SA516371253B1 - استخدام مشتقات بنز إيميدازول – برولاين - Google Patents
استخدام مشتقات بنز إيميدازول – برولاين Download PDFInfo
- Publication number
- SA516371253B1 SA516371253B1 SA516371253A SA516371253A SA516371253B1 SA 516371253 B1 SA516371253 B1 SA 516371253B1 SA 516371253 A SA516371253 A SA 516371253A SA 516371253 A SA516371253 A SA 516371253A SA 516371253 B1 SA516371253 B1 SA 516371253B1
- Authority
- SA
- Saudi Arabia
- Prior art keywords
- methyl
- phenyl
- methanone
- compound
- pyrrolidine
- Prior art date
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- UBSOHWJGTKOSAS-VWMHFEHESA-N 1H-benzimidazole (2S)-pyrrolidine-2-carboxylic acid Chemical class OC(=O)[C@@H]1CCCN1.c1nc2ccccc2[nH]1 UBSOHWJGTKOSAS-VWMHFEHESA-N 0.000 title description 5
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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| LT2855453T (lt) | 2012-06-04 | 2017-02-27 | Actelion Pharmaceuticals Ltd. | Benzimidazolo prolino dariniai |
| UA119151C2 (uk) | 2013-12-03 | 2019-05-10 | Ідорсія Фармасьютікалз Лтд | КРИСТАЛІЧНА СОЛЬОВА ФОРМА (S)-(2-(6-ХЛОР-7-МЕТИЛ-1H-БЕНЗО[d]ІМІДАЗОЛ-2-ІЛ)-2-МЕТИЛПІРОЛІДИН-1-ІЛ)(5-МЕТОКСИ-2-(2H-1,2,3-ТРИАЗОЛ-2-ІЛ)ФЕНІЛ)МЕТАНОНУ ЯК АНТАГОНІСТ ОРЕКСИНОВОГО РЕЦЕПТОРА |
| PT3077389T (pt) | 2013-12-03 | 2017-12-15 | Idorsia Pharmaceuticals Ltd | Forma cristalina de (s)-(2-(6-cloro-7-metil-1hbenzo[d]imidazol-2-il)-2-metilpirrolidin-1-il)(5-metoxi-2-(2h-1,2,3-triazol-2-il)fenil)metanona e a sua utilização como como antagonistas do receptor de orexina |
| SI3077391T1 (sl) | 2013-12-04 | 2018-11-30 | Idorsia Pharmaceuticals Ltd | Uporaba benzimidazol-prolinskih derivatov |
| WO2017012502A1 (en) | 2015-07-17 | 2017-01-26 | Sunshine Lake Pharma Co., Ltd. | Substituted quinazoline compounds and preparation and uses thereof |
| WO2017088759A1 (en) | 2015-11-23 | 2017-06-01 | Sunshine Lake Pharma Co., Ltd. | OCTAHYDROPYRROLO [3, 4-c] PYRROLE DERIVATIVES AND USES THEREOF |
| EP3619199B1 (en) | 2017-05-03 | 2021-07-07 | Idorsia Pharmaceuticals Ltd | Preparation of 2-([1,2,3]triazol-2-yl)-benzoic acid derivatives |
| IL297234A (en) * | 2020-04-19 | 2022-12-01 | Idorsia Pharmaceuticals Ltd | Medical use of daridorexant |
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| PT3077389T (pt) | 2013-12-03 | 2017-12-15 | Idorsia Pharmaceuticals Ltd | Forma cristalina de (s)-(2-(6-cloro-7-metil-1hbenzo[d]imidazol-2-il)-2-metilpirrolidin-1-il)(5-metoxi-2-(2h-1,2,3-triazol-2-il)fenil)metanona e a sua utilização como como antagonistas do receptor de orexina |
| UA119151C2 (uk) | 2013-12-03 | 2019-05-10 | Ідорсія Фармасьютікалз Лтд | КРИСТАЛІЧНА СОЛЬОВА ФОРМА (S)-(2-(6-ХЛОР-7-МЕТИЛ-1H-БЕНЗО[d]ІМІДАЗОЛ-2-ІЛ)-2-МЕТИЛПІРОЛІДИН-1-ІЛ)(5-МЕТОКСИ-2-(2H-1,2,3-ТРИАЗОЛ-2-ІЛ)ФЕНІЛ)МЕТАНОНУ ЯК АНТАГОНІСТ ОРЕКСИНОВОГО РЕЦЕПТОРА |
| SI3077391T1 (sl) | 2013-12-04 | 2018-11-30 | Idorsia Pharmaceuticals Ltd | Uporaba benzimidazol-prolinskih derivatov |
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- 2014-12-03 MA MA39165A patent/MA39165A1/fr unknown
- 2014-12-03 AU AU2014358766A patent/AU2014358766B2/en active Active
- 2014-12-03 DK DK14827273.5T patent/DK3077391T3/en active
- 2014-12-03 CN CN201480065780.6A patent/CN105873921B/zh active Active
- 2014-12-03 KR KR1020167017709A patent/KR102330133B1/ko active Active
- 2014-12-03 TR TR2018/15342T patent/TR201815342T4/tr unknown
- 2014-12-03 WO PCT/IB2014/066548 patent/WO2015083094A1/en not_active Ceased
- 2014-12-03 MY MYPI2016702036A patent/MY179605A/en unknown
- 2014-12-03 HR HRP20181710TT patent/HRP20181710T1/hr unknown
- 2014-12-03 HU HUE14827273A patent/HUE040555T2/hu unknown
- 2014-12-03 US US15/101,871 patent/US9914721B2/en active Active
- 2014-12-03 CA CA2930053A patent/CA2930053A1/en not_active Abandoned
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2016
- 2016-05-26 PH PH12016500985A patent/PH12016500985B1/en unknown
- 2016-05-30 IL IL245914A patent/IL245914B/en active IP Right Grant
- 2016-06-01 SA SA516371253A patent/SA516371253B1/ar unknown
- 2016-06-02 CL CL2016001349A patent/CL2016001349A1/es unknown
- 2016-07-01 ZA ZA2016/04502A patent/ZA201604502B/en unknown
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2018
- 2018-11-15 CY CY181101212T patent/CY1121089T1/el unknown
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