SE453089B - Imidazo-rifamycinderivat, forfarande for framstellning derav och farmaceutisk komposition - Google Patents

Imidazo-rifamycinderivat, forfarande for framstellning derav och farmaceutisk komposition

Info

Publication number
SE453089B
SE453089B SE8103216A SE8103216A SE453089B SE 453089 B SE453089 B SE 453089B SE 8103216 A SE8103216 A SE 8103216A SE 8103216 A SE8103216 A SE 8103216A SE 453089 B SE453089 B SE 453089B
Authority
SE
Sweden
Prior art keywords
nothing
formula
hydrogen
imidazo
chemical bond
Prior art date
Application number
SE8103216A
Other languages
English (en)
Swedish (sv)
Other versions
SE8103216L (sv
Inventor
E Marchi
L Montecchi
Original Assignee
Alfa Farmaceutici Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alfa Farmaceutici Spa filed Critical Alfa Farmaceutici Spa
Publication of SE8103216L publication Critical patent/SE8103216L/xx
Publication of SE453089B publication Critical patent/SE453089B/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
SE8103216A 1980-05-22 1981-05-21 Imidazo-rifamycinderivat, forfarande for framstellning derav och farmaceutisk komposition SE453089B (sv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT03429/80A IT1154655B (it) 1980-05-22 1980-05-22 Derivati imidazo-rifamicinici metodi per la loro preparazione e loro uso come sostanza ad azione antibatterica

Publications (2)

Publication Number Publication Date
SE8103216L SE8103216L (sv) 1981-11-23
SE453089B true SE453089B (sv) 1988-01-11

Family

ID=11107198

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8103216A SE453089B (sv) 1980-05-22 1981-05-21 Imidazo-rifamycinderivat, forfarande for framstellning derav och farmaceutisk komposition

Country Status (25)

Country Link
US (1) US4341785A (fr)
JP (1) JPS5711987A (fr)
AR (1) AR226212A1 (fr)
AT (1) AT373599B (fr)
AU (1) AU537093B2 (fr)
BE (1) BE888895A (fr)
CA (1) CA1142518A (fr)
CH (1) CH648037A5 (fr)
DE (1) DE3120460A1 (fr)
DK (1) DK157876C (fr)
EG (1) EG14891A (fr)
ES (1) ES502906A0 (fr)
FI (1) FI69467C (fr)
FR (1) FR2482967A1 (fr)
GB (1) GB2079270B (fr)
GR (1) GR75640B (fr)
IE (1) IE51204B1 (fr)
IT (1) IT1154655B (fr)
LU (1) LU83376A1 (fr)
NL (1) NL187022C (fr)
NO (1) NO155622C (fr)
PH (2) PH17207A (fr)
PT (1) PT73064B (fr)
SE (1) SE453089B (fr)
ZA (1) ZA813430B (fr)

