RU2536933C2 - Новое лечение острого лимфобластного лейкоза у детей - Google Patents

Новое лечение острого лимфобластного лейкоза у детей Download PDF

Info

Publication number
RU2536933C2
RU2536933C2 RU2011122827/10A RU2011122827A RU2536933C2 RU 2536933 C2 RU2536933 C2 RU 2536933C2 RU 2011122827/10 A RU2011122827/10 A RU 2011122827/10A RU 2011122827 A RU2011122827 A RU 2011122827A RU 2536933 C2 RU2536933 C2 RU 2536933C2
Authority
RU
Russia
Prior art keywords
children
mrd
acute lymphoblastic
cells
treatment
Prior art date
Application number
RU2011122827/10A
Other languages
English (en)
Russian (ru)
Other versions
RU2011122827A (ru
Inventor
Герхард ЦУГМАЙЕР
Original Assignee
Эмджен Рисерч (Мьюник)ГмбХ,
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эмджен Рисерч (Мьюник)ГмбХ, filed Critical Эмджен Рисерч (Мьюник)ГмбХ,
Publication of RU2011122827A publication Critical patent/RU2011122827A/ru
Application granted granted Critical
Publication of RU2536933C2 publication Critical patent/RU2536933C2/ru

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3061Blood cells
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46Hybrid immunoglobulins
    • C07K16/468Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
RU2011122827/10A 2008-11-07 2009-11-06 Новое лечение острого лимфобластного лейкоза у детей RU2536933C2 (ru)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US11232308P 2008-11-07 2008-11-07
US61/112,323 2008-11-07
US18329109P 2009-06-02 2009-06-02
US61/183,291 2009-06-02
US22126909P 2009-06-29 2009-06-29
US61/221,269 2009-06-29
PCT/EP2009/007969 WO2010052013A1 (en) 2008-11-07 2009-11-06 Treatment of pediatric acute lymphoblastic leukemia

Related Child Applications (1)

Application Number Title Priority Date Filing Date
RU2014141180A Division RU2677324C2 (ru) 2008-11-07 2014-10-13 Новое лечение острого лимфобластного лейкоза у детей

Publications (2)

Publication Number Publication Date
RU2011122827A RU2011122827A (ru) 2012-12-20
RU2536933C2 true RU2536933C2 (ru) 2014-12-27

Family

ID=41796119

Family Applications (3)

Application Number Title Priority Date Filing Date
RU2011122827/10A RU2536933C2 (ru) 2008-11-07 2009-11-06 Новое лечение острого лимфобластного лейкоза у детей
RU2014141180A RU2677324C2 (ru) 2008-11-07 2014-10-13 Новое лечение острого лимфобластного лейкоза у детей
RU2018144313A RU2736802C2 (ru) 2008-11-07 2018-12-14 Новое лечение острого лимфобластного лейкоза у детей

Family Applications After (2)

Application Number Title Priority Date Filing Date
RU2014141180A RU2677324C2 (ru) 2008-11-07 2014-10-13 Новое лечение острого лимфобластного лейкоза у детей
RU2018144313A RU2736802C2 (ru) 2008-11-07 2018-12-14 Новое лечение острого лимфобластного лейкоза у детей

Country Status (27)

Country Link
US (2) US20110262440A1 (enExample)
EP (4) EP2344539B1 (enExample)
JP (2) JP5798036B2 (enExample)
KR (1) KR101695329B1 (enExample)
CN (2) CN102209729B (enExample)
AU (1) AU2009313039B2 (enExample)
BR (1) BRPI0921341A2 (enExample)
CA (1) CA2742242C (enExample)
CY (3) CY1116160T1 (enExample)
DK (3) DK2918604T3 (enExample)
ES (3) ES2748126T3 (enExample)
HK (1) HK1255590B (enExample)
HR (3) HRP20150400T1 (enExample)
HU (3) HUE025452T2 (enExample)
IL (1) IL212651A (enExample)
LT (2) LT2918604T (enExample)
MX (1) MX2011002931A (enExample)
NO (1) NO2918604T3 (enExample)
NZ (1) NZ591312A (enExample)
PL (3) PL2918604T3 (enExample)
PT (3) PT2344539E (enExample)
RS (3) RS53980B1 (enExample)
RU (3) RU2536933C2 (enExample)
SG (1) SG195549A1 (enExample)
SI (3) SI2344539T1 (enExample)
SM (3) SMT201800149T1 (enExample)
WO (1) WO2010052013A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2677324C2 (ru) * 2008-11-07 2019-01-16 Эмджен Рисерч (Мьюник) Гмбх Новое лечение острого лимфобластного лейкоза у детей

