SG11201407775WA - Methods of treating a metabolic syndrome by modulating heat shock protein (hsp) 90-beta - Google Patents

Methods of treating a metabolic syndrome by modulating heat shock protein (hsp) 90-beta

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Publication number
SG11201407775WA
SG11201407775WA SG11201407775WA SG11201407775WA SG11201407775WA SG 11201407775W A SG11201407775W A SG 11201407775WA SG 11201407775W A SG11201407775W A SG 11201407775WA SG 11201407775W A SG11201407775W A SG 11201407775WA SG 11201407775W A SG11201407775W A SG 11201407775WA
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SG
Singapore
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international
metabolic syndrome
street
methods
hsp
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SG11201407775WA
Inventor
Niven Rajin Narain
Rangaprasad Sarangarajan
Vivek K Vishnudas
Enxuan Jing
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Berg Llc
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Publication date
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Publication of SG11201407775WA publication Critical patent/SG11201407775WA/en

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5308—Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
    • G—PHYSICS
    • G01—MEASURING; TESTING
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    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/11—Antisense
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/14—Type of nucleic acid interfering N.A.
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/04—Endocrine or metabolic disorders
    • G01N2800/042—Disorders of carbohydrate metabolism, e.g. diabetes, glucose metabolism

Abstract

(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 28 November 2013 (28.11.2013) WIPOIPCT (10) International Publication Number WO 2013/177535 A2 (51) International Patent Classification: A61K 48/00 (2006.01) (21) International Application Number: (22) International Filing Date: (25) Filing Language: (26) Publication Language: PCT/US2013/042692 24 May 2013 (24.05.2013) English English (30) Priority Data: 61/652,023 25 May 2012 (25.05.2012) (84) US (71) Applicant: BERG PHARMA LLC [US/US]; 1845 Elm Hill Pike, Nashville, TN 37210 (US). (72) Inventors: NARAIN, Niven, Rajin; 73 Fresh Pond Park­ way, Cambridge, MA 02138 (US). SARANGARAJAN, Rangaprasad; 45 Central Street, Boylston, MA 01505 (US). VISHNUDAS, Vivek, K.; 91 Stamford Street, Apt. 1, Newton, MA 02466 (US). JING, Enxuan; 200 Maple Street, West Roxbury, MA 02132 (US). (74) Agents: HANLEY, Elizabeth, A. et al.; Mccarter & Eng­ lish, LLP, 265 Franklin Street, Boston, MA 02110 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available)'. AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. Designated States (unless otherwise indicated, for every kind of regional protection available)'. ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG). Published: — without international search report and to be republished upon receipt of that report (Rule 48.2(g)) — with sequence listing part of description (Rule 5.2(a)) (54) Title: METHODS OF TREATING A METABOLIC SYNDROME BY MODULATING HEAT SHOCK PROTEIN (HSP) 90- BETA Delta-Delta Networks DD_NG.vs.HG.vs.HGT 1 ,cys [ NG vs. HG ] vs. [ HS vs. HGT1 ] CJ m i> i> T-H rn T-H O (57) Abstract: The invention provides methods of treatment of metabolic syndrome with HSP90 inhibitors, particularly HSP90P in- ^ hibitors. The invention provides methods of diagnosis and monitoring of metabolic syndrome using HSP90, particularly HSP90p, Q expression and activity level.
SG11201407775WA 2012-05-25 2013-05-24 Methods of treating a metabolic syndrome by modulating heat shock protein (hsp) 90-beta SG11201407775WA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261652023P 2012-05-25 2012-05-25
PCT/US2013/042692 WO2013177535A2 (en) 2012-05-25 2013-05-24 Methods of treating a metabolic syndrome by modulating heat shock protein (hsp) 90-beta

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SG11201407775WA true SG11201407775WA (en) 2014-12-30