Families Citing this family (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1199374B (it) 1984-05-15 1988-12-30 Alfa Farmaceutici Spa Processo per la preparazione di pirido-imidazo-rifamicine
IT1264494B1 (it) * 1993-03-23 1996-09-24 Alfa Wassermann Spa Uso di rifaximin e di formulazioni che la contengono nel trattamento delle dispepsie gastriche originate da helicobacter
US7048906B2 (en) 1995-05-17 2006-05-23 Cedars-Sinai Medical Center Methods of diagnosing and treating small intestinal bacterial overgrowth (SIBO) and SIBO-related conditions
US6861053B1 (en) 1999-08-11 2005-03-01 Cedars-Sinai Medical Center Methods of diagnosing or treating irritable bowel syndrome and other disorders caused by small intestinal bacterial overgrowth
US5981522A (en) * 1995-09-01 1999-11-09 Kaneka Corporation Treatment of disease caused by infection of Helicobacter
DE69829905T2 (de) * 1997-02-28 2006-03-09 Kaneka Corp. Heilmittel für durch Helicobacter verursachte Krankheit
WO2003045319A2 (fr) * 2001-11-21 2003-06-05 Activbiotics, Inc. Agents therapeutiques cibles et leurs utilisations
US7078399B2 (en) * 2001-12-13 2006-07-18 Activbiotics, Inc. Sulfhydryl rifamycins and uses thereof
WO2004041240A1 (fr) * 2002-11-05 2004-05-21 Piero Chiarelli Delivrance continue et regulee de rifaximine et/ou d'autres substances
US7820652B2 (en) * 2003-09-24 2010-10-26 Activbiotics Pharma, Llc Regimen for the administration of rifamycin-class antibiotics
US7923553B2 (en) * 2003-11-07 2011-04-12 Alfa Wassermann, S.P.A. Processes for the production of polymorphic forms of rifaximin
US7906542B2 (en) * 2004-11-04 2011-03-15 Alfa Wassermann, S.P.A. Pharmaceutical compositions comprising polymorphic forms α, β, and γ of rifaximin
US20080262024A1 (en) * 2003-11-07 2008-10-23 Giuseppe Claudio Viscomi Rifaximin compositions and method of use
ITMI20032144A1 (it) * 2003-11-07 2005-05-08 Alfa Wassermann Spa Forme polimorfe di rifaximina, processi per ottenerle e
US7902206B2 (en) * 2003-11-07 2011-03-08 Alfa Wassermann, S.P.A. Polymorphic forms α, β and γ of rifaximin
US7256187B2 (en) * 2004-03-10 2007-08-14 Cumbre Pharmaceuticals Inc. Rifamycin C-11 oxime derivatives effective against drug-resistant microbes
US7265107B2 (en) * 2004-03-10 2007-09-04 Cumbre Pharmaceuticals Inc. Rifamycin C-11 oxime cyclo derivatives effective against drug-resistant microbes
US7202246B2 (en) * 2004-06-09 2007-04-10 Cumbre Pharmaceuticals Inc. Spiro-rifamycin derivatives targeting RNA polymerase
US20060210492A1 (en) * 2005-03-02 2006-09-21 Kodsi Robert E Use of rifaximin for treatment and prevention of periodontal conditions
US20060210483A1 (en) * 2005-03-02 2006-09-21 Kodsi Robert E Non-systemic antibiotic formulations and related method of use and treatment of upper respiratory infections
US8003118B2 (en) * 2005-03-02 2011-08-23 Kodsi Robert E Use of rifaximin for the prevention of aspiration pneumonia and/or sepsis
SI1698630T1 (sl) * 2005-03-03 2015-01-30 Alfa Wassermann S.P.A. Nove polimorfne oblike rifaksimina, postopki za njihovo pripravo in njihova uporaba v medicinskih pripravkih
