oxime derivatives for cholesterol synthesis inhibition |
EP0337548A3 (de) * | 1988-04-15 | 1991-08-14 | Merck & Co. Inc. | Inhibitoren von HMG-COA-Reduktase, hergestellt durch Nocardia SP.(MA6455)(ATCC 53695) |
US4997755A (en) * | 1988-04-15 | 1991-03-05 | Merck & Co., Inc. | HMG-CoA reductase inhibitors produced by Nocardia sp. (MA 6455) |
US4963538A (en) * | 1988-06-29 | 1990-10-16 | Merck & Co., Inc. | 5-oxygenated HMG-CoA reductase inhibitors |
US5001241A (en) * | 1989-06-09 | 1991-03-19 | Merck & Co., Inc. | 3-KETO HMG-CoA reductase inhibitors |
US4937259A (en) * | 1989-06-09 | 1990-06-26 | Merck & Co., Inc. | Antihypercholesterolemic compounds |
US5041562A (en) * | 1989-06-09 | 1991-08-20 | Merck & Co., Inc. | 3-keto HMG-CoA reductase inhibitors |
US4970231A (en) * | 1989-06-09 | 1990-11-13 | Merck & Co., Inc. | 4-substituted HMG-CoA reductase inhibitors |
US5010105A (en) * | 1989-06-09 | 1991-04-23 | Merck & Co., Inc. | Antihypercholesterolemic compounds |
US4965200A (en) * | 1989-06-23 | 1990-10-23 | Merck & Co., Inc. | Process for the preparation of 3-keto, 5-hydroxy simvastatin analogs |
US4997849A (en) * | 1989-06-23 | 1991-03-05 | Merck & Co., Inc. | Microbial transformation of simvastatin |
US5112857A (en) * | 1990-09-04 | 1992-05-12 | Merck & Co., Inc. | Hmg-coa reductase inhibitor metabolites |
NZ250609A (en) * | 1992-12-28 | 1995-07-26 | Sankyo Co | Hexahydronaphthalene esters and ring closed lactones; preparation and medicaments |
US6043064A (en) * | 1993-10-22 | 2000-03-28 | Bristol-Myers Squibb Company | Enzymatic hydroxylation process for the preparation of HMG-CoA reductase inhibitors and intermediates thereof |
US5942423A (en) * | 1995-06-07 | 1999-08-24 | Massachusetts Institute Of Technology | Conversion of compactin to pravastatin by actinomadura |
SI9800144A (sl) * | 1998-05-21 | 1999-12-31 | LEK, tovarna farmacevtskih in kemičnih izdelkov, d.d. | Nov biotehnološki postopek pridobivanja 3-hidroksi-ML-236B derivatov poznanih kot M-4 in M-4' |
SI20305A (sl) * | 1999-08-06 | 2001-02-28 | LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. | Kristali natrijeve soli pravastatina |
AU3074300A (en) * | 1999-01-20 | 2000-08-07 | Kyowa Hakko Kogyo Co. Ltd. | Process for producing hmg-coa reductase inhibitors |
US7049111B1 (en) * | 1999-01-29 | 2006-05-23 | Kyowa Hakko Kogyo Co., Ltd. | Process for producing HMG-CoA reductase inhibitor |
US6682913B1 (en) | 1999-02-03 | 2004-01-27 | Institute For Drug Research Ltd. | Microbial process for preparing pravastatin |
HUP9902352A1 (hu) | 1999-07-12 | 2000-09-28 | Gyógyszerkutató Intézet Kft. | Eljárás pravasztatin mikrobiológiai előállítására |
AU2002211462A1 (en) * | 2000-10-05 | 2002-04-22 | Teva Gyogyszergyar Reszvenytarsasag | Pravastatin sodium substantially free of pravastatin lactone and epi-pravastatin, and compositions containing same |