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US (2) US9533002B2 (en)
EP (1) EP2854865B1 (en)
JP (1) JP6478908B2 (en)
KR (1) KR20150010793A (en)
CN (1) CN104812898B (en)
AU (1) AU2013266086B2 (en)
BR (1) BR112014029301A2 (en)
CA (1) CA2874676A1 (en)
EA (1) EA201492184A1 (en)
HK (1) HK1209035A1 (en)
IL (1) IL235910A0 (en)
MX (1) MX2014014188A (en)
NZ (1) NZ702169A (en)
SG (1) SG11201407775WA (en)
WO (1) WO2013177535A2 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA201492184A1 (en) * 2012-05-25 2015-07-30 Берг Ллк METHODS OF TREATMENT OF METABOLIC SYNDROME BY MODULATING PROTEIN HEAT SHOCK (HSP) 90-BETA
RU2650646C2 (en) 2012-09-27 2018-04-16 Дзе Чилдрен'З Медикал Сентер Корпорейшн Compounds for the treatment of obesity and methods of use thereof
CA3044998A1 (en) * 2014-03-26 2015-10-01 The Children's Medical Center Corporation Celastrol and derivatives for the treatment of obesity
US10023864B2 (en) 2014-06-06 2018-07-17 Berg Llc Methods of treating a metabolic syndrome by modulating heat shock protein (HSP) 90-beta
EP3154547B1 (en) * 2014-06-13 2023-06-07 Yuma Therapeutics, Inc. Pyrimidine compounds and methods using the same
US20180110978A1 (en) * 2015-03-19 2018-04-26 Old Dominion University Research Foundation Synergistic regulated cell death induction with hsp90 inhibitors and nanosecond pulsed electric fields
US10662218B2 (en) * 2015-10-23 2020-05-26 Erx Pharmaceuticals, Inc. Analogs of celastrol
CN105920018B (en) * 2016-06-15 2019-01-11 上海市内分泌代谢病研究所 Celastrol combines the purposes of jamaicin preparation treatment antiobesity agents
CN107543929A (en) * 2016-06-23 2018-01-05 中国医学科学院肿瘤医院 Kit based on protein marker HSP90AB1 diagnosing patients
CN107028953A (en) * 2017-03-27 2017-08-11 北京大学 A kind of stimulant of sympathetic activity
IL296355A (en) * 2017-04-24 2022-11-01 Samus Therapeutics Inc Hsp90 inhibitor oral formulations and related methods
WO2018235251A1 (en) 2017-06-23 2018-12-27 株式会社ニコン Analysis device, analysis program, and analysis method
CN112156188A (en) * 2020-11-10 2021-01-01 上海交通大学医学院附属瑞金医院 Application of Hsp90 in preparation of drugs for preventing and treating steroid diabetes
CN113332308A (en) * 2021-02-22 2021-09-03 广东省妇幼保健院 Application of preparation for regulating HSP90B1 expression level in preparation of medicine for preventing or treating polycystic ovarian syndrome
CN113160983A (en) * 2021-04-09 2021-07-23 南京医科大学附属逸夫医院 Metabolism-related fatty liver disease clinical prediction model