ITBO20050123A1 (it) 2005-03-07 2005-06-06 Alfa Wassermann Spa Formulazioni farmaceutiche gastroresistenti contenenti rifaximina
BRPI0614758A2 (pt) 2005-08-11 2011-04-12 Targanta Therapeutics Inc rifamicinas fosfonadas e usos destas para a prevenção e tratamento de infecções na articulação e osso
ES2747259T3 (es) 2006-03-09 2020-03-10 Salix Pharmaceuticals Inc Preparación anti-disfunción rectal de rifaximina
PL2054066T3 (pl) 2006-08-02 2015-12-31 Salix Pharmaceuticals Inc Sposoby leczenia popromiennego zapalenia jelit
ITMI20061692A1 (it) 2006-09-05 2008-03-06 Alfa Wassermann Spa Uso di polioli per ottenere forme polimorfe stabili di rifaximina
KR101667534B1 (ko) * 2006-09-22 2016-10-19 씨아이피엘에이 엘티디. 리팍시민
US20080159987A1 (en) * 2007-01-03 2008-07-03 Leonard Weinstock Use of Rifaximin for the Treatment of Restless Legs Syndrome
US20080161337A1 (en) * 2007-01-03 2008-07-03 Leonard Weinstock Use of Rifaximin for the Treatment of Chronic Prostatitis
ITMI20071241A1 (it) * 2007-06-20 2008-12-21 Solmag S P A Processo per la preparazione di rifaximina amorfa e rifaximina amorfa cosi' ottenuta
US8383151B2 (en) 2007-07-06 2013-02-26 Lupin Limited Pharmaceutical compositions of rifaximin
EP2837378A1 (fr) 2007-07-06 2015-02-18 Lupin Limited Compositions pharmaceutiques de rifaximine
US7709634B2 (en) * 2007-09-20 2010-05-04 Apotex Pharmachem Inc. Amorphous form of rifaximin and processes for its preparation
MX2010009389A (es) * 2008-02-25 2010-11-22 Salix Pharmaceuticals Ltd Formas de rifaximina y sus usos.
US8486956B2 (en) * 2008-02-25 2013-07-16 Salix Pharmaceuticals, Ltd Forms of rifaximin and uses thereof
ES2727728T3 (es) 2008-02-26 2019-10-18 Salix Pharmaceuticals Ltd Métodos para el tratamiento del síndrome del intestino irritable
US11779571B2 (en) 2008-02-26 2023-10-10 Salix Pharmaceuticals, Inc. Methods for treating irritable bowel syndrome (IBS)
SI2294012T1 (sl) 2008-05-07 2014-11-28 Salix Pharmaceuticals, Ltd. Dajanje ÄŤistila za ÄŤrevo in antibiotika za zdravljenje ÄŤrevesne bolezni
US8524691B2 (en) 2008-08-13 2013-09-03 The Medicines Company Phosphonated rifamycins and uses thereof for the prevention and treatment of bone and joint infections
RU2011116400A (ru) 2008-09-26 2012-11-10 Аска Фармасьютикал Ко., Лтд. (Jp) Средство для предотвращения и/или лечения функционального расстройства желудочно-кишечного тракта
US20100204173A1 (en) 2008-10-02 2010-08-12 Salix Pharmaceuticals, Ltd. Methods of treating hepatic encephalopathy
CA2745980C (fr) 2008-12-10 2017-10-31 Cipla Limited Complexes de rifaximine
IT1397617B1 (it) * 2009-04-20 2013-01-18 Alfa Wassermann Spa Nuovi derivati della rifamicina
MX2011012829A (es) 2009-06-02 2012-02-28 Salix Pharmaceuticals Ltd Metodos para tratar encefalopatia hepatica.
RU2582940C2 (ru) 2009-09-13 2016-04-27 Саликс Фармасьютикалз, Лтд. Способы лечения синдрома раздраженного кишечника (срк)
JP6211768B2 (ja) 2009-10-27 2017-10-11 ルピン・リミテッド リファキシミンの固溶体
WO2011061519A2 (fr) 2009-11-23 2011-05-26 Cipla Limited Composition de mousse topique
US8952159B2 (en) 2009-12-28 2015-02-10 Silvio Massimo Lavagna Method for the production of amorphous rifaximin
JP5896380B2 (ja) 2010-02-18 2016-03-30 サリックス ファーマスーティカルズ，リミテッド 感染症を治療するための方法
