CA2742242C - Treatment of pediatric acute lymphoblastic leukemia with a cd19xcd3 bispecific single chain antibody - Google Patents
Treatment of pediatric acute lymphoblastic leukemia with a cd19xcd3 bispecific single chain antibody Download PDFInfo
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- CA2742242C CA2742242C CA2742242A CA2742242A CA2742242C CA 2742242 C CA2742242 C CA 2742242C CA 2742242 A CA2742242 A CA 2742242A CA 2742242 A CA2742242 A CA 2742242A CA 2742242 C CA2742242 C CA 2742242C
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- single chain
- pediatric
- chain antibody
- bispecific single
- cd19xcd3 bispecific
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- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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- C—CHEMISTRY; METALLURGY
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| EP3594237A1 (en) * | 2008-11-07 | 2020-01-15 | Amgen Research (Munich) GmbH | Treatment of pediatric acute lymphoblastic leukemia |
| WO2010079339A2 (en) * | 2009-01-09 | 2010-07-15 | Oxford Biomedica (Uk) Limited | Factors |
| US20150231241A1 (en) * | 2012-08-14 | 2015-08-20 | Ibc Pharmaceuticals, Inc. | Combination therapy for inducing immune response to disease |
| JOP20200236A1 (ar) | 2012-09-21 | 2017-06-16 | Regeneron Pharma | الأجسام المضادة لمضاد cd3 وجزيئات ربط الأنتيجين ثنائية التحديد التي تربط cd3 وcd20 واستخداماتها |
| BR112015010740B1 (pt) * | 2012-11-13 | 2024-01-30 | Biontech Ag | Agentes para tratamento de doenças cancerosas expressando claudina |
| TWI635098B (zh) | 2013-02-01 | 2018-09-11 | 再生元醫藥公司 | 含嵌合恆定區之抗體 |
| CN103131777A (zh) * | 2013-02-05 | 2013-06-05 | 南京艾迪康医学检验所有限公司 | 用于检测e2a-pbx融合基因相对表达量的试剂盒 |
| EP3105252B1 (en) | 2014-02-12 | 2019-07-24 | Michael Uhlin | Bispecific antibodies for use in stem cell transplantation |
| TWI701042B (zh) | 2014-03-19 | 2020-08-11 | 美商再生元醫藥公司 | 用於腫瘤治療之方法及抗體組成物 |
| PL3531133T3 (pl) | 2014-05-30 | 2024-01-29 | Amgen Research (Munich) Gmbh | Stratyfikacja ryzyka u pacjentów z ostrą białaczką limfoblastyczną z prekursorów b |
| EP3175244A4 (en) * | 2014-07-30 | 2018-06-13 | Mor Research Applications Ltd. | Compositions for treatment of acute lymphoblastic leukemia and methods of use thereof |
| WO2016061368A1 (en) * | 2014-10-15 | 2016-04-21 | The Children's Hospital Of Philadelphia | Compositions and methods for treating b-lymphoid malignancies |
| LT3699198T (lt) | 2014-11-17 | 2025-05-12 | Regeneron Pharmaceuticals, Inc. | Būdai navikams gydyti naudojant cd3×cd20 bispecifinį antikūną |
| US10988533B2 (en) | 2015-02-05 | 2021-04-27 | Unm Rainforest Innovations | Anti-pre-BCR antagonists and methods |
| EP3277725B1 (en) | 2015-03-30 | 2020-11-25 | Regeneron Pharmaceuticals, Inc. | Heavy chain constant regions with reduced binding to fc gamma receptors |
| HUE059218T2 (hu) | 2015-04-08 | 2022-11-28 | Novartis Ag | CD20-terápiák, CD22-terápiák és kombinációs terápiák CD19 kiméra antigénreceptort (CAR-t) expresszáló sejttel |
| LT3298042T (lt) | 2015-05-20 | 2025-02-10 | Amgen Research (Munich) Gmbh | B-ląstelių naikinimas kaip diagnostinis žymuo |