JP3236282B1 (ja) * | 2000-10-16 | 2001-12-10 | 三共株式会社 | プラバスタチンを精製する方法 |
JP2003093045A (ja) * | 2001-09-26 | 2003-04-02 | Godo Shusei Co Ltd | 有用変換微生物 |
CA2480325A1 (en) * | 2002-04-16 | 2003-10-30 | Merck & Co., Inc. | Solid forms of salts with tyrosine kinase activity |
US20040198800A1 (en) * | 2002-12-19 | 2004-10-07 | Geoffrey Allan | Lipoxygenase inhibitors as hypolipidemic and anti-hypertensive agents |
AU2003283769A1 (en) | 2002-12-20 | 2004-07-14 | Pfizer Products Inc. | Dosage forms comprising a cetp inhibitor and an hmg-coa reductase inhibitor |
US20040132771A1 (en) * | 2002-12-20 | 2004-07-08 | Pfizer Inc | Compositions of choleseteryl ester transfer protein inhibitors and HMG-CoA reductase inhibitors |
KR100470078B1 (ko) * | 2003-06-12 | 2005-02-04 | 씨제이 주식회사 | 컴팩틴을 프라바스타틴으로 전환할 수 있는 스트렙토마이세스 종(Streptomyces sp.)CJPV 975652 및 그를 이용한 프라바스타틴의 제조방법 |
JP4553899B2 (ja) | 2003-08-21 | 2010-09-29 | メルク フロスト カナダ リミテツド | カテプシンシステインプロテアーゼ阻害剤 |
US20050101927A1 (en) * | 2003-09-11 | 2005-05-12 | Kimberly-Clark Worldwide, Inc. | Absorbent products comprising a moisturizing and lubricating composition |
CN1882327A (zh) | 2003-11-19 | 2006-12-20 | 症变治疗公司 | 含磷的新的拟甲状腺素药 |
TWI252253B (en) * | 2004-01-09 | 2006-04-01 | Chinese Petroleum Corp | A novel Pseudonocardia sp RMRC PAH4 and a process for bioconverting compactin into pravastatin using the same |
US20110217412A1 (en) * | 2004-07-30 | 2011-09-08 | Jinis Biopharmaceuticals Co. | Cholesterol lowering supplement and low cholesterol egg produced by using the same |
KR100637762B1 (ko) * | 2004-07-30 | 2006-10-23 | 주식회사 지니스 | 저콜레스테롤 란을 생산하기 위한 가금류용 사료첨가제 및 이를 이용한 저콜레스테롤 란의 생산방법 |
TWI307360B (en) | 2004-12-03 | 2009-03-11 | Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag | Process for constructing strain having compactin hydroxylation ability |
US7511152B2 (en) | 2004-12-09 | 2009-03-31 | Merck & Co., Inc. | Estrogen receptor modulators |
US8722734B2 (en) | 2005-03-02 | 2014-05-13 | Merck Sharp & Dohme Corp. | Composition for inhibition of cathepsin K |
WO2006123182A2 (en) | 2005-05-17 | 2006-11-23 | Merck Sharp & Dohme Limited | Cyclohexyl sulphones for treatment of cancer |
TWI387592B (zh) * | 2005-08-30 | 2013-03-01 | Novartis Ag | 經取代之苯并咪唑及其作為與腫瘤形成相關激酶之抑制劑之方法 |
GB0603041D0 (en) | 2006-02-15 | 2006-03-29 | Angeletti P Ist Richerche Bio | Therapeutic compounds |
KR101464385B1 (ko) | 2006-04-19 | 2014-11-21 | 노파르티스 아게 | 6-o-치환된 벤즈옥사졸 및 벤조티아졸 화합물, 및 csf-1r 신호전달의 억제 방법 |
EP2083831B1 (de) | 2006-09-22 | 2013-12-25 | Merck Sharp & Dohme Corp. | Verfahren zur behandlung von fettsäure-synthese-hemmern |
US20110218176A1 (en) | 2006-11-01 | 2011-09-08 | Barbara Brooke Jennings-Spring | Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development |
EP2336120B1 (de) | 2007-01-10 | 2014-07-16 | MSD Italia S.r.l. | Kombinationspräparate enthaltend amidsubstituierte Indazole als Poly-(ADP-ribose)-Polymerase (PARP)-Hemmer |