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6358588A (ja) * 1986-08-29 1988-03-14 Toshiba Corp バ−コ−ド読取装置
DE10254601A1 (de) 2002-11-22 2004-06-03 Ganymed Pharmaceuticals Ag Differentiell in Tumoren exprimierte Genprodukte und deren Verwendung
ES2565439T3 (es) * 2009-01-09 2016-04-04 Oxford Biomedica (Uk) Ltd Factores
US20150231241A1 (en) * 2012-08-14 2015-08-20 Ibc Pharmaceuticals, Inc. Combination therapy for inducing immune response to disease
JOP20200236A1 (ar) 2012-09-21 2017-06-16 Regeneron Pharma الأجسام المضادة لمضاد cd3 وجزيئات ربط الأنتيجين ثنائية التحديد التي تربط cd3 وcd20 واستخداماتها
HK1209434A1 (en) * 2012-11-13 2016-04-01 Astellas Pharma Inc. Agents for treatment of claudin expressing cancer diseases
TWI635098B (zh) 2013-02-01 2018-09-11 再生元醫藥公司 含嵌合恆定區之抗體
CN103131777A (zh) * 2013-02-05 2013-06-05 南京艾迪康医学检验所有限公司 用于检测e2a-pbx融合基因相对表达量的试剂盒
WO2015121383A1 (en) 2014-02-12 2015-08-20 Michael Uhlin Bispecific antibodies for use in stem cell transplantation
TWI701042B (zh) 2014-03-19 2020-08-11 美商再生元醫藥公司 用於腫瘤治療之方法及抗體組成物
LT3149480T (lt) 2014-05-30 2019-04-25 Amgen Research (Munich) Gmbh B ląstelių pirmtakų ūmia limfoblastine leukemija (all) sergančių pacientų rizikos stratifikacijos būdas
EP3175001B1 (en) 2014-07-30 2021-02-10 Mor Research Applications Ltd. Prognostic methods and systems of treatment for acute lymphoblastic leukemia
WO2016061368A1 (en) * 2014-10-15 2016-04-21 The Children's Hospital Of Philadelphia Compositions and methods for treating b-lymphoid malignancies
SMT202000438T1 (it) 2014-11-17 2020-09-10 Regeneron Pharma Metodi per trattamento di tumore usando l'anticorpo bispecifico cd3xcd20
AU2016215110A1 (en) * 2015-02-05 2017-09-21 Stc.Unm Anti-pre-BCR antagonists and methods
PL3277725T3 (pl) 2015-03-30 2021-06-14 Regeneron Pharmaceuticals, Inc. Regiony stałe łańcucha ciężkiego o zmniejszonym wiązaniu do receptorów Fc gamma
PT3280729T (pt) 2015-04-08 2022-08-01 Novartis Ag Terapias para cd20, terapias para cd22 e terapias de combinação com uma célula que expressa o recetor de antigénio quimérico (car) para cd19
DK3298042T3 (da) * 2015-05-20 2025-02-24 Amgen Res Munich Gmbh B-celledepletering som en diagnostisk markør
KR20180087401A (ko) * 2015-12-22 2018-08-01 리제너론 파아마슈티컬스, 인크. 급성 림프아구성 백혈병을 치료하기 위한 이중특이성 항-cd20/항-cd3 항체
GB201602974D0 (en) * 2016-02-19 2016-04-06 Clube Jasper R Engineered cells & methods (1)
BR112018068628A2 (pt) * 2016-03-14 2019-07-30 Millennium Pharm Inc método de prevenção de doença do enxerto contra hospedeiro
MA45341A (fr) * 2016-06-06 2019-04-10 Hutchinson Fred Cancer Res Procédés de traitement de malignités de lymphocytes b au moyen d'une thérapie cellulaire adoptive
JP2020511462A (ja) 2016-12-03 2020-04-16 ジュノー セラピューティクス インコーポレイテッド キナーゼ阻害剤との組み合わせで治療用t細胞を使用するための方法および組成物
UY37726A (es) * 2017-05-05 2018-11-30 Amgen Inc Composición farmacéutica que comprende constructos de anticuerpos biespecíficos para almacenamiento y administración mejorados
MX2019014268A (es) 2017-06-02 2020-08-03 Juno Therapeutics Inc Artículos de manufactura y métodos para tratamiento usando terapia celular adoptiva.
US12031975B2 (en) 2017-11-01 2024-07-09 Juno Therapeutics, Inc. Methods of assessing or monitoring a response to a cell therapy
KR102083481B1 (ko) 2018-03-22 2020-03-02 강원대학교산학협력단 아연-키토산 나노 입자를 포함한 급성 림프구성 백혈병 치료용 약학조성물
LT3844189T (lt) 2018-08-31 2025-02-25 Regeneron Pharmaceuticals, Inc. Cd3/cd20 bispecifinių antikūnų dozavimo strategija, mažinanti citokinų išsiskyrimo sindromą
BR112021014255A2 (pt) * 2019-01-30 2022-01-18 Wistar Inst Molécula de ácido nucleico, composição, e, método de prevenção ou tratamento de uma doença ou distúrbio
IL322315A (en) 2019-05-14 2025-09-01 Provention Bio Inc Methods and preparations for preventing type 1 diabetes
CU20210096A7 (es) 2019-05-21 2022-06-06 Novartis Ag Moléculas de unión a cd19
TWI809286B (zh) 2019-07-05 2023-07-21 日商小野藥品工業股份有限公司 以pd-1/cd3雙特異性蛋白質所進行之血液性癌症治療
MX2022015872A (es) 2020-06-11 2023-05-16 Provention Bio Inc Metodos y composiciones para prevenir diabetes tipo 1.
IL305188A (en) 2021-02-16 2023-10-01 Childrens Health Care D/B/A Childrens Minnesota Methods for treating B-ALL by administering a pre-BCR complex antagonist
WO2023062188A1 (en) 2021-10-15 2023-04-20 Amgen Research (Munich) Gmbh Subcutaneous administration of cd19-binding t cell engaging antibodies
US20250146017A1 (en) 2023-11-06 2025-05-08 City Of Hope Methods comprising oncolytic viruses expressing cd19t and bispecific t cell engagers
WO2025137344A1 (en) 2023-12-20 2025-06-26 Bristol-Myers Squibb Company Antibodies targeting il-18 receptor beta (il-18rβ) and related methods