Family Cites Families (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7078375B1 (en) * 1996-10-25 2006-07-18 Peter Mose Larsen Diabetes-mediating proteins and therapeutic uses thereof
US20040048256A1 (en) * 2001-09-07 2004-03-11 Agee Michele L. Novel proteins and nucleic acids encoding same
WO2004033657A2 (en) 2002-10-07 2004-04-22 Antigenics, Inc. Heat shock protein binding fragments of cd91, and uses thereof
US7189723B2 (en) 2003-02-10 2007-03-13 Cgi Pharmaceuticals, Inc. Certain 8-heteroaryl-6-phenyl-imidazo[1,2-a]pyrazines as modulators of kinase activity
GB0309637D0 (en) 2003-04-28 2003-06-04 Cancer Rec Tech Ltd Pyrazole compounds
BRPI0413861A (en) 2003-08-29 2006-10-24 Vernalis Cambridge Ltd pyrimidothiophene compounds
US20070249540A1 (en) 2004-05-24 2007-10-25 Adonia Papathanassiu Methods for Inhibiting Proteasome and Heat Shock Protein 90
CA2574727A1 (en) 2004-07-19 2006-02-23 University Of Rochester Biomarkers of neurodegenerative disease
US20060094682A1 (en) * 2004-10-29 2006-05-04 Odyssey Thera, Inc. Kinase inhibitors for the treatment of diabetes and obesity
US9120774B2 (en) 2004-11-03 2015-09-01 University Of Kansas Novobiocin analogues having modified sugar moieties
FR2885904B1 (en) 2005-05-19 2007-07-06 Aventis Pharma Sa NOVEL FLUORENE DERIVATIVES, COMPOSITIONS CONTAINING SAME AND USE THEREOF
JP2009504673A (en) 2005-08-11 2009-02-05 ノバルティス アクチエンゲゼルシャフト A combination comprising a protein kinase inhibitor which is a pyrimidylaminobenzamide compound and an HSP90 inhibitor such as 17-AAG
US20070207950A1 (en) 2005-12-21 2007-09-06 Duke University Methods and compositions for regulating HDAC6 activity
WO2007077042A1 (en) 2006-01-06 2007-07-12 Topotarget Switzerland Sa New method for the treatment of gout or pseudogout
WO2007097839A2 (en) 2006-02-16 2007-08-30 Massachusetts Eye And Ear Infirmary Ansamycin analogs or heat shock 90 inhibitors in combination with pdt treatin conditions of the eye
EP2007800A1 (en) 2006-03-17 2008-12-31 Crossbeta Biosciences B.V. Methods of binding of cross-beta structures by chaperones
WO2007137239A2 (en) 2006-05-19 2007-11-29 The Scripps Research Institute Treatment of protein misfolding
JP5441690B2 (en) 2006-05-25 2014-03-12 シンタ ファーマシューティカルズ コーポレーション Triazole compounds that modulate Hsp90 activity
EP2069325A2 (en) 2006-08-24 2009-06-17 Serenex, Inc. Isoquinoline, quinazoline and phthalazine derivatives
WO2008024974A1 (en) 2006-08-24 2008-02-28 Serenex, Inc. Pyrimidine and pyrazine derivatives
US20110160175A1 (en) 2006-09-11 2011-06-30 Christine Martin 18,21-Didesoxymacbecin Derivatives for the Treatment of Cancer
JP5721949B2 (en) 2006-10-12 2015-05-20 アステックス、セラピューティックス、リミテッドＡｓｔｅｘ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｌｉｍｉｔｅｄ Compound drug
JP5518478B2 (en) 2006-10-12 2014-06-11 アステックス、セラピューティックス、リミテッド Pharmaceutical compounds
GB0620259D0 (en) * 2006-10-12 2006-11-22 Astex Therapeutics Ltd Pharmaceutical compounds
GB0622084D0 (en) 2006-11-06 2006-12-13 Chroma Therapeutics Ltd Inhibitors of HSP90
US7855192B2 (en) 2007-01-26 2010-12-21 Kosan Biosciences, Inc. Macrolactams by engineered biosynthesis
SI2069324T1 (en) 2007-03-20 2013-10-30 Curis, Inc. Fused amino pyridine as hsp90 inhibitors
GB2449293A (en) 2007-05-17 2008-11-19 Evotec Compounds having Hsp90 inhibitory activity
US20100298280A1 (en) 2007-06-13 2010-11-25 Petra Kioschis-Schneider Compounds for the Modulation of Huntingtin Aggregation, Methods and Means for Identifying Such Compounds
IL184671A0 (en) 2007-07-17 2008-12-29 Hadasit Med Res Service Substances directed to heparanase c-terminal domain-or substance derived therefrom and uses thereof as modulators of heparanas biological activities
