NL194373C - Werkwijze voor de bereiding van 3-hydroxy-ML-236B derivaten, bekend als M-4 en M-4'. - Google Patents

Werkwijze voor de bereiding van 3-hydroxy-ML-236B derivaten, bekend als M-4 en M-4'. Download PDF

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Publication number
NL194373C
NL194373C NL8204505A NL8204505A NL194373C NL 194373 C NL194373 C NL 194373C NL 8204505 A NL8204505 A NL 8204505A NL 8204505 A NL8204505 A NL 8204505A NL 194373 C NL194373 C NL 194373C
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NL
Netherlands
Prior art keywords
nocardia
ferm
compound
microorganism
lactone
Prior art date
Application number
NL8204505A
Other languages
English (en)
Dutch (nl)
Other versions
NL194373B (nl
NL8204505A (nl
Original Assignee
Sankyo Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co filed Critical Sankyo Co
Publication of NL8204505A publication Critical patent/NL8204505A/nl
Publication of NL194373B publication Critical patent/NL194373B/xx
Application granted granted Critical
Publication of NL194373C publication Critical patent/NL194373C/nl

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/365—Nocardia
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/872—Nocardia

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Veterinary Medicine (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pyrane Compounds (AREA)
NL8204505A 1981-11-20 1982-11-19 Werkwijze voor de bereiding van 3-hydroxy-ML-236B derivaten, bekend als M-4 en M-4'. NL194373C (nl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP56186641A JPS5889191A (ja) 1981-11-20 1981-11-20 ３−ヒドロキシ−ｍｌ−２３６ｂ誘導体の製造法
JP18664181 1981-11-20

Publications (3)

Publication Number Publication Date
NL8204505A NL8204505A (nl) 1983-06-16
NL194373B NL194373B (nl) 2001-10-01
NL194373C true NL194373C (nl) 2002-02-04

Family

ID=16192138

Family Applications (1)

Application Number Title Priority Date Filing Date
NL8204505A NL194373C (nl) 1981-11-20 1982-11-19 Werkwijze voor de bereiding van 3-hydroxy-ML-236B derivaten, bekend als M-4 en M-4'.

Country Status (18)

Country Link
US (1) US4537859A (de)
JP (1) JPS5889191A (de)
KR (1) KR880002483B1 (de)
AT (1) AT387585B (de)
AU (1) AU551720B2 (de)
BE (1) BE895080A (de)
CA (1) CA1186647A (de)
CH (1) CH651065A5 (de)
DE (1) DE3242849A1 (de)
DK (1) DK159328C (de)
ES (1) ES517542A0 (de)
FI (1) FI70925C (de)
FR (1) FR2516935A1 (de)
GB (1) GB2111052B (de)
IT (1) IT1191235B (de)
NL (1) NL194373C (de)
SE (1) SE453996B (de)
ZA (1) ZA828535B (de)

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* Cited by examiner, † Cited by third party
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USRE36481E (en) * 1986-06-23 2000-01-04 Merck & Co., Inc. HMG-CoA reductase inhibitors
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US4833258A (en) * 1987-02-17 1989-05-23 Merck & Co., Inc. Intermediates useful in the preparation of HMG-COA reductase inhibitors
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US4997848A (en) 1987-10-27 1991-03-05 Sankyo Company, Limited Octahydronaphthalene oxime derivatives for cholesterol synthesis inhibition
EP0337548A3 (de) * 1988-04-15 1991-08-14 Merck & Co. Inc. Inhibitoren von HMG-COA-Reduktase, hergestellt durch Nocardia SP.(MA6455)(ATCC 53695)
US4997755A (en) * 1988-04-15 1991-03-05 Merck & Co., Inc. HMG-CoA reductase inhibitors produced by Nocardia sp. (MA 6455)
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US4937259A (en) * 1989-06-09 1990-06-26 Merck & Co., Inc. Antihypercholesterolemic compounds
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US4997849A (en) * 1989-06-23 1991-03-05 Merck & Co., Inc. Microbial transformation of simvastatin
US5112857A (en) * 1990-09-04 1992-05-12 Merck & Co., Inc. Hmg-coa reductase inhibitor metabolites
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US6043064A (en) * 1993-10-22 2000-03-28 Bristol-Myers Squibb Company Enzymatic hydroxylation process for the preparation of HMG-CoA reductase inhibitors and intermediates thereof
US5942423A (en) * 1995-06-07 1999-08-24 Massachusetts Institute Of Technology Conversion of compactin to pravastatin by actinomadura
SI9800144A (sl) * 1998-05-21 1999-12-31 LEK, tovarna farmacevtskih in kemičnih izdelkov, d.d. Nov biotehnološki postopek pridobivanja 3-hidroksi-ML-236B derivatov poznanih kot M-4 in M-4'
SI20305A (sl) * 1999-08-06 2001-02-28 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Kristali natrijeve soli pravastatina
CN1240844C (zh) * 1999-01-20 2006-02-08 协和发酵工业株式会社 HMG－CoA还原酶抑制剂的制备方法
US7049111B1 (en) * 1999-01-29 2006-05-23 Kyowa Hakko Kogyo Co., Ltd. Process for producing HMG-CoA reductase inhibitor
US6682913B1 (en) * 1999-02-03 2004-01-27 Institute For Drug Research Ltd. Microbial process for preparing pravastatin
HUP9902352A1 (hu) 1999-07-12 2000-09-28 Gyógyszerkutató Intézet Kft. Eljárás pravasztatin mikrobiológiai előállítására
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Also Published As

Publication number Publication date
FI823978L (fi) 1983-05-21
ES8402350A1 (es) 1984-01-16
SE8206580D0 (sv) 1982-11-18
IT1191235B (it) 1988-02-24
KR880002483B1 (ko) 1988-11-19
DE3242849C2 (de) 1989-01-05
CA1186647A (en) 1985-05-07
DK516182A (da) 1983-05-21
US4537859A (en) 1985-08-27
ZA828535B (en) 1983-10-26
SE8206580L (sv) 1983-05-21
NL194373B (nl) 2001-10-01
DK159328B (da) 1990-10-01
BE895080A (fr) 1983-03-16
FR2516935A1 (fr) 1983-05-27
DE3242849A1 (de) 1983-06-01
GB2111052B (en) 1985-05-09
KR840002451A (ko) 1984-07-02
CH651065A5 (de) 1985-08-30
IT8268359A0 (it) 1982-11-22
JPH0371116B2 (de) 1991-11-12
JPS5889191A (ja) 1983-05-27
SE453996B (sv) 1988-03-21
FI70925B (fi) 1986-07-18
FI70925C (fi) 1986-10-27
AU551720B2 (en) 1986-05-08
NL8204505A (nl) 1983-06-16
FR2516935B1 (de) 1985-02-08
GB2111052A (en) 1983-06-29
AU9061082A (en) 1983-05-26
DK159328C (da) 1991-02-25
ATA425182A (de) 1988-07-15
ES517542A0 (es) 1984-01-16
AT387585B (de) 1989-02-10
FI823978A0 (fi) 1982-11-19

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