CY1121166T1 - Ενωσεις για τη θεραπεια παχυσαρκιας και μεθοδοι χρησης αυτων - Google Patents
Ενωσεις για τη θεραπεια παχυσαρκιας και μεθοδοι χρησης αυτωνInfo
- Publication number
- CY1121166T1 CY1121166T1 CY20181101181T CY181101181T CY1121166T1 CY 1121166 T1 CY1121166 T1 CY 1121166T1 CY 20181101181 T CY20181101181 T CY 20181101181T CY 181101181 T CY181101181 T CY 181101181T CY 1121166 T1 CY1121166 T1 CY 1121166T1
- Authority
- CY
- Cyprus
- Prior art keywords
- weight loss
- obese
- administered
- loss agents
- obesity
- Prior art date
Links
- 208000008589 Obesity Diseases 0.000 title abstract 2
- 235000020824 obesity Nutrition 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title 1
- 239000000883 anti-obesity agent Substances 0.000 abstract 3
- 238000009472 formulation Methods 0.000 abstract 2
- NRYBAZVQPHGZNS-ZSOCWYAHSA-N leptin Chemical compound O=C([C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CC(C)C)CCSC)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CS)C(O)=O NRYBAZVQPHGZNS-ZSOCWYAHSA-N 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 102000016267 Leptin Human genes 0.000 abstract 1
- 108010092277 Leptin Proteins 0.000 abstract 1
- 210000000577 adipose tissue Anatomy 0.000 abstract 1
- 230000037406 food intake Effects 0.000 abstract 1
- 235000012631 food intake Nutrition 0.000 abstract 1
- 230000014101 glucose homeostasis Effects 0.000 abstract 1
- 229940039781 leptin Drugs 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 150000003648 triterpenes Chemical class 0.000 abstract 1
- 230000004580 weight loss Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/2264—Obesity-gene products, e.g. leptin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Obesity (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
Παρέχονται στο παρόν παράγοντες απώλειας βάρους πεντακυκλικού τριτερπενίου. Επίσης παρέχονται φαρμακοτεχνικές μορφές που περιέχουν θεραπευτικώς αποτελεσματική ποσότητα ενός ή περισσοτέρων παραγόντων απώλειας βάρους ή φαρμακευτικώς αποδεκτών αλάτων ή προφαρμάκων αυτών σε συνδυασμό με ένα ή περισσότερα φαρμακευτικώς αποδεκτά έκδοχα. Οι φαρμακοτεχνικές μορφές μπορεί να χορηγηθούν σε προ-παχύσαρκο, παχύσαρκο ή παθολογικά παχύσαρκο ασθενή για πρόκληση απώλειας βάρους, μείωση σωματικού λίπους, μείωση πρόσληψης τροφής, βελτίωση ομοιόστασης γλυκόζης, πρόληψη παχυσαρκίας ή συνδυασμό αυτών. Οι παράγοντες απώλειας βάρους επίσης μπορεί να συγχορηγούνται με λεπτίνη ή ανάλογο λεπτίνης.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261706153P | 2012-09-27 | 2012-09-27 | |
| PCT/US2013/061911 WO2014052583A1 (en) | 2012-09-27 | 2013-09-26 | Compounds for the treatment of obesity and methods of use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1121166T1 true CY1121166T1 (el) | 2020-05-29 |
Family
ID=49304418
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20181101181T CY1121166T1 (el) | 2012-09-27 | 2018-11-08 | Ενωσεις για τη θεραπεια παχυσαρκιας και μεθοδοι χρησης αυτων |
Country Status (21)
| Country | Link |
|---|---|
| US (5) | US9968575B2 (el) |
| EP (3) | EP3434268B1 (el) |
| JP (2) | JP6480864B2 (el) |
| CN (3) | CN111529534A (el) |
| AU (3) | AU2013323528B2 (el) |
| BR (1) | BR112015006848A2 (el) |
| CA (2) | CA2886393C (el) |
| CY (1) | CY1121166T1 (el) |
| DK (1) | DK2900230T3 (el) |
| ES (1) | ES2696626T3 (el) |
| HK (1) | HK1213190A1 (el) |
| HR (1) | HRP20181879T1 (el) |
| HU (1) | HUE040496T2 (el) |
| LT (1) | LT2900230T (el) |
| PL (1) | PL2900230T3 (el) |
| PT (1) | PT2900230T (el) |
| RS (1) | RS58010B1 (el) |
| RU (2) | RU2768868C2 (el) |
| SI (1) | SI2900230T1 (el) |
| TR (1) | TR201815668T4 (el) |
| WO (1) | WO2014052583A1 (el) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3434268B1 (en) | 2012-09-27 | 2022-04-20 | The Children's Medical Center Corporation | Compounds for the treatment of obesity and methods of use thereof |
| BR112016021985B1 (pt) * | 2014-03-26 | 2022-08-30 | The General Hospital Corporation | Formulação farmacêutica |
| WO2015153933A1 (en) * | 2014-04-03 | 2015-10-08 | The Children's Medical Center Corporation | Hsp90 inhibitors for the treatment of obesity and methods of use thereof |
| CN105985401B (zh) * | 2015-02-16 | 2020-10-09 | 上海华拓医药科技发展有限公司 | 一种雷公藤红素衍生物、其制备方法及用途 |
| CA3002924A1 (en) * | 2015-10-23 | 2017-04-27 | Erx Pharmaceuticals Inc. | Analogs of celastrol |
| CN106905404B (zh) * | 2017-01-13 | 2019-08-27 | 广东工业大学 | 熊果酸衍生物及其制备方法和应用 |
| KR102470686B1 (ko) * | 2022-06-07 | 2022-11-23 | 서울대학교산학협력단 | 디메틸제일아스테럴을 포함하는 대사성 질환 예방 또는 치료용 약학 조성물 |
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2013
- 2013-09-26 EP EP18181547.3A patent/EP3434268B1/en active Active
- 2013-09-26 US US14/431,412 patent/US9968575B2/en active Active
- 2013-09-26 AU AU2013323528A patent/AU2013323528B2/en active Active
- 2013-09-26 RS RS20181365A patent/RS58010B1/sr unknown
- 2013-09-26 LT LTEP13773562.7T patent/LT2900230T/lt unknown
- 2013-09-26 ES ES13773562T patent/ES2696626T3/es active Active
- 2013-09-26 EP EP13773562.7A patent/EP2900230B1/en active Active
- 2013-09-26 WO PCT/US2013/061911 patent/WO2014052583A1/en active Application Filing
- 2013-09-26 JP JP2015534652A patent/JP6480864B2/ja active Active
- 2013-09-26 SI SI201331170T patent/SI2900230T1/sl unknown
- 2013-09-26 DK DK13773562.7T patent/DK2900230T3/en active
- 2013-09-26 CA CA2886393A patent/CA2886393C/en active Active
- 2013-09-26 TR TR2018/15668T patent/TR201815668T4/tr unknown
- 2013-09-26 RU RU2018112067A patent/RU2768868C2/ru active
- 2013-09-26 CN CN202010540726.XA patent/CN111529534A/zh active Pending
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