RU2650646C2 - Соединения, предназначенные для лечения ожирения, и способы их применения - Google Patents

Соединения, предназначенные для лечения ожирения, и способы их применения Download PDF

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Publication number
RU2650646C2
RU2650646C2 RU2015115696A RU2015115696A RU2650646C2 RU 2650646 C2 RU2650646 C2 RU 2650646C2 RU 2015115696 A RU2015115696 A RU 2015115696A RU 2015115696 A RU2015115696 A RU 2015115696A RU 2650646 C2 RU2650646 C2 RU 2650646C2
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celastrol
obesity
mice
body weight
day
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RU2015115696A
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RU2015115696A (ru
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Умут ОЗКАН
Джозеф МАДЖЗУБ
Ральф Мацичек
Исин ЧАКИР
Серкан ЧАБИ
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Дзе Чилдрен'З Медикал Сентер Корпорейшн
Дзе Дженерал Хоспитал Корпорейшн
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/2264—Obesity-gene products, e.g. leptin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Obesity (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
RU2015115696A 2012-09-27 2013-09-26 Соединения, предназначенные для лечения ожирения, и способы их применения RU2650646C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261706153P 2012-09-27 2012-09-27
US61/706,153 2012-09-27
PCT/US2013/061911 WO2014052583A1 (en) 2012-09-27 2013-09-26 Compounds for the treatment of obesity and methods of use thereof

Related Child Applications (1)

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RU2015115696A RU2015115696A (ru) 2016-11-20
RU2650646C2 true RU2650646C2 (ru) 2018-04-16

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RU2015115696A RU2650646C2 (ru) 2012-09-27 2013-09-26 Соединения, предназначенные для лечения ожирения, и способы их применения
RU2018112067A RU2768868C2 (ru) 2012-09-27 2013-09-26 Соединения, предназначенные для лечения ожирения, и способы их применения

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US (6) US9968575B2 (https=)
EP (3) EP4082541A1 (https=)
JP (2) JP6480864B2 (https=)
CN (3) CN111529535A (https=)
AU (3) AU2013323528B2 (https=)
BR (1) BR112015006848A2 (https=)
CA (2) CA2886393C (https=)
CY (1) CY1121166T1 (https=)
DK (1) DK2900230T3 (https=)
ES (1) ES2696626T3 (https=)
HR (1) HRP20181879T1 (https=)
HU (1) HUE040496T2 (https=)
LT (1) LT2900230T (https=)
PL (1) PL2900230T3 (https=)
PT (1) PT2900230T (https=)
RS (1) RS58010B1 (https=)
RU (2) RU2650646C2 (https=)
SI (1) SI2900230T1 (https=)
SM (1) SMT201800604T1 (https=)
TR (1) TR201815668T4 (https=)
WO (1) WO2014052583A1 (https=)

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RU2650646C2 (ru) * 2012-09-27 2018-04-16 Дзе Чилдрен'З Медикал Сентер Корпорейшн Соединения, предназначенные для лечения ожирения, и способы их применения
CA3044998A1 (en) * 2014-03-26 2015-10-01 The Children's Medical Center Corporation Celastrol and derivatives for the treatment of obesity
US20170209408A1 (en) * 2014-04-03 2017-07-27 The Children's Medical Center Corporation Hsp90 inhibitors for the treatment of obesity and methods of use thereof
CN105985401B (zh) * 2015-02-16 2020-10-09 上海华拓医药科技发展有限公司 一种雷公藤红素衍生物、其制备方法及用途
JP7034078B2 (ja) * 2015-10-23 2022-03-11 イーアールエックス ファーマシューティカルズ インコーポレイテッド セラストロールの類似体
CN106905404B (zh) * 2017-01-13 2019-08-27 广东工业大学 熊果酸衍生物及其制备方法和应用
EP4392044A4 (en) * 2021-09-09 2025-01-22 Junion Labs Pte. Ltd. SUPERABSORBENT HYDROGELS WITH LIPASE INHIBITOR
KR102470686B1 (ko) * 2022-06-07 2022-11-23 서울대학교산학협력단 디메틸제일아스테럴을 포함하는 대사성 질환 예방 또는 치료용 약학 조성물
CN119431489A (zh) * 2024-11-13 2025-02-14 肇源县总医院 一种雷公藤红素衍生物及其制备方法

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EP2900230B1 (en) 2018-08-15
EP3434268B1 (en) 2022-04-20
EP2900230A1 (en) 2015-08-05
CA2886393C (en) 2019-02-26
JP6743211B2 (ja) 2020-08-19
PT2900230T (pt) 2018-11-26
AU2013323528B2 (en) 2016-11-10
CN104822374A (zh) 2015-08-05
US20210008019A1 (en) 2021-01-14
ES2696626T3 (es) 2019-01-17
RU2768868C2 (ru) 2022-03-25
AU2016247206B2 (en) 2018-08-02
SMT201800604T1 (it) 2019-01-11
DK2900230T3 (en) 2018-11-12
RU2018112067A (ru) 2019-03-07
HUE040496T2 (hu) 2019-03-28
CA3030272C (en) 2021-09-28
RU2015115696A (ru) 2016-11-20
EP4082541A1 (en) 2022-11-02
JP6480864B2 (ja) 2019-03-13
HRP20181879T1 (hr) 2019-02-08
US20210275482A1 (en) 2021-09-09
JP2015531376A (ja) 2015-11-02
PL2900230T3 (pl) 2019-02-28
WO2014052583A1 (en) 2014-04-03
EP3434268A1 (en) 2019-01-30
CN111529535A (zh) 2020-08-14
US20170304245A1 (en) 2017-10-26
CA2886393A1 (en) 2014-04-03
US11045439B2 (en) 2021-06-29
BR112015006848A2 (en) 2018-05-22
SI2900230T1 (sl) 2019-01-31
CY1121166T1 (el) 2020-05-29
AU2018256619A1 (en) 2018-11-22
TR201815668T4 (tr) 2018-11-21
US10653654B2 (en) 2020-05-19
LT2900230T (lt) 2019-01-10
CN111529534A (zh) 2020-08-14
US20250161252A1 (en) 2025-05-22
HK1213190A1 (en) 2016-06-30
AU2013323528A1 (en) 2015-04-09
AU2016247206A1 (en) 2016-11-10
CA3030272A1 (en) 2014-04-03
US9925161B2 (en) 2018-03-27
US20180185314A1 (en) 2018-07-05
US9968575B2 (en) 2018-05-15
RS58010B1 (sr) 2019-02-28
RU2018112067A3 (https=) 2021-06-24
US20150250753A1 (en) 2015-09-10
AU2018256619B2 (en) 2020-07-23
JP2019070052A (ja) 2019-05-09
US12064408B2 (en) 2024-08-20

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