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007068354A1 (en) * 2005-12-16 2007-06-21 Micromet Ag Means and methods for the treatment of tumorous diseases
RU2005141512A (ru) * 2003-05-31 2007-07-20 Микромет Аг (De) Фармацевтические композиции, включающие биспецифические анти-cd3, анти-cd19 конструкции антител для лечения расстройств, связанных с b-клетками

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998008875A1 (de) * 1996-08-28 1998-03-05 Viva Diagnostika Diagnostische Produkte Gmbh Kombinationspräparationen und ihre verwendung in der immundiagnostik und immuntherapie
JP4169478B2 (ja) * 1998-04-21 2008-10-22 マイクロメット アーゲー Cd19×cd3特異的ポリペプチドおよびその使用
US8076459B2 (en) * 2003-10-16 2011-12-13 Micromet Ag Multispecfic deimmunized CD3-binders
ES2402591T3 (es) * 2006-08-14 2013-05-07 Xencor Inc. Anticuerpos optimizados que seleccionan como diana CD19
ES2582603T5 (es) * 2008-10-01 2022-12-02 Amgen Res Munich Gmbh Anticuerpos biespecíficos de cadena sencilla con especificidad por antígenos diana de alto peso molecular
RS53980B1 (sr) * 2008-11-07 2015-10-30 Amgen Research (Munich) Gmbh Tretiranje akutne limfoblastne leukemije kod dece
PL2511264T3 (pl) * 2009-01-19 2015-08-31 Abbvie Inc Środki indukujące apoptozę do leczenia raka oraz chorób immunologicznych i autoimmunologicznych
AU2010204555B2 (en) * 2009-01-19 2013-03-07 Abbvie Inc. Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
CN102459236B (zh) * 2009-05-27 2014-10-29 Abbvie公司 激酶活性的嘧啶抑制剂
CA2771984A1 (en) * 2009-09-20 2011-03-24 Abbott Laboratories Abt-263 crystalline forms and solvates for use in treating bcl-2 protein related diseases
US8840888B2 (en) * 2009-10-27 2014-09-23 Micromet Ag Dosage regimen for administering a CD19XCD3 bispecific antibody

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2005141512A (ru) * 2003-05-31 2007-07-20 Микромет Аг (De) Фармацевтические композиции, включающие биспецифические анти-cd3, анти-cd19 конструкции антител для лечения расстройств, связанных с b-клетками
WO2007068354A1 (en) * 2005-12-16 2007-06-21 Micromet Ag Means and methods for the treatment of tumorous diseases

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BARGOU et al., "Tumor regression in cancer patients by very low doses of a T cell engaging antibody", Science, 15.08.2008, vol.321, no.5891, стр. 974-976. ANDERSON et al., "G19.4(aCD3)XB43(aCD19) Monoclonal Antibody Heteroconjugate Triggers CD19 Antigen-Specific Lysis of t(4;ll) Acute Lymphoblastic Leukemia Cells by Activated CD3 Antigen-Positive Cytotoxic T Cells", Blood, 1992, Vol.80, No.11, стр. 2826-2834. JJM VAN DONGEN et al., "Standardized RT-PCR analysis of fusion gene transcripts from chromosome aberrations in acute leukemia for detection of minimal residual disease", Leukemia, 1999, 13, стр.1901-1928. MOLHOJ et al., "CD19-/CD3-bispecific antibody of the BiTE class is far superior to tandem diabody with respect to redirected tumor cell lysis", Mol Immunol. 2007, 44(8), реферат. *
При публикации сведений о выдаче патента будет использовано первоначальное описание. При публикации сведений о выдаче патента будут использованы первоначальные чертежи. . Приложения: Реферат, скорректированный экспертизой, на 1л. в 1 экз *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2677324C2 (ru) * 2008-11-07 2019-01-16 Эмджен Рисерч (Мьюник) Гмбх Новое лечение острого лимфобластного лейкоза у детей