JP5330274B2 (ja) | 2007-03-01 | 2013-10-30 | ノバルティス アーゲー | Pimキナーゼ阻害剤およびその使用方法 |
AU2008254425A1 (en) | 2007-05-21 | 2008-11-27 | Novartis Ag | CSF-1R inhibitors, compositions, and methods of use |
US8389553B2 (en) | 2007-06-27 | 2013-03-05 | Merck Sharp & Dohme Corp. | 4-carboxybenzylamino derivatives as histone deacetylase inhibitors |
DK2222636T3 (da) | 2007-12-21 | 2013-06-03 | Ligand Pharm Inc | Selektive androgenreceptormodulatorer (SARMS) og anvendelser deraf |
CN102016054A (zh) * | 2008-04-25 | 2011-04-13 | 株式会社太平洋 | 用生物转化系统制备正二羟基异黄酮的方法 |
WO2010093601A1 (en) | 2009-02-10 | 2010-08-19 | Metabasis Therapeutics, Inc. | Novel sulfonic acid-containing thyromimetics, and methods for their use |
US8691825B2 (en) | 2009-04-01 | 2014-04-08 | Merck Sharp & Dohme Corp. | Inhibitors of AKT activity |
KR101485645B1 (ko) | 2009-10-14 | 2015-01-22 | 머크 샤프 앤드 돔 코포레이션 | p53 활성을 증가시키는 치환된 피페리딘 및 그의 용도 |
US8999957B2 (en) | 2010-06-24 | 2015-04-07 | Merck Sharp & Dohme Corp. | Heterocyclic compounds as ERK inhibitors |
CN107090456B (zh) | 2010-08-02 | 2022-01-18 | 瑟纳治疗公司 | 使用短干扰核酸的RNA干扰介导的联蛋白(钙粘蛋白关联蛋白质),β1基因表达的抑制 |
EP4079856A1 (de) | 2010-08-17 | 2022-10-26 | Sirna Therapeutics, Inc. | Rna-interferenz-vermittelte hemmung der hepatitis b-virus (hbv)-genexpression mittels kurzer interferierender nukleinsäure (sina) |
EP2608669B1 (de) | 2010-08-23 | 2016-06-22 | Merck Sharp & Dohme Corp. | Neue pyrazolo-[1,5-a-]pyrimidinderivate als mtor-hemmer |
WO2012030685A2 (en) | 2010-09-01 | 2012-03-08 | Schering Corporation | Indazole derivatives useful as erk inhibitors |
EP2615916B1 (de) | 2010-09-16 | 2017-01-04 | Merck Sharp & Dohme Corp. | Kondensierte pyrazolderivate als neue erk-hemmer |
WO2012058210A1 (en) | 2010-10-29 | 2012-05-03 | Merck Sharp & Dohme Corp. | RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACIDS (siNA) |
EP2654748B1 (de) | 2010-12-21 | 2016-07-27 | Merck Sharp & Dohme Corp. | Indazolderivate als erk-hemmer |
WO2012112363A1 (en) | 2011-02-14 | 2012-08-23 | Merck Sharp & Dohme Corp. | Cathepsin cysteine protease inhibitors |
US20140045847A1 (en) | 2011-04-21 | 2014-02-13 | Piramal Enterprises Limited | Crystalline form of a salt of a morpholino sulfonyl indole derivative and a process for its preparation |
EP2770987B1 (de) | 2011-10-27 | 2018-04-04 | Merck Sharp & Dohme Corp. | Neue verbindungen als erk-hemmer |
EP2844261B1 (de) | 2012-05-02 | 2018-10-17 | Sirna Therapeutics, Inc. | Sina-zusammensetzungen |
EP2900241B1 (de) | 2012-09-28 | 2018-08-08 | Merck Sharp & Dohme Corp. | Neuartige verbindungen als erk-hemmer |
SI2925888T1 (en) | 2012-11-28 | 2018-02-28 | Merck Sharp & Dohme Corp. | Compounds and methods for the treatment of cancer |
RU2690663C2 (ru) | 2012-12-20 | 2019-06-05 | Мерк Шарп И Доум Корп. | Замещенные имидазопиридины в качестве ингибиторов hdm2 |
US9540377B2 (en) | 2013-01-30 | 2017-01-10 | Merck Sharp & Dohme Corp. | 2,6,7,8 substituted purines as HDM2 inhibitors |
