RU2737882C2 - Биспецифические антигенсвязывающие конструкции против her2 - Google Patents

Биспецифические антигенсвязывающие конструкции против her2 Download PDF

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RU2737882C2
RU2737882C2 RU2016125551A RU2016125551A RU2737882C2 RU 2737882 C2 RU2737882 C2 RU 2737882C2 RU 2016125551 A RU2016125551 A RU 2016125551A RU 2016125551 A RU2016125551 A RU 2016125551A RU 2737882 C2 RU2737882 C2 RU 2737882C2
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her2
antigen
construct
binding
cell
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RU2016125551A
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RU2016125551A (ru
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Нина Е. ВАЙССЕР
Гордон Иу Кон НГ
Грант Раймонд УИКМАН
Сержит Бхимарао ДИКСИТ
Эрик ЭСКОБАР-КАБРЕРА
Марио САНЧЕС
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Займворкс Инк.
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
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    • C07K—PEPTIDES
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Urology & Nephrology (AREA)
  • General Chemical & Material Sciences (AREA)
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  • Pregnancy & Childbirth (AREA)
  • Peptides Or Proteins (AREA)
RU2016125551A 2013-11-27 2014-11-27 Биспецифические антигенсвязывающие конструкции против her2 RU2737882C2 (ru)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201361910026P 2013-11-27 2013-11-27
US61/910,026 2013-11-27
US201462000908P 2014-05-20 2014-05-20
US62/000,908 2014-05-20
US201462009125P 2014-06-06 2014-06-06
US62/009,125 2014-06-06
PCT/CA2014/051140 WO2015077891A1 (en) 2013-11-27 2014-11-27 Bispecific antigen-binding constructs targeting her2

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RU2016125551A RU2016125551A (ru) 2018-01-09
RU2737882C2 true RU2737882C2 (ru) 2020-12-04

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US (5) US10947319B2 (es)
EP (1) EP3074424A4 (es)
JP (3) JP6817064B2 (es)
KR (1) KR102357906B1 (es)
CN (1) CN105980409B (es)
AU (2) AU2014357292B2 (es)
CA (1) CA2931356A1 (es)
MX (2) MX2016006572A (es)
RU (1) RU2737882C2 (es)
WO (1) WO2015077891A1 (es)

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HRP20211773T1 (hr) 2011-11-04 2022-03-04 Zymeworks Inc. Stabilna heterodimerni dizajn antitijela s mutacijama u fc domeni
WO2014004586A1 (en) 2012-06-25 2014-01-03 Zymeworks Inc. Process and methods for efficient manufacturing of highly pure asymmetric antibodies in mammalian cells
US9914785B2 (en) 2012-11-28 2018-03-13 Zymeworks Inc. Engineered immunoglobulin heavy chain-light chain pairs and uses thereof
CA2931356A1 (en) 2013-11-27 2015-06-04 Zymeworks Inc. Bispecific antigen-binding constructs targeting her2
MX2016007958A (es) 2013-12-17 2016-08-03 Genentech Inc Anticuerpos anti-cd3 y metodos de uso.
US11566082B2 (en) 2014-11-17 2023-01-31 Cytiva Bioprocess R&D Ab Mutated immunoglobulin-binding polypeptides
EP3223848A4 (en) * 2014-11-27 2018-07-18 Zymeworks Inc. Methods of using bispecific antigen-binding constructs targeting her2
CA2984458A1 (en) 2015-05-13 2016-11-17 Zymeworks Inc. Antigen-binding constructs targeting her2
CN107531788B (zh) * 2015-06-24 2022-06-21 豪夫迈·罗氏有限公司 对her2和血脑屏障受体特异性的三特异性抗体及使用方法
EP3322735A4 (en) 2015-07-15 2019-03-13 Zymeworks Inc. BISPECIFIC ANTIGEN-BINDING CONSTRUCTS CONJUGATED TO A MEDICINAL PRODUCT
EP3416671A4 (en) * 2016-02-19 2019-10-30 Genisphere, LLC NUCLEIC ACID CARRIER AND THERAPEUTIC METHODS OF USE
EP3416691A4 (en) 2016-02-19 2020-02-26 Genisphere, LLC NUCLEIC ACID CARRIER AND THERAPEUTIC METHOD FOR USE
US20200297862A1 (en) * 2016-04-25 2020-09-24 Zymeworks Inc. Methods of using bispecific antigen-binding constructs targeting her2
US10889615B2 (en) 2016-05-11 2021-01-12 Cytiva Bioprocess R&D Ab Mutated immunoglobulin-binding polypeptides
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