Also Published As

Publication number Publication date
SMT201500104B (it) 2015-07-09
RU2018144313A3 (enExample) 2020-06-15
KR101695329B1 (ko) 2017-01-23
BRPI0921341A2 (pt) 2016-04-26
LT3330293T (lt) 2019-10-10
CN102209729B (zh) 2016-05-25
HK1158667A1 (en) 2012-07-20
RS53980B1 (sr) 2015-10-30
CN102209729A (zh) 2011-10-05
CY1122428T1 (el) 2021-01-27
JP5798036B2 (ja) 2015-10-21
EP3594237A1 (en) 2020-01-15
US20230235053A1 (en) 2023-07-27
PL2344539T3 (pl) 2015-07-31
HK1215258A1 (en) 2016-08-19
DK2344539T3 (en) 2015-05-04
PT2918604T (pt) 2018-03-02
ES2535257T3 (es) 2015-05-07
RS59348B1 (sr) 2019-10-31
SMT201800149T1 (it) 2018-05-02
HUE025452T2 (en) 2016-05-30
HRP20180426T1 (hr) 2018-04-20
RU2014141180A3 (enExample) 2018-06-09
EP2918604B1 (en) 2017-12-20
SMT201900546T1 (it) 2019-11-13
SI2918604T1 (en) 2018-04-30
ES2662929T3 (es) 2018-04-10
AU2009313039A1 (en) 2010-05-14
PL2918604T3 (pl) 2018-05-30
WO2010052013A1 (en) 2010-05-14
RU2018144313A (ru) 2020-06-15
IL212651A (en) 2015-03-31
HRP20191715T1 (hr) 2019-12-13
CY1116160T1 (el) 2017-02-08
KR20110091669A (ko) 2011-08-12
HRP20150400T1 (hr) 2015-05-08
US20110262440A1 (en) 2011-10-27
CN106390114A (zh) 2017-02-15
HUE046222T2 (hu) 2020-02-28
RS56989B1 (sr) 2018-05-31
DK3330293T3 (da) 2019-10-07
PT3330293T (pt) 2019-10-18
CA2742242C (en) 2023-01-10
CA2742242A1 (en) 2010-05-14
HK1255590B (en) 2020-07-10
RU2736802C2 (ru) 2020-11-20
CY1120022T1 (el) 2018-12-12
RU2677324C2 (ru) 2019-01-16
LT2918604T (lt) 2018-03-26
SI2344539T1 (sl) 2015-06-30
NZ591312A (en) 2012-09-28
EP3330293B1 (en) 2019-07-24
MX2011002931A (es) 2011-04-11
PL3330293T3 (pl) 2020-02-28
PT2344539E (pt) 2015-04-01
HUE036922T2 (hu) 2018-08-28
EP2344539A1 (en) 2011-07-20
ES2748126T3 (es) 2020-03-13
IL212651A0 (en) 2011-07-31
SG195549A1 (en) 2013-12-30
RU2014141180A (ru) 2016-05-10
JP2012508163A (ja) 2012-04-05
AU2009313039B2 (en) 2015-06-18
EP2918604A1 (en) 2015-09-16
DK2918604T3 (en) 2018-03-19
NO2918604T3 (enExample) 2018-05-19
SI3330293T1 (sl) 2019-10-30
EP3330293A1 (en) 2018-06-06
JP2015232023A (ja) 2015-12-24
RU2011122827A (ru) 2012-12-20
JP6130451B2 (ja) 2017-05-17
EP2344539B1 (en) 2015-02-11

Similar Documents

Publication Publication Date Title
RU2536933C2 (ru) Новое лечение острого лимфобластного лейкоза у детей
US20240109964A1 (en) Treatment of acute lymphoblastic leukemia
HK1255590A1 (en) Treatment of pediatric acute lymphoblastic leukemia with bispecific antibodies against cd3xcd19
HK40022438A (en) Treatment of pediatric acute lymphoblastic leukemia
HK1215258B (en) Treatment of pediatric acute lymphoblastic leukemia
HK1158667B (en) Treatment of pediatric acute lymphoblastic leukemia

Legal Events

Date Code Title Description
HZ9A Changing address for correspondence with an applicant