EP3041938A1 (de) | 2013-09-03 | 2016-07-13 | Moderna Therapeutics, Inc. | Kreisförmige polynukleotide |
WO2015051479A1 (en) | 2013-10-08 | 2015-04-16 | Merck Sharp & Dohme Corp. | Cathepsin cysteine protease inhibitors |
JP6454335B2 (ja) | 2013-10-08 | 2019-01-16 | メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. | カテプシンシステインプロテアーゼ阻害剤 |
EP3094323A4 (de) | 2014-01-17 | 2017-10-11 | Ligand Pharmaceuticals Incorporated | Verfahren und zusammensetzungen zur modulierung von hormonspiegeln |
WO2015120580A1 (en) | 2014-02-11 | 2015-08-20 | Merck Sharp & Dohme Corp. | Cathepsin cysteine protease inhibitors |
JO3589B1 (ar) | 2014-08-06 | 2020-07-05 | Novartis Ag | مثبطات كيناز البروتين c وطرق استخداماتها |
US10947234B2 (en) | 2017-11-08 | 2021-03-16 | Merck Sharp & Dohme Corp. | PRMT5 inhibitors |
EP3833668A4 (de) | 2018-08-07 | 2022-05-11 | Merck Sharp & Dohme Corp. | Prmt5-inhibitoren |
US11981701B2 (en) | 2018-08-07 | 2024-05-14 | Merck Sharp & Dohme Llc | PRMT5 inhibitors |
CA3160153A1 (en) | 2019-12-17 | 2021-06-24 | Michelle Machacek | Prmt5 inhibitors |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3392171A (en) * | 1964-03-20 | 1968-07-09 | Upjohn Co | 4-morpholino-4'-hydroxy bicyclohexyls |
US3281330A (en) * | 1964-03-20 | 1966-10-25 | Upjohn Co | Microbiological process for the oxygenation of cycloalkanes |
MX7065E (es) * | 1980-06-06 | 1987-04-10 | Sankyo Co | Un procedimiento microbiologico para preparar derivados de ml-236b |
-
1981
- 1981-11-20 JP JP56186641A patent/JPS5889191A/ja active Granted
-
1982
- 1982-11-16 CA CA000415650A patent/CA1186647A/en not_active Expired
- 1982-11-16 AU AU90610/82A patent/AU551720B2/en not_active Expired
- 1982-11-18 SE SE8206580A patent/SE453996B/sv not_active IP Right Cessation
- 1982-11-18 US US06/442,840 patent/US4537859A/en not_active Expired - Lifetime
- 1982-11-19 DE DE19823242849 patent/DE3242849A1/de active Granted
- 1982-11-19 CH CH6754/82A patent/CH651065A5/de not_active IP Right Cessation
- 1982-11-19 FR FR8219433A patent/FR2516935A1/fr active Granted
- 1982-11-19 FI FI823978A patent/FI70925C/fi not_active IP Right Cessation
- 1982-11-19 DK DK516182A patent/DK159328C/da not_active IP Right Cessation
- 1982-11-19 ES ES517542A patent/ES517542A0/es active Granted
- 1982-11-19 BE BE0/209527A patent/BE895080A/fr unknown
- 1982-11-19 ZA ZA828535A patent/ZA828535B/xx unknown
- 1982-11-19 NL NL8204505A patent/NL194373C/nl not_active IP Right Cessation
- 1982-11-20 KR KR8205250A patent/KR880002483B1/ko active
- 1982-11-22 GB GB08233267A patent/GB2111052B/en not_active Expired
- 1982-11-22 IT IT68359/82A patent/IT1191235B/it active Protection Beyond IP Right Term
- 1982-11-22 AT AT0425182A patent/AT387585B/de not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
FI70925C (fi) | 1986-10-27 |
ZA828535B (en) | 1983-10-26 |
SE8206580D0 (sv) | 1982-11-18 |