IT1398550B1 (it) 2010-03-05 2013-03-01 Alfa Wassermann Spa Formulazioni comprendenti rifaximina utili per ottenere un effetto prolungato nel tempo
JP6092629B2 (ja) 2010-03-10 2017-03-08 ルピン・リミテッドＬｕｐｉｎ Ｌｉｍｉｔｅｄ リファキシミン使用準備済懸濁液
PL2593463T3 (pl) 2010-07-12 2020-11-02 Salix Pharmaceuticals, Inc. Formulacje ryfaksyminy i ich zastosowania
WO2012035544A2 (fr) 2010-09-13 2012-03-22 Sequent Scientific Ltd. Nouvelle forme polymorphe de rifaximine et son procédé de préparation
KR20140026379A (ko) 2011-02-11 2014-03-05 샐릭스 파마슈티컬스 리미티드 리팍시민의 형태 및 이의 용도
EP2705042A1 (fr) 2011-05-02 2014-03-12 Ranbaxy Laboratories Limited Solvate de diméthylformamide rifaximine
ITMI20110890A1 (it) 2011-05-19 2012-11-20 A M S A Anonima Materie Sint & Affini S P A Polimorfo di rifaximina e processo per la sua preparazione
ITBO20110461A1 (it) 2011-07-29 2013-01-30 Alfa Wassermann Spa Composizioni farmaceutiche comprendenti rifaximina, processi per la loro preparazione e loro uso nel trattamento di infezioni vaginali.
RU2496475C2 (ru) 2011-10-26 2013-10-27 Александр Васильевич Иващенко Фармацевтическая композиция и набор для лечения бактериальных инфекций
AU2012332211B2 (en) 2011-11-02 2016-11-24 Salix Pharmaceuticals, Ltd. Methods for treating irritable bowel syndrome (IBS) and infections
CA2861104A1 (fr) * 2012-01-25 2013-08-01 Salix Pharmaceuticals, Ltd. Derive de rifaximine et ses utilisations
ITBO20120368A1 (it) 2012-07-06 2014-01-07 Alfa Wassermann Spa Composizioni comprendenti rifaximina e amminoacidi, cristalli di rifaximina derivanti da tali composizioni e loro uso.
WO2014091432A1 (fr) 2012-12-12 2014-06-19 Ranbaxy Laboratories Limited Compositions pharmaceutiques de rifaximine
WO2014140995A2 (fr) 2013-03-15 2014-09-18 Alfa Wassermann S.P.A. Procédé pour diagnostiquer des infections vaginales
EP2968283A1 (fr) 2013-03-15 2016-01-20 ALFA WASSERMANN S.p.A. Rifaximine destinée à être utilisée dans le traitement d'infections vaginales
EP2983647B1 (fr) 2013-04-12 2020-09-09 Alfasigma S.p.A. Administration d'ains, compositions, procédés et systèmes associés
US9018225B1 (en) 2013-07-26 2015-04-28 Novel Laboratories Rifaximin crystalline forms and methods of preparation thereof
ES2621557T3 (es) 2014-03-31 2017-07-04 Euticals S.P.A. Mezcla polimórfica de rifaximina y su uso para la preparación de formulaciones sólidas
EP3140313B1 (fr) 2014-05-04 2020-02-26 Salix Pharmaceuticals, Inc. Microbiote du syndrome du côlon irritable et utilisations associées
PT3143027T (pt) * 2014-05-12 2019-09-20 Alfasigma Spa Nova forma de cristal solvatado de rifaximina, produção, composições e utilização dos mesmos
EP2982764A1 (fr) 2014-08-05 2016-02-10 ALFA WASSERMANN S.p.A. Identification de bactérie vaginale
US9988398B2 (en) 2016-06-07 2018-06-05 Cadila Healthcare Limited Crystalline form of rifaximin and process for its preparation
KR20240124428A (ko) 2016-09-30 2024-08-16 샐릭스 파마슈티컬스 인코포레이티드 리팍시민의 고체 분산물 형태
RU2020102511A (ru) * 2017-06-26 2021-07-27 Биофер С.П.А. Соединения пиридо-имидазо рифамицина в качестве антибактериального средства
IT201700091912A1 (it) * 2017-08-08 2019-02-08 Biofer Spa Nuove pirido-imidazo rifamicine

