SE445348B - Karbostyrilderivat, forfarande for framstellning derav och hjertsterkande komposition som innehaller detsamma - Google Patents

Karbostyrilderivat, forfarande for framstellning derav och hjertsterkande komposition som innehaller detsamma

Info

Publication number
SE445348B
SE445348B SE8200916A SE8200916A SE445348B SE 445348 B SE445348 B SE 445348B SE 8200916 A SE8200916 A SE 8200916A SE 8200916 A SE8200916 A SE 8200916A SE 445348 B SE445348 B SE 445348B
Authority
SE
Sweden
Prior art keywords
group
lower alkyl
alkyl group
phenyl ring
phenyl
Prior art date
Application number
SE8200916A
Other languages
English (en)
Swedish (sv)
Other versions
SE8200916L (sv
Inventor
Michiaki Tominaga
Yung-Hsiung Yang
Hidenori Ogawa
Kazuyuki Nakagawa
Original Assignee
Otsuka Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP56022437A external-priority patent/JPS57136517A/ja
Priority claimed from JP56057732A external-priority patent/JPS57171974A/ja
Priority claimed from JP12714581A external-priority patent/JPS5829766A/ja
Application filed by Otsuka Pharma Co Ltd filed Critical Otsuka Pharma Co Ltd
Publication of SE8200916L publication Critical patent/SE8200916L/xx
Publication of SE445348B publication Critical patent/SE445348B/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/57—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
SE8200916A 1981-02-17 1982-02-16 Karbostyrilderivat, forfarande for framstellning derav och hjertsterkande komposition som innehaller detsamma SE445348B (sv)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP56022437A JPS57136517A (en) 1981-02-17 1981-02-17 Cardiotonic
JP56057732A JPS57171974A (en) 1981-04-15 1981-04-15 Carbostyril derivative
JP12714581A JPS5829766A (ja) 1981-08-12 1981-08-12 カルボスチリル誘導体

Publications (2)

Publication Number Publication Date
SE8200916L SE8200916L (sv) 1982-08-18
SE445348B true SE445348B (sv) 1986-06-16

Family

ID=27283844

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8200916A SE445348B (sv) 1981-02-17 1982-02-16 Karbostyrilderivat, forfarande for framstellning derav och hjertsterkande komposition som innehaller detsamma

Country Status (21)