ES8402350A1 (es) | 1984-01-16 |
CH651065A5 (de) | 1985-08-30 |
KR840002451A (ko) | 1984-07-02 |
BE895080A (fr) | 1983-03-16 |
DE3242849C2 (de) | 1989-01-05 |
DK159328C (da) | 1991-02-25 |
NL194373B (nl) | 2001-10-01 |
FI823978L (fi) | 1983-05-21 |
FI70925B (fi) | 1986-07-18 |
DK516182A (da) | 1983-05-21 |
CA1186647A (en) | 1985-05-07 |
GB2111052B (en) | 1985-05-09 |
AT387585B (de) | 1989-02-10 |
IT8268359A0 (it) | 1982-11-22 |
FR2516935A1 (fr) | 1983-05-27 |
JPH0371116B2 (de) | 1991-11-12 |
ES517542A0 (es) | 1984-01-16 |
IT1191235B (it) | 1988-02-24 |
GB2111052A (en) | 1983-06-29 |
US4537859A (en) | 1985-08-27 |
FR2516935B1 (de) | 1985-02-08 |
AU551720B2 (en) | 1986-05-08 |
DE3242849A1 (de) | 1983-06-01 |
JPS5889191A (ja) | 1983-05-27 |
KR880002483B1 (ko) | 1988-11-19 |
ATA425182A (de) | 1988-07-15 |
SE8206580L (sv) | 1983-05-21 |
DK159328B (da) | 1990-10-01 |
NL8204505A (nl) | 1983-06-16 |
NL194373C (nl) | 2002-02-04 |
AU9061082A (en) | 1983-05-26 |
FI823978A0 (fi) | 1982-11-19 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
SE453996B (sv) | Forfarande for framstellning av 3-hydroxi-ml-236b-derivat | |
CA1197484A (en) | Mb-530b derivatives, their preparation and pharmaceutical compositions containing them | |
US4294846A (en) | Hypocholesteremic fermentation products and products of preparation | |
US4376863A (en) | Hypocholesterolemic fermentation products | |
US4420491A (en) | Hypocholesteremic fermentation products and process of preparation | |
EP0215665B1 (de) | Hydroxy-ML-236B-Derivate, deren Herstellung und Anwendung | |
RU2235780C2 (ru) | Гидроксилирование компактина до правастатина с помощью micromonospora | |
JP2003528576A5 (de) | ||
US4965200A (en) | Process for the preparation of 3-keto, 5-hydroxy simvastatin analogs | |
JP2792629B2 (ja) | 新規な10員環ラクトンおよびその製造方法 | |
DK151273B (da) | Fremgangsmaade til fremstilling af cholesterolbiosynteseinhibitoren mb- 530a. | |
US4387242A (en) | Hypocholesterolemic fermentation products and process of preparation | |
US4997755A (en) | HMG-CoA reductase inhibitors produced by Nocardia sp. (MA 6455) | |
CA2009043A1 (en) | Process for the preparation of 6-alpha-hydroxymethyl lovastatin derivatives | |
US5272174A (en) | Hydroxy-ML-236B derivatives, their preparation and use | |
JPH0333698B2 (de) | ||
US4686299A (en) | Aerocavin antibiotics | |
EP0337548A2 (de) | Inhibitoren von HMG-COA-Reduktase, hergestellt durch Nocardia SP.(MA6455)(ATCC 53695) | |
US4745202A (en) | Aerocyanidin-antibiotic | |
JPH0366297B2 (de) | ||
JPH0592967A (ja) | 10員環ラクトン構造を有する新規な天然物質 | |
JPH0482135B2 (de) | ||
JP3892427B2 (ja) | ヒドロキシクエン酸の製造方法 | |
WO1991009959A1 (en) | Process for producing optically active 3-hydroxy-2-methylbutyrates | |
JPS6316119B2 (de) |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
NAL | Patent in force |
Ref document number: 8206580-6 Format of ref document f/p: F |
|
NUG | Patent has lapsed |