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE273377C (fr) *
AT273377B (de) * 1967-03-01 1969-08-11 Lepetit Spa Verfahren zur Herstellung von neuen Rifamycinen
AT344898B (de) * 1975-06-13 1978-08-10 Archifar Ind Chim Trentino Verfahren zur herstellung neuer rifamycin-verbindungen
DK345977A (da) * 1976-09-30 1978-03-31 Archifar Ind Chim Trentino G rifamycinforbindelser og fremgangsmaade til deres fremstillin
CH629212A5 (it) * 1976-10-18 1982-04-15 Erba Farmitalia Procedimento per la preparazione di composti di rifamicina.
CH633014A5 (en) * 1978-06-09 1982-11-15 Erba Farmitalia Rifamycin compounds

Also Published As

Publication number Publication date
FI69467C (fi) 1986-02-10
DE3120460A1 (de) 1982-03-11
IE811139L (en) 1981-11-22
PH17207A (en) 1984-06-19
NO155622C (no) 1987-04-29
ES8203388A1 (es) 1982-04-01
GB2079270B (en) 1984-01-18
FI811565L (fi) 1981-11-23
ZA813430B (en) 1982-06-30
FI69467B (fi) 1985-10-31
FR2482967B1 (fr) 1985-03-29
IE51204B1 (en) 1986-10-29
AT373599B (de) 1984-02-10
DK157876B (da) 1990-02-26
ATA222781A (de) 1983-06-15
NL187022C (nl) 1991-05-01
AR226212A1 (es) 1982-06-15
IT1154655B (it) 1987-01-21
NO155622B (no) 1987-01-19
CH648037A5 (de) 1985-02-28
AU7065581A (en) 1981-11-26
IT8003429A0 (it) 1980-05-22
AU537093B2 (en) 1984-06-07
DE3120460C2 (fr) 1990-12-13
DK224781A (da) 1981-11-23
JPS5711987A (en) 1982-01-21
CA1142518A (fr) 1983-03-08
NL8102290A (nl) 1981-12-16
LU83376A1 (fr) 1981-09-11
JPS6123192B2 (fr) 1986-06-04
US4341785A (en) 1982-07-27
PH18704A (en) 1985-09-05
EG14891A (en) 1985-12-31
DK157876C (da) 1990-07-30
ES502906A0 (es) 1982-04-01
GR75640B (fr) 1984-08-02
NO811731L (no) 1981-11-23
FR2482967A1 (fr) 1981-11-27
PT73064A (en) 1981-06-01
PT73064B (en) 1982-07-05
SE8103216L (sv) 1981-11-23
BE888895A (fr) 1981-09-16
NL187022B (nl) 1990-12-03
GB2079270A (en) 1982-01-20

Similar Documents

Publication Publication Date Title
SE453089B (sv) Imidazo-rifamycinderivat, forfarande for framstellning derav och farmaceutisk komposition
EP0161534B1 (fr) Procédé pour la synthèse de pyridoimidazo rifamycines
PL118475B1 (en) Process for preparing novel alkyloximes of derivatives of 7-amino-thiazolyl-acetamido-cephalosporanic acidino-tiazolilo-acetamido-cefalosporanovojj kisloty
GB2053894A (en) Benzodiazepines processes for producing them and compositions containing them
AU655718B2 (en) Novel alkylenediammonium diclavulanate derivatives, a process for the preparation thereof as well as the use thereof
EP0080818B1 (fr) Dérivés d'erythromycine-B
US4007169A (en) Method of preparing derivatives of rifamycin S
EP0080819A1 (fr) Dérivés de 11-0-alkylérythromycine A
CA1218650A (fr) Synthese des pyrido-imidazo-rifamycines
GB2025422A (en) 17-acetylene derivatives of androst-4-ene
KR910002841B1 (ko) 3-아지노메틸 리파마이신의 제조방법
WO1996004299A1 (fr) Derives de streptogramine, leur preparation et les compositions pharmaceutiques qui les contiennent
SE453194B (sv) Rifamycinderivat, forfarande for framstellning derav samt farmaceutiska kompositioner innehallande dessa
DE2402200C2 (de) N-(Benzolsulfonyl)-erythromycylaminderivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
DE1960643A1 (de) Verfahren zur Herstellung neuer Derivate der 7-Aminocephalosporansaeure
DE2025838A1 (fr)
US4430500A (en) Process for purifying cephalosporin compounds
US4225717A (en) 2-Hydrazino-3-pyridinol-1-oxide hydrobromide
US4394312A (en) Process for preparing rifamycin derivatives
DE2654627B2 (de) Oleandomycinderivate und deren nicht-toxische Säureanlagerungsalze, Verfahren zu deren Herstellung sowie diese Verbindungen enthaltende antibakterielle Arzneimittel
SE436035B (sv) Forfarande for framstellning av 4-deoxi-tiazolo/5,4-c/-rifamycin-sv-derivat
GB2102409A (en) Rifamycin derivatives
GB2073737A (en) Rifamycins
CH654832A5 (de) Stickstoffhaltige prostaglandin/prostacyclin-synthone und verfahren zu ihrer herstellung.
KR20010029475A (ko) 약제학적 화합물의 제조 방법

Legal Events

Date Code Title Description
NAL Patent in force

Ref document number: 8103216-1

Format of ref document f/p: F

NUG Patent has lapsed

Ref document number: 8103216-1

Format of ref document f/p: F