FI70925C - Foerfarande foer framstaellning av 3-hydroxy-ml-236b-derivaterm-4 och m4' - Google Patents

Foerfarande foer framstaellning av 3-hydroxy-ml-236b-derivaterm-4 och m4' Download PDF

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Publication number
FI70925C
FI70925C FI823978A FI823978A FI70925C FI 70925 C FI70925 C FI 70925C FI 823978 A FI823978 A FI 823978A FI 823978 A FI823978 A FI 823978A FI 70925 C FI70925 C FI 70925C
Authority
FI
Finland
Prior art keywords
nocardla
ferm
compound
brown
microorganism
Prior art date
Application number
FI823978A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI823978A0 (fi
FI70925B (fi
FI823978L (fi
Inventor
Akira Terahara
Minoru Tanaka
Original Assignee
Sankyo Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co filed Critical Sankyo Co
Publication of FI823978A0 publication Critical patent/FI823978A0/fi
Publication of FI823978L publication Critical patent/FI823978L/fi
Publication of FI70925B publication Critical patent/FI70925B/fi
Application granted granted Critical
Publication of FI70925C publication Critical patent/FI70925C/fi

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/365—Nocardia
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/872—Nocardia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Vascular Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pyrane Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
FI823978A 1981-11-20 1982-11-19 Foerfarande foer framstaellning av 3-hydroxy-ml-236b-derivaterm-4 och m4' FI70925C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP56186641A JPS5889191A (ja) 1981-11-20 1981-11-20 ３−ヒドロキシ−ｍｌ−２３６ｂ誘導体の製造法
JP18664181 1981-11-20

Publications (4)

Publication Number Publication Date
FI823978A0 FI823978A0 (fi) 1982-11-19
FI823978L FI823978L (fi) 1983-05-21
FI70925B FI70925B (fi) 1986-07-18
FI70925C true FI70925C (fi) 1986-10-27

Family

ID=16192138

Family Applications (1)

Application Number Title Priority Date Filing Date
FI823978A FI70925C (fi) 1981-11-20 1982-11-19 Foerfarande foer framstaellning av 3-hydroxy-ml-236b-derivaterm-4 och m4'

Country Status (18)

Country Link
US (1) US4537859A (de)
JP (1) JPS5889191A (de)
KR (1) KR880002483B1 (de)
AT (1) AT387585B (de)
AU (1) AU551720B2 (de)
BE (1) BE895080A (de)
CA (1) CA1186647A (de)
CH (1) CH651065A5 (de)
DE (1) DE3242849A1 (de)
DK (1) DK159328C (de)
ES (1) ES517542A0 (de)
FI (1) FI70925C (de)
FR (1) FR2516935A1 (de)
GB (1) GB2111052B (de)
IT (1) IT1191235B (de)
NL (1) NL194373C (de)
SE (1) SE453996B (de)
ZA (1) ZA828535B (de)

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EP0337548A3 (de) * 1988-04-15 1991-08-14 Merck & Co. Inc. Inhibitoren von HMG-COA-Reduktase, hergestellt durch Nocardia SP.(MA6455)(ATCC 53695)
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US5010105A (en) * 1989-06-09 1991-04-23 Merck & Co., Inc. Antihypercholesterolemic compounds
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US4965200A (en) * 1989-06-23 1990-10-23 Merck & Co., Inc. Process for the preparation of 3-keto, 5-hydroxy simvastatin analogs
US5112857A (en) * 1990-09-04 1992-05-12 Merck & Co., Inc. Hmg-coa reductase inhibitor metabolites
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US5942423A (en) * 1995-06-07 1999-08-24 Massachusetts Institute Of Technology Conversion of compactin to pravastatin by actinomadura
SI9800144A (sl) * 1998-05-21 1999-12-31 LEK, tovarna farmacevtskih in kemičnih izdelkov, d.d. Nov biotehnološki postopek pridobivanja 3-hidroksi-ML-236B derivatov poznanih kot M-4 in M-4'
SI20305A (sl) * 1999-08-06 2001-02-28 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Kristali natrijeve soli pravastatina
CA2358927A1 (en) 1999-01-20 2000-07-27 Shin-Ichi Hashimoto Process for producing hmg-coa reductase inhibitors
CN1329508C (zh) 1999-01-29 2007-08-01 协和发酵工业株式会社 HMG－CoA还原酶抑制剂的制备方法
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Also Published As

Publication number Publication date
NL194373C (nl) 2002-02-04
FI823978A0 (fi) 1982-11-19
CH651065A5 (de) 1985-08-30
US4537859A (en) 1985-08-27
GB2111052B (en) 1985-05-09
ES8402350A1 (es) 1984-01-16
NL194373B (nl) 2001-10-01
FI70925B (fi) 1986-07-18
KR880002483B1 (ko) 1988-11-19
AU551720B2 (en) 1986-05-08
CA1186647A (en) 1985-05-07
ZA828535B (en) 1983-10-26
AT387585B (de) 1989-02-10
DK516182A (da) 1983-05-21
SE453996B (sv) 1988-03-21
NL8204505A (nl) 1983-06-16
IT1191235B (it) 1988-02-24
JPH0371116B2 (de) 1991-11-12
AU9061082A (en) 1983-05-26
SE8206580D0 (sv) 1982-11-18
FI823978L (fi) 1983-05-21
SE8206580L (sv) 1983-05-21
FR2516935B1 (de) 1985-02-08
DE3242849C2 (de) 1989-01-05
JPS5889191A (ja) 1983-05-27
GB2111052A (en) 1983-06-29
FR2516935A1 (fr) 1983-05-27
DK159328C (da) 1991-02-25
KR840002451A (ko) 1984-07-02
DE3242849A1 (de) 1983-06-01
ATA425182A (de) 1988-07-15
DK159328B (da) 1990-10-01
BE895080A (fr) 1983-03-16
ES517542A0 (es) 1984-01-16
IT8268359A0 (it) 1982-11-22

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