Country Link
US (3) US4487772A (fr)
KR (1) KR860001337B1 (fr)
AT (1) AT386198B (fr)
AU (1) AU530264B2 (fr)
BE (1) BE892148A (fr)
CA (1) CA1199915A (fr)
CH (1) CH651827A5 (fr)
DE (1) DE3204892A1 (fr)
DK (1) DK152287C (fr)
ES (2) ES8305334A1 (fr)
FI (1) FI77852C (fr)
FR (1) FR2512818B1 (fr)
GB (1) GB2094789B (fr)
IT (1) IT1157002B (fr)
MX (1) MX156153A (fr)
NL (1) NL8200593A (fr)
NO (1) NO159446C (fr)
PH (1) PH18085A (fr)
PT (1) PT74440B (fr)
SE (1) SE445348B (fr)
SU (1) SU1331426A3 (fr)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH17194A (en) * 1980-03-06 1984-06-19 Otsuka Pharma Co Ltd Novel carbostyril derivatives,and pharmaceutical composition containing the same
FI77852C (fi) * 1981-02-17 1989-05-10 Otsuka Pharma Co Ltd Foerfarande foer framstaellning av nya, saosom hjaertmediciner anvaendbara substituerade amid- och (maettad heterocykel)karbonylkarbostyrilderivat.
AU532361B2 (en) * 1981-09-01 1983-09-29 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives
FI80022C (fi) * 1982-07-05 1990-04-10 Otsuka Pharma Co Ltd Foerfarande foer framstaellning av ett nytt, terapeutiskt anvaendbart karbostyrilderivat.
US4845100A (en) * 1985-04-12 1989-07-04 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives and salts thereof, processes for preparing the same and cardiotonic composition containing the same
US4792561A (en) * 1986-05-29 1988-12-20 Syntex (U.S.A.) Inc. Carbostyril derivatives as combined thromboxane synthetase and cyclic-AMP phosphodiesterase inhibitors
US4921862A (en) * 1986-05-29 1990-05-01 Syntex (U.S.A.) Inc. Carbostyril derivatives as combined thromboxane synthetase and cyclic-amp phosphodiesterase inhibitors
EP0255134B1 (fr) * 1986-07-31 1993-03-03 Otsuka Pharmaceutical Co., Ltd. Dérivés de carbostyryle et leurs sels, leur procédé de préparation et composition cardiotonique les contenant
GB8709448D0 (en) * 1987-04-21 1987-05-28 Pfizer Ltd Heterobicyclic quinoline derivatives
US5227381A (en) * 1988-05-02 1993-07-13 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivative
DE3818830A1 (de) * 1988-06-03 1989-12-14 Boehringer Mannheim Gmbh Bicyclische carboxamide, verfahren zu ihrer herstellung, deren vorstufen, und diese verbindungen enthaltende arzneimittel
JP2686887B2 (ja) * 1992-08-11 1997-12-08 キッセイ薬品工業株式会社 ピペリジノ−３，４−ジヒドロカルボスチリル誘導体
JPH06239858A (ja) * 1993-02-16 1994-08-30 Otsuka Pharmaceut Co Ltd 末梢血管拡張剤
WO1994022826A1 (fr) * 1993-04-07 1994-10-13 Otsuka Pharmaceutical Co., Ltd. Agents vasodilatateurs peripheriques comportant comme principe actif des derives de la piperidine 4-amino n-acylee
ATE174915T1 (de) * 1994-10-31 1999-01-15 Merck Patent Gmbh Benzylpiperidinderivate mit hoher affinität zu bindungsstellen von aminosäure-rezeptoren
US6340685B1 (en) * 1998-05-22 2002-01-22 Scios, Inc. Compounds and methods to treat cardiac failure and other disorders
US6867209B1 (en) 1998-05-22 2005-03-15 Scios, Inc. Indole-type derivatives as inhibitors of p38 kinase
US6448257B1 (en) 1998-05-22 2002-09-10 Scios, Inc. Compounds and methods to treat cardiac failure and other disorders
US6589954B1 (en) 1998-05-22 2003-07-08 Scios, Inc. Compounds and methods to treat cardiac failure and other disorders
IL146309A (en) 1999-05-21 2008-03-20 Scios Inc Derivatives of the indole type and pharmaceutical preparations containing them as inhibitors of kinase p38
AU2003253149A1 (en) * 2002-08-13 2004-02-25 Warner-Lambert Company Llc 3,4-dihydroquinolin-2-one, 5,6-fused oxazin-3-one, and 5,6-fused thiazin-3-one derivatives as matrix metalloproteinase inhibitors
AU2004299183B2 (en) * 2003-12-10 2010-09-23 Janssen Pharmaceutica N.V. Substituted 6-cyclohexylalkyl substituted 2-quinolinones and 2-quinoxalinones as poly(ADP-ribose) polymerase inhibitors
MY142362A (en) * 2004-01-29 2010-11-30 Otsuka Pharma Co Ltd Pharmaceutical composition for promoting angiogenesis
EP2808020A1 (fr) 2006-04-21 2014-12-03 The Government Of The United States, As Represented by The Secretary Of Health And Human Services Agents d'imagerie tep de bêta-amyloïdes
WO2010021681A2 (fr) * 2008-08-18 2010-02-25 Combinatorx (Singapore) Pte. Ltd. Compositions et procédés pour le traitement de maladies virales
RS56352B2 (sr) 2009-06-25 2023-02-28 Alkermes Pharma Ireland Ltd Heterociklična jedinjenja za lečenje neuroloških i psiholoških poremećaja
EP2566329B1 (fr) 2010-05-04 2020-09-09 Alkermes Pharma Ireland Limited Procédé de synthèse de lactames oxydés
ES2691671T3 (es) 2010-06-24 2018-11-28 Alkermes Pharma Ireland Limited Profármacos de compuestos NH-acídicos: derivados de éster, carbonato, carbamato y fosfonato
JP7269948B2 (ja) * 2017-11-28 2023-05-09 エフ． ホフマン－ラ ロシュ アーゲー 新規複素環式化合物
WO2019134985A1 (fr) 2018-01-08 2019-07-11 F. Hoffmann-La Roche Ag Octahydropyrido[1,2-alpha]pyrazines en tant qu'inhibiteurs de magl
CN109651285B (zh) * 2019-01-30 2020-06-30 苏州大学 多溴代苯并[1,3]噁嗪衍生物的合成方法
BR112023003580A2 (pt) 2020-09-03 2023-04-04 Hoffmann La Roche Compostos heterocíclicos