| EP3394102A1 (en) * | 2015-12-22 | 2018-10-31 | Regeneron Pharmaceuticals, Inc. | Bispecific anti-cd20/anti-cd3 antibodies to treat acute lymphoblastic leukemia |
| GB201602974D0 (en) * | 2016-02-19 | 2016-04-06 | Clube Jasper R | Engineered cells & methods (1) |
| MX2018011169A (es) * | 2016-03-14 | 2018-12-06 | Millennium Pharm Inc | Metodo para prevenir la enfermedad del injerto contra huesped. |
| MA45341A (fr) * | 2016-06-06 | 2019-04-10 | Hutchinson Fred Cancer Res | Procédés de traitement de malignités de lymphocytes b au moyen d'une thérapie cellulaire adoptive |
| WO2018102785A2 (en) | 2016-12-03 | 2018-06-07 | Juno Therapeutics, Inc. | Methods and compositions for use of therapeutic t cells in combination with kinase inhibitors |
| UY37726A (es) * | 2017-05-05 | 2018-11-30 | Amgen Inc | Composición farmacéutica que comprende constructos de anticuerpos biespecíficos para almacenamiento y administración mejorados |
| US11413310B2 (en) | 2017-06-02 | 2022-08-16 | Juno Therapeutics, Inc. | Articles of manufacture and methods for treatment using adoptive cell therapy |
| US12031975B2 (en) | 2017-11-01 | 2024-07-09 | Juno Therapeutics, Inc. | Methods of assessing or monitoring a response to a cell therapy |
| KR102083481B1 (ko) | 2018-03-22 | 2020-03-02 | 강원대학교산학협력단 | 아연-키토산 나노 입자를 포함한 급성 림프구성 백혈병 치료용 약학조성물 |
| FI3844189T3 (fi) | 2018-08-31 | 2025-03-05 | Regeneron Pharma | Annostusstrategia, joka lieventää bispesifisten CD3/CD20-vasta-aineiden sytokiinien vapautumisoireyhtymää |
| KR20210122268A (ko) * | 2019-01-30 | 2021-10-08 | 더 위스타 인스티튜트 오브 아나토미 앤드 바이올로지 | 암 항원을 표적화하는 dna-인코딩된 이중특이적 t-세포 인게이저 및 암 치료에서 사용 방법 |
| JOP20210298A1 (ar) | 2019-05-14 | 2023-01-30 | Provention Bio Inc | طرق وتركيبات للوقاية من مرض السكري من النوع الأول |
| KR102878895B1 (ko) | 2019-05-21 | 2025-10-31 | 노파르티스 아게 | Cd19 결합 분자 및 이의 용도 |
| TWI809286B (zh) | 2019-07-05 | 2023-07-21 | 日商小野藥品工業股份有限公司 | 以pd-1/cd3雙特異性蛋白質所進行之血液性癌症治療 |
| KR20230092863A (ko) | 2020-06-11 | 2023-06-26 | 프로벤션 바이오, 인코포레이티드 | 제1형 당뇨병을 예방하기 위한 방법 및 조성물 |
| IL305188A (en) | 2021-02-16 | 2023-10-01 | Childrens Health Care D/B/A Childrens Minnesota | Methods for treating B-ALL by administering a pre-BCR complex antagonist |
| IL311714A (en) | 2021-10-15 | 2024-05-01 | Amgen Res Munich Gmbh | Subcutaneous administration of antibodies that engage CD19-binding T cells |
| WO2025101672A1 (en) | 2023-11-06 | 2025-05-15 | City Of Hope | Methods comprising oncolytic viruses expressing cd19t and bispecific t cell engagers |
| WO2025137344A1 (en) | 2023-12-20 | 2025-06-26 | Bristol-Myers Squibb Company | Antibodies targeting il-18 receptor beta (il-18rβ) and related methods |
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| AU4119397A (en) * | 1996-08-28 | 1998-03-19 | Viva Diagnostika Diagnostische Produkte Gmbh | Novel combination preparations and their use in immunodiagnosis and immunotherapy |
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| RU2005141512A (ru) * | 2003-05-31 | 2007-07-20 | Микромет Аг (De) | Фармацевтические композиции, включающие биспецифические анти-cd3, анти-cd19 конструкции антител для лечения расстройств, связанных с b-клетками |
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