DE102007041116A1 (en) 2007-08-30 2009-03-05 Merck Patent Gmbh 1,3-dihydro-isoindole derivatives
TW200920357A (en) 2007-09-10 2009-05-16 Curis Inc HSP90 inhibitors containing a zinc binding moiety
EP2060565A1 (en) 2007-11-16 2009-05-20 4Sc Ag Novel bifunctional compounds which inhibit protein kinases and histone deacetylases
US20110218143A1 (en) 2007-11-20 2011-09-08 University Of Florida Research Foundation Compositions and methods for tissue repair
EP2226632B1 (en) 2007-12-28 2014-02-12 Takeda Pharmaceutical Company Limited Method for screening of cell-protecting agent
US8461194B2 (en) * 2008-03-07 2013-06-11 Aziende Chimiche Riunite Angelini Francesco A. C. R. A. F. S. P. A. 1-benzyl-3-hydroxymethylindazole derivatives and use thereof in the treatment of diseases based on the expression of MCP-1, CX3CR1 and P40
WO2009114470A2 (en) 2008-03-10 2009-09-17 Curis, Inc. Tetrahydroindole and tetrahdyroindazole as hsp90 inhibitors containing a zinc binding moiety
EP2100879A1 (en) 2008-03-13 2009-09-16 4Sc Ag Novel N-substituted tetrahydroisoquinoline/isoindoline hydroxamic acid compounds
BRPI0822354B1 (en) 2008-05-19 2020-11-10 Hewlett Packard Development Company, L.P method to support pre-boot login on computer systems, computer-readable media and computer system
CN104530052A (en) * 2008-06-10 2015-04-22 普莱希科公司 5H-Pyrrolo [2,3-B] pyrazine derivatives for kinase modulation, and indications therefor
WO2010014617A1 (en) 2008-07-28 2010-02-04 University Of Kansas Heat shock protein 90 inhibitor dosing methods
US8299275B2 (en) 2008-08-04 2012-10-30 Dsm Ip Assets B.V. Process for producing carnosol from carnosic acid using hydrogen peroxide or peracids
WO2010019965A1 (en) 2008-08-15 2010-02-18 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods for modulating epsilon protein kinase c-mediated cytoprotection
US20110230551A1 (en) 2008-09-15 2011-09-22 Leslie Gunatilaka Withaferin a analogs and uses thereof
CN102227221A (en) 2008-11-28 2011-10-26 诺瓦提斯公司 Pharmaceutical combination containing hsp90 inhibitor and mtor inhibitor
WO2010117425A1 (en) 2009-03-31 2010-10-14 Biogen Idec Ma Inc. Certain substituted pyrimidines, pharmaceutical compositions thereof, and methods for their use
US20130030007A1 (en) * 2010-01-07 2013-01-31 Akron Molecules Gmbh Obesity Small Molecules
US20110201587A1 (en) * 2010-02-16 2011-08-18 Bio Holding, Inc. Hsp90 inhibitors and methods of use
EP2536714A4 (en) 2010-02-17 2013-07-03 Il Dong Pharma A novel 5-membered heterocycle derivatives and manufacturing process thereof
CA2697887A1 (en) 2010-03-12 2011-09-12 Institut De Recherches Cliniques De Montreal Modulating and/or detecting activation induced deaminase and methods of use thereof
WO2011133659A2 (en) 2010-04-20 2011-10-27 Emory University Inhibitors of hif and angiogenesis
US9249087B2 (en) 2011-02-01 2016-02-02 The Board Of Trustees Of The University Of Illinois HDAC inhibitors and therapeutic methods using the same
US8598339B2 (en) 2011-02-01 2013-12-03 University Of Kansas Withanolide isolated from Physalis longifolia and analogs and methods of use thereof
US8685966B2 (en) 2011-04-08 2014-04-01 University Of Kansas GRP94 inhibitors
WO2013015661A2 (en) 2011-07-28 2013-01-31 Ildong Pharm Co.,Ltd. Novel prodrugs of 5-(2,4-dihydroxy-5-isopropylphenyl)-n-ethyl-4-(5-methyl1-1,2,4-oxadiazol-3-yl)isoxazole-3-carboxamide
EA201492184A1 (en) * 2012-05-25 2015-07-30 Берг Ллк METHODS OF TREATMENT OF METABOLIC SYNDROME BY MODULATING PROTEIN HEAT SHOCK (HSP) 90-BETA
CN102772399A (en) * 2012-08-16 2012-11-14 厦门大学 Application of gambogic acid serving as protein kinase agonist activated by 5'-ampicillin (AMP)

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