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2997474A (en) * 1959-10-12 1961-08-22 Paul A J Janssen 1-aryl-omega-(4-arylpiperazine) alkanols
US3555030A (en) * 1964-11-25 1971-01-12 Smith Kline French Lab Muscle relaxant and analgesic compositions
US4115569A (en) * 1971-11-19 1978-09-19 Hoechst Aktiengesellschaft Cyclic diamine derivatives
US4256890A (en) * 1972-09-14 1981-03-17 Otsukapharmaceutical Co., Ltd. 3,4-Dihydrocarbostyril derivatives and process for producing the same
IT998326B (it) * 1973-08-06 1976-01-20 Montedison Spa Derivati degli acidi chinolin 8 carbossilici ad attivita antiparas sitaria
US4022784A (en) * 1974-01-31 1977-05-10 Otsuka Pharmaceutical Company Limited 5-[1-Hydroxy-2-(substituted-amino)]alkyl-8-substituted-carbostyril and -3,4-dihydrocarbostyril derivatives
US4022776A (en) * 1974-01-31 1977-05-10 Otsuka Pharmaceutical Company Limited 5-[1-Hydroxy-2-(substituted-amino)]ethyl-8-hydroxycarbostyril derivatives
US4145542A (en) * 1974-06-13 1979-03-20 Otsuka Pharmaceutical Co., Ltd. 5- 1-Hydroxy-2-(heterocyclic-amino)!alkyl-8-hydroxy-3,4-dihydrocarbostyril derivatives
US4070470A (en) * 1974-06-24 1978-01-24 Otsuka Pharmaceutical Co., Ltd. Platelet aggregation inhibiting carbostyrils, their compositions and method of use
JPS51118771A (en) * 1975-04-09 1976-10-18 Otsuka Pharmaceut Co Ltd Method for preparing carbostyryl derivatives
US3994900A (en) * 1976-01-23 1976-11-30 E. R. Squibb & Sons, Inc. 6-(Or 8)-[[(substituted amino)alkyl]oxy(or thio)]-3,4-dihydro-4-phenyl-2(1H)-quinolinones
US4210753A (en) * 1976-03-17 1980-07-01 Otsuka Pharmaceutical Co., Ltd. Carbostyril compounds
GB1589871A (en) * 1976-07-19 1981-05-20 Conder Group Serv Ltd Tank construction
JPS609713B2 (ja) * 1976-10-08 1985-03-12 大塚製薬株式会社 カルボスチリル誘導体
IE46852B1 (en) * 1977-06-10 1983-10-05 Otsuka Pharma Co Ltd Novel carbostyril derivatives
JPS5416478A (en) * 1977-07-08 1979-02-07 Otsuka Pharmaceut Co Ltd 3,4-dihydrocarbostyril herivative
DE2928583A1 (de) * 1979-07-14 1981-01-29 Thomae Gmbh Dr K Verfahren zur herstellung von carbostyrilderivaten
PH17194A (en) * 1980-03-06 1984-06-19 Otsuka Pharma Co Ltd Novel carbostyril derivatives,and pharmaceutical composition containing the same
FI77852C (fi) * 1981-02-17 1989-05-10 Otsuka Pharma Co Ltd Foerfarande foer framstaellning av nya, saosom hjaertmediciner anvaendbara substituerade amid- och (maettad heterocykel)karbonylkarbostyrilderivat.

Also Published As

Publication number Publication date
DK66582A (da) 1982-08-18
US4454130A (en) 1984-06-12
ES8401959A1 (es) 1984-01-01
FR2512818B1 (fr) 1985-06-21
PT74440A (en) 1982-03-01
GB2094789A (en) 1982-09-22
PT74440B (en) 1983-08-24
SE8200916L (sv) 1982-08-18
NO820479L (no) 1982-08-18
US4468402A (en) 1984-08-28
GB2094789B (en) 1985-01-23
AU8052882A (en) 1982-11-11
FR2512818A1 (fr) 1983-03-18
AT386198B (de) 1988-07-11
FI77852B (fi) 1989-01-31
AU530264B2 (en) 1983-07-07
ES509693A0 (es) 1983-04-01
ATA59582A (de) 1987-12-15
ES518303A0 (es) 1984-01-01
IT8267177A0 (it) 1982-02-17
FI77852C (fi) 1989-05-10
BE892148A (fr) 1982-08-16
NL8200593A (nl) 1982-09-16
DE3204892C2 (fr) 1988-03-24
NO159446C (no) 1988-12-28
FI820338L (fi) 1982-08-18
KR860001337B1 (ko) 1986-09-15
US4487772A (en) 1984-12-11
DE3204892A1 (de) 1982-09-23
SU1331426A3 (ru) 1987-08-15
KR830009036A (ko) 1983-12-17
PH18085A (en) 1985-03-20
DK152287C (da) 1988-07-11
NO159446B (no) 1988-09-19
ES8305334A1 (es) 1983-04-01
MX156153A (es) 1988-07-19
IT1157002B (it) 1987-02-11
DK152287B (da) 1988-02-15
CH651827A5 (de) 1985-10-15
CA1199915A (fr) 1